Pleomorphic anaplastic neuroblastoma
... with anaplasia. However, within-stage differences were not significant, although cases without anaplasia fared better in each ... Additionally there was a main cell population with a DNA index of 2 indicating a tetraploid DNA content and a high expression ... Dehner LP (1989). Anaplasia in solid malignant tumors of childhood. Arch Pathol Lab Med 113:11-12. Shimada H, Ambros IM, Dehner ... Chatten argued that increasing anaplasia in stage IV in comparison with stage III found in her cases suggested a trend toward ...
Anaplastic carcinoma
Anaplasia in a tumor may be focal or diffuse. Specific types include: anaplastic astrocytoma anaplastic large-cell lymphoma ... such as the glandular formation or special cellular junctions that are typical of adenocarcinoma and squamous cell carcinoma, ... carcinoma is a general term for a malignant neoplasm arising from the uncontrolled proliferation of transformed cells of ...
Anaplasia
... (from Ancient Greek: ἀνά ana, "backward" + πλάσις plasis, "formation") is a condition of cells with poor cellular ... Anaplasia is the most extreme disturbance in cell growth encountered in the spectrum of cellular proliferations. Pleomorphism ... "Anaplasia". Medical Definition from MediLexicon. "Anaplasia". Biology-Online Dictionary. Archived from the original on 2019-12- ... rather than dedifferentiation of specialized cells, account for undifferentiated tumors. Anaplastic cells display marked ...
Actinic keratosis
It works in two ways, first by disrupting cell membranes and mitochondria resulting cell death, and then by inducing antibody- ... Keratinocytes in the stratum malphigii may show a loss of polarity, pleomorphism, and anaplasia. Some irregular downward ... Clinical practice guide: basal cell carcinoma, squamous cell carcinoma (and related lesions): a guide to clinical management in ... These cells have been observed to proliferate into the dermis as buds and duct-like structures. Lichenoid: Demonstrate a band- ...
David Paul von Hansemann
He is remembered for his work in the field of oncology, in particular, his concept pertaining to anaplasia of cancer cells. He ... About asymmetrical cell division in epithelial cancers and their biological significance, Anaplasia first described). Die ... His name is associated with "Hansemann macrophages" (also known as "Hansemann cells"), which are large mononuclear cells ...
Pleomorphism (cytology)
Anaplasia Cell growth Cytopathology Giant cell carcinoma of the lung Nuclear atypia Schmoller, Kurt M.; Skotheim, Jan M. ( ... Certain benign cell types may also exhibit pleomorphism, e.g. neuroendocrine cells, Arias-Stella reaction. A rare type of ... December 2015). "The Biosynthetic Basis of Cell Size Control". Trends Cell Biol. 25 (12): 793-802. doi:10.1016/j.tcb.2015.10. ... Pleomorphism is a term used in histology and cytopathology to describe variability in the size, shape and staining of cells and ...
Cystadenocarcinoma
The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. ...
Metastasis
The cells which constitute the tumor eventually undergo metaplasia, followed by dysplasia then anaplasia, resulting in a ... including the blood vessel cells (endothelial cells), immune cells or stromal cells. The growth of a new network of blood ... Besides forces, the regulation of various types of cell-cell and cell-matrix adhesions is crucial during metastasis. The ... When tumor cells metastasize, the new tumor is called a secondary or metastatic tumor, and its cells are similar to those in ...
Prosoplasia
... unlike anaplasia (a backward differentiation). Examples of prosoplasia include the forward differentiation of cells in the ... Assuming an increasing cellular peculiarity from a presupposed stem-cell fate, prosoplasia is therefore a forward ... Prosoplasia (from Ancient Greek: προσωπον prósopon , "face" + πλάσις plasis, "formation") is the differentiation of cells ... Articles containing Ancient Greek (to 1453)-language text, Oncology, Induced stem cells). ...
Neuroendocrine tumor
... together with nearby cells, are damaged by the attached radiation. Not all cells are immediately killed; cell death can go on ... There is usually minimal pleomorphism but less commonly there can be anaplasia, mitotic activity, and necrosis.[citation needed ... small-cell lung cancer (SCLC) large cell neuroendocrine carcinoma of the lung (LCNEC) Extrapulmonary small cell carcinomas ( ... Histologically, NETs are an example of "small blue cell tumors," showing uniform cells which have a round to oval stippled ...
Gemistocyte
Usually, gliomas begin in the glial cells that surround the nerve cells to help them function. Many gliomas exhibit cells that ... leading to the discovery of the relationship between tumor anaplasia and degeneration. Tumor and brain tissue can be examined ... fibroblast lineage cells, different types of inflammatory cells, and various types of glia and neural-lineage progenitor cells ... All types of tumors are derived from either multipotent stem cells, or progenitor cells. Gene expression patterns are very ...
Grading (tumors)
The neoplastic grading is a measure of cell anaplasia (reversion of differentiation) in the sampled tumor and is based on the ... to excessive cell proliferation rates, typically longer cell lifespans and poor differentiation. The grade score (numerical: G1 ... it reflects how much the tumor cells differ from the cells of the normal tissue they have originated from (see 'Categories' ... In pathology, grading is a measure of the cell appearance in tumors and other neoplasms. Some pathology grading systems apply ...
List of MeSH codes (C23)
... anaplasia MeSH C23.550.727.152 - cell transformation, neoplastic MeSH C23.550.727.152.110 - blast crisis MeSH C23.550.727.152. ... plasma cell MeSH C23.550.382.875.500 - granuloma, plasma cell, orbital MeSH C23.550.382.875.750 - granuloma, plasma cell, ... neoplasm circulating cells MeSH C23.550.727.650.830 - neoplasm seeding MeSH C23.550.727.650.895 - neoplasms, unknown primary ... 160 - cell transformation, viral MeSH C23.550.727.160 - cocarcinogenesis MeSH C23.550.727.645 - neoplasm invasiveness MeSH ...
Precancerous condition
... a collection of highly abnormal cells which, in some cases, has an increased risk of progressing to anaplasia and invasive ... September 2021). "Elevated T cell repertoire diversity is associated with progression of lung squamous cell premalignant ... A precancerous condition is a condition, tumor or lesion involving abnormal cells which are associated with an increased risk ... Bronchial premalignant lesions can progress to squamous cell carcinoma of the lung. Pathologically, precancerous tissue can ...
Wilms' tumor
Contains diffuse anaplasia (poorly developed cells) Mutations of the WT1 gene which is located on the short arm of chromosome ... In most cases, a biopsy is not done first because there is a risk of cancer cells spreading during the procedure. Treatment in ... Staging is based on anatomical findings and tumor cells pathology. According to the extent of tumor tissue at the time of ... Genome-wide copy number and LOH status can be assessed with virtual karyotyping of tumor cells (fresh or paraffin-embedded).[ ...
Embryonal rhabdomyosarcoma
Tumor suppressors signal the cell to stop the cell cycle and start apoptosis, known as programmed cell death, when the cell ... An international study of more than 600 people with RMS showed worst outcomes in cases with anaplasia, regardless of fusion- ... The chemotherapy works to kill all the remaining cancer cells and to stop future growth of any possible cancerous cells. Safety ... "small round blue cell tumor" because of the characteristic microscopic appearance of its cells after histological staining with ...
Anaplastic large-cell lymphoma
... cells lacking many T-cell receptor proteins) with "Hallmark" cell features of anaplasia, pleomorphism, and kidney- and horse ... a small-cell pattern consisting of small to medium-sized neoplastic cells with clear cytoplasm and "hallmark" cells that are ... These cells do not express ALK and often lack the characteristic surface marker proteins of T-cells. Identification of the ... Anaplastic large-cell lymphoma (ALCL) refers to a group of non-Hodgkin lymphomas in which aberrant T cells proliferate ...
Brain tumor
Cells can become anaplastic in two ways: neoplastic tumor cells can dedifferentiate to become anaplasias (the dedifferentiation ... Anaplastic cells have lost total control of their normal functions and many have deteriorated cell structures. Anaplastic cells ... Necrotic cells send the wrong chemical signals which prevent phagocytes from disposing of the dead cells, leading to a buildup ... It is made up of the same cells as the brain: neurons and glial cells. Although there is no specific or singular symptom or ...
Malignancy
Viral agents are able to assist the formation of malignant tumours due to a mechanism of cell transformation. This cell ... Malignancy in cancers is characterized by anaplasia, invasiveness, and metastasis. Malignant tumors are also characterized by ... At the same time, inflammatory cells can also interact with malignant cells to form an inflammatory tumour microenvironment. ... cell membrane and cytoskeleton within each cell is affected indirectly and/or through multiple pathways. The combination of ...
Pleomorphic xanthoastrocytoma
Also called radiotherapy, this treatment uses high-energy radiation to damage or kill cancer cells and shrink tumors. Symptoms ... Grade III anaplastic pleomorphic xanthoastrocytomas may evolve and show signs of anaplasia, according to evidence in the ...
Dedifferentiation
Anaplasia is defined as cells being in an undifferentiated state and it is often associated with cancer. Often this loss of ... differentiated cell. Re-entry into the cell cycle allows the cell to go through mitosis, dividing to make more cells that would ... Articles with short description, Short description matches Wikidata, Cells, Cell biology, Stem cells). ... as seen by an increase in cell cycle re-entry and loss of cellular adhesion. Cell plasticity [9] is the idea that cells can ...