The protein is expressed at constant levels throughout the cell cycle. The gene coding for the Dbf4 or ASK protein is regulated ... Although expression levels of the protein appear to be constant throughout the cell cycle, the protein kinase activity appears ... Cell division cycle 7-related protein kinase is an enzyme that in humans is encoded by the CDC7 gene. The Cdc7 kinase is ... The product encoded by this gene is predominantly localized in the nucleus and is a cell division cycle protein with kinase ...

Retinoblastoma-like protein 1 p130 - Retinoblastoma-like protein 2 They play crucial roles in the metazoan cell cycle through ... Cobrinik D (2005). "Pocket proteins and cell cycle control". Oncogene. 24 (17): 2796-809. doi:10.1038/sj.onc.1208619. PMID ... Pocket protein family consists of three proteins: RB - Retinoblastoma protein p107 - ... v t e (Articles with short description, Short description matches Wikidata, All stub articles, Protein stubs, Protein families) ...

"Polar gradients of the DYRK-family kinase Pom1 couple cell length with the cell cycle". Nature. 459 (7248): 852-6. Bibcode: ... of the total cell length before the cell enters mitosis. When the cell enters mitosis, Cdr2 is distributed diffusely through ... Pom1 is a serine/threonine protein kinase that localizes to the cell tips. It is a partial mechanism for the formation of the ... However, the cells still enter mitosis, presumably because Cdr2 is the link in only one pathway that couples cell length to ...

... ubiquitin ligase ubiquitin proteasome system cell cycle Simchen G, Hirschberg J (May 1977). "Effects of the mitotic cell-cycle ... In order for the cell cycle to proceed, several inhibitory proteins, as well as cyclins, have to be eliminated at given time ... There is a Cdc4p/Cdc53p-binding region on Cdc34p.) All three proteins are stable throughout the cell cycle. Various cellular ... Cdc4 (cell division control protein 4) is a substrate recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ...

ID proteins also promote cell cycle progression, delaying senescence, and help facilitate cell migration. In contrast, ... Zebedee Z, Hara E (December 2001). "Id proteins in cell cycle control and cellular senescence". Oncogene. 20 (58): 8317-25. doi ... When ID proteins are overexpressed, cell proliferation is enhanced and cells become insensitive to growth factor depletion. ... Wang LH, Baker NE (2015). "E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease". Dev Cell. 35 (3 ...

Cell cycle, Proteins, EC 2.7.11, Cell cycle regulators). ... "Cell cycle sibling rivalry: Cdc2 vs. Cdk2". Cell Cycle. 4 (11 ... This suggests that Cdk2 is non-essential for the cell cycle of healthy cells, but essential for meiosis and reproduction. Cells ... whose activity is restricted to the G1-S phase of the cell cycle, where cells make proteins necessary for mitosis and replicate ... Cobrinik D (April 2005). "Pocket proteins and cell cycle control". Oncogene. 24 (17): 2796-809. doi:10.1038/sj.onc.1208619. ...

In cycling cells, there is a resassortment of Cip/Kip proteins between CDK4/5 and CDK2 as cells progress through G1. Their ... INK4 proteins are cell-cycle inhibitors. When they bind to CDK4 and CDK6, they induce an allosteric change that leads to the ... is to block progression of the cell cycle beyond the G1 restriction point. In addition, INK4 proteins play roles in cellular ... but not CDK4 activity in activated T cells that suggest p18INK4c may set an inhibitory threshold in resting T cells. Cells ...

Cell cycle, Saccharomyces cerevisiae genes, Proteins). ... and thereby the degradation of cell cycle regulators. Mad1 is ... Cell Biol. 8 (5): 379-93. doi:10.1038/nrm2163. PMID 17426725. S2CID 205494124. Yu H (Apr 2006). "Structural activation of Mad2 ... Eukaryotic cells show a mitotic arrest in the presence of microtubule polymerization inhibitors. A spindle assembly checkpoint ... Against this idea, it was shown that cancer cells undergo apoptosis when components of the SAC are not present. In this model, ...

The balance between repressor and activator E2F regulate cell cycle progression. When activator E2F family proteins are knocked ... E2F family members play a major role during the G1/S transition in mammalian and plant cell cycle (see KEGG cell cycle pathway ... Activators such as E2F1, E2F2, E2F3a promote and help carryout the cell cycle, while repressors inhibit the cell cycle. Yet, ... The repressor genes E2F7/E2F8, located on chromosome 7, are transcription factors responsible for protein coding cell cycle ...

"Cell cycle-regulated phosphorylation of the human SIX1 homeodomain protein". The Journal of Biological Chemistry. 275 (29): ... Ford HL, Kabingu EN, Bump EA, Mutter GL, Pardee AB (October 1998). "Abrogation of the G2 cell cycle checkpoint associated with ... Homeobox protein SIX1 (Sine oculis homeobox homolog 1) is a protein that in humans is encoded by the SIX1 gene. The vertebrate ... and Dach proteins mediated through CREB binding protein". Molecular and Cellular Biology. 22 (19): 6759-66. doi:10.1128/MCB. ...

PER1 also interacts with proteins ATM and Chk2. These proteins are key checkpoint proteins in the cell cycle. Cancer patients ... PER1 expression may have significant effects on the cell cycle. Cancer is often a result of unregulated cell growth and ... Period circadian protein homolog 1 is a protein in humans that is encoded by the PER1 gene. The PER1 protein is important to ... "The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells". Mol. Cell. 22 (3 ...

Bartkova J, Grøn B, Dabelsteen E, Bartek J (February 2003). "Cell-cycle regulatory proteins in human wound healing". Archives ... Stem cells give rise to progenitor cells, which are cells that are not self-renewing, but can generate several types of cells. ... Macrophages are a type of repairing cell that devour dead cells and pathogens, and trigger other immune cells to respond to ... Transmembrane receptor proteins called integrins, which are made of glycoproteins and normally anchor the cell to the basement ...

"GNL3L Is a Nucleo-Cytoplasmic Shuttling Protein: Role in Cell Cycle Regulation". PLOS ONE. 10 (8): e0135845. Bibcode:2015PLoSO ... G protein nucleolar 3 like is a protein that in humans is encoded by the GNL3L gene. The protein encoded by this gene appears ... Oktar PA, Yildirim S, Balci D, Can A (2011). "Continual expression throughout the cell cycle and downregulation upon adipogenic ... "Entrez Gene: G protein nucleolar 3 like". Retrieved 2017-10-23. Du X, Rao MR, Chen XQ, Wu W, Mahalingam S, Balasundaram D (2006 ...

Loor G, Zhang SJ, Zhang P, Toomey NL, Lee MY (1998). "Identification of DNA replication and cell cycle proteins that interact ... DNA-binding subunit Replication protein A Replication protein A2 Replication protein A3 Single-stranded binding protein GRCh38 ... Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the RPA1 gene. Replication protein ... Amacker M, Hottiger M, Mossi R, Hübscher U (1997). "HIV-1 nucleocapsid protein and replication protein A influence the strand ...

Cell cycle, Proteins, EC 2.7.11, Cell cycle regulators). ... "Cell cycle sibling rivalry: Cdc2 vs. Cdk2". Cell Cycle. 4 (11 ... ISBN 978-0-19-920610-0. Nasmyth K (April 1993). "Control of the yeast cell cycle by the Cdc28 protein kinase". Curr. Opin. Cell ... Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that ... phosphorylation of these proteins leads to cell cycle progression. Cdk1 is a small protein (approximately 34 kilodaltons), and ...

... evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2". Cell. 58 (5): 833-46. doi: ... Reduction of cyclin B1 can stop cells in the G2 phase of the cell cycle and triggers cell death by preventing the chromosomes ... Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2". Cell. 58 (5): 833-846. doi ... One of the hallmarks of cancer is the lack of regulation in the cell cycle. The role of cyclin B1 is to transition the cell ...

Woitach JT, Zhang M, Niu CH, Thorgeirsson SS (Aug 1998). "A retinoblastoma-binding protein that affects cell-cycle control and ... Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene. Retinoblastoma-like protein 2 has been ... "Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins". ... are expressed in the early phases of the cell cycle". Proceedings of the National Academy of Sciences of the United States of ...

In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. ... The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is ... Woitach JT, Zhang M, Niu CH, Thorgeirsson SS (Aug 1998). "A retinoblastoma-binding protein that affects cell-cycle control and ... phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein ...

... more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues". Cell Cycle. 14 (1 ... Docking can also be achieved via E2F proteins binding to sequences known as cell cycle-dependent element sites (CDEs). Some ... Entry into the cell cycle dissociates p130 from the complex and leads to subsequent recruitment of activating E2F proteins. ... complex is a protein complex responsible for the regulation of cell cycle-dependent gene expression. The complex is ...

Knauer SH, Artsimovitch I, Rösch P (December 2012). "Transformer proteins". Cell Cycle. 11 (23): 4289-4290. doi:10.4161/cc. ... A transformer protein (TFP) also known as a metamorphic protein is a protein that can interconvert between two or more shapes ( ... v t e (Proteins by function, Proteins by structure, All stub articles, Protein stubs). ... Prusiner SB, Scott MR, DeArmond SJ, Cohen FE (May 1998). "Prion protein biology". Cell. 93 (3): 337-348. doi:10.1016/S0092-8674 ...

Proteins, 53, 917-930 Wrzeszczynski K.O. and Rost,B. (2004) Cataloguing proteins in cell cycle control. Methods Mol. Biol., 241 ... and annotations homology to proteins involved in cell-cycle control. The PredictProtein web service is available at www. ... "Twilight zone of protein sequence alignments". Protein Engineering. 12 (2): 85-94. doi:10.1093/protein/12.2.85. PMID 10195279. ... Proteins, 46, 195-205. Jones D.T. (1999) Protein secondary structure prediction based on position-specific scoring matrices. J ...

This protein functions as a regulator at the early steps of DNA replication. It localizes in the cell nucleus during cell cycle ... Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene. The protein encoded by this ... and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis". Mol. Cell ... and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis". Mol. Cell ...

... and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis". Mol. Cell ... Fujita M, Yamada C, Goto H, Yokoyama N, Kuzushima K, Inagaki M, Tsurumi T (1999). "Cell cycle regulation of human CDC6 protein ... The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. MCM3 has been shown to ... "Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 ...

This also produces translational attenuation of the protein machinery involved in running the cell cycle, producing cell cycle ... Brewer JW, Diehl JA (November 2000). "PERK mediates cell-cycle exit during the mammalian unfolded protein response". ... The aforementioned sugar molecule remains the means by which the cell monitors protein folding, as the misfolding protein ... An important example is that the proapoptotic protein CHOP (CCAAT/-enhancer-binding protein homologous protein), is upregulated ...

"Entrez Gene: CDC2L1 cell division cycle 2-like 1 (PITSLRE proteins)". Zhang, Songwen; Cai Mingmei; Zhang Si; Xu Songli; Chen ... 1990). "Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle". Proc. Natl. Acad. Sci. U.S.A. ... 2000). "Identification and characterization of a novel cell cycle-regulated internal ribosome entry site". Mol. Cell. 5 (4): ... The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. ...

SLBP levels are controlled by cell-cycle proteins, causing SLBP to accumulate as cells enter S phase and degrade as cells leave ... These proteins are synthesized during S phase of the cell cycle. There are different mechanisms which contribute to the ... "Phosphorylation of stem-loop binding protein (SLBP) on two threonines triggers degradation of SLBP, the sole cell cycle- ... who believed that transcription was activated by protein-DNA and protein-protein interactions on largely naked DNA templates, ...

In adult cells, TGF-β inhibits cell cycle progression, stopping cells from making the G1/S phase transition. This phenomenon is ... maintaining multi-potency in stem cells, and promoting continuous cell cycling. Therefore, downregulating ID proteins is a ... Knocking out Id2 and Id3 genes in epithelial cells enhances cell cycle inhibition by TGF-B, showing that they are important in ... "Transcriptional control of cell cycle-dependent kinase 4 by Smad proteins--implications for Alzheimer's disease". Neurobiology ...

"Nuclear translocation of the Hsp70/Hsp90 organizing protein mSTI1 is regulated by cell cycle kinases". Journal of Cell Science ... The TPR motif is a very common structural feature used by many proteins and provides the ability of directing protein-protein ... The family of these proteins is referred to as STI1 (stress inducible protein) and can be divided into yeast, plant, and animal ... The Hsp70-Hsp90 Organizing Protein (Hop, STIP1 in humans) is the co-chaperone responsible for the transfer of client proteins ...

... and other phorbol esters interact with protein kinase C (PKC). Protein kinase C controls the cell cycle, so chemicals ... Black A, Black J (2013). "Protein kinase C signaling and cell cycle regulation. Review". Front Immunol. 3 (423): 423. doi: ... affecting the activity of several intracellular pathways that regulate cell cycle and apoptosis among others. PKC binding to ... but can create circumstances in which initiated cells are more susceptible to additional mutations or in which initiated cells ...

Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been ... Lysine methyltransferase 2E is a protein that in humans is encoded by the KMT2E gene. This gene is a member of the myeloid/ ... lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET ...