"CD40CD40 ligand." Journal of leukocyte biology 67.1 (2000): 2-17. Banchereau, Jacques, et al. "Immune and clinical responses ... "Long-term human B cell lines dependent on interleukin-4 and antibody to CD40." Science251.4989 (1991): 70-72. Banchereau, ...
It is a CD40 ligand inhibitor. Medicine portal Antibody Monoclonal antibody Immunology Media Update: Anti-CD40L antibody ...
van Kooten C, Banchereau J (January 2000). "CD40-CD40 ligand". Journal of Leukocyte Biology. 67 (1): 2-17. doi:10.1002/jlb.67.1 ... many features and purposes of the CD40 signaling pathway in B cells were made determined to the detection of CD40 ligand (CD154 ... but interacts with CD40 indirectly. CD40 also interacts with CD40L, due to the role of CD40 in stimulating immune synapses when ... 1994). "The CD40 antigen and its ligand". Annual Review of Immunology. 12: 881-922. doi:10.1146/annurev.iy.12.040194.004313. ...
May 1992). "Molecular and biological characterization of a murine ligand for CD40". Nature. 357 (6373): 80-82. Bibcode: ... Richard Armitage at Immunex cloned a cDNA encoding CD154 by screening an expression library with CD40-Ig. Randolph Noelle at ... Triggering PD-1 expressed on activated monocytes by its ligand PD-L1, induces IL-10 production which inhibits CD4 T-cell ... CD40 (protein) and CD40L) and through cytokines. Th cells are not a monolithic immunological entity because they are diverse in ...
van Kooten C, Banchereau J (January 2000). "CD40-CD40 ligand". Journal of Leukocyte Biology. 67 (1): 2-17. doi:10.1002/jlb.67.1 ... CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells and is a member of the ... Wang JH, Zhang YW, Zhang P, Deng BQ, Ding S, Wang ZK, Wu T, Wang J (September 2013). "CD40 ligand as a potential biomarker for ... "Entrez Gene: CD40LG CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome)". Lederman S, Yellin MJ, Krichevsky A, Belko J ...
... the signalling axis between the protein CD40 and its ligand, CD40L. Lutgens identified that the CD40 ligand was expressed in ... Lutgens focussed on the signalling pathways of CD40. She found that interactions between TRAF6 and CD40L were key drivers of ... She has developed lipid lowering compounds that can target the TRAF6 binding pocket for CD40. 2013 Netherlands Organisation for ...
This gene codes for the CD40 ligand, which is expressed on T cells. When the CD40 ligand binds CD40 on B cells, then the B cell ...
March 2001). "Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA". Nature. 410 (6826): 383-7. Bibcode: ... AKNA is known to upregulate expression of the receptor CD40 and its ligand CD40L/CD154. AKNA is an essential part in the ... December 2018). "The Human Papillomavirus (HPV) E6 Oncoprotein Regulates CD40 Expression via the AT-Hook Transcription Factor ...
February 2006). "Autoantibody to CD40 ligand in systemic lupus erythematosus: association with thrombocytopenia but not ...
Th1 cells activate macrophages by signaling with IFN-gamma and displaying the protein CD40 ligand. Other signals include TNF- ...
SAg activation in T-cells leads to production of CD40 ligand which activates isotype switching in B cells to IgG and IgM and ... Jabara HH, Geha RS (October 1996). "The superantigen toxic shock syndrome toxin-1 induces CD40 ligand expression and modulates ...
Dendritic cells secrete and respond to chemokines after stimulation to LPS, TNFα, or CD40 ligand. In maturing of DC production ... Chemokine (C-C motif) ligands 4 (also CCL4) previously known as macrophage inflammatory protein (MIP-1β), is a protein which in ...
"Growth Inhibition of Human Multiple Myeloma Cells by an Oncolytic Adenovirus Carrying the CD40 Ligand Transgene". Clinical ... Wickham, Thomas J. (2003). "Ligand-directed targeting of genes to the site of disease". Nature Medicine. 9 (1): 135-9. doi: ... fused to a natural ligand for a cell-surface receptor. The use of adapter molecules has been shown to increase viral ... "Shaping the Tumor Stroma and Sparking Immune Activation by CD40 and 4-1BB Signaling Induced by an Armed Oncolytic Virus". ...
Han S, Hathcock K... Kelsoe G (1995). Cellular interaction in germinal centers: Roles of CD40 ligand and B7-2 in established ...
CD40 is a co-stimulatory receptor on B cells that, when bound to CD40 ligand (CD40L), sends a signal to the B-cell receptor. ... Many CD40 Ligand Deficiency are first diagnosed after having PCP in their first year of life. The fungus is common and is ... The most common causes are mutations in the CD40 Ligand (CD40LG) gene located at Xq26.3-27 leading to X-linked HIGM (XHIGM) in ... CD40L-CD40 interaction is the first step in B cell stimulation for class switch recombination (CSR) and somatic hyper mutation ...
2001). "Structure of CD40 ligand in complex with the Fab fragment of a neutralizing humanized antibody". Structure. 9 (4): 321- ...
2001). "Structure of CD40 ligand in complex with the Fab fragment of a neutralizing humanized antibody". Structure. 9 (4): 321- ...
"Immune responses to Pneumocystis murina are robust in healthy mice but largely absent in CD40 ligand-deficient mice". Journal ...
As assistant professor at Columbia, Lederman discovered the CD40-Ligand (CD154) and elucidated the molecular basis of T cell ... Dartmouth College challenged the CD40-Ligand patents, but the challenge (called an interference) was rejected on all claims. ... Lederman discovered the CD40-Ligand (CD154) and elucidated the molecular basis of T cell helper function. He also collaborated ... with Professor David Baltimore in identifying and functionally characterizing the CD40 signaling molecule, TRAF-3. Lederman's " ...
As mentioned above, CD40 is expressed on the surface of B cells, and its binding to CD40 ligand on activated T cells induces Ig ... The mutation in the TNFSF5 gene causes there to be no recognition of CD40 by CD40 ligand, and thus the T cells do not induce Ig ... Normally, CD40 ligand is expressed on activated T cells, and is necessary to induce immunoglobulin class switching from IgM to ... CD40 ligand is also required in the functional maturation of T lymphocytes and macrophages, so patients with this disorder have ...
1995). "HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 ( ...
1995). "HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 ( ...
1995). "HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 ( ...
1995). "HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 ( ...
"Signaling lymphocytic activation molecule is expressed on CD40 ligand-activated dendritic cells and directly augments ... Li SC, Gish G, Yang D, Coffey AJ, Forman-Kay JD, Ernberg I, Kay LE, Pawson T (2000). "Novel mode of ligand binding by the SH2 ...
1995). "HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 ( ...
1995). "HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 ( ...
Watanabe N, Hanabuchi S, Marloie-Provost MA, Antonenko S, Liu YJ, Soumelis V (June 2005). "Human TSLP promotes CD40 ligand- ... Liu YJ (August 2007). "Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated ...
Responses to human CD40 ligand/human interleukin-2 autologous cell vaccine in patients with B-cell chronic lymphocytic leukemia ...
In in vitro studies, it inhibited cell proliferation induced by CD40 ligands and induced cell lysis. Over three Phase 1 trials ... It is an antagonist to CD40 that was created by scientists at Chiron using Abgenix' XenoMouse transgenic mouse to generate ... Hassan SB, Sørensen JF, Olsen BN, Pedersen AE (April 2014). "Anti-CD40-mediated cancer immunotherapy: an update of recent and ... 627-II) A Fully Human Anti-CD40 Antagonistic Antibody, CHIR-12.12, Inhibit the Proliferation of Human B Cell Non-Hodgkin's ...