It has been proposed that this protein plays a role in the cell cycle. GRCh38: Ensembl release 89: ENSG00000100632 - Ensembl, ... "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi:10.1016/j.cell ... The Drosophila protein enhancer of rudimentary protein is a small protein of 104 amino acids. It has been found to be an ... "The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals". Gene. ...

"Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways". Structure. 11 (9): 1163-70 ... Cell. 120 (5): 675-85. doi:10.1016/j.cell.2004.12.036. PMID 15766530. S2CID 13785447. Rual JF, Venkatesan K, Hao T, Hirozane- ... protein kinase by the hMOB1 protein". The Journal of Biological Chemistry. 279 (34): 35228-35. doi:10.1074/jbc.M404542200. PMID ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ...

"Loss of Peter Pan protein is associated with cell cycle defects and apoptotic events". Biochimica et Biophysica Acta (BBA) - ... is required for proper cycling of cells since down regulation of PPAN in cancer cells results in a p53-independent cell cycle ... The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. ...

... a novel adenovirus E1A-interacting protein that complements a yeast cell cycle defect". J. Biol. Chem. 271 (42): 25906-11. doi: ... For example, sumoylation may affect a protein's localization in the cell, its ability to interact with other proteins or DNA. ... The UBC9 protein encoded by the UBE2I gene constitutes a core machinery in the cell's sumoylation pathway. Sumoylation is a ... UBC9 performs the third step in the sumoylation life cycle: the conjugation step. When SUMO protein precursors are first ...

"Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells". Biol. Cell. 98 (4): 253-63. doi: ... 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ... Yarden RI, Brody LC (2002). "Identification of proteins that interact with BRCA1 by Far-Western library screening". J. Cell. ... 2006). "CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis". Cell Cycle. 4 (6): 806-11 ...

"The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase". The EMBO Journal. 22 (14): 3524- ... This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell ... "Entrez Gene: CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae)". Li L, Ljungman M, Dixon JE (January 2000). "The ... Dual specificity protein phosphatase CDC14B is an enzyme that in humans is encoded by the CDC14B gene. The protein encoded by ...

"The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1". Hum. Mol. Genet. 11 (22 ... "The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1". Hum. Mol. Genet. 11 (22 ... Aryl-hydrocarbon-interacting protein-like 1 is a protein that in humans is encoded by the AIPL1 gene. Leber congenital ... potential role of AIPL1 in cell cycle exit and/or differentiation of photoreceptors". Adv. Exp. Med. Biol. 533: 287-95. doi: ...

"CHMP1 is a novel nuclear matrix protein affecting chromatin structure and cell-cycle progression". Journal of Cell Science. 114 ... September 2003). "The protein network of HIV budding". Cell. 114 (6): 701-13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570 ... Charged multivesicular body protein 1a is a protein that in humans is encoded by the CHMP1A gene. This gene encodes a member of ... The initial prediction of the protein sequence encoded by this gene suggested that the encoded protein was a metallopeptidase. ...

... cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma". Cell Cycle. 5 (22): 2676-87. doi: ... Denticleless protein homolog is a protein that in humans is encoded by the DTL gene. DTL (gene) has been shown to interact with ... Cell Cycle. 5 (15): 1719-29. doi:10.4161/cc.5.15.3150. PMID 16861890. Higa LA, Banks D, Wu M, Kobayashi R, Sun H, Zhang H (2007 ... Cell Cycle. 5 (15): 1675-80. doi:10.4161/cc.5.15.3149. PMID 16861906. Jin J, Arias EE, Chen J, Harper JW, Walter JC (2006). "A ...

The protein then is involved in ciliary function, cell cycle control and intracellular transport. In addition, the protein is ... It has a role in the proper function, maintenance and formation of cilia, which are found in all types of cells in the body. At ... Metformin (biguanide): decreases the amount blood sugar being released by the liver and by stimulating the cells within muscles ... Some of these medications includes: Meglitinides (repaglinide and nateglinide): taken to stimulate the cells found in the ...

"The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1". Human Molecular ... "The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1". Human Molecular ... "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative ... NEDD8 ultimate buster 1 is a protein that in humans is encoded by the NUB1 gene. NUB1 interacts with and negatively regulates ...

2000). "The Centrosomal Protein C-Nap1 Is Required for Cell Cycle-Regulated Centrosome Cohesion". J. Cell Biol. 151 (4): 837-46 ... "Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic ... Centrosomal protein of 164 kDa, also known as CEP164, is a protein that in humans is encoded by the CEP164 gene. Its function ... 2007). "Cep164, a novel centriole appendage protein required for primary cilium formation". J. Cell Biol. 179 (2): 321-30. doi: ...

2000). "The Centrosomal Protein C-Nap1 Is Required for Cell Cycle-Regulated Centrosome Cohesion". J. Cell Biol. 151 (4): 837-46 ... 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ... "Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic ... Centrosomal protein of 76 kDa, also known as CEP76, is a protein that in humans is encoded by the CEP76 gene. GRCh38: Ensembl ...

Wang Y, Zhan Q (2007). "Cell cycle-dependent expression of centrosomal ninein-like protein in human cells is regulated by the ... Ninein-like protein is a protein that in humans is encoded by the NINL gene. It is part of the centrosome. Model organisms have ... 2003). "Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation". Dev. Cell. 5 (1): 113-25. ... Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9-13. doi:10.1016/j.cell.2006.12.018. ...

"Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins". Cell Cycle. 4 (1): 155-65. doi:10.4161/cc ... "Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27". Cell Cycle. 6 (15): 1937-45. doi:10.4161/cc. ... a novel cell cycle regulator that enhances proliferation through activation of Cdk2". The Journal of Cell Biology. 157 (3): 357 ... Speedy protein A is a protein that in humans is encoded by the SPDYA gene. SPDYA has been shown to interact with CDKN1B. GRCh38 ...

It is a licensing factor that functions to limit DNA from replicating more than once per cell cycle. The protein encoded by ... Kulartz M, Knippers R (2004). "The replicative regulator protein geminin on chromatin in the HeLa cell cycle". J. Biol. Chem. ... The activity of CDT1 during the cell cycle is tightly regulated during the S phase by the protein geminin, which inhibits it, ... thus ensuring that DNA is only replicated once per cell cycle. CDT1 belongs to a family of replication proteins conserved from ...

... a multifactor regulated multifunctional protein". Cell Cycle. 15 (6): 781-786. doi:10.1080/15384101.2016.1151581. PMC 4845917. ... Rousseau D, Gingras AC, Pause A, Sonenberg N (1997). "The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth ... Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in ... Eukaryotic translation initiation factor 4E-binding protein 1 (also known as 4E-BP1) is a protein that in humans is encoded by ...

2006). "RGS14 is a microtubule-associated protein". Cell Cycle. 4 (7): 953-60. doi:10.4161/cc.4.7.1787. PMID 15917656. S2CID ... Regulator of G-protein signaling 14 (RGS14) is a protein that in humans is encoded by the RGS14 gene. RGS14 is a member of the ... 2004). "RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote". Dev. Cell. 7 (5): 763-9 ... This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco motif. The protein attenuates the ...

The early proteins produced in Papillomaviruses and Polyomaviruses regulate the cell cycle and activate DNA replication. In ... In Polyomavirus, the early proteins are T antigens. The late proteins make up the virus capsid. In Polyomaviruses, they are ... The late class consists primarily of structural proteins and assembly enzymes, and is dependent in all three families on the ... After the late class is expressed, the virions can assemble and exit the cell. ...

By inhibiting protein kinase C, signaling pathways are disrupted, inducing cell cycle arrest. Chelerythrine Chloride from ... These mechanisms include inducing apoptosis, arrest of the cell cycle, promoting autophagy of cancerous cells, and the ... and cell-permeable protein kinase C inhibitor in vitro. And an efficacious antagonist of G-protein-coupled CB1 receptors. This ... This molecule has the ability to disrupt a bacteria's cell wall and cell membrane, as well as preventing bacterial growth, all ...

... 's targets include members of the Ras superfamily of small GTP-binding proteins critical to cell cycle ... S-farnesyl protein + diphosphate Thus, the two substrates of this enzyme are farnesyl diphosphate and protein-cysteine, whereas ... Farnesyltransferase posttranslationally-modifies proteins by adding an isoprenoid lipid called a farnesyl group to the -SH of ... There are four binding pockets in FTase, which accommodate the last four amino acids on the carboxyl-terminus of a protein. ...

Both an increase and a decrease in STIL protein levels during the cell cycle have an impact on centriole control and cause ... SCL-interrupting locus protein is a protein that in humans is encoded by the STIL gene. STIL is present in many different cell ... STIL silencing might facilitate the development of primary cilia and prevent the production of cell cycle-related proteins. ... STIL plays a crucial role in cell mitosis and centriole replication. The early stages of the cell cycle see a slow increase in ...

APCCdh1 is responsible for the degradation of various proteins that promote proper cell cycle progression. Geminin is a protein ... The Cell Cycle and Programmed Cell Death". Molecular Biology of the Cell (4th ed.). Garland Science. ISBN 0-8153-3218-1. ... These proteins target the APC/C to specific sets of substrates at different times in the cell cycle, thus driving it forward. ... Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins ...

"Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2". Proc. Natl. Acad ... "Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteins". Mol. Cell. Biol. 19 (9 ... Cell. Biol. 20 (1): 402-15. doi:10.1128/MCB.20.1.402-415.2000. PMC 85095. PMID 10594042. Xie W, Hong H, Yang NN, Lin RJ, Simon ... Cell. Biol. 17 (5): 2735-44. doi:10.1128/MCB.17.5.2735. PMC 232124. PMID 9111344. Voegel JJ, Heine MJ, Tini M, Vivat V, Chambon ...

"Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2". Proceedings of ... Thus, ERβ helps control Aβ levels by maintaining the protein it is derived from, β-amyloid precursor protein. ERβ helps by up- ... However, ERβ has been found to have proliferative effects in some breast cell lines. Expression of ERα and ERβ in the mammary ... ERβ may inhibit cell proliferation and opposes the actions of ERα in reproductive tissue. ERβ may also have an important role ...

... protein. Increased levels of the p27Kip1 protein typically cause cells to arrest in the G1 phase of the cell cycle. Likewise, ... and thus controls the cell cycle progression at G1. It is often referred to as a cell cycle inhibitor protein because its major ... regulation of cell cycle and cell motility". Cell Cycle. 8 (21): 3455-61. doi:10.4161/cc.8.21.9789. PMID 19829074. Baldassarre ... Since CDKN1B prevents cells from entering the cell cycle, inhibition of the protein could cause re-entry and subsequent ...

... a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression". J Biol Chem. 279 (31): 32839-47. doi: ... Thioredoxin-like protein 4B is a protein that in humans is encoded by the TXNL4B gene. TXNL4B has been shown to interact with ... Zhang YZ, Gould KL, Dunbrack RL JR, Cheng H, Roder H, Golemis EA (2001). "The evolutionarily conserved Dim1 protein defines a ... crystallization and preliminary X-ray diffraction studies of the human spliceosomal protein TXNL4B". Acta Crystallographica ...

"Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2". Proceedings of ... January 2001). "Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor". Nature Cell ... Studies in cell extracts and intact cells and their implications for hormone-dependent transcriptional activation". The Journal ... June 1998). "Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell". The Journal of Cell ...

"Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2". Proc. Natl. Acad ... "Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2". Proc. Natl. Acad ... "Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1". Cell. 93 (1): 81-91. doi ... Mitotic spindle assembly checkpoint protein MAD2A is a protein that in humans is encoded by the MAD2L1 gene. MAD2L1 is a ...

"Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors". Mol. Cell. Biol. 22 (7): ... effectively preventing proper cell cycle regulation. FOXO4 activates the cell cycle dependent kinase inhibitor, P27, which in ... It does this by causing cell cycle arrest between the Go and S phases, preventing cell proliferation, as well as by inhibiting ... Forkhead box protein O4 is a protein that in humans is encoded by the FOXO4 gene. FOXO4 is a member of the forkhead family ...

Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate ... 2009). "Evaluation of mRNA by Q-RTPCR and Protein Expression by AQUA of the M2 Subunit of Ribonucleotide Reductase (RRM2) in ... 2009). "Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in ... Click on genes, proteins and metabolites below to link to respective articles. [[File ...

"Role of the kinetochore/cell cycle checkpoint protein ZW10 in interphase cytoplasmic dynein function". J. Cell Biol. 172 (5): ... "Role of the kinetochore/cell cycle checkpoint protein ZW10 in interphase cytoplasmic dynein function". J. Cell Biol. 172 (5): ... Cell. 18 (10): 4129-42. doi:10.1091/mbc.E07-01-0080. PMC 1995728. PMID 17699596. v t e (Genes on human chromosome 11, Protein ... The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to ...

This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. Alternative gene splicing is ... The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target ... Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA, Dynlacht BD (Jan 2002). "E2F integrates cell cycle progression with ... Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D (May 1997). "The subcellular localization of E2F-4 is cell-cycle dependent". ...

This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell ... The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target ... "Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins". ... "Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction". Mol. Cell. Biol. 16 (4): 1668-75 ...

... a Novel Centrosomal Coiled-Coil Protein and Candidate Substrate of the Cell Cycle-regulated Protein Kinase Nek2". J Cell Biol. ... 2000). "The Centrosomal Protein C-Nap1 Is Required for Cell Cycle-Regulated Centrosome Cohesion". J. Cell Biol. 151 (4): 837-46 ... a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1". Biochem. J. 349 (Pt 2 ... This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The ...

2000). "The Centrosomal Protein C-Nap1 Is Required for Cell Cycle-Regulated Centrosome Cohesion". J. Cell Biol. 151 (4): 837-46 ... "Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic ... Centrosomal protein of 78 kDa, also known as Cep78, is a protein that in humans is encoded by the CEP78 gene. Mutations in this ... 2003). "Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation". Dev. Cell. 5 (1): 113-25. ...

"Negative cell cycle regulation and DNA damage-inducible phosphorylation of the BRCT protein 53BP1". The Journal of Biological ... Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a protein that in humans is encoded by ... Ordinarily during the G1 phase of the cell cycle, when a sister chromatid is unavailable for HR, NHEJ is the predominant ... "Entrez Gene: TP53BP1 tumor protein p53 binding protein 1". Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J, van der ...

"Adenovirus Overrides Cellular Checkpoints for Protein Translation". Cell Cycle. 4 (7): 883-888. doi:10.4161/cc.4.7.1791. PMID ... "Visualizing viral protein structures in cells using genetic probes for correlated light and electron microscopy". Methods. 90: ... doi:10.1016/j.cell.2015.07.058. PMC 4681434. PMID 26317467. Higginbotham, Jennifer M.; O'Shea, Clodagh C. (15 October 2015). ... Clodagh C. O'Shea is a professor of molecular and cell biology and current Wicklow Chair at the Salk Institute for Biological ...

Pauli U, Chrysogelos S, Stein G, Stein J, Nick H (Jul 1987). "Protein-DNA interactions in vivo upstream of a cell cycle- ... 2003). "Maintenance of open chromatin and selective genomic occupancy at the cell cycle-regulated histone H4 promoter during ... 2003). "Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein". Mol. Cell. ... Histone H4 is a protein that in humans is encoded by the HIST2H4A gene. Histones are basic nuclear proteins that are ...