... hybridoma lines) are simply called monoclonals. Monoclonal neoplasm (tumor): A single aberrant cell which has undergone ... Monoclonal plasma cell (also called plasma cell dyscrasia): A single aberrant plasma cell which has undergone carcinogenesis ... In biology, monoclonality refers to the state of a line of cells that have been derived from a single clonal origin. Thus, " ... The use of the term typically implies that there is some method to distinguish between the cells of the original population ...
... interrelationship between DRIM gene expression and cytogenetic and phenotypic characteristics in human breast tumor cell lines ... Schwirzke M, Gnirke A, Bork P, Tarin D, Weidle UH (Aug 1998). "Differential gene expression in mammary carcinoma cell lines: ... Cell. 13 (11): 4100-9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849. Goodison S, Viars C, Grazzini M, Urquidi V (2004 ... Eukaryot Cell. 3 (6): 1619-26. doi:10.1128/EC.3.6.1619-1626.2004. PMC 539036. PMID 15590835. Peng WT, Robinson MD, Mnaimneh S, ...
... ensifolia displayed a dose-dependent effect on both tumor cell lines. This may be contributed to the reported tumor motility ... and human breast adenocarcinoma cell line. The essential oil of the D. ... The cytotoxicity of the essential oil was also examined against liver hepatocellular cells, ... the potential to inhibit cell growth and proliferation, and in-vivo protective effects against juglone-induced oxidative stress ...
DNA from a rhabdomyosarcoma cell line and a fibrosarcoma cell line transformed a NIH/3T3 mouse fibroblast cell line. After ... injection into mice, tumors started to form in as little as 10 days. Next, the transforming activities of the rhabdomyosarcoma ... cells. Downregulation of RhoA in the HBE cell lines using siRNAs showed a lack of apical junction formation in contrast with ... Further DNA testing showed that the transforming sequences in the two cancer cell lines were the same, and the gene was later ...
3 arm study in subjects with first-line metastatic Stage IV non-squamous non-small-cell lung cancer. The tumors must not have ... For non-small cell lung cancer Celgene will approximately make $1.7 billion in 2027 and $550 million in 2028. OncoMed ... Phase 1a trials shows that the drug will be a durable anti-tumor response. In the Phase 1b trials shows the safety and ... Notch signaling has been implicated as a key signaling pathway in cancer stem cells. By treating patients with a combination of ...
"Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli". Cell Proliferation. 24 (2): 203- ... There are about 24,000 oxidative DNA adducts per cell in young rats and 66,000 adducts per cell in old rats. Likewise, any ... Reactive oxygen species can disrupt the function of immune cells, promoting immune evasion of leukemic cells. On the other hand ... In neuronal progenitor cells, DNA damage is associated with increased secretion of amyloid beta proteins Aβ40 and Aβ42. This ...
Although initially, Calanolide A did not show any activity against cancer cell lines in the 1980s, later experimentation in ... TPA (12-O-Tetradecanoylphorbol-13-acetate) is a tumour promoter used in biomedical research. EBV-EA is Epstein-Barr virus early ... A sample which was labelled "Burley-and-Lee-351" although showing no effect when tested against cancer cells in cultures, was ... antiproliferative and antitumor-promoting property through inhibition of TPA-induced EBV-EA activation in Raji cell lines. ...
2001). "Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line". Genes Cells. 6 (3): 237-47. doi:10.1046 ... "Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells". Biol. Cell. 98 (4): 253-63. doi: ... 2005). "Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines". Gynecol. ... 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ...
The modified virus was also found to efficiently kill human glioblastoma tumour cell lines. Alphavirus Sindbis virus ... "Recombinant Semliki forest virus infects and kills human prostate cancer cell lines and prostatic duct epithelial cells ex vivo ... The SFV virus was genetically modified with microRNA target sequences so that it only replicated in brain tumour cells and not ... in normal brain cells. The modified virus reduced tumour growth and prolonged survival of mice with brain tumours. ...
miR-744 plays a role in tumour development and growth in mouse cell lines. Its expression induces cyclin B1 expression, whilst ... Short-term overexpression of miR-744 in mouse cell lines has been seen to enhance cell proliferation, whilst chromosomal ... mIR-744 also upregulates during resveratrol treatment of MCF7 breast cancer cells. MicroRNA Huang V, Place RF, Portnoy V, Wang ... "Abated microRNA-195 expression protected mesangial cells from apoptosis in early diabetic renal injury in mice". Journal of ...
... which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely ... Rivenbark AG, Jones WD, Coleman WB (2007). "DNA methylation-dependent silencing of CST6 in human breast cancer cell lines". Lab ... 2006). "The candidate tumor suppressor CST6 alters the gene expression profile of human breast carcinoma cells: down-regulation ... 2004). "Cystatin M suppresses the malignant phenotype of human MDA-MB-435S cells". Oncogene. 23 (12): 2206-15. doi:10.1038/sj. ...
In many organisms, including humans, miRNAs are linked to the formation of tumors and dysregulation of the cell cycle. Here, ... "RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines". Cancer Gene Therapy ... Lian S, Jakymiw A, Eystathioy T, Hamel J, Fritzler M, Chan E (2006). "GW bodies, microRNAs and the cell cycle". Cell Cycle. 5 ( ... RNAi is a valuable research tool, both in cell culture and in living organisms, because synthetic dsRNA introduced into cells ...
... whole necrotic or apoptotic tumor cells, tumor cell lysates and DC-fused with tumor cells. An advantage to using tumor cell ... usually from cancer cell lines. "What Is Cancer?". National Cancer Institute. 2007-09-17. Retrieved 2019-04-15. Anand P, ... Dendritic cells (DCs) are considered the most potent APC (antigen presenting cell) of the immune system. DC cells have a unique ... Autologous tumor cell vaccines These vaccines are made from antigens taken from the patient's own cancer cells. Autologous ...
Remarkably, one CTC line-isolated long before the appearance of brain metastasis in patient-was highly competent to generate ... while larger rare cells, including circulating tumor cells and fetal cells get caught. Trapped cells can either be ... propidium excluding EpCAM positive cells are counted as potential tumor cells. Only living cells can grow into tumors, ... A circulating tumor cell (CTC) is a cell that has shed into the vasculature or lymphatics from a primary tumor and is carried ...
March 2006). "Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and ... Zhou L, Wei X, Cheng L, Tian J, Jiang JJ (March 2007). "CD133, one of the markers of cancer stem cells in Hep-2 cell line". The ... Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. Stem cells can ... 2005). "Somatic stem cell marker prominin-1/CD133 is expressed in embryonic stem cell-derived progenitors". Stem Cells. 23 (6 ...
... the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines". Proc. Natl. Acad. Sci. U.S.A. 89 (5 ... and the opposing ephrin-bearing cell ("reverse" signaling) following cell-cell contact, which is known as bi-directional ... The ability of Ephs and ephrins to mediate a variety of cell-cell interactions places the Eph/ephrin system in an ideal ... Genander M, Frisén J (October 2010). "Ephrins and Eph receptors in stem cells and cancer". Curr. Opin. Cell Biol. 22 (5): 611-6 ...
"Proto-oncogene WNT10B is up-regulated by tumor necrosis factor alpha in human gastric cancer cell line MKN45". Int. J. Oncol. ... Cell. 4 (12): 1267-75. doi:10.1091/mbc.4.12.1267. PMC 275763. PMID 8167409. Bergstein I, Eisenberg LM, Bhalerao J, et al. (1998 ... Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". ... These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate ...
"Inhibitory Effects of Naringenin on Tumor Growth in Human Cancer Cell Lines and Sarcoma S-180-Implanted Mice". Biological and ... Naringenin has also been shown to reduce hepatitis C virus production by infected hepatocytes (liver cells) in cell culture. ... This seems to be secondary to naringenin's ability to inhibit the secretion of very-low-density lipoprotein by the cells. The ... Mucsi, I.; Prágai, B. M. (1985-07-01). "Inhibition of virus multiplication and alteration of cyclic AMP level in cell cultures ...
... has similar activity on small cell lung cancer (SCLC) cell lines and has entered clinical trials. While clinical responses with ... in patients with small-cell lung cancer and other solid tumors". Journal of Clinical Oncology. 29 (7): 909-16. doi:10.1200/JCO. ... In healthy tissue, these antibodies react with B-cells in the mantle zone, as well as some T-cells. However, positive cells ... of apoptotic signals and causes single-agent-mechanism-based killing of cells in small-cell lung carcinoma and lymphoma lines.[ ...
... and flavopiridol limiting tumor growth in vitro. The HCT116 cell line was found to have two variations; one with a large ... HCT116 is a human colon cancer cell line used in therapeutic research and drug screenings. HCT116 cells have a mutation in ... The cell line has been used in tumorigenicity studies, along with other research that has shown that Cyclin D1 holds large ... Cellosaurus entry for HCT116 v t e v t e (Human cell lines, Colorectal cancer, All stub articles, Oncology stubs, Genetics ...
... a Putative Mammalian Homeotic Gene Differentially Expressed in Small Cell Lung Carcinoma and Neuroendocrine Tumor Cell Line". ... "High delta-like 1 expression in a subset of neuroblastoma cell lines corresponds to a differentiated chromaffin cell type". ... EntrezGene 8788 Wang Y, Sul HS (2009). "Pref-1 Regulates Mesenchymal Cell Commitment and Differentiation through Sox9". Cell ... "Retroviral mediated expression of the human myeloid nuclear antigen in a null cell line upregulatesDlk1 expression". Journal of ...
These studies led to the potent anti-tumor agent plinabulin, which is active in multidrug-resistant (MDR) tumor cell lines. ... Phenylahistin is a microtubule binding agent that exhibits cytotoxic activities against a wide variety of tumor cell lines. A ... A new mammalian cell cycle inhibitor produced by aspergillus ustus". Bioorganic & Medicinal Chemistry Letters. 7 (22): 2847- ... in-vitro evidence for activity as a tumor vascular-disrupting agent". Anticancer Drugs. 17 (1): 25-31. doi:10.1097/01.cad. ...
... the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines". Proc Natl Acad Sci U S A. 89 (5): ... from a human pre-B cell line". J Biol Chem. 267 (5): 3262-7. doi:10.1016/S0021-9258(19)50725-6. PMID 1737782. Wicks IP, ... Eph Nomenclature Committee". Cell. 90 (3): 403-4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020. S2CID 26773768. Lackmann M, ... "Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro". Eur. J. Neurosci. 10 (5 ...
Optimizations of mammalian cell cultures have led to increase the yield of antibodies from HEK293 or CHO cell lines to over 12g ... "A bispecific diabody that mediates natural killer cell cytotoxicity against xenotransplantated human Hodgkin's tumors". Blood. ... The hybridoma cell lines, which produced large quantities of relatively pure and predictable antibodies was first introduced in ... In comparison to antibodies derived from hybridoma cell lines the recombinant antibodies do not cause immunogenicity, the ...
OSM-induced biological effects on breast tumor- derived cell lines were specifically mediated through the gp130/OSMRB complex. ... OSMR is widely expressed across non-haematopoietic, hepatocytes, mesothelial cells, glial cells and epithelial cell types ... Underhill-Day N, Heath JK (November 2006). "Oncostatin M (OSM) cytostasis of breast tumor cells: characterization of an OSM ... the OSM receptor (OSMR) is overexpressed in cervical squamous cell carcinomas and, independent of tumor stage, is associated ...
... A-C exhibits cytotoxicity against human colon tumor cell line HCT-116 with IC50 value of 0.5 µg/mL. Aciculitin D ... exhibits cytotoxicity against human colon tumor cell line HCT-116 with IC50 value of 0.51 µM. Aciculitin D also exhibits ... cytotoxicity against HeLa, human cervical cells with IC50 value of 0.57 µM. Otero‐Gonzáiez, Anselmo Jesus; Magalhães, Beatriz ...
"Arctigenin Anti-Tumor Activity in Bladder Cancer T24 Cell Line Through Induction of Cell-Cycle Arrest and Apoptosis". The ...
"The study of anti-tumor effect of Tetrandrine combined with Nedaplatin on human liver cancer cell line 7402". Zhong Yao Cai = ... "Proteomic analysis of anti-tumor effects by tetrandrine treatment in HepG2 cells". Phytomedicine. 17 (13): 1000-1005. doi: ... Tetrandrine has also been shown to inhibit entry of Ebola virus into host cells in vitro and showed therapeutic efficacy ... It inhibits the degranulation of mast cells. It has a quinidine-like anti-arrhythmic effect. It has vasodilatory properties and ...
"Tumor self-seeding by circulating cancer cells". Cell. 139 (7): 1315-26. doi:10.1016/j.cell.2009.11.025. PMC 2810531. PMID ... Human cell lines can be used to model disease but it is difficult to study processes at the tissue level, within an organ or ... Metastasis is a process of migration of tumour cells from the primary cancer site to a distant location where the cancer cells ... In the absence of specific markers for mammary cells, models with genetic marking of tumor cells gives the best experimental ...
... experimental metastatic activities differentiate primary tumor-derived vs metastasis-derived mouse prostate cancer cell lines ... renal cell cancer and urothelial (transitional cell) cancer affecting the kidneys and bladder, with special focus on the use of ... February 2003). "IFN-gamma sensitization of prostate cancer cells to Fas-mediated death: a gene therapy approach". Mol. Ther. 7 ... Solomon Silver Award in Clinical Medicine, Mount Sinai School of Medicine Autologous PAP-loaded dendritic cell vaccine (APC8015 ...
... was found to be a potent inhibitor of tumor cell growth in several MDR cancer cell lines. (+)-discodermolide ... and A549 cells exhibited moderated to high levels of β-galactosidase activity in all four cell lines. The β-galactosidase ... Hyper-stabilization of the mitotic spindle causes cell cycle arresting at G2 and M phase and eventually leads to cell death by ... Cells resume normal cycling within 48 hours after removal of (+)-discodermolide from the cell culture medium. (+)- ...
Cell culture studies in mice and human microglia lines also find increased C/EBPβ activity associated with pathogenic ... A Previously Unrecognized Tumor Suppressor that Limits the Oncogenic Potential of Pancreatic Ductal Adenocarcinoma Cells". ... Moreover, ectopic expression of C/EBPα in various fibroblast cell lines promotes adipogenesis. C/EBPα probably promotes ... C/EBPβ plays a role in neuronal differentiation, in learning, in memory processes, in glial and neuronal cell functions, and in ...
The rabbit formed a myeloma-like tumor, allowing the isolation of a plasmacytoma cell line, named 240E-1. Fusion of 240E-1 ... A rabbit hybridoma is a hybrid cell line formed by the fusion of an antibody producing rabbit B cell with a cancerous B-cell ( ... a new cell line named 240E-W, was identified and which expressed better fusion efficiency and stability. Cell line 240E-W has ... After immunization, B-cells are fused with a candidate rabbit fusion partner cell line to form hybridomas. Resulting antibodies ...
B16 melanoma is a murine tumor cell line used for research as a model for human skin cancers. B16 cells are useful models for ... Over time, cells in that line injected into the skin would almost always become lung tumors. The same directed etiology, ... Microscopic: tumor cells polyhedral or spindle-shaped, arranged in perivascular mantles and diffuse masses; some cells contain ... Tumor cells from lungs, for instance, would be harvested from a deceased mouse and transplanted into another mouse's skin, and ...
... which are typical of the tumor microenvironment. CRISPR-Cas9 inactivation of C11orf53 in an acute myeloid leukemia cell line ... "The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis". Developmental Cell. 55 (4): 387- ... lowers the expression of C11orf53 has been observed in the colonic mucosal cells immediately adjacent to colon cancer tumors. ... July 2019). "The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells". Cancer Discovery ...
This gene was found to be expressed in brain, colon tissues, and several different tumor-derived cell lines. The biological ... Cell. Biol. 21 (4): 1077-88. doi:10.1128/MCB.21.4.1077-1088.2001. PMC 99562. PMID 11158295. Cong F, Spencer S, Côté JF, et al ... Cell. Proteomics. 4 (9): 1240-50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569. Tao WA, Wollscheid B, O'Brien R, et al. (2005 ... Cell. 6 (6): 1413-23. doi:10.1016/S1097-2765(00)00138-6. PMID 11163214. Wise CA, Gillum JD, Seidman CE, et al. (2003). " ...
Antioxidant activity and antiproliferative action of methanolic extract of Geum quellyon Sweet roots in human tumor cell lines ...
... cancer models have found that a high expression of lymphotoxin can lead to increased growth of tumors and cancerous cell lines ... Lymphotoxin has cytotoxic properties that can aid in the destruction of tumor cells and promote the death of cancerous cells. ... "Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell ... expressed on T cells, dendritic cells, macrophages, and epithelial cells. There is also evidence that LTα3 signaling through ...
This proto-oncogene, highly expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase ... Among the top 20 receptor tyrosine kinases identified in this analysis, 15 were identified in both cell lines and tumors, and ... Gene rearrangements involving the ROS1 gene were first detected in glioblastoma tumors and cell lines. In 2007 a ROS1 ... Ceritinib is US FDA approved for first line treatment of ALK+ metastatic non-small cell lung cancer. TPX-0005 preclinical data ...
Cancer stem cells (CSCs) constitute a small proportion of the tumor, usually between 1 and 5%. But they are essential for tumor ... Cell lines and colon cancer tissues with K-Ras mutations all had significantly higher levels of GAST mRNA than wild type K-Ras ... Its expression has also been demonstrated in ovarian cancers, liver tumors and pancreatic tumors. Thus, several types of tumors ... decreased tumor burden and increased cell differentiation in the remaining tumors in transgenic mice developing Wnt-induced ...
"Distinct p53-independent apoptotic cell death signalling pathways in testicular germ cell tumour cell lines". International ... which occur frequently in solid tumors, and can contribute to tumor evolution through altered gene expression. Hamster cell ... Re-expression of the wild-type gene in cancer cells in vitro has been shown to inhibit cell proliferation, induce cell cycle ... Such damage will trigger programmed cell death (e.g. apoptosis) in cancer cells. Cisplatin resistance occurs when cancer cells ...
... the invasion of cancer cells into the lymphatic system). In vitro, when breast tumour cell lines with endothelins are ... resulting in increased expression of ET-2 by breast tumour cells. This increased ET-2 expression provides the tumour with ... Grimshaw MJ (May 2005). "Endothelins in breast tumour cell invasion". Cancer Letters. 222 (2): 129-38. doi:10.1016/j.canlet. ... The breast tumour microenvironment is particularly hypoxic which allows it to modulate the expression of numerous 'pro-tumour' ...
With RT-PCR and Northern blot techniques, they detected the expression of BASE RNA in several breast cancer cell lines but not ... In particular, BASE/BPIFA4P expression was present in tumors with high levels of ERα estrogen receptor but not in tumors with ... However, a non-functional protein does appear; it known as BASE protein, secreted by breast cancer cell lines and salivary ... researchers at the National Cancer Institute discovered in 2003 a previously uncharacterized gene in breast cancer cell lines. ...
DCC's role as a tumour suppressor is tied to its dependence receptor characteristics. DCC induces cell death on epithelial ... Researchers found that addition of DCC to an immortalized cell line suppressed tumorigenicity rather definitively. However no ... In head and neck squamous cell carcinoma, 77.3% of tumour samples presented DCC promoter hypermethylation versus 0.8% in non- ... The division of these cells occurs at the base of villi, and cells are pushed upwards by subsequent divisions to the tip where ...
In addition some cisplatin resistant tumour cell lines were sensitive to satraplatin treatment in vitro. This may be due to an ... "Phase I study of JM-216 with concurrent radiation in non-small cell lung cancer and squamous cell head and neck cancer". Proc ... This unfortunately happens to not only cancer cells but other regular functioning cells as well causing some of the harsh side ... The proposed mode of action is that the compound binds to the DNA of cancer cells rendering them incapable of dividing. The ...
This transcript was found to be aberrantly expressed in many breast tumour cells lines and breast tumours. Transgenic mice ... Transcription and cell-based assays demonstrated a role for p110 CUX1 in stimulating cell cycle progression and cell ... Cell Cycle 2004, 3(8):986-9. Michl P, and Downward J. "CUTL1: a key mediator of TGFbeta-induced tumor invasion". Cell Cycle ... CUX1 knockdown delays DNA repair in multiple cell lines. Mouse embryo fibroblasts (MEFs) derived from a Cux1-/- knockout mouse ...