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*  Nc/Nga mice model
This infiltrate consists mainly of CD4 positive T lymphocytes with less CD8 positive lymphocytes and macrophages. Infiltration ... All these genes or their products more precisely are involved in T lymphocytes development. Derm1 region is conserved on human ...
*  Autoimmune pancreatitis
... or CD8-positive lymphocytes and IgG4-positive plasma cells, and exhibits interstitial fibrosis and acinar cell atrophy in later ... It has been proposed that a cytologic smear primarily composed of acini rich in chronic inflammatory cells (lymphocytes, plasma ... Histopathologic examination of the pancreas shows fibrotic changes with lymphocyte and plasma cell infiltrate. For diagnosis, ...
*  IRF1
Homozygous mutant animals had abnormal peripheral blood lymphocytes, specifically decreased CD8-positive T cell and NK cell ... numbers and an increase in CD4-positive T cells. The mice also had an abnormal integument phenotype determined by a study of ...
*  Xanthogranulomatous inflammation
Many T lymphocytes were identified by these authors positive to CD4 and CD8. Macrophages and T lymphocytes demonstrated a ... The foam cells of monocyte/macrophage origin are positive for KP1, HAM56, CD11b and CD68 as pointed out by Nakashiro et al. in ... Under microscope, the cellular infiltrate includes neutrophils, lymphocytes, plasma cells, erythrocytes, hemosiderin-laden ...
*  List of MeSH codes (A11)
... cd8-positive t-lymphocytes MeSH A11.118.637.555.567.569.220.200 - t-lymphocytes, cytotoxic MeSH A11.118.637.555.567.569.500 - t ... cd4-positive t-lymphocytes MeSH A11.118.637.555.567.569.200.400 - t-lymphocytes, helper-inducer MeSH A11.118.637.555.567.569. ... b-lymphocyte subsets MeSH A11.118.637.555.567.550.500 - t-lymphocyte subsets MeSH A11.118.637.555.567.562 - b-lymphocytes MeSH ... lymphocyte subsets MeSH A11.118.637.555.567.622 - lymphocytes, null MeSH A11.118.637.555.567.650 - lymphocytes, tumor- ...
*  Infectious mononucleosis
CD8-positive) T cells against infected B lymphocytes, resulting in enlarged, atypical lymphocytes (Downey cells). When the ... When positive, they feature similar specificity to the heterophile antibody test. Therefore, these tests are useful for ... The atypical lymphocytes resembled monocytes when they were first discovered, thus the term "mononucleosis" was coined. A ... Usually, a patient has few, if any, further symptoms or problems from the latent B lymphocyte infection. However, in ...
*  List of MeSH codes (A15)
... cd8-positive t-lymphocytes MeSH A15.145.229.637.555.567.569.220.200 --- t-lymphocytes, cytotoxic MeSH A15.145.229.637.555.567. ... t-lymphocytes, regulatory MeSH A15.382.490.555.567.569.220 --- cd8-positive t-lymphocytes MeSH A15.382.490.555.567.569.220.200 ... cd4-positive t-lymphocytes MeSH A15.382.490.555.567.569.200.400 --- t-lymphocytes, helper-inducer MeSH A15.382.490.555.567.569. ... t-lymphocytes MeSH A15.145.229.637.555.567.569.200 --- cd4-positive t-lymphocytes MeSH A15.145.229.637.555.567.569.200.400 --- ...
*  Avian reovirus
The most activity was observed during the subacute phase with an increase in CD8 and CD4 lymphocytes. At this phase, clusters ... During the chronic phase, a high amount of CD4 T- cells and a few IgM-positive B-cells were observed. Immunosuppression ... Within the synovium collected, plasma cells and T-lymphocytes were the primary inflammatory cells present. During the acute- ... and T and B-lymphocytes were observed to determine its effects on cellular infiltrates during the development of reovirus ...
*  Helper/suppressor ratio
CD8 ratio) is a basic laboratory test in which the percentage of CD3-positive lymphocytes in the blood positive for CD4 (T ... production of HIV specific CD8 positive cells will cause a large fall in the ratio, but subsequent immunosuppression over time ... Normal values (95% confidence intervals) are approximately 30-60% CD4 and 10-30% CD8 depending on age (ratio 0.9 to 3.7 in ... The T-Lymphocyte Helper/Suppressor Profile (Helper/Suppressor ratio, T4:T8 ratio, CD4: ...
*  Hypereosinophilia
CD7 positive T cells, CD3 negative, CD4 positive T cells, or CD3 positive, CD4 negative, CD8 negative T cells) and is thought ... In on study of 16 lymphocyte-variant hypereosinophilia patients with the aberrant CD3 negative, CD41 positive immunophenotype, ... in T-cells or the proliferation of lymphocytes with the CD3 negative, CD41 positive immunophenotype may occur during the ... Lymphocyte-variant hypereosinophilia is a disorder attributed to the expansion of a cytokine-producing, aberrant population of ...
*  Thymocyte
... positive for both CD4 and CD8). The final stage in maturation is the single positive stage (positive for either CD4 or CD8). In ... Thymopoiesis is the process in the thymus by which thymocytes differentiate into mature T lymphocytes. The primary function of ... At this stage thymocytes upregulate both CD4 and CD8, becoming double positive cells. Double positive thymocytes that have a T ... Expression of both CD4 and CD8 makes them double positive, and matures into either CD4+ or CD8+ cells. Thymocytes are ...
*  T-cell prolymphocytic leukemia
T-PLL has the immunophenotype of a mature (post-thymic) T-lymphocyte, and the neoplastic cells are typically positive for pan-T ... The immunophenotype CD4+/CD8- is present in 60% of cases, the CD4+/CD8+ immunophenotype is present in 25%, and the CD4-/CD8+ ... A high lymphocyte count (> 100 x 109/L) along with low amounts of red blood cells and platelets in the blood are common ... In the peripheral blood, T-PLL consists of medium-sized lymphocytes with single nucleoli and basophilic cytoplasm with ...
*  Human leukocyte antigen
... also called CD8 positive- or cytotoxic T-cells) that destroy cells. MHC class I proteins associate with β2-microglobulin, which ... HLAs corresponding to MHC class II (DP, DM, DOA, DOB, DQ, and DR) present antigens from outside of the cell to T-lymphocytes. ... A representative cellular assay is the mixed lymphocyte culture (MLC) and used to determine the HLA class II types. The ... These particular antigens stimulate the multiplication of T-helper cells (also called CD4 positive T cells), which in turn ...
*  Autoimmune lymphoproliferative syndrome
... for ALPS Mild elevations also found in other autoimmune diseases Thought to be cytotoxic T lymphocytes that have lost CD8 ... Can have antibodies to blood cells (DAT, anti-neutrophil, anti-platelet). Also, can have positive ANA, RF, ANCA Defective in ... It affects lymphocyte apoptosis. It is a RASopathy. It is a rare genetic disorder of abnormal lymphocyte survival caused by ... Sirolimus may not be as immune suppressive in normal lymphocytes as other agents. Some patients have had improvement in immune ...
*  McDonald criteria
... and different lymphocyte subtypes, reacting to CD3, CD4, CD8, CD20 and CD138. The sensitivity of McDonald criteria is low with ... In order to reduce false positives, McDonald et al. propose that their criteria should be applied only after any other disease ... ", "dissemination" and a "positive MRI", etc. Later they were revised again in 2010. McDonald's criteria are the standard ...
*  Harald von Boehmer
... has studied the role of T lymphocytes in the immune system. In particular he has addressed the contribution ... Questions concerned with the role of positive and negative selection of developing T cells by peptide-MHC complexes in the ... Nature 261, 141 (1976). Allo-MHC-restricted CD4 and CD8 T cells in hemopoietic chimeras reveal plasticity of MHC-restricted ... Harald von Boehmer (born November 30, 1942) is a German/Swiss immunologist best known for his work on T lymphocytes. The ...
*  ZAP70
CLL that is positive for the marker ZAP-70 has an average survival of 8 years. CLL that is negative for ZAP-70 has an average ... T lymphocytes are activated by engagement of the T cell receptor with processed antigen fragments presented by professional ... Upon this activation, the TCR co-receptor CD4 or CD8 binds to the MHC, activating the co-receptor associated tyrosine kinase ... "Differential Requirements for Src-Family Kinases in SYK or ZAP70-Mediated SLP-76 Phosphorylation in Lymphocytes". Frontiers in ...
*  RBBP7
... hemizygous mutant males had decreased CD4-positive and CD8-positive T cell numbers. RBBP7 has been shown to interact with: ... ". "Peripheral blood lymphocytes data for Rbbp7". Wellcome Trust Sanger Institute. [dead link] Gerdin AK (2010). "The Sanger ...
*  T cell
For example, miR-181a was found to play a role in the positive selection of T lymphocytes. The thymus contributes fewer cells ... These thymocytes will then express both CD4 and CD8 and progresses to the double positive (DP) stage where selection of the α- ... If the cell does not lose its signal, it will continue downregulating CD8 and become a CD4+, single positive cell. But, if ... A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated ...
*  MHC restriction
This is called positive selection. During positive selection, co-receptors CD4 and CD8 initiate a signaling cascade following ... When primary lymphocytes are developing and differentiating in the thymus or bone marrow, T cells die by apoptosis if they ... It follows that MHC restriction is imposed by CD4 and CD8 co-receptors during positive selection of T cell selection. A ... T cell maturation involves two distinct developmental stages: positive selection and negative selection. Positive selection ...
*  ARL4D
Homozygous mutant females had decreased bone mineral content, heart weight, lean body mass and CD8-positive, alpha-beta memory ... "Peripheral blood lymphocytes data for Arl4d". Wellcome Trust Sanger Institute. "Heart weight data for Arl4d". Wellcome Trust ... "Recognition of ADP-ribosylation factor 4-like by HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes from patients ...
*  Large granular lymphocytic leukemia
"Clonal expansion of lymphocytes bearing the gamma delta T-cell receptor in a patient with large granular lymphocyte disorder". ... Immunohistochemistry for perforin, TIA-1, and granzyme B are usually positive. Clonal rearrangements of the T-cell receptor ( ... are transformed CD8+ T-cell with clonal rearrangements of β chain T-cell receptor genes for the majority of cases and a CD8- T- ... The neoplastic lymphocytes seen in this disease are large in size with azurophilic granules that contains proteins involved in ...
*  Postpartum thyroiditis
Women who test positive for thyroid antibodies may be at increased risk of developing symptoms associated with postpartum ... CD8 ratio) TSH-receptor antibodies (TSH-R Abs) This condition is commonly undiagnosed by physicians due to either unfamiliarity ... increase in TPOAb subclasses IgG1-IgG3 lymphocyte infiltration and follicle formation within thyroid gland (Hashimoto's ...
*  Munir Pirmohamed
... fever and positive lymphocyte transformation test in a patient on irbesartan". The British Journal of Dermatology. 155 (2): 491 ... CD8(+), and CD4(+)CD8(+) T-cell clones from patients with carbamazopine hypersensitivity Herbal medicines and acute medical ... fever and positive lymphocyte transformation test in a patient on irbesartan Serious carbamazepine-induced hypersensitivity ... Owen, A; Goldring, C; Morgan, P; Park, BK; Pirmohamed, M (August 2006). "Induction of P-glycoprotein in lymphocytes by ...
*  Angioimmunoblastic T-cell lymphoma
The polymorphous infiltrate consists of lymphocytes of moderate size with pale/clear cytoplasm and smaller reactive lymphocytes ... AITL typically has the phenotype of a mixture of CD4+ and CD8+ T-cells, with a CD4:CD8 ratio greater than unity. Polyclonal ... and positive rheumatoid factor. The normal architecture of a lymph node is partially effaced by a polymorphous infiltrate and ...
*  GNLY
2003). "CD8 T cell-mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T cells and IL-15". ... Granulysin is present in cytolytic granules of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Granulysin is made ... Recombinant 9 kD granulysin is broadly cytolytic against tumors and microbes, including gram positive and gram negative ... Donlon TA, Krensky AM, Clayberger C (1990). "Localization of the human T lymphocyte activation gene 519 (D2S69E) to chromosome ...