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*  Cell division cycle 7-related protein kinase
The protein is expressed at constant levels throughout the cell cycle. The gene coding for the Dbf4 or ASK protein is regulated ... Although expression levels of the protein appear to be constant throughout the cell cycle, the protein kinase activity appears ... Cell division cycle 7-related protein kinase is an enzyme that in humans is encoded by the CDC7 gene. The Cdc7 kinase is ... The product encoded by this gene is predominantly localized in the nucleus and is a cell division cycle protein with kinase ...
*  RNA Helicase A
Loor G, Zhang SJ, Zhang P, Toomey NL, Lee MY (Dec 1997). "Identification of DNA replication and cell cycle proteins that ... Westberg C, Yang JP, Tang H, Reddy TR, Wong-Staal F (Jul 2000). "A novel shuttle protein binds to RNA helicase A and activates ... Westberg C, Yang JP, Tang H, Reddy TR, Wong-Staal F (Jul 2000). "A novel shuttle protein binds to RNA helicase A and activates ... This gene encodes a DEAD box protein with RNA helicase activity. It may participate in melting of DNA:RNA hybrids, such as ...
*  RFC5
Loor G, Zhang SJ, Zhang P, Toomey NL, Lee MY (Dec 1997). "Identification of DNA replication and cell cycle proteins that ... binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". The ... binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". The ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038/ ...
*  Replication protein A1
Loor G, Zhang SJ, Zhang P, Toomey NL, Lee MY (1998). "Identification of DNA replication and cell cycle proteins that interact ... Replication protein A Replication protein A2 Replication protein A3 Single-stranded binding protein GRCh38: Ensembl release 89 ... Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the RPA1 gene. Replication protein ... Amacker M, Hottiger M, Mossi R, Hübscher U (1997). "HIV-1 nucleocapsid protein and replication protein A influence the strand ...
*  Saccharomyces cerevisiae
... these proteins include cell cycle proteins, signaling proteins, and protein-processing enzymes. S. cerevisiae is currently the ... since bud formation occupies the whole cell cycle. Both mother and daughter cells can initiate bud formation before cell ... In yeast cultures growing more slowly, cells lacking buds can be seen, and bud formation only occupies a part of the cell cycle ... Budding yeast form a bud from the mother cell. This bud grows during the cell cycle and detaches; fission yeast divide by ...
*  RFC4
... p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins". ... Loor G, Zhang SJ, Zhang P, Toomey NL, Lee MY (Dec 1997). "Identification of DNA replication and cell cycle proteins that ... binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". The ... binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". The ...
*  CDC14B
Gray CH, Good VM, Tonks NK, Barford D (2003). "The structure of the cell cycle protein Cdc14 reveals a proline-directed protein ... This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell ... 2003). "Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle". Mol. Cell. Biol ... "Entrez Gene: CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae)". Li, L; Ljungman M; Dixon J E (January 2000). "The ...
*  Yeast
... these proteins include cell cycle proteins, signaling proteins, and protein-processing enzymes. On 24 April 1996, S. cerevisiae ... Here, a small bud (also known as a bleb), or daughter cell, is formed on the parent cell. The nucleus of the parent cell splits ... The bud continues to grow until it separates from the parent cell, forming a new cell. The daughter cell produced during the ... for the study of fundamental cellular processes such as the cell cycle, DNA replication, recombination, cell division, and ...
*  Alfonso Valencia
"An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins". Proceedings ... Krallinger, M; Leitner, F; Rodriguez-Penagos, C; Valencia, A (2008). "Overview of the protein-protein interaction annotation ... Pazos, F; Helmer-Citterich, M; Ausiello, G; Valencia, A (1997). "Correlated mutations contain information about protein-protein ... Protein-protein interactions". Proceedings / ... International Conference on Intelligent Systems for Molecular Biology ; ISMB. ...
*  Cdc14
"The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase". EMBO J. 22: 3524-3535. doi: ... Cell. 134: 256-267. doi:10.1016/j.cell.2008.05.043. PMC 2591934 . PMID 18662541. Ah Fong, A; Judelson, HS (2003). "Cell cycle ... Consistent with such multiple roles, ScCdc14 has been found to bind several proteins that regulate the cell cycle and DNA ... cells deleted for the genes showed no defects in growth or mitosis, and a similar failure of a cell cycle defect was also shown ...
*  Cyclin B
When p53 build-up triggers cell cycle arrest the levels of downstream proteins p21 and WAF1 are increased which prevents ... Begnami MD, Fregnani JH, Nonogaki S, Soares FA (August 2010). "Evaluation of cell cycle protein expression in gastric cancer: ... Ford HL, Pardee AB (1999). "Cancer and the cell cycle". J. Cell. Biochem. Suppl 32-33: 166-72. doi:10.1002/(SICI)1097-4644(1999 ... Cyclin B is necessary for the progression of the cells into and out of M phase of the cell cycle. At the end of S phase the ...
*  Mitosis
All these phases in the cell cycle are highly regulated by cyclins, cyclin-dependent kinases, and other cell cycle proteins. ... Some G0 cells have the ability to re-enter the cell cycle. In plant cells only, prophase is preceded by a pre-prophase stage. ... Cells may also temporarily or permanently leave the cell cycle and enter G0 phase to stop dividing. This can occur when cells ... In animal cells, a cell membrane pinches inward between the two developing nuclei to produce two new cells. In plant cells, a ...
*  CKS1B
2001). "The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27". Nat. Cell Biol. 3 ( ... Protein destruction: Adapting roles for Cks proteins. Cur Biol. 11: R431-R435 Xu, K., Belunis, C., et al. 2003. Protein-protein ... "The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27". Nat. Cell Biol. 3 (3): 321- ... "Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1". Cell. 84 ...
*  Proteasome
Apoptosis is mediated through disrupting the regulated degradation of pro-growth cell cycle proteins. However, some cell lines ... anti-apoptotic proteins with tumorigenic properties". Cell Cycle. 5 (22): 2592-601. doi:10.4161/cc.5.22.3448. PMID 17106261. ... inducing apoptosis by disrupting the regulated degradation of pro-growth cell cycle proteins. This approach of selectively ... activated by specific cyclins that demarcate phases of the cell cycle. Mitotic cyclins, which persist in the cell for only a ...
*  CHUK
IKK-α has also been reported to regulate the cell cycle protein cyclin D1 in an NF-κB-independent manner. Inhibition of IκB ... IKK-α is a member of the serine/threonine protein kinase family and forms a complex in the cell with IKK-β and NEMO. NF-κB ... In the mouse, IKK-α is required for cell cycle exit and differentiation of the embryonic keratinocytes. IKK-α null mice have a ... Their epidermis retains a proliferative precursor cell population and lacks the outer two most differentiated cell layers. This ...
*  ATM serine/threonine kinase
Mehdipour P, Karami F, Javan F, Mehrazin M (2015). "Linking ATM Promoter Methylation to Cell Cycle Protein Expression in Brain ... The cell cycle has different DNA damage checkpoints, which inhibit the next or maintain the current cell cycle step. There are ... during the cell cycle, which preserve correct progression. ATM plays a role in cell cycle delay after DNA damage, especially ... It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint, leading to cell cycle arrest, DNA ...
*  Cyclin E1
... the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated ... whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded ... "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3 ... whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as ...
*  Oncolytic adenovirus
... the host cell must be induced into S phase by viral proteins interfering with cell cycle proteins. The adenoviral E1A gene is ... It blocks cell progression in response to cellular stress or DNA damage. Many viruses replicate by altering the cell cycle and ... Tumours form in cells when mutations in genes involved in cell cycle control and apoptosis accumulate over time. Most tumours ... E1B proteins produced by adenoviruses protect the infected cell by binding to and degrading the p53 transcription factors, ...
*  CDKN3
"Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3 ... 1993). "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases". Cell. 75 (4): 805-16. doi: ... 2002). "Human HTm4 is a hematopoietic cell cycle regulator". J. Clin. Invest. 109 (1): 51-8. doi:10.1172/JCI14025. PMC 150822 ... The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin- ...
*  Cdc25
As with other cell cycle proteins or genes such as Cdc2 and Cdc4, the "cdc" in its name refers to "cell division cycle". Dual- ... "Normal Cell Cycle and Checkpoint Responses in Mice and Cells Lacking Cdc25B and Cdc25C Protein Phosphatases". Mol. Cell. Biol. ... The Cdc25 family appears to have expanded in relation to the complexity of the cell-cycle and life-cycle of higher animals. ... Cdc25 proteins control entry into and progression through various phases of the cell cycle, including mitosis and S ("Synthesis ...
*  CCNC (gene)
1995). "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and ... The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin- ... The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms ... 1995). "Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat ...
*  Histone
SLBP levels are controlled by cell-cycle proteins, causing SLBP to accumulate as cells enter S phase and degrade as cells leave ... These proteins are synthesized during S phase of the cell cycle. There are different mechanisms which contribute to the ... "Phosphorylation of stem-loop binding protein (SLBP) on two threonines triggers degradation of SLBP, the sole cell cycle- ... who believed that transcription was activated by protein-DNA and protein-protein interactions on largely naked DNA templates, ...
*  Retinoblastoma protein
Embryonic hair cells require Rb, among other important proteins, to exit the cell-cycle and stop dividing, which allows ... One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. ... "A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle". ... the cell is then unable to exit the cell cycle, resulting in continuous division. DNA damage to G0 cells activates Cyclin D - ...
*  Cyclin B1
... evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2". Cell. 58 (5): 833-46. doi: ... Reduction of cyclin B1 can stop cells in the G2 phase of the cell cycle and triggers cell death by preventing the chromosomes ... Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2". Cell. 58 (5): 833-846. doi ... One of the hallmarks of cancer is the lack of regulation in the cell cycle. The role of cyclin B1 is to transition the cell ...
*  Anaphase-promoting complex
APCCdh1 is responsible for the degradation of various proteins that promote proper cell cycle progression. Geminin is a protein ... The Cell Cycle and Programmed Cell Death". Molecular Biology of the Cell (4th ed.). Garland Science. ISBN 0-8153-3218-1. ... These proteins target the APC/C to specific sets of substrates at different times in the cell cycle, thus driving it forward. ... Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins ...