*  ACTR3
"The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42". Proceedings of the National ... Actin-related protein 3 is a protein that in humans is encoded by the ACTR3 gene. The specific function of this gene has not ... Winter D, Podtelejnikov AV, Mann M, Li R (Jul 1997). "The complex containing actin-related proteins Arp2 and Arp3 is required ... Higgs HN, Blanchoin L, Pollard TD (Nov 1999). "Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the ...
*  ARHGDIA
Hoffman GR, Nassar N, Cerione RA (2000). "Structure of the Rho family GTP-binding protein Cdc42 in complex with the ... "Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1". Structure. 8 (1): 47-55. doi:10.1016/ ... "Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1". Structure. 8 (1): 47-55. doi:10.1016/ ... Li X, Bu X, Lu B, Avraham H, Flavell RA, Lim B (February 2002). "The hematopoiesis-specific GTP-binding protein RhoH is GTPase ...
*  PAK4
They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological ... PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a ... PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical ... Serine/threonine-protein kinase PAK 4 is an enzyme that in humans is encoded by the PAK4 gene. PAK4 is one of six members of ...
*  P21-activated kinases
They serve as targets for the small GTP binding proteins CDC42 and Rac and have been implicated in a wide range of biological ... PAK1 p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)". "Entrez Gene: PAK2 p21 (CDKN1A)-activated kinase 2". "Entrez ...
*  PAK1
These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of ... ARG-binding protein 2γ, hepatitis B virus X protein, STE20-related kinase adaptor protein α, RhoI, Klotho, N-acetylglucosaminyl ... Seoh ML, Ng CH, Yong J, Lim L, Leung T (March 2003). "ArhGAP15, a novel human RacGAP protein with GTPase binding property". ... Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L (January 1994). "A brain serine/threonine protein kinase activated by Cdc42 and ...
*  CDC42
... GTP-Binding Protein at the US National Library of Medicine Medical Subject Headings (MeSH) CDC42 Info with links in the ... "CDC42 (cell division cycle 42 (GTP binding protein, 25kDa))". atlasgeneticsoncology.org. Retrieved 2016-04-22. Stengel K, Zheng ... Cdc42 cycles between an active GTP-bound state and an inactive GDP-bound state. This process is regulated by guanine nucleotide ... a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for ...
*  PAK2
The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and ... The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and ... Serine/threonine-protein kinase PAK 2 is an enzyme that in humans is encoded by the PAK2 gene. PAK2 is one of three members of ... The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in ...
*  ERRFI1
... a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for ... ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene. MIG6 is a Cytoplasmic protein ... 2002). "A novel mechanism of nuclear factor kappaB activation through the binding between inhibitor of nuclear factor- ... a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain". Mol Cell Biol. 20 (20): 7735-7750. doi:10.1128/ ...
*  Palmitoyl acyltransferase
The example of substrate includes H-Ras, N-ras, R-Ras, RhoB, Cdc42 inform 2, Rab10, Galpha subunit of trimeric GTP binding ... The protein polymitoylation is a reversible process. The addition of palmitoyl group increase the membrane association of the ... Palmitoyl acyltransferase is a group of enzymes that transfer palmityl group to -SH group on cysteine on a protein. This ... The catalytic domain of the protein has aspartate-histidine-histidine-cystein (DHHC) in the core and therefore is called DHHC ...
*  T-cell lymphoma invasion and metastasis-inducing protein 1
TIAM1 modulates the activity of Rho GTP-binding proteins and connects extracellular signals to cytoskeletal activities. In ... Wennerberg K, Ellerbroek SM, Liu RY, Karnoub AE, Burridge K, Der CJ (Dec 2002). "RhoG signals in parallel with Rac1 and Cdc42 ... UMich Orientation of Proteins in Membranes protein/pdbid-1foe - Calculated spatial position of TIAM1-RAC2 complex in membrane. ... T-cell lymphoma invasion and metastasis-inducing protein 1 is a protein that in humans is encoded by the TIAM1 gene. TIAM1 is ...
*  Cytoskeleton
Septins are a group of the highly conserved GTP binding proteins found in eukaryotes. Different septins form protein complexes ... Rac for lamellipodia and Cdc42 for filopodia. Functions include: Muscle contraction Cell movement Intracellular transport/ ... Actin structures are controlled by the Rho family of small GTP-binding proteins such as Rho itself for contractile acto-myosin ... The same holds true for the actin-like proteins and their structure and ATP binding domain. Cytoskeletal proteins are usually ...
*  IQGAP1
Instead, it binds the active (GTP-bound) forms of RAC1 and CDC42 with higher affinity than GDP-bound forms, and stabilizes the ... Bashour AM, Fullerton AT, Hart MJ, Bloom GS (1997). "IQGAP1, a Rac- and Cdc42-binding protein, directly binds and cross-links ... This domain binds calmodulin, a protein known as a calcium sensor that can bind and regulate many target proteins. A GRD ( ... which mediates actin-binding and binds calponin. The WW, or poly-proline protein-protein domain, so named because of two ...
*  RALB
Hsieh CL, Swaroop A, Francke U (1990). "Chromosomal localization and cDNA sequence of human ralB, a GTP binding protein". Somat ... RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity". J. Biol. Chem. 270 (38): 22473-7. doi:10.1074/jbc. ... "Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of ... Jilkina O, Bhullar RP (1997). "Generation of antibodies specific for the RalA and RalB GTP-binding proteins and determination ...
*  RACGAP1
... and CDC42 (MIM 116952). GTPase-activating proteins (GAPs) bind activated forms of Rho GTPases and stimulate GTP hydrolysis. ... a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male ... Rac GTPase-activating protein 1 is an enzyme that in humans is encoded by the RACGAP1 gene. Rho GTPases control a variety of ... Tapon N, Nagata K, Lamarche N, Hall A (March 1998). "A new rac target POSH is an SH3-containing scaffold protein involved in ...
*  Clostridium difficile toxin A
... and Cdc42 regulate their activity by alternating between an active GTP-bound state, and an inactive GDP-bound state. Guanine ... Just I, Selzer J, von Eichel-Streiber C, Aktories K (March 1995). "The low molecular mass GTP-binding protein Rho is affected ... In Rac and Cdc42, the sugar moiety is transferred to the Thr-35. The glucosylation prevents proper binding of GTP and blocks ... TcdA acts preferentially on the GDP-bound form of the GTPase proteins since this configuration exposes the threonine residue ...
*  C-Raf
... like many other small G-protein associating domains) and selectively binds GTP-bound Ras proteins only. (You can see this ... upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1". J. Biol. Chem. 275 (38): 29788-93. doi:10.1074/jbc. ... "The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors". Oncogene. 23 (2): 559-68 ... most importantly GTP-bound Ras. Activated small G-proteins can thus break up the intramolacular interactions: this results in a ...
*  Membrane ruffling
The GTP-binding protein Rac is the regulator of this membrane ruffling. Changes in the Polyphosphoinositide metabolism and ... Rac1 and cdc42. Some bacteria such as enteropathogenic E. coli and enterohemorrhagic E. coli can induce membrane ruffling by ... A number of actin-binding and organizing proteins localize to membrane ruffles and potentially target to transducing molecules ...
*  CDC42EP4
This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, ... "Entrez Gene: CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4". Human CDC42EP4 genome location and CDC42EP4 gene details ... The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family ... Cdc42 effector protein 4 is a protein that in humans is encoded by the CDC42EP4 gene. ...
*  Chimerin 1
... is a GTPase activating protein specific for RAC GTP-binding proteins. It is expressed primarily in the brain and may ... CHN1 is transferred to the plasma membrane and negatively regulates Rho-family small GTPases RAC1 and CDC42, thus causing the ... Buttery P, Beg AA, Chih B, Broder A, Mason CA, Scheiffele P (February 2006). "The diacylglycerol-binding protein α1-chimaerin ... the C-terminal RhoGAP domain and the central C1 domain similar to protein kinase C. When lipid diacylglycerol (DAG) binds to ...
*  Wiskott-Aldrich syndrome protein
The cooperative binding of CDC42 and PIP2 is thermodynamically favored; binding of one enhances binding of the other. CDC42 and ... WASp and N-WASP are analogs, they contain an N-terminal EVH1 domain, a C-terminal VCA domain and central B and GBD (GTP binding ... "Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules". The Journal of ... "Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the ...
*  DLC1
... functions to enhance the GTPase activity of the Rho-GTPase proteins RhoA and Cdc42, promoting the hydrolysis of their bound GTP ... its ability to enhance activated GTP-bound Rho-GTPases' (specifically, RhoA and Cdc42) intrinsic ability to convert their GTP ... Constitutive activation of Cdc42 due to the absence of RhoGAP proteins such as DLC1 will contribute to the continual repetition ... Deleted in Liver Cancer 1 also known as DLC1 and StAR-related lipid transfer protein 12 (STARD12) is a protein which in humans ...
*  Citron kinase
... interacting only with the GTP bound forms of rho and rac 1. Displaying a distinctive protein organization, this protein defines ... myotonic dystrophy protein kinase (MDPK) and the CDC42 effector known as MRCK or GEK. Citron kinase, which resembles the ROCK ... This GTPase cycles between an inactive GDP-bound form and an active GTP-bound form, and this RhoA flux seems important for ... Madaule P, Furuyashiki T, Reid T, Ishizaki T, Watanabe G, Morii N, Narumiya S (Dec 1995). "A novel partner for the GTP-bound ...
*  Formins
... this link is broken when GTP-bound Rho binds to the GBD and activates the protein. The addition of the DAD to mammalian cells ... Mammalian Drf3 contains a CRIB-like motif within its GBD for binding to Cdc42, which is required for Cdc42 to activate and ... including the actin-binding protein profilin, SH3 (Src homology 3) domain proteins, and WW domain proteins. The actin ... The FH2 domain is required for the self-association of formin proteins through the ability of FH2 domains to directly bind each ...
*  GDI1
... small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular ... GDI1 has been shown to interact with CDC42. GRCh38: Ensembl release 89: ENSG00000203879 - Ensembl, May 2017 GRCm38: Ensembl ... "Molecular cloning and characterization of a novel type of regulatory protein (GDI) for smg p25A, a ras p21-like GTP-binding ... GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed ...
*  Small GTPase
A typical G-protein is active when bound to GTP and inactive when bound to GDP (i.e. when the GTP is hydrolyzed to GDP). The ... the human homolog of the yeast cell cycle gene CDC42". Mol Cell Biol. 10 (11): 5977-82. ISSN 0270-7306. PMC 361395 . PMID ... GTP-binding protein regulators Wennerberg K, Rossman KL, Der CJ (March 2005). "The Ras superfamily at a glance". J. Cell Sci. ... Therefore, a G-protein can be switched on and off. GTP hydrolysis is accelerated by GTPase activating proteins (GAPs), while ...
*  RHOJ
Rho-related GTP-binding protein RhoJ is a protein that in humans is encoded by the RHOJ gene. ARHJ belongs to the Rho family of ... 2005). "Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes". ... small GTP-binding proteins. Rho proteins regulate the dynamic assembly of cytoskeletal components for several physiologic ... 2004). "The GTP/GDP Cycling of Rho GTPase TCL Is an Essential Regulator of the Early Endocytic Pathway". Mol. Biol. Cell. 14 ( ...