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*  MCF2
"Entrez Gene: MCF2 MCF.2 cell line derived transforming sequence". Ron D, Zannini M, Lewis M, et al. (1991). "A region of proto- ... dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human ... evidence that its overexpression is sufficient to transform NIH/3T3 cells". EMBO J. 7 (8): 2465-73. PMC 457116 . PMID 3056717. ... Cell. Biol. 21 (2): 425-37. doi:10.1128/MCB.21.2.425-437.2001. PMC 86589 . PMID 11134331. Vanni C, Mancini P, Gao Y, et al. ( ...
*  MCF2L
"Entrez Gene: MCF2L MCF.2 cell line derived transforming sequence-like". Gerdin AK (2010). "The Sanger Mouse Genetics Programme ... Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9-13. doi:10.1016/j.cell.2006.12.018. PMID ... Cell. 154 (2): 452-64. doi:10.1016/j.cell.2013.06.022. PMC 3717207 . PMID 23870131. "Infection and Immunity Immunophenotyping ( ... A conditional knockout mouse line called Mcf2ltm1a(EUCOMM)Hmgu was generated at the Wellcome Trust Sanger Institute. Male and ...
*  Oncolytics Biotech
Hashiro, G; Loh, PC; Yau, JT (1977). "The preferential cytotoxicity of reovirus for certain transformed cell lines". Archives ... cells to recognize and attack cancer cells; and Adaptive immune response - antigen presenting cells (APCs) display tumor- ... Duncan, MR; Stanish, SM; Cox, DC (1978). "Differential sensitivity of normal and transformed human cells to reovirus infection ... It has since been shown to replicate specifically in cells that have an activated Ras pathway with very little effect in cells ...
*  Reolysin
Hashiro, G; Loh, PC; Yau, JT (1977). "The preferential cytotoxicity of reovirus for certain transformed cell lines". Archives ... cells to recognize and attack cancer cells; and Adaptive immune response - antigen presenting cells (APCs) display tumor- ... Duncan, MR; Stanish, SM; Cox, DC (1978). "Differential sensitivity of normal and transformed human cells to reovirus infection ... This cycle of infection, replication and cell death is believed to be repeated until all tumour cells carrying an activated Ras ...
*  William A. Haseltine
"Biological and Biochemical Characterization of an SV40 Transformed Xeroderma Pigmentosum Cell Line". Experimental Cell Research ... Pedersen, FS; Crowther RL; Hays EF; Nowinski RC; Haseltine WA (1982). "Structure of Retroviral RNAs Produced by Cell Lines ... Pedersen, FS; Crowther RL; Tenney DY; Reimold AM; Haseltine WA (1981). "Novel Leukemogenic Retroviruses Isolated from Cell Line ... After he was briefed on the project to isolate human embryonic stem cells and embryonic germ cells at Geron Corporation in ...
*  STAT3
Cao X, Tay A, Guy GR, Tan YH (April 1996). "Activation and association of Stat3 with Src in v-Src-transformed cell lines". ... "Active Stat3 is required for survival of human squamous cell carcinoma cells in serum-free conditions". Molecular Cancer. 5 (1 ... STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular ... Zhang J, Yang J, Roy SK, Tininini S, Hu J, Bromberg JF, Poli V, Stark GR, Kalvakolanu DV (August 2003). "The cell death ...
*  MiR-155
"Increased expression of microRNA-155 in Epstein-Barr virus transformed lymphoblastoid cell lines". Genes, Chromosomes & Cancer ... or human T-cell leukemia virus type 1-transformed cells through induction of BIC expression". Journal of Virology. 85 (16): ... leukemic cells to healthy B cells and promote their transformation to tumorigenic-like cells Selection of competent B cells ... that was specific for hematopoietic cells including B-cells, T-cells, monocytes and granulocytes. Together these results ...
*  Chelidonine
This benzophenanthridine alkaloid can induce apoptosis in some transformed or malignant cell lines. D-Chelidonine, the main ... Plant and Cell Physiology, 1(26), 4. Necas, M., Dostal, J., Kejnovska, I., Vorlickova, M., & Slavik, J. (2005). Molecular and ... Kemeny-Beke, A., Aradi, J., Beck, Z., Facsko, A., Berta, A., & Bodnar, A. (2006). Apoptotic response of uveal melanoma cells ...
*  Mdm2
"Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line". Somatic Cell ... from the transformed mouse cell line 3T3-DM. Mdm2 overexpression, in cooperation with oncogenic Ras, promotes transformation of ... Ivanchuk SM, Mondal S, Rutka JT (June 2008). "p14ARF interacts with DAXX: effects on HDM2 and p53". Cell Cycle. 7 (12): 1836-50 ... Dai MS, Sun XX, Lu H (July 2008). "Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via ...
*  HEK 293 cells
Graham FL, Smiley J, Russell WC, Nairn R (July 1977). "Characteristics of a human cell line transformed by DNA from human ... 293 cells, or less precisely as HEK cells, are a specific cell line originally derived from human embryonic kidney cells grown ... An important variant of this cell line is the 293T cell line. It contains the SV40 Large T-antigen that allows for episomal ... Various retroviral packaging cell lines are also based on these cells. Depending on various conditions, the gene expression of ...
*  NASP (gene)
"Comparison of mouse and human NASP genes and expression in human transformed and tumor cell lines". Gene. 274 (1-2): 67-75. doi ... The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The ... Cell. 17 (2): 301-11. doi:10.1016/j.molcel.2004.12.018. PMID 15664198. Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a ... In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the ...
*  Warren Jackson Pledger
Platelet-derived growth factor-modulated proteins: constitutive synthesis by a transformed cell line. Proc Natl Acad Sci U S A ... A model of cell cycle control: sequential events regulated by growth factors. Mol Cell Endocrinol. 1983 Aug;31(2-3):167-86. ... Pledger's research focuses on the mechanisms governing cell cycle progression. He was the first to show that the cell cycle is ... His current projects address the impact of cell cycle inhibition on tumor cell survival, and the hallmarks of cancer during the ...
*  3-Alkylpyridinium
The most widely employed are cytotoxicity assays on different normal or transformed cell lines, or antimicrobial assays. The ... It appears that the 3-APs compounds that are polymeric in nature are able to permeabilize the cells. In addition the compounds ...
*  Cell division cycle 7-related protein kinase
"A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines". Gene. 211 (1): 133-40. doi: ... However, when the cell enters this arrested state, levels of p53 may increase. These increased levels of p53 may initiate cell ... activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells". Mol. Cell. Biol. 19 (7): 5083-95 ... activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells". Mol. Cell. Biol. 19 (7): 5083-95 ...
*  Cancer epigenetics
"Epigenetic regulation of the human p53 gene promoter by the CTCF transcription factor in transformed cell lines". Oncogene. 29 ... Histone modification profiles of healthy and cancerous cells tend to differ. In comparison to healthy cells, cancerous cells ... In fact, cancer cell genomes have 20-50% less methylation at individual CpG dinucleotides across the genome. In cancer cells " ... In somatic cells, patterns of DNA methylation are in general transmitted to daughter cells with high fidelity. However, ...
*  DREAM complex
... is not critical to regulate the G2/M genes in HPV-transformed cell lines". Anticancer research. 34 (11): 6557-63 ... Apart from its role in cell cycle control, the DREAM complex has been shown to be involved in the programmed cell death of ... Due to its regulatory role in the cell cycle, targeting the DREAM complex might enhance anticancer treatments such as imatinib ... Journal of Cell Science. 125 (Pt 10): 2393-406. doi:10.1242/jcs.097253. PMID 22344256. Beall, E. L.; Lewis, P. W.; Bell, M.; ...
*  Neuroblastoma RAS viral oncogene homolog
"A transforming gene present in human sarcoma cell lines". Nature. 299 (5879): 171-3. doi:10.1038/299171a0. PMID 6287287. ... Padua RA, Barrass NC, Currie GA (1985). "Activation of N-ras in a human melanoma cell line". Mol. Cell. Biol. 5 (3): 582-5. PMC ... "Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line". PNAS. 80 (2): 383-7. ... 1986). "Transforming genes in human leukemia cells". Blood. 66 (6): 1371-8. PMID 2998510. Neri A, Knowles DM, Greco A, et al. ( ...
*  Coilin
"Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines". J. Cell Sci. ... Cell. 11 (12): 4159-71. doi:10.1091/mbc.11.12.4159. PMC 15064 . PMID 11102515. Young PJ, Le TT, Dunckley M, Nguyen TM, Burghes ... Cell. 3 (3): 329-37. doi:10.1016/S1534-5807(02)00222-8. PMID 12361597. Shpargel KB, Ospina JK, Tucker KE, Matera AG, Hebert MD ... Cell. 3 (3): 329-37. doi:10.1016/s1534-5807(02)00222-8. PMID 12361597. Hebert MD, Szymczyk PW, Shpargel KB, Matera AG (Oct 2001 ...
*  Beta-actin
... and gamma-cytoplasmic actins in a stably transformed human cell line". Cell. 22 (3): 893-9. doi:10.1016/0092-8674(80)90566-8. ... Beta actin is usually used as a loading control, for among others, the integrity of cells, protein degradation, in PCR and ... Anderson JL, Hope TJ (Apr 2004). "HIV accessory proteins and surviving the host cell". Current HIV/AIDS Reports. 1 (1): 47-53. ... Pederson T, Aebi U (Nov 2005). "Nuclear actin extends, with no contraction in sight". Molecular Biology of the Cell. 16 (11): ...
*  Alan Hall
DNA from a rhabdomyosarcoma cell line and a fibrosarcoma cell line transformed a NIH/3T3 mouse fibroblast cell line. After ... Next, the transforming activities of the rhabdomyosarcoma and fibrosarcoma cell lines were measured after being digested with ... Further DNA testing showed that the transforming sequences in the two cancer cell lines were the same, and the gene was later ... In 1982, Hall helped identify transforming sequences in human sarcoma cells lines at the Institute for Cancer Research in ...
*  CCR5
"CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed metastatic prostate cancer cell lines". Cancer ... When T-cells modified so they no longer express CCR5 were mixed with unmodified T-cells expressing CCR5 and then challenged by ... as HIV-1 kills the non-modified T-cells. This same method might be used in vivo to establish a virus-resistant cell pool in ... dendritic cells, eosinophils, microglia and a subpopulation of ether breast or prostate cancer cells. It is likely that CCR5 ...
*  HaCaT
... is a spontaneously transformed aneuploid immortal keratinocyte cell line from adult human skin, widely used in scientific ... "Normal Keratinization in a Spontaneously Immortalized Aneuploid Human Keratinocyte Cell Line". The Journal of Cell Biology. 106 ... Lehmann, Bodo (1 January 1997). "HaCaT Cell Line as a Model System for Vitamin D3 Metabolism in Human Skin". Journal of ... "Lipid composition and synthesis of HaCaT cells, an immortalized human keratinocyte line, in comparison with normal human adult ...
*  MAGEA2
1993). "Differential expression of MAGE-1, -2, and -3 messenger RNA in transformed and normal human cell lines". Cancer Res. 53 ...
*  Chiaho Shih
Shih, C.; Weinberg, R.A. (1982). "Isolation of a transforming sequence from a human bladder carcinoma cell line". Cell. 29 (1 ...
*  Massachusetts Institute of Technology
Shih, C.; Weinberg, R. A. (1982). "Isolation of a transforming sequence from a human bladder carcinoma cell line". Cell. 29 (1 ... Jerome Lettvin transformed the study of cognitive science with his paper "What the frog's eye tells the frog's brain". ... The Kendall MBTA Red Line station is located on the northeastern edge of the campus, in Kendall Square. The Cambridge ... In 2006-2007, MIT's denial of tenure to African-American stem cell scientist professor James Sherley reignited accusations of ...
*  Proto-oncogene tyrosine-protein kinase Src
"Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming ... Chang YM, Bai L, Yang I (2002). "Survey of Src activity and Src-related growth and migration in prostate cancer lines". Proc Am ... Lyn and Fgr are highly expressed in malignant prostate cells compared to normal prostate cells. When the primary prostate cells ... Src, Fyn and Yes are expressed ubiquitously in all cell types while the others are generally found in hematopoietic cells. c- ...