... was shown in 2014 to be viable cell line for tumor xenografts in C57BL/6 nude mice,[35] and was subsequently used to ... is an immortal cell line used in scientific research. It is the oldest and most commonly used human cell line.[1] The line was ... and isolated one specific cell, multiplied it, and developed a cell line. Previously, cells cultured from other human cells ... Many cell lines were cross-contaminated during establishment; this means that all work using those cell lines has incorrectly ...
NCI-60 Human Tumor Cell Lines ScreenEdit. The evolution of strategies at the National Cancer Institute (NCI) illustrates the ... In the Molecular Target Program thousands of molecular targets have been measured in the NCI panel of 60 human tumor cell lines ... Those passing certain thresholds are subjected to a 5 dose screen of the same 60 cell-line panel to determine a more detailed ... Under the label "Discovery & Development Services" several services are offered, among them the NCI-60 human cancer cell line ...
"Genetic analysis of BRCA1 function in a defined tumor cell line". Molecular Cell. 4 (6): 1093-9. doi:10.1016/S1097-2765(00) ... "Genetic analysis of BRCA1 function in a defined tumor cell line". Molecular Cell. 4 (6): 1093-9. doi:10.1016/S1097-2765(00) ... Inhibiting cancer cells' BRCA1/BARD1 heterodimer from relocating to DNA damage sites would induce tumor cell death rather than ... cell nucleus. • nucleoplasm. • nuclear speck. • cytoplasmic ribonucleoprotein granule. Biological process. • regulation of ...
... "mRNA expression of tumor-associated antigens in melanoma tissues and cell lines". Experimental Dermatology. 11 (4): 292-301. ... Yan M, Ghorab Z, Nadji M (June 2003). "Renal cell carcinoma antigen is expressed by yolk sac tumors and yolk sac elements of ... Genes to Cells. 4 (5): 299-309. doi:10.1046/j.1365-2443.1999.00261.x. PMID 10421840. "Entrez Gene: RAGE renal tumor antigen". ... "Generation of RAGE-1 and MAGE-9 peptide-specific cytotoxic T-lymphocyte lines for transfer in patients with renal cell ...
"Phosphorylation of pyruvate kinase and glycolytic metabolism in three human glioma cell lines". Tumour Biology. 12 (6): 339-352 ... In tumor cells, PKM2 is mainly in the dimeric form and has, therefore, been termed Tumor M2-PK. The quantification of Tumor M2- ... such as normal proliferating cells, embryonic cells, and especially tumor cells. Two isozymes are encoded by the PKM gene: PKM1 ... which are greatly needed by highly proliferating cells, such as tumor cells. Due to the key position of pyruvate kinase within ...
Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been ... Tumor suppressor candidate 3 is a protein that in humans is encoded by the TUSC3 gene. This gene is a candidate tumor ... "Entrez Gene: TUSC3 tumor suppressor candidate 3". Pak BJ, Park H, Chang ER, et al. (1998). "Differential display analysis of ... Cell. 12 (1): 101-11. doi:10.1016/S1097-2765(03)00243-0. PMID 12887896. Anderson NL, Polanski M, Pieper R, et al. (2004). "The ...
"NCI-60 DTP Human Tumor Cell Line Screen". Developmental Therapeutics Program, National Cancer Institute. Archived from the ... "60-cell line screen" The complete chemical synthesis of halichondrin B was achieved by Yoshito Kishi and colleagues at Harvard ... these authors also reported the exquisite anticancer activity of halichondrin B against murine cancer cells both in culture and ...
ARK5 is often overexpressed in multiple myeloma cell lines. ARK5 promotes tumor cell survival under regulation by Akt. ARK5 ... also inhibits ARK5 and reduces proliferation of multiple myeloma and mantle cell lymphoma cell lines. NUAK1 has been shown to ... 2004). "ARK5 is a tumor invasion-associated factor downstream of Akt signaling". Mol. Cell. Biol. 24 (8): 3526-35. doi:10.1128/ ... Suzuki A, Kusakai G, Kishimoto A, Lu J, Ogura T, Esumi H (Sep 2003). "ARK5 suppresses the cell death induced by nutrient ...
Expression of IL-10 from transfected tumor cell lines. in IL-10 transgenic mice. or dosing with IL-10 leads to control of ... mast cells, CD4+CD25+Foxp3+ regulatory T cells, and in a certain subset of activated T cells and B cells. IL-10 can be produced ... In melanoma cell lines, IL-10 modules the surface expression of NKG2D ligands. Knockout studies in mice suggested the function ... it is also stimulatory towards certain T cells (Th2) and mast cells and stimulates B cell maturation and antibody production. ...
"A human pituitary tumor-derived folliculo-stellate cell line". J Clin Endocrinol Metab. 85: 1180-1187. doi:10.1210/jc.85.3.1180 ... This tumor is thought to be derived from the parenchymal cells of the posterior lobe of the pituitary gland, called pituicytes ... Some researchers believe that they arise from the folliculostellate cells in the anterior lobe of the pituitary. As such, it is ... Inoue K, Couch EF, Takano K, Ogawa S (1999). "The structure and function of folliculo-stellate cells in the anterior pituitary ...
"Isolation and characterization of spheroid cells from human malignant melanoma cell line WM-266-4". Tumour Biol. 30 (5-6): 300- ... Wang Q, Chen ZG, Du CZ, Wang HW, Yan L, Gu J (2009). "Cancer stem cell marker CD133+ tumour cells and clinical outcome in ... CD133 is expressed in hematopoietic stem cells, endothelial progenitor cells, glioblastoma, neuronal and glial stem cells, ... "CD133+ negative glioma cells form tumors in nude rats and give rise to CD133+ positive cells". Int J Cancer. 122 (4): 761-768. ...
... expressing tumor cell lines suggesting that ALOX5 acts as a pro-malignancy factor for them and by extension their parent tumors ... In skin, Langerhans cells strongly express ALOX5. Fibroblasts, smooth muscle cells and endothelial cells express low levels of ... these tumors and cell lines include those of the pancreas, prostate and colon. ALOX5 products, particularly 5- ... mast cells, dendritic cells, and B-lymphocytes express ALOX5. Platelets, T cells, and erythrocytes are ALOX5-negative. ...
Most of the available breast cancer cell lines issued from metastatic tumors, mainly from pleural effusions. Effusions provided ... Breast cancer cell lines[edit]. See also: List of breast cancer cell lines ... viable tumor cells with little or no contamination by fibroblasts and other tumor stroma cells. Many of the currently used BCC ... In cancer, the cells that would normally line up in an orderly way to make up the milk ducts become disorganized. Cell division ...
"Expression and regulation of CD97 in colorectal carcinoma cell lines and tumor tissues". The American Journal of Pathology. 161 ... cell-cell signaling. • G-protein coupled receptor signaling pathway. • cell surface receptor signaling pathway. • movement of ... Several treatments reduce CD97 expression in tumor cells such as cytokine tumor growth factor (TGF)β as well as the compounds ... immune cells, epithelial cells, muscle cells as well as their malignant counterparts.[12][13][14][15][16][17] In the case of ...
... the cysts are lined by tall mucin-producing cells. These are the tumor cells. The tumor cells "sit" on ovarian-type stroma. ... This means that these tumors make mucin (a thick sticky fluid), they do not arise in the larger pancreatic ducts, and they have ... Pancreatic mucinous cystic neoplasm, also mucinous cystic neoplasm of the pancreas and mucinous cystic tumour, is a grouping of ... Some mucinous cystic neoplasms are confined to the tumor. These are designated using various names including "mucinous cystic ...
The anti-tumor activity of withaferin A was tested on human prostate cancer cell line, PC-3 and confirmed in PC-3 xenografts in ... "Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves". Life Sciences. 74 (1): 125-132. ... It has been suggested that sensitization of cancer cells to radiation is due to the inhibition of NF-κB. It exhibits anti-tumor ... Withaferin A has been shown to enhance radiation-induced apoptosis in certain cell lines. However, its mechanism of action on ...
Sep 2003). "Protein profiles of medulloblastoma cell lines DAOY and D283: identification of tumor-related proteins and ... Sep 2016). "Top-down proteomic characterization of DAOY medulloblastoma tumor cell line". EuPA Open Proteomics. 12: 13-21. ... DAOY is a widely used human primary medulloblastoma cell line. It has epithelial morphology and was obtained from a 4-year-old ... Srivastava VK, Nalbantoglu J (Oct 2008). "Flow cytometric characterization of the DAOY medulloblastoma cell line for the cancer ...
It also has strong cytotoxicity against various tumor cell lines. Because of its potent biological activities, kendomcyin has ...
The widely used angiotensin-II-responsive steroid-producing cell line H295R was originally isolated from a tumor diagnosed as ... On microscopic examination, the tumor usually displays sheets of atypical cells with some resemblance to the cells of the ... Wang T, Rainey WE (2012). "Human Adrenocortical Carcinoma Cell Lines". Mol. Cell. Endocrinol. 351 (1): 58-65. doi:10.1016/j.mce ... Adrenocortical adenoma Renal cell carcinoma Adrenal medullary tumors Hepatocellular carcinoma The only curative treatment is ...
Tumors or cell lines harboring this genetic lesion are not responsive to EGFR inhibitors. Although KRAS amplification is an ... homeostasis of number of cells within a tissue. • striated muscle cell differentiation. • Ras protein signal transduction. • ... When it functions normally, it controls cell proliferation. When it is mutated, negative signalling is disrupted. Thus, cells ... "Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells". Science. 325 (5947): 1555-9. doi: ...
Notably, a recent survey of cellular senescence induced by multiple treatments to several cell lines does not identify p16 as ... This gene is frequently mutated or deleted in a wide variety of tumors and is known to be an important tumor suppressor gene. ... Homozygous deletion of p16 are frequently found in esophageal cancer and gastric cancer cell lines. Germline mutations in ... p16 plays an important role in cell cycle regulation by decelerating cells progression from G1 phase to S phase, and therefore ...
It is produced by certain tumor cell lines and by macrophages. This chemokine is located on chromosome 17 in humans, in a large ... Van Damme J, Proost P, Lenaerts JP, Opdenakker G (1992). "Structural and functional identification of two human, tumor-derived ... 1999). "Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling". J. ... 1997). "Expression of monocyte chemotactic protein-3 in human monocytes and endothelial cells". Eur. Cytokine Netw. 8 (3): 271- ...
... near the promoters of tumor suppressor genes have been documented in specific tumor cell lines. In the case of the tumor ... In both human normal and tumor cell lines, YPEL3 has been shown to be a p53-inducible gene. Two putative p53 binding sites have ... YPEL3 has growth inhibitory effects in normal and tumor cell lines. One of five family members (YPEL1-5), YPEL3 was named in ... Campisi J (2005). "Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors". Cell. 120 (4): 513- ...
"Seven genes that are differentially transcribed in colorectal tumor cell lines". Cancer Lett. 160 (1): 37-43. doi:10.1016/S0304 ... Cell. 118 (5): 607-17. doi:10.1016/j.cell.2004.08.009. PMID 15339665. Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The ... doi:10.1016/j.cell.2006.02.020. PMID 16499958. Kalesnikoff J, Rios EJ, Chen CC, et al. (2007). "Roles of RabGEF1/Rabex-5 ... Cell. 12 (7): 2219-28. doi:10.1091/mbc.12.7.2219. PMC 55678 . PMID 11452015. de Renzis S, Sönnichsen B, Zerial M (2002). " ...
Major, E. O. (1983). "JC virus T protein expression in owl monkey tumor cell lines". Progress in clinical and biological ... Molinaro, G. A.; Major, E. O.; Bernhardt, G.; Dray, S.; Di Mayorca, G. (1977). "Similar cell surface antigens on hamster cells ... Major, E. O.; Di Mayorca, G. (1973). "Malignant Transformation of BHK21 Clone 13 Cells by BK Virus-A Human Papovavirus". ... Major, E. O.; Matsumura, P. (1984). "Human embryonic kidney cells: stable transformation with an origin-defective simian virus ...
A tumor cell line with defective δ-catenin, low levels of E-cadherin and poor cell-to-cell adhesion could be restored to normal ... F9 embryonal carcinoma cells are similar to the P19 cells shown in Figure 1 and normally have cell-to-cell adhesion mediated by ... However, decreases in this adhesion ability of the cell has been linked to metastasis and tumor progression. In normal cells, α ... "Knockdown of Sec6 improves cell-cell adhesion by increasing α-E-catenin in oral cancer cells". FEBS Lett. 586 (6): 924-33. doi: ...