... appears to act as a regulatory protein interacting with many other proteins at multiple points in the cell cycle. It is ... CDC20 is a protein related to the beta subunit of heterotrimeric G proteins. Near its C-terminus it contains seven WD40 repeats ... CDC20, along with a handful of other Cdc proteins, was discovered in the early 1970s when Hartwell and colleagues made cell- ... The cell division cycle protein 20 homolog is an essential regulator of cell division that is encoded by the CDC20 gene in ...

Fang G, Yu H, Kirschner MW (1998). "The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the ... Fang G, Yu H, Kirschner MW (June 1998). "The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex ... Mitotic spindle assembly checkpoint protein MAD2A is a protein that in humans is encoded by the MAD2L1 gene. MAD2L1 is a ... "Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20". Nat. Struct. Biol. 7 (3): 224-9. doi ...

CDC4 and CDC20, an activator of APC, interact genetically. Cdc4 recruits several other substrates than Sic1 to the SCF core ... This results in proteins that differ only at their N-termini. Cdc4 protein interacts with Cdc34, an ubiquitin-conjugating ... Cdc4 (cell division control protein 4) is a substrate recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ... Thus, Sic1 protein degradation is necessary to enter S-phase. SCF (Cdc4) complex's regulatory function concerning S-phase entry ...

"Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family". Current Biology. 8 (22): 1207-10. ... a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins ... Cell division cycle protein 27 homolog is a protein that in humans is encoded by the CDC27 gene. The protein encoded by this ... This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly ...

Fang G, Yu H, Kirschner MW (August 1998). "Direct binding of CDC20 protein family members activates the anaphase-promoting ... Fizzy-related protein homolog, also known as hCDH1, is a protein that in humans is encoded by the FZR1 gene. FZR1 has been ... "Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family". Current Biology. 8 (22): 1207-S4. ... "Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family". Current Biology. 8 (22): 1207-10. ...

Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in ... a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2". J. Cell Biol ... a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1". Biochem. J. 349 (Pt 2 ... Serine/threonine-protein kinase Nek2 is an enzyme that in humans is encoded by the NEK2 gene. NEK2 has been shown to interact ...

Amon's team demonstrated that CDC20 is the target protein in the spindle checkpoint during mitosis. Amon's more recent work has ... More specifically, she demonstrated that CDC28 protein kinase is not required for the metaphase to anaphase transition and CLB2 ... Vistinin, Rosella; Prinz, Susanne; Amon, Angelika (1997). "CDC20 and CDH1: A Family of Substrate-Specific Activators of APC- ... and interference with protein biosynthesis. Amon has also examined trisomy in the mouse as a model of mammalian cell growth and ...

Cyclin-A1 interacts with: CDC20, Cyclin-dependent kinase 2, E2F1, GNB2L1, GPS2, MYBL2, and Retinoblastoma protein. GRCh38: ... Cyclin-A1 is a protein that in humans is encoded by the CCNA1 gene. The protein encoded by this gene belongs to the highly ... Wang H, Shao N, Ding QM, Cui J, Reddy ES, Rao VN (1997). "BRCA1 proteins are transported to the nucleus in the absence of serum ... This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F1, and ...

Fang G, Yu H, Kirschner MW (August 1998). "Direct binding of CDC20 protein family members activates the anaphase-promoting ... Mitotic checkpoint protein BUB3 is a protein that in humans is encoded by the BUB3 gene. Bub3 is a protein involved with the ... The complex of proteins which regulate the cell arrest are BUB1, BUB2, BUB3 (this protein), Mad1, Mad2, Mad3 and MPS1. At ... a protein kinase). When the SAC is activated, the production of the Bub3-Cdc20 complex is activated. After kinetochore ...

"Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20". The ... Sclerostin domain-containing protein 1 is a protein that in humans is encoded by the SOSTDC1 gene. This gene is a member of the ... This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, ... a bone morphogenetic protein antagonist abundantly expressed in the kidney". Biochemical and Biophysical Research ...

The APC is activated by CDC20, a protein that is silenced by the mitotic checkpoint complex (MCC). Of interest in relation to ... TRIP13/PCH2 also functions as a kinetochore protein that interacts with the silencing protein p31-Comet. Meiosis in mammalian ... "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758-65. doi:10.1101/gr.180101. PMC ... Evidence shows that TRIP13/PCH2 uses p31-Comet as an adaptor protein to convert C-Mad2 into O-Mad2. However, the connection ...

"The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner". Current Biology ... Securin is a protein that in humans is encoded by the PTTG1 gene. The encoded protein is a homolog of yeast securin proteins, ... Pei L (Jan 1999). "Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue ... "Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in ...

It is hypothesized that spindle checkpoint proteins that inhibit APC/CCdc20 only associate with a subset of the Cdc20 ... Cdc20 can still be phosphorylated and bind to APC/C, but bound Emi1 blocks Cdc20's interaction with APC targets. Emi1 ... These TPR subunits, Cdc16, Cdc27, Cdc23, and Apc5, mainly provide scaffolding and support to mediate other protein-protein ... Cdc20 and Cdh1 are the two activators of particular importance to the cell cycle. These proteins target the APC/C to specific ...

The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with ... ANAPC7 has been shown to interact with ANAPC1, ANAPC4, CDC27 and CDC20. GRCh38: Ensembl release 89: ENSG00000196510 - Ensembl, ... Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme ... 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase- ...

A protein called hMAD2 can form an inactive trimer with APC and CDC20, forming the hMAD2-CDC-APC complex. Upon the ... coordinate the cellular localisation of proteins; activate and inactivate proteins; and modulate protein-protein interactions. ... coordinate the cellular localisation of proteins; activate and inactivate proteins; and modulate protein-protein interactions. ... Fang G, Yu H, Kirschner MW (June 1998). "The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex ...

When STAU1 protein interacts with APC/C adapter proteins Cdc20 and Cdh1, proteasomal degradation is promoted in mitotic cells. ... Double-stranded RNA-binding protein Staufen homolog 1 is a protein that in humans is encoded by the STAU1 gene. Staufen is a ... Monshausen M, Rehbein M, Richter D, Kindler S (2002). "The RNA-binding protein Staufen from rat brain interacts with protein ... 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs ...

This protein and two other APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain ... CDC16 has been shown to interact with CDC27 and CDC20. GRCh38: Ensembl release 89: ENSG00000130177 - Ensembl, May 2017 GRCm38: ... This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ... Cell division cycle protein 16 homolog is a protein that in humans is encoded by the CDC16 gene. ...

BubR1 and Bub3 can also form complexes with Cdc20, but it remains to be seen if these proteins facilitate Cdc20 binding to Open ... Mad2 uses the same site to bind either Mad1 or Cdc20 and, thus, can only bind one of the two proteins at a time. Since ... Binding partners of Mad2 include either Cdc20 or Mad1. Mad1 and Cdc20 bind Mad2 in an identical fashion. ... APCCdc20 is a ubiquitin-protein ligase that tags the protein, securin, for destruction. Securin destruction liberates and ...

Destruction of Clb5 and Clb6 is usually mediated by APC-Cdc20. Studies have also shown that cells lacking Clb5 and Clb6 have ... Clb5, in particular, has unique hydrophobic section of amino acids that allows specific interactions with proteins in the pre- ... During S-phase, Clb5 and Clb6 are simultaneously expressed with other genes encoding proteins required for individual DNA ... These gene regulatory proteins control G1/S genes, and their negative regulation assists in shutting off expression of G1 ...

CDC20 and the SAC proteins concentrate at the kinetochores before attachment to the spindle assembly. These proteins keep the ... In human cells, binding of BUBR1 to CDC20 requires prior binding of MAD2 to CDC20, so it is possible that the MAD2-CDC20 ... Phosphorylated Spc105 is then able to recruit the downstream signaling proteins Bub1 and 3; Mad 1,2, and 3; and Cdc20. ... Securin is recognized only if Cdc20, the activator subunit, is bound to the APC/C core. When securin, Cdc20, and E2 are all ...

The N-terminal region mediates binding of Hs-BUB1 to the mitotic kinetochore protein blinkin (a protein also commonly referred ... Tang Z, Shu H, Oncel D, Chen S, Yu H (Nov 2004). "Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C ... Bub1 is a serine/threonine protein kinase first identified in genetic screens of Saccharomyces cerevisiae. The protein is bound ... The protein kinase Bub1 possesses versatile and distinct functions during the cell cycle, mainly in the SAC and chromosome ...

This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and ... F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene. This gene encodes a member of the F-box protein ... and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this ... The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box ...

... proteins including Mad and Bub inhibit APC-Cdc20 to delay entry into anaphase and B-type cyclin degradations. In addition, when ... APC in association with Cdc20 (APC-Cdc20) ubiquitinates and targets mitotic cyclins (Clb2) for degradation at initial phase. ... Cdc20 and Cdh1, which are the activators of APC, recruit substrates such as securin and B-type cyclins(Clb) for ubiquitination ... This allows for the transcription of S phase genes encoding for proteins that amplify the G1 to S phase switch. Many different ...

... proteins including Mad and Bub inhibit APC-Cdc20 to delay entry into anaphase and B-type cyclin degradations. In addition, when ... APC in association with Cdc20 (APC-Cdc20) ubiquitinates and targets mitotic cyclins (Clb2) for degradation at initial phase. ... Cdc20 and Cdh1, which are the activators of APC, recruit substrates such as securin and B-type cyclins(Clb) for ubiquitination ... feedback loop is initiated from APC-Cdc20-dependent degradation of Cdk1-Clb2 and release of Cdc14 from nucleolar protein Net1/ ...

This second c-MAD2 is transferred to Cdc20 with yet unknown mechanism and forms Cdc20-c-Mad2 complex. This complex is an ... Mad1 is a non-essential protein which in yeast has a function in the spindle assembly checkpoint (SAC). This checkpoint ... show that Mad1 functions such as to slow down the rate of Mad2-Cdc20 complex formation and therefore acts as a competitive ... In vivo, Mad1 acts as a competitive inhibitor of the Mad2-Cdc20 complex. Mad1 is phosphorylated by Mps1 which then leads ...

This is usually achieved by mutations in the p53 protein or by loss of the chromosome region that contains the genetic code for ... Cdc20, BubR1, and Bub3 in humans. When the mitotic checkpoint complex is formed, it binds to the anaphase promoting complex and ... p53 acts to prevent the propagation of tumor cells and is considered a major tumor suppressor protein. p53 works by either ... Unattached kinetochores promote the formation of the mitotic checkpoint complex which is composed of four different proteins ...

Securin is a protein which inhibits a protease known as separase. The destruction of securin unleashes separase which then ... Interphase Prophase Prometaphase Metaphase Telophase Cytoskeleton Anaphase I Anaphase II Cdc20 "Chromosome condensation through ... Microtubules attach to the midpoint of chromosomes (the centromere) via protein complexes (kinetochores). The attached ... and by motor proteins such as dyneins or kinesins. Anaphase accounts for approximately 1% of the cell cycle's duration. It ...

At this moment, the checkpoint proteins that bind to and inhibit Cdc20 (Mad1-Mad2 and BubR1), release Cdc20, which binds and ... and the spindle checkpoint proteins (such as Mad1, Mad2, BubR1 and Cdc20). These proteins assemble on the kinetochore in high ... KNL/KBP proteins (kinetochore-null/KNL-binding protein), MIS proteins and CENP-F. Together with the constitutive components, ... Other proteins in the kinetochore adhere it to the microtubules (MTs) of the mitotic spindle. There are also motor proteins, ...

HDAC2 is broadly regulated by protein kinase 2 (CK2) and protein phosphatase 1 (PP1), but biochemical analysis suggests its ... Histone deacetylase 2 has been shown to interact with: Ataxia telangiectasia and Rad3 related, BUB3, CDC20, CDH1, CHD3, CHD4, ... Yao YL, Yang WM (October 2003). "The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone ... This protein also forms transcriptional repressor complexes by associating with many different proteins, including YY1, a ...

... exotoxins secreted by bacteria Cell-division cycle in biology cdc20 cdc25 Cdc42, cell-division cycle protein Complement- ...