Tumor metabolome
January 1998). "6-Aminonicotinamide sensitizes human tumor cell lines to cisplatin". Clinical Cancer Research. 4 (1): 117-30. ... Pyruvate kinase type M2 or PKM2 is present in embryonic, adult stem cells. It is also expressed by many tumor cells. The ... Hypoxic adaptation by cancer cells is essential for survival and progression of a tumor. In addition to cell-autonomous changes ... it gives advantage in both growth and survival of the cell. It has also been seen that metabolic phenotype of tumor cells ...
Neuroendocrine tumor
... "islet cell tumors", or "pancreatic endocrine tumors" The PanNET denomination is in line with current WHO guidelines. ... islet cell tumors of the pancreas, gastrointestinal carcinoids, Merkel cell tumors and pheochromocytoma/paraganglioma. However ... NETs include certain tumors of the gastrointestinal tract and of the pancreatic islet cells, certain thymus and lung tumors, ... Histologically, NETs are an example of "small blue cell tumors," showing uniform cells which have a round to oval stippled ...
Tumour heterogeneity
"Colorectal Cancer Cell Lines Lack the Molecular Heterogeneity of Clinical Colorectal Tumors". Clinical Colorectal Cancer. 9 (1 ... The cancer stem cell model asserts that within a population of tumour cells, there is only a small subset of cells that are ... and tumour aggression that occurs during the natural process of tumour formation. Evolution of the initial tumour cell may ... Bulk tumour sequencing can be utilized, where DNA is extracted from a mixture of tumour cells and analyzed all at once. The ...
Mouse mammary tumor virus
"Transcription profile of a human breast cancer cell line expressing MMTV-like sequences". Infectious Agents and Cancer. 1 (1): ... when expressed on the surface of B cells or other antigen-presenting cells, activates a large number of T cells by interaction ... Reuss, FU; Coffin, JM (July 1998). "Mouse mammary tumor virus superantigen expression in B cells is regulated by a central ... The resulting T-cell response in turn stimulates the infected B cells to proliferate and thus amplifies the number of virus- ...
Atypical teratoid rhabdoid tumor
There are also some emerging mouse models of the AT/RT cancer as well as experimental cell lines derived from tumors. Despite ... and Choroid Plexus Tumors Rare Tumors 3: Brain Tumors---Germ Cell Tumors, Atypical Teratoid/Rhabdoid Tumors, and Choroid Plexus ... both tumors resemble rhabdomyosarcoma[citation needed]. AT/RT Histology with numerous rhabdoid tumor cells Rhabdoid Tumor Cell ... The tissue of this tumor contains many different types of cells including the rhabdoid cells, large spindled cells, epithelial ...
Desmoplastic small-round-cell tumor
"Establishment and characterization of a novel human desmoplastic small round cell tumor cell line, JN-DSRCT-1". Laboratory ... desmoplastic small round blue cell tumor; intra-abdominal desmoplastic small round blue cell tumor; desmoplastic small cell ... "Orphanet: Desmoplastic small round cell tumor". www.orpha.net. Retrieved 17 November 2019. "Desmoplastic Small Round Cell Tumor ... In 2002, Nishio and al, established a novel human tumor cell line derived from the pleural effusion of a patient with a typical ...
Tumor of the stomach
These tumors arise from the cells of the gastric mucosa which lines the stomach. Typically, most gastric tumors are cancerous ... Within these glands are four different cell types: goblet cells, parietal cells, chief cells, and enteroendocrine cells. ... the cell will undergo apoptosis. In the case of tumors, the cells display a level of abnormal growth. In most cases, this ... In a benign tumor, the proliferated cells stay in one location where they do not impact or spread to other surrounding tissues ...
Sertoli-Leydig cell tumour
The tumour is subdivided into many different subtypes. The most typical is composed of tubules lined by Sertoli cells and ... Sertoli-Leydig cell tumour is a group of tumors composed of variable proportions of Sertoli cells, Leydig cells, and in the ... Sertoli-Leydig cell tumour (a sex-cord stromal tumor), is a testosterone-secreting ovarian tumor and is a member of the sex ... High magnification micrograph of a Leydig cell tumour. H&E stain. High magnification micrograph of a Sertoli cell tumour. H&E ...
Serous tumour
Benign tumors contain clear fluid and have a smooth lining composed of columnar epithelial cells with cilia. On gross ... A serous tumour is a neoplasm that typically has papillary to solid formations of tumor cells with crowded nuclei, and which ... Such ovarian tumors are part of the surface epithelial-stromal tumour group of ovarian tumors. They are common neoplasms with a ... The "low grade" classification of serous tumors includes benign and borderline tumors, as well as low grade malignant tumors. ...
Ovarian mucinous tumor
... this mucus is produced by mucus-secreting goblet cells very similar to the cells lining normal intestine. These tumors may ... Rarely, the tumor is seen bilaterally; approximately 5% of primary mucinous tumors are bilateral. Benign mucinous tumors are ... Mucinous tumors are part of the surface epithelial-stromal tumor group of ovarian neoplasms, and account for approximately 36% ... 10-year survival rates for mucinous tumors is excellent in the absence of invasion. In the case of borderline tumors confined ...
Doxycycline
"Effects of matrix metalloproteinase inhibitor doxycycline and CD147 antagonist peptide-9 on gallbladder carcinoma cell lines". ... tumor necrosis factor-alpha (TNF-α), and matrix metalloproteinases (MMPs) while increasing the production of anti-inflammatory ... The first-line treatment for brucellosis is a combination of doxycycline and streptomycin and the second-line is a combination ... A Comparative Study in Human Mesenchymal Stem Cells". Cells. 12 (18): 2244. doi:10.3390/cells12182244. PMC 10526833. PMID ...
CD133
"Isolation and characterization of spheroid cells from human malignant melanoma cell line WM-266-4". Tumour Biology. 30 (5-6): ... Wang Q, Chen ZG, Du CZ, Wang HW, Yan L, Gu J (September 2009). "Cancer stem cell marker CD133+ tumour cells and clinical ... CD133 is expressed in hematopoietic stem cells, endothelial progenitor cells, glioblastoma, neuronal and glial stem cells, ... "CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells". International Journal of Cancer. ...
PKM2
"Phosphorylation of pyruvate kinase and glycolytic metabolism in three human glioma cell lines". Tumour Biology. 12 (6): 339-52 ... In tumor cells, PKM2 is mainly in the dimeric form and has, therefore, been termed Tumor M2-PK. The quantification of Tumor M2- ... Thus, PKM2 is a regulator of LPS- and tumor-induced PD-L1 expression on macrophages and dendritic cells as well as tumor cells ... such as normal proliferating cells, embryonic cells, and especially tumor cells. Two isozymes are encoded by the PKM gene: PKM1 ...
RAGE (gene)
... "mRNA expression of tumor-associated antigens in melanoma tissues and cell lines". Experimental Dermatology. 11 (4): 292-301. ... Yan M, Ghorab Z, Nadji M (June 2003). "Renal cell carcinoma antigen is expressed by yolk sac tumors and yolk sac elements of ... Genes to Cells. 4 (5): 299-309. doi:10.1046/j.1365-2443.1999.00261.x. PMID 10421840. "Entrez Gene: RAGE renal tumor antigen". ... "Generation of RAGE-1 and MAGE-9 peptide-specific cytotoxic T-lymphocyte lines for transfer in patients with renal cell ...
Effector cell
... even if the cancerous tumor cells were in advanced stages. At the moment, the exact mechanism of tumor recognition in CIK cells ... They are the first line of immune defense in the CNS. Microglia are of utmost importance in brain maintenance. They constantly ... CIK cells respond to lymphokines by lysing tumorous cells that are resistant to NK cells or LAK cell activity. CIK cells show a ... A mast cell is a white blood cell. Mast cells are protective cells that are involved in wound healing and blood-brain barrier ...
List of breast cancer cell lines
Cailleau R, Young R, Olivé M, Reeves WJ Jr (1974). "Breast tumor cell lines from pleural effusions". Journal of the National ... Lasfargues EY, Coutinho WG, Redfield ES (1978). "Isolation of two human tumor epithelial cell lines from solid breast ... 2006). "A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes". Cancer Cell. 10 (6): ... "Molecular Profiling of Breast Cancer Cell Lines Defines Relevant Tumor Models and Provides a Resource for Cancer Gene Discovery ...
Endometrioid tumor
... the epithelial cells lining an endometriotic cyst within the ovary are exposed to a highly oxidative environment that promotes ... Endometrioid tumors are a class of tumor characterized by a resemblance to endometrium/ endometrial carcinoma, and over a third ... "Ovary tumor - Endometrioid tumors - General". Pathology Outlines. Archived from the original on 2020-02-16. Retrieved 2020-03- ... the tumor is cystic and may be solid and some arise in cystic endometriosis. In 40% of cases, endometrioid tumors are found ...
TUSC3
Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been ... Tumor suppressor candidate 3 is a protein that in humans is encoded by the TUSC3 gene. This gene is a candidate tumor ... "Entrez Gene: TUSC3 tumor suppressor candidate 3". Pak BJ, Park H, Chang ER, et al. (1998). "Differential display analysis of ... Cell. 12 (1): 101-11. doi:10.1016/S1097-2765(03)00243-0. PMID 12887896. Anderson NL, Polanski M, Pieper R, et al. (2004). "The ...
Halichondrin B
"NCI-60 DTP Human Tumor Cell Line Screen". Developmental Therapeutics Program, National Cancer Institute. Archived from the ... "60-cell line screen" The complete chemical synthesis of halichondrin B was achieved by Yoshito Kishi and colleagues at Harvard ... these authors also reported the exquisite anticancer activity of halichondrin B against murine cancer cells both in culture and ...
NUAK1
ARK5 is often overexpressed in multiple myeloma cell lines. ARK5 promotes tumor cell survival under regulation by Akt. ARK5 ... also inhibits ARK5 and reduces proliferation of multiple myeloma and mantle cell lymphoma cell lines. NUAK1 has been shown to ... Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. ARK5 is important in tumor ... 2004). "ARK5 is a tumor invasion-associated factor downstream of Akt signaling". Mol. Cell. Biol. 24 (8): 3526-35. doi:10.1128/ ...
Tumors of the hematopoietic and lymphoid tissues
The myeloid cell line normally produces granulocytes, erythrocytes, thrombocytes, macrophages and mast cells; the lymphoid cell ... cell tumour Interdigitating dendritic cell sarcoma Follicular dendritic cell sarcoma Fibroblastic reticular cell tumour ... NOS Germinal centre B-cell subtype Activated B-cell subtype T-cell/histiocyte-rich large B-cell lymphoma Primary DLBCL of the ... Hematological malignancies may derive from either of the two major blood cell lineages: myeloid and lymphoid cell lines. ...
Immortalised cell line
A549 cells - derived from a cancer patient lung tumor. HeLa cells - a widely used human cell line isolated from cervical cancer ... Huh7 cells - hepatocyte-derived carcinoma cell line Jurkat cells - a human T lymphocyte cell line isolated from a case of ... Cellosaurus, knowledge base of cell lines IGRhCellID, database of cell lines List of breast cancer cell lines Conditionally ... Immortalised cell lines have also found uses in biotechnology. An immortalised cell line should not be confused with stem cells ...
Schiller-Duval body
The structure is located in open cystic space also lined by tumoral cells. All those structures together are called a Schiller- ... Schiller-Duval body is a cellular structure seen by microscope in endodermal sinus tumors (yolk sac tumors) which are the most ... They have a mesodermal core with a central capillary, all lined by flattened layers of both visceral and parietal cells. ... 2022). "Yolk Sac Tumor of the Omentum: A Case Report and Literature Review". Diagnostics (Basel). 12 (2). doi:10.3390/ ...
Pituicytoma
"A human pituitary tumor-derived folliculo-stellate cell line". J Clin Endocrinol Metab. 85 (3): 1180-1187. PMID 10720059. ... This tumor is thought to be derived from the parenchymal cells of the posterior lobe of the pituitary gland, called pituicytes ... Some researchers believe that they arise from the folliculostellate cells in the anterior lobe of the pituitary. As such, it is ... Inoue K, Couch EF, Takano K, Ogawa S (1999). "The structure and function of folliculo-stellate cells in the anterior pituitary ...
HAP1 cells
... are a near-haploid cell line derived from the KBM-7 cell line. KBM-7 was found in a patient with chronic myeloid ... Chromosomal abnormalities are common in cancer cells. Due to the haploid karyotype, the tumor suppressor genes have been lost, ... HAP1 cells are derived from leukemic cells, which develop from mutated myeloid cells in the bone marrow. Healthy myeloid cells ... HAP1 cells are malignant neoplastic cells, also known as cancer cells. These cells are characterized primarily by uninhibited ...
Translationally controlled tumor protein
"Human recombinant histamine-releasing factor activates human eosinophils and the eosinophilic cell line, AML14-3D10". Blood. 96 ... TCTP is a regulator of the cancer stem cell compartment, the tumor reversion, tumor progression and certain forms of ... growth-related mouse tumor protein TCTP. TCTP was originally described as a growth related protein of tumor cells. Its mRNA ... TCTP knockdown in primary mammary tumor cells, results in increased p53 expression and a decreased number of stem-like cancer ...
Hybrid cell line
Tumor hybrid cells: fusion of tumor cells with normal bodily cells. These tend to take on new properties which make them more ... A hybrid cell line is a fusion of cells from two different cell types. When the membrane of two cells merge, the nuclei combine ... The cells will homogenate into a single cell. Hybridoma: a fusion of B-cells and immortal cancer cells with the purpose of ... of the main purposes of generating hybrid cell lines is to fuse cells that secrete a useful product with an immortal cell line ...
DAOY (biology)
Sep 2016). "Top-down proteomic characterization of DAOY medulloblastoma tumor cell line". EuPA Open Proteomics. 12: 13-21. doi: ... Sep 2003). "Protein profiles of medulloblastoma cell lines DAOY and D283: identification of tumor-related proteins and ... Cellosaurus entry for DAOY v t e (Human cell lines, All stub articles, Cell biology stubs). ... DAOY is a widely used human medulloblastoma cell line. It has epithelial morphology and was obtained from a 4-year-old ...
Kendomycin
It also has strong cytotoxicity against various tumor cell lines. Because of its potent biological activities, kendomycin has ...
CCR5
... inhibitors including maraviroc and leronlimab have been shown to block lung metastasis of human breast cancer cell lines. ... October 2015). "Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor- ... When T-cells modified so they no longer express CCR5 were mixed with unmodified T-cells expressing CCR5 and then challenged by ... Recent studies suggest that CCR5 is expressed in a subset of cancer cells with characteristics of cancer stem cells, which are ...
Fetal bovine serum
"Ethical Challenges Using Human Tumor Cell Lines in Cancer Research". Ethical Challenges in Cancer Diagnosis and Therapy. Recent ... However, the effectiveness of serum-free media is limited as many cell lines still require serum in order to grow, and many ... Fetal bovine serum is the most widely used serum-supplement for the in vitro cell culture of eukaryotic cells. This is due to ... When changing from batch to batch it is usual to adapt the cells to the new batch of material, for example, by mixing 50% of ...
Cell synchronization
... tumor cell lines are not usually able to undergo contact inhibition, though there are exceptions. Cell synchronization protocol ... maximizing cell-to-cell contact. This triggers arrest in early G1 in normal cells. Arrest is reversed by replating cells at a ... Cell synchronization is a process by which cells in a culture at different stages of the cell cycle are brought to the same ... Larger cells sediment faster, so a cell in G2, which has experienced more growth time, will sediment faster than a cell in G1 ...