*CD154

"CD40-CD40 ligand". Journal of Leukocyte Biology. 67 (1): 2-17. PMID 10647992. Schattner EJ (May 2000). "CD40 ligand in CLL ... CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells and is a member of the ... Wang JH, Zhang YW, Zhang P, Deng BQ, Ding S, Wang ZK, Wu T, Wang J (September 2013). "CD40 ligand as a potential biomarker for ... "Entrez Gene: CD40LG CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome)". Lederman S, Yellin MJ, Krichevsky A, Belko J ...

*Seth Lederman

January 1996). "The central role of the CD40-ligand and CD40 pathway in T-lymphocyte-mediated differentiation of B lymphocytes ... Lederman discovered the CD40-Ligand (CD154) and elucidated the molecular basis of T cell helper function. Dr. Lederman's work ... Lederman discovered the CD40-Ligand (CD154) and elucidated the molecular basis of T cell helper function. Lederman also ... July 1993). "Deletions in the ligand for CD40 in X-linked immunoglobulin deficiency with normal or elevated IgM (HIGMX-1)". Int ...

*T helper cell

CD40 (protein) and CD40L) and through cytokines. CD154, also called CD40 ligand or CD40L, is a cell surface protein that ... "Entrez Gene: CD40LG CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome)". Armitage RJ, Fanslow WC, Strockbine L, Sato ... May 1992). "Molecular and biological characterization of a murine ligand for CD40". Nature. 357 (6373): 80-2. doi:10.1038/ ... It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. CD154 acts ...

*Hyper-IgM syndrome type 1

This gene codes for the CD40 ligand, which is expressed on T cells. When the CD40 ligand binds CD40 on B cells, then the B cell ...

*AKNA

Mar 2001). "Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA". Nature. 410 (6826): 383-7. doi: ... AKNA is known to upregulate expression of CD40 and CD154. Siddiqa A, Sims-Mourtada JC, Guzman-Rojas L, et al. ( ...

*Ruplizumab

"Autoantibody to CD40 ligand in systemic lupus erythematosus: association with thrombocytopenia but not thromboembolism". ...

*Phagocyte

Th1 cells activate macrophages by signaling with IFN-gamma and displaying the protein CD40 ligand. Other signals include TNF- ...

*Superantigen

SAg activation in T-cells leads to production of CD40 ligand which activates isotype switching in B cells to IgG and IgM and ... Jabara HH, Geha RS (October 1996). "The superantigen toxic shock syndrome toxin-1 induces CD40 ligand expression and modulates ...

*Lucatumumab

In in vitro studies, it inhibited cell proliferation induced by CD40 ligands and induced cell lysis. Over three Phase 1 trials ... It is an antagonist to CD40 that was created by scientists at Chiron using Abgenix' XenoMouse transgenic mouse to generate ... 627-II) A Fully Human Anti-CD40 Antagonistic Antibody, CHIR-12.12, Inhibit the Proliferation of Human B Cell Non-Hodgkin's ... Hassan, SB; Sørensen, JF; Olsen, BN; Pedersen, AE (April 2014). "Anti-CD40-mediated cancer immunotherapy: an update of recent ...

*Lentiviral vector in gene therapy

More specifically, Lentiviruses attach to the CD40 ligand glycoproteins on the surface of T-lymphocyte cells. The viral ...

*Hyper IgM syndrome

CD40 is a co-stimulatory receptor on B cells that, when bound to CD40 ligand (CD40L), sends a signal to the B-cell receptor. ... Many CD40 Ligand Deficiency are first diagnosed after having PCP in their first year of life. The fungus is common and is ... "CD40 gene". Genetics Home Reference. Retrieved 27 November 2016. Lougaris V, Badolato R, Ferrari S, Plebani A (2005). "Hyper ... When there is a defect in CD40, this leads to defective T-cell interaction with B cells. Consequently, humoral immune response ...

*IGKC

2001). "Structure of CD40 ligand in complex with the Fab fragment of a neutralizing humanized antibody". Structure. 9 (4): 321- ...

*CD80

"HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71)". ... It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and ...

*Pneumocystis murina

"Immune responses to Pneumocystis murina are robust in healthy mice but largely absent in CD40 ligand-deficient mice". Journal ...

*HLA-DOB

1995). "HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 ( ...

*SLAMF1

"Signaling lymphocytic activation molecule is expressed on CD40 ligand-activated dendritic cells and directly augments ... Li SC, Gish G, Yang D, Coffey AJ, Forman-Kay JD, Ernberg I, Kay LE, Pawson T (2000). "Novel mode of ligand binding by the SH2 ...

*Immunotransplant

Responses to human CD40 ligand/human interleukin-2 autologous cell vaccine in patients with B-cell chronic lymphocytic leukemia ...

*RNF128

The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy". ...

*Thymic stromal lymphopoietin

2005). "Human TSLP promotes CD40 ligand-induced IL-12 production by myeloid dendritic cells but maintains their Th2 priming ... Liu YJ (2007). "Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic ...

*Tumor necrosis factor superfamily

Peitsch MC, Jongeneel CV (February 1993). "A 3-D model for the CD40 ligand predicts that it is a compact trimer similar to the ... "Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1- ... Suda T, Takahashi T, Golstein P, Nagata S (December 1993). "Molecular cloning and expression of the Fas ligand, a novel member ... All members of the TNF family, with the exception of the secreted lymphotoxin and a proliferation-inducing ligand (APRIL), are ...

*TACI-CRD2 protein domain

Peitsch MC, Jongeneel CV (February 1993). "A 3-D model for the CD40 ligand predicts that it is a compact trimer similar to the ... contains full affinity for both ligands. The ligands are type II transmembrane protein cytokines that have various effects on ... TACI binds two ligands, APRIL and BAFF, which it binds to with high affinity and contains two cysteine-rich domains (CRDs) in ... This shorter form is capable of ligand-induced cell signaling and that the second CRD alone (TACI-CRD2) ...

*Odulimomab

... monoclonal antibody inhibits CD40 ligand-independent immune responses and prevents chronic vasculopathy in CD40 ligand- ...

*Dendritic cell

1997). "In Vivo Microbial Stimulation Induces Rapid CD40 Ligand-independent Production of Interleukin 12 by Dendritic Cells and ... September 2003). "The Inducible CXCR3 Ligands Control Plasmacytoid Dendritic Cell Responsiveness to the Constitutive Chemokine ... and CD40 greatly enhancing their ability to activate T-cells. They also upregulate CCR7, a chemotactic receptor that induces ...

*Hypergammaglobulinemia

As mentioned above, CD40 is expressed on the surface of B cells, and its binding to CD40 ligand on activated T cells induces Ig ... The mutation in the TNFSF5 gene causes there to be no recognition of CD40 by CD40 ligand, and thus the T cells do not induce Ig ... Normally, CD40 ligand is expressed on activated T cells, and is necessary to induce immunoglobulin class switching from IgM to ... CD40 ligand is also required in the functional maturation of T lymphocytes and macrophages, so patients with this disorder have ...

*Antigen-presenting cell

... with CD28 and CD40 ligand on the T cell. Only licensed dendritic cells are able to activate cytotoxic T cells. T cell licensing ... When a T helper cell with a TCR specific for that peptide binds, the B cell marker CD40 binds to CD40L on the T cell surface. ... It also upregulates several co-stimulatory molecules required for T cell activation, including CD40 and B7. The latter can ... This occurs through the interaction of co-stimulatory molecules including B7 and CD40 on the dendritic cell, ...

*Cytokine receptor

... and includes several other non-cytokine ligands like receptors, CD40, CD27 and CD30, besides the ligands on which the family is ... Arimont A, Sun S, Smit MJ, Leurs R, de Esch IJ, de Graaf C (2017). "Structural Analysis of Chemokine Receptor-Ligand ...