March 1995). "Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk ... It is regulated by cyclins, more specifically by Cyclin D proteins and Cyclin-dependent kinase inhibitor proteins. The protein ... This kinase is a catalytic subunit of the protein kinase complex, important for the G1 phase progression and G1/S transition of ... August 1992). "A family of human cdc2-related protein kinases". The EMBO Journal. 11 (8): 2909-2917. doi:10.1002/j.1460- ...

"A family of human cdc2-related protein kinases." The EMBO Journal 11.8 (1992): 2909. Whyte, Peter, Nicola M. Williamson, and E ... Meyerson, M (1992). "A family of human cdc2-related protein kinases". EMBO J. 11: 2909-17. doi:10.1002/j.1460-2075.1992.tb05360 ... Among Harlow's discoveries was the demonstration that the retinoblastoma protein interacts with viral transforming proteins, ... "The retinoblastoma protein is phosphorylated during specific phases of the cell cycle." Cell 58.6 (1989): 1097-1105. van den ...

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a ... "A family of human cdc2-related protein kinases". EMBO J. 11 (8): 2909-17. doi:10.1002/j.1460-2075.1992.tb05360.x. PMC 556772. ... two members of a novel cdc2/CDC28-related protein kinase gene family". Oncogene. 7 (11): 2249-58. PMID 1437147. "Entrez Gene: ... Serine/threonine-protein kinase PCTAIRE-1 is an enzyme that in humans is encoded by the PCTK1 gene. ...

... PCTAIRE protein kinase 3". Meyerson M, Enders GH, Wu CL, et al. (1992). "A family of human cdc2-related protein kinases ... two members of a novel cdc2/CDC28-related protein kinase gene family". Oncogene. 7 (11): 2249-58. PMID 1437147. "Entrez Gene: ... Serine/threonine-protein kinase PCTAIRE-3 is an enzyme that in humans is encoded by the PCTK3 gene. GRCh38: Ensembl release 89 ... Palmer KJ, Konkel JE, Stephens DJ (2005). "PCTAIRE protein kinases interact directly with the COPII complex and modulate ...

... PCTAIRE protein kinase 2". Meyerson M, Enders GH, Wu CL, et al. (1992). "A family of human cdc2-related protein kinases ... The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity ... Serine/threonine-protein kinase PCTAIRE-2 is an enzyme that in humans is encoded by the PCTK2 gene. ... Hirose T, Tamaru T, Okumura N, Nagai K, Okada M (Dec 1997). "PCTAIRE 2, a Cdc2-related serine/threonine kinase, is ...

This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the cell nucleus, the ... Johnson KW, Smith KA (1991). "Molecular cloning of a novel human cdc2/CDC28-like protein kinase". J. Biol. Chem. 266 (6): 3402- ... Colwill K, Feng LL, Yeakley JM, Gish GD, Cáceres JF, Pawson T, Fu XD (1996). "SRPK1 and Clk/Sty protein kinases show distinct ... Dual specificity protein kinase CLK1 is an enzyme that in humans is encoded by the CLK1 gene. ...

2006). "A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins". Cell Res. 16 (6): 539-47. ... Lazzaro MA, Albert PR, Julien JP (Jul 1997). "A novel cdc2-related protein kinase expressed in the nervous system". J Neurochem ... Serine/threonine-protein kinase PFTAIRE-1 is an enzyme that in humans is encoded by the PFTK1 gene. PFTK1 has been shown to ... "Entrez Gene: PFTK1 PFTAIRE protein kinase 1". Yang, Tao; Gao Yan-Kun; Chen Jiang-Ye (Jul 2002). "KIAA0202, a human septin ...

"The Wee1 protein kinase regulates T14 phosphorylation of fission yeast Cdc2". Mol Biol Cell. 6 (4): 371-85. doi:10.1091/mbc.6.4 ... The corresponding proteins are Wee1-like protein kinase and Wee1-like protein kinase 2 which act on the human Cdk1 homologue ... Wee1-like protein kinase Cell cycle β-transducin repeat-containing protein 1/2 (β-TrCP1/2) F-box protein-containing SKP1/Cul1/F ... The M-phase kinases Polo-like kinase (Plk1) and Cdc2 phosphorylate two serine residues in Wee1A which are recognized by SCFβ- ...

"Downregulation of the cdc2/cyclin B protein kinase activity by binding of p53 to p34(cdc2)". Biochem. Biophys. Res. Commun. 283 ... Cdk1 is comprised mostly by the bare protein kinase motif, which other protein kinases share. Cdk1, like other kinases, ... "Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45". Oncogene. 18 (18 ... Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that ...

Walworth, N.; Davey, S.; Beach, D. (1993). "Fission yeast chkl protein kinase links the rad checkpoint pathway to cdc2". Nature ... The cell cycle is driven by proteins called cyclin dependent kinases that associate with cyclin regulatory proteins at ... These kinases act upstream of Cdc25 and Wee1, the direct regulators of the CyclinB-Cdc2 complex. Chk1 and Chk2 phosphorylate ... Many proteins involved in this positive feedback loop drive the activation of the CyclinB-Cdc2 complex because entry into ...

Pathan NI, Geahlen RL, Harrison ML (Nov 1996). "The protein-tyrosine kinase Lck associates with and is phosphorylated by Cdc2 ... microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase". Molecular and Cellular ... Tyrosine-protein kinase Lyn is a protein that in humans is encoded by the LYN gene. Lyn is a member of the Src family of ... "Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen ...

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in ... "Entrez Gene: CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase)". Human CDKL2 genome location and CDKL2 gene details ... Taglienti CA, Wysk M, Davis RJ (Feb 1997). "Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 ... Cyclin-dependent kinase-like 2 is an enzyme that in humans is encoded by the CDKL2 gene. ...

Ko TK, Kelly E, Pines J (Oct 2001). "CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles ... CDK12 cyclin-dependent kinase 12 is a protein kinase that in humans is encoded by the CDK12 gene. This enzyme is a member of ... 2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry" (PDF). ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355-64. doi: ...

"Mitotic reorganization of the intermediate filament protein nestin involves phosphorylation by cdc2 kinase". Journal of ... Nestin (protein) has been shown to interact with Cyclin-dependent kinase 5. GRCh38: Ensembl release 89: ENSG00000132688 - ... Nestin is a protein that in humans is encoded by the NES gene. Nestin (acronym for neuroepithelial stem cell protein) is a type ... These intermediate filament proteins are expressed mostly in nerve cells where they are implicated in the radial growth of the ...

... protein kinases CDC2 and CDC7. MCM2 has been shown to interact with: AKAP8, Cell division cycle 7-related protein kinase, MCM3 ... "Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication". J. Biol. Chem. 278 (29): 26750- ... A role for cdc2 kinase". J. Biol. Chem. 273 (27): 17095-101. doi:10.1074/jbc.273.27.17095. PMID 9642275. Jiang W, McDonald D, ... The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be ...

This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the ... This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. ... Wee1-like protein kinase has been shown to interact with YWHAB and PIN1. GRCh38: Ensembl release 89: ENSG00000166483 - Ensembl ... Booher RN, Holman PS, Fattaey A (1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity ...

... and purification of a Cdc2-activating threonine-161 protein kinase from human cells". Archives of Biochemistry and Biophysics. ... Cyclin-dependent kinase 7, or cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene. The ... This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an ... protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly ...

Agarwal-Mawal A, Paudel HK (June 2001). "Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 ... Cyclin-dependent kinase 5 activator 2 is an enzyme that in humans is encoded by the CDK5R2 gene. The protein encoded by this ... It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share ... cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II ...

1999). "Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45". Oncogene. ... "Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45". Oncogene. 18 (18 ... Vairapandi M, Balliet AG, Hoffman B, Liebermann DA (September 2002). "GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors ... 2000). "The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression". J. Biol. Chem. 275 (22): ...

... pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The ... The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene ... Cyclin-dependent kinase 4 also known as cell division protein kinase 4 is an enzyme that in humans is encoded by the CDK4 gene ... 1995). "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C". Proc. Natl. Acad. ...

"Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45". Oncogene. 18 (18 ... Vairapandi M, Balliet AG, Hoffman B, Liebermann DA (September 2002). "GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors ... G2/mitotic-specific cyclin-B1 is a protein that in humans is encoded by the CCNB1 gene. Cyclin B1 is a regulatory protein ... "G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently". J. ...

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in ... Cyclin dependent kinase like 1 is a protein that in humans is encoded by the CDKL1 gene. ... "Entrez Gene: Cyclin dependent kinase like 1". Retrieved 2016-06-07. Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). " ...

"Cdc2 kinase directly phosphorylates the cis-Golgi matrix protein GM130 and is required for Golgi fragmentation in mitosis". ... The golgins are a family of proteins, of which the protein encoded by this gene is a member, that are localized to the Golgi. ... Golgin subfamily A member 2, also known as 130 kDa cis-Golgi matrix protein 1 (GM130) is a protein that in humans is encoded by ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ...

The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin ... Cyclin-H is a protein that in humans is encoded by the CCNH gene. The protein encoded by this gene belongs to the highly ... This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. ... Drapkin R, Le Roy G, Cho H, Akoulitchev S, Reinberg D (Jun 1996). "Human cyclin-dependent kinase-activating kinase exists in ...

"Downregulation of the cdc2/cyclin B protein kinase activity by binding of p53 to p34(cdc2)". Biochemical and Biophysical ... "Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex". The ... Phosphorylation of the N-terminal end of p53 by the above-mentioned protein kinases disrupts Mdm2-binding. Other proteins, such ... "The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and ...

... like the MAP kinase kinase kinase protein MOS, that are vital to the completion of meiosis in Xenopus Oocytes. Prior to the ... Myt1, in complex with RSK, is now unable to inhibit cdc2. As a consequence, cdc2 permits entry into meiosis. A similar Aurora A ... The human genome contains three members of the aurora kinase family: Aurora kinase A, Aurora kinase B and Aurora C kinase. The ... Aurora kinase A also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene. ...

"Phosphorylation by cdc2 kinase modulates DNA binding activity of high mobility group I nonhistone chromatin protein". The ... High-mobility group protein HMG-I/HMG-Y is a protein that in humans is encoded by the HMGA1 gene. This gene encodes a non- ... "Identification of sites on chromosomal protein HMG-I phosphorylated by casein kinase II". FEBS Letters. 257 (1): 101-4. doi: ... HMGB and HMGN proteins. HMGA1-GFP fusion proteins are highly dynamic in vivo (determined using FRAP analysis), but in contrast ...

In S. pombe, Rad proteins, S. pombe Mek1 (with FHA kinase domain), Cdc25, Cdc2 and unknown factor is thought to form a ... the cell synthesizes its vast array of proteins, including the enzymes and structural proteins it will need for growth. In G1, ... The protein complex cohesin holds sister chromatids together from the time of their replication until anaphase. In mitosis, the ... there is a role of MeiRNA binding protein for entry to meiotic cell division. It has been suggested that Yeast CEP1 gene ...

This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, also known as Cdk1 in ... The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases. ... Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the ... Cheng A, Kaldis P, Solomon MJ (November 2000). "Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type ...

"The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M ... Messenger MM, Saulnier RB, Gilchrist AD, Diamond P, Gorbsky GJ, Litchfield DW (Jun 2002). "Interactions between protein kinase ... "The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M ... The enzyme binds to a subset of proteins and thus plays a role as a post phosphorylation control in regulating protein function ...

Graña X, Claudio PP, De Luca A, Sang N, Giordano A (Jul 1994). "PISSLRE, a human novel CDC2-related protein kinase". Oncogene. ... "Entrez Gene: CDK10 cyclin-dependent kinase (CDC2-like) 10". Kasten M, Giordano A (Apr 2001). "Cdk10, a Cdc2-related kinase, ... Cell division protein kinase 10 is an enzyme that in humans is encoded by the CDK10 gene. The protein encoded by this gene ... "Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, ...

1995). "Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk ... "A family of human cdc2-related protein kinases". EMBO J. 11 (8): 2909-17. doi:10.1002/j.1460-2075.1992.tb05360.x. PMC 556772. ... Cell division protein kinase 3 is an enzyme that in humans is encoded by the CDK3 gene. CDK3 complements cdc28 mutants of ... Meikrantz W, Schlegel R (1996). "Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases". J ...

"The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2". EMBO ... Nebreda, A.R.; Hunt, T. (1993). "The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but ... He and others subsequently showed that cyclins bind and activate a family of protein kinases, now called the cyclin-dependent ... of protein synthesis is mediated by reversible phosphorylation of initiation factor eIF-2 by two distinct protein kinases and ...

... also known as MAPK-activated protein kinase-1 (MAPKAP-K1), and p70rsk, also known as S6-H1 Kinase or simply S6 Kinase. There ... an inhibitor of cdc2. RSK phosphorylation of SOS1 (Son of Sevenless) at Serines 1134 and 1161 creates 14-3-3 docking site. This ... Ribosomal+Protein+S6+Kinases,+90-kDa at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Ribosomal+Protein ... In molecular biology, ribosomal s6 kinase (rsk) is a family of protein kinases involved in signal transduction. There are two ...

The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. ... A role for cdc2 kinase". J. Biol. Chem. 273 (27): 17095-101. doi:10.1074/jbc.273.27.17095. PMID 9642275. You Z, Komamura Y, ... This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase ... The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be ...