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*  Cyclin-dependent kinase 10
... a human novel CDC2-related protein kinase". Oncogene. 9 (7): 2097-103. PMID 8208557. Brambilla R, Draetta G (Oct 1994). " ... "Entrez Gene: CDK10 cyclin-dependent kinase (CDC2-like) 10". Kasten M, Giordano A (Apr 2001). "Cdk10, a Cdc2-related kinase, ... Cell division protein kinase 10 is an enzyme that in humans is encoded by the CDK10 gene. The protein encoded by this gene ... "Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, ...
*  Ed Harlow
"A family of human cdc2-related protein kinases." The EMBO Journal 11.8 (1992): 2909. Whyte, Peter, Nicola M. Williamson, and E ... Meyerson, M (1992). "A family of human cdc2-related protein kinases". EMBO J. 11: 2909-17. PMC 556772 . PMID 1639063. Whyte, P ... Among Harlow's discoveries was the demonstration that the retinoblastoma protein interacts with viral transforming proteins, ... "The retinoblastoma protein is phosphorylated during specific phases of the cell cycle." Cell 58.6 (1989): 1097-1105. van den ...
*  Cyclin-dependent kinase 5
"A cdc2-related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline-directed protein ... Cell division protein kinase 5 is an enzyme that in humans is encoded by the CDK5 gene. The protein encoded by this gene is ... "A family of human cdc2-related protein kinases". The EMBO Journal. 11 (8): 2909-17. PMC 556772 . PMID 1639063. Patrick GN, ... membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase". The Journal of Neuroscience. 23 (12): ...
*  Cyclin-dependent kinase 3
1995). "Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk ... "A family of human cdc2-related protein kinases". EMBO J. 11 (8): 2909-17. PMC 556772 . PMID 1639063. "Entrez Gene: CDK3 cyclin- ... Cell division protein kinase 3 is an enzyme that in humans is encoded by the CDK3 gene. CDK3 complements cdc28 mutants of ... Meikrantz W, Schlegel R (1996). "Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases". J ...
*  PCTK3
... PCTAIRE protein kinase 3". Meyerson M, Enders GH, Wu CL, et al. (1992). "A family of human cdc2-related protein kinases ... two members of a novel cdc2/CDC28-related protein kinase gene family". Oncogene. 7 (11): 2249-58. PMID 1437147. "Entrez Gene: ... Serine/threonine-protein kinase PCTAIRE-3 is an enzyme that in humans is encoded by the PCTK3 gene. GRCh38: Ensembl release 89 ... Palmer KJ, Konkel JE, Stephens DJ (2005). "PCTAIRE protein kinases interact directly with the COPII complex and modulate ...
*  PCTK2
... PCTAIRE protein kinase 2". Meyerson M, Enders GH, Wu CL, et al. (1992). "A family of human cdc2-related protein kinases ... The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity ... Serine/threonine-protein kinase PCTAIRE-2 is an enzyme that in humans is encoded by the PCTK2 gene. ... 2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. ...
*  CLK1
This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the cell nucleus, the ... Johnson KW, Smith KA (1991). "Molecular cloning of a novel human cdc2/CDC28-like protein kinase". J. Biol. Chem. 266 (6): 3402- ... Colwill K, Feng LL, Yeakley JM, Gish GD, Cáceres JF, Pawson T, Fu XD (1996). "SRPK1 and Clk/Sty protein kinases show distinct ... Dual specificity protein kinase CLK1 is an enzyme that in humans is encoded by the CLK1 gene. ...
*  PFTK1
2006). "A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins". Cell Res. 16 (6): 539-47. ... "A novel cdc2-related protein kinase expressed in the nervous system". J Neurochem. 69 (1): 348-64. doi:10.1046/j.1471-4159.1997 ... Serine/threonine-protein kinase PFTAIRE-1 is an enzyme that in humans is encoded by the PFTK1 gene. PFTK1 has been shown to ... "Entrez Gene: PFTK1 PFTAIRE protein kinase 1". Yang, Tao; Gao Yan-Kun; Chen Jiang-Ye (Jul 2002). "KIAA0202, a human septin ...
*  CDK12
Ko TK, Kelly E, Pines J (Oct 2001). "CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles ... CDK12 cyclin-dependent kinase 12 is a protein kinase that in humans is encoded by the CDK12 gene. This enzyme is a member of ... 2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355-64. doi: ...
*  Cyclin-dependent kinase 6
"Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, ... It is regulated by cyclins, more specifically by Cyclin D proteins and Cyclin-dependent kinase inhibitor proteins. The protein ... This kinase is a catalytic subunit of the protein kinase complex, important for the G1 phase progression and G1/S transition of ... "A family of human cdc2-related protein kinases". The EMBO Journal. 11 (8): 2909-17. PMC 556772 . PMID 1639063. "Entrez Gene: ...
*  PCTK1
The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a ... "A family of human cdc2-related protein kinases". EMBO J. 11 (8): 2909-17. PMC 556772 . PMID 1639063. Knight JC, Renwick PJ, ... two members of a novel cdc2/CDC28-related protein kinase gene family". Oncogene. 7 (11): 2249-58. PMID 1437147. "Entrez Gene: ... Serine/threonine-protein kinase PCTAIRE-1 is an enzyme that in humans is encoded by the PCTK1 gene. ...
*  Wee1
"The Wee1 protein kinase regulates T14 phosphorylation of fission yeast Cdc2". Mol Biol Cell. 6 (4): 371-85. doi:10.1091/mbc.6.4 ... The corresponding proteins are Wee1-like protein kinase and Wee1-like protein kinase 2 which act on the human Cdk1 homologue ... Wee1-like protein kinase Cell cycle β-transducin repeat-containing protein 1/2 (β-TrCP1/2) F-box protein-containing SKP1/Cul1/F ... The M-phase kinases Polo-like kinase (Plk1) and Cdc2 phosphorylate two serine residues in Wee1A which are recognized by SCFβ- ...
*  G2-M DNA damage checkpoint
Walworth, N.; Davey, S.; Beach, D. (1993). "Fission yeast chkl protein kinase links the rad checkpoint pathway to cdc2". Nature ... Accumulation of cyclin B increases the activity of the cyclin dependent kinase cdc2 as cells prepare to enter mitosis. Cdc2 ... The cell cycle is driven by proteins called cyclin dependent kinases that associate with cyclin regulatory proteins at ... Early signaling proteins in the checkpoint pathway are members of a family of phosphotidylinositol 3-kinases, rad3 in yeast and ...
*  MCM2
... protein kinases CDC2 and CDC7. MCM2 has been shown to interact with: AKAP8, Cell division cycle 7-related protein kinase, MCM3 ... "Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication". J. Biol. Chem. 278 (29): 26750- ... A role for cdc2 kinase". J. Biol. Chem. 273 (27): 17095-101. doi:10.1074/jbc.273.27.17095. PMID 9642275. Jiang W, McDonald D, ... The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be ...
*  CDKL2
This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in ... "Entrez Gene: CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase)". Human CDKL2 genome location and CDKL2 gene details ... "Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE". Oncogene. 13 (12): 2563-74. PMID ... Cyclin-dependent kinase-like 2 is an enzyme that in humans is encoded by the CDKL2 gene. ...
*  Cyclin dependent kinase like 1
This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in ... Cyclin dependent kinase like 1 is a protein that in humans is encoded by the CDKL1 gene. ... Cyclin dependent kinase like 1". Retrieved 2016-06-07. Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized ...
*  CDK5R2
Agarwal-Mawal A, Paudel HK (2001). "Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and ... Cyclin-dependent kinase 5 activator 2 is an enzyme that in humans is encoded by the CDK5R2 gene. The protein encoded by this ... It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share ... 2004). "Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells". J. ...
*  RPS6KA3
Paudel HK (November 1997). "Phosphorylation by neuronal cdc2-like protein kinase promotes dimerization of Tau protein in vitro ... This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non- ... "Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the ... Ribosomal protein S6 kinase, 90kDa, polypeptide 3, also known as RPS6KA3, is an enzyme that in humans is encoded by the RPS6KA3 ...
*  Cyclin-dependent kinase 1
... human CDC2 is capable of rescuing fission yeast carrying a cdc2 mutation. Cdk1 is comprised mostly by the bare protein kinase ... "Downregulation of the cdc2/cyclin B protein kinase activity by binding of p53 to p34(cdc2)". Biochem. Biophys. Res. Commun. 283 ... "Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45". Oncogene. 18 (18 ... Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that ...
*  LYN
Pathan NI, Geahlen RL, Harrison ML (Nov 1996). "The protein-tyrosine kinase Lck associates with and is phosphorylated by Cdc2 ... microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase". Molecular and Cellular ... Tyrosine-protein kinase Lyn is a protein that in humans is encoded in humans by the LYN gene. Lyn is a member of the Src family ... "Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen ...
*  List of MeSH codes (D12.776)
... cdc2 protein kinase MeSH D12.776.167.200.067.500 - cdc28 protein kinase, s cerevisiae MeSH D12.776.167.200.067.875 - cyclin- ... dependent kinase 5 MeSH D12.776.167.200.067.900 - cyclin-dependent kinase 9 MeSH D12.776.167.200.580.500 - cdc2 protein kinase ... RNA-binding protein EWS MeSH D12.776.624.664.700.250 - lymphocyte specific protein tyrosine kinase p56(lck) MeSH D12.776. ... wnt1 protein MeSH D12.776.624.664.700.978 - wnt2 protein MeSH D12.776.624.776.355.100 - cyclin-dependent kinase inhibitor p15 ...
*  PPP1R2
Agarwal-Mawal A, Paudel HK (2001). "Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and ... Wang H, Brautigan DL (2003). "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2". J. ... 2004). "Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells". J. ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038 ...
*  Cell nucleus
... a process regulated by phosphorylation of the lamins by protein kinases such as the CDC2 protein kinase. Towards the end of the ... The PML protein is the key organizer of these domains that recruits an ever-growing number of proteins, whose only common known ... Observations that myxobacteria are motile, can form multicellular complexes, and possess kinases and G proteins similar to ... The nuclear lamina is composed mostly of lamin proteins. Like all proteins, lamins are synthesized in the cytoplasm and later ...
*  Wee1-like protein kinase
This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the ... This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. ... Wee1-like protein kinase has been shown to interact with YWHAB and PIN1. GRCh38: Ensembl release 89: ENSG00000166483 - Ensembl ... Booher RN, Holman PS, Fattaey A (1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity ...
*  Replication protein A2
... in the p34 subunit of human single-stranded DNA-binding protein phosphorylated by DNA-dependent protein kinase and Cdc2 kinase ... Single-stranded binding protein Replication protein A Replication protein A1 Replication protein A3 GRCh38: Ensembl release 89 ... Replication protein A 32 kDa subunit is a protein that in humans is encoded by the RPA2 gene. RPA2 has been shown to interact ... Dutta A, Stillman B (Jun 1992). "cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA ...