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*  Nc/Nga mice model
This infiltrate consists mainly of CD4 positive T lymphocytes with less CD8 positive lymphocytes and macrophages. Infiltration ... All these genes or their products more precisely are involved in T lymphocytes development. Derm1 region is conserved on human ...
*  Marian Diamond
In humans, cognitive stimulation increases circulating CD4-positive T lymphocytes, supporting the idea that immunity can be ... and the link between positive thinking and immune health. Marian Cleeves was born in Glendale, California to Dr. Montague ... voluntarily modulated, in other words, that positive thinking can impact the immune system. Council for Advancement & Support ...
*  Xanthogranulomatous inflammation
Many T lymphocytes were identified by these authors positive to CD4 and CD8. Macrophages and T lymphocytes demonstrated a ... The foam cells of monocyte/macrophage origin are positive for KP1, HAM56, CD11b and CD68 as pointed out by Nakashiro et al. in ... Under microscope, the cellular infiltrate includes neutrophils, lymphocytes, plasma cells, erythrocytes, hemosiderin-laden ...
*  HAVCR2
CD4-positive T helper lymphocytes can be divided into several types (including types 1 (Th1) and 2 (Th2)) on the basis of their ... HAVCR2 expression is up regulated in tumor-infiltrating lymphocytes in lung, gastric, head and neck cancer, schwannoma, ... and lymphocyte activation gene 3 protein (LAG3). TIM3, an immune checkpoint, is a Th1-specific cell surface protein that ...
*  List of MeSH codes (A11)
... cd4-positive t-lymphocytes MeSH A11.118.637.555.567.569.200.400 - t-lymphocytes, helper-inducer MeSH A11.118.637.555.567.569. ... cd8-positive t-lymphocytes MeSH A11.118.637.555.567.569.220.200 - t-lymphocytes, cytotoxic MeSH A11.118.637.555.567.569.500 - t ... b-lymphocyte subsets MeSH A11.118.637.555.567.550.500 - t-lymphocyte subsets MeSH A11.118.637.555.567.562 - b-lymphocytes MeSH ... lymphocyte subsets MeSH A11.118.637.555.567.622 - lymphocytes, null MeSH A11.118.637.555.567.650 - lymphocytes, tumor- ...
*  Autoimmune pancreatitis
... or CD8-positive lymphocytes and IgG4-positive plasma cells, and exhibits interstitial fibrosis and acinar cell atrophy in later ... Histopathologic examination of the pancreas reveals a characteristic lymphoplasmacytic infiltrate of CD4- ... It has been proposed that a cytologic smear primarily composed of acini rich in chronic inflammatory cells (lymphocytes, plasma ... Histopathologic examination of the pancreas shows fibrotic changes with lymphocyte and plasma cell infiltrate. For diagnosis, ...
*  List of MeSH codes (A15)
... cd4-positive t-lymphocytes MeSH A15.382.490.555.567.569.200.400 --- t-lymphocytes, helper-inducer MeSH A15.382.490.555.567.569. ... t-lymphocytes MeSH A15.145.229.637.555.567.569.200 --- cd4-positive t-lymphocytes MeSH A15.145.229.637.555.567.569.200.400 --- ... cd8-positive t-lymphocytes MeSH A15.145.229.637.555.567.569.220.200 --- t-lymphocytes, cytotoxic MeSH A15.145.229.637.555.567. ... t-lymphocytes, regulatory MeSH A15.382.490.555.567.569.220 --- cd8-positive t-lymphocytes MeSH A15.382.490.555.567.569.220.200 ...
*  Helper/suppressor ratio
CD4:CD8 ratio) is a basic laboratory test in which the percentage of CD3-positive lymphocytes in the blood positive for CD4 (T ... infection.The loss of CD4-positive cells to HIV infection can result in various distortions in the ratio, as in the initial ... One reason for abnormal results is the loss of CD4-positive cells to the Human Immunodeficiency Virus (HIV) ... Normal values (95% confidence intervals) are approximately 30-60% CD4 and 10-30% CD8 depending on age (ratio 0.9 to 3.7 in ...
*  Alfred Singer
He is best known for his work regarding lymphocyte development, particularly the differentiation of immature CD4+8+ (double ... positive) thymocytes into mature T cells. Singer's work is foundational in the understanding of T cells and MHC-restricted ... SInger A, Adoro S, Park JH: Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice. ... models and mechanisms of CD4- versus CD8-lineage choice". Nature Reviews Immunology. 8 (10): 788-801. doi:10.1038/nri2416. ISSN ...
*  Avian reovirus
The most activity was observed during the subacute phase with an increase in CD8 and CD4 lymphocytes. At this phase, clusters ... During the chronic phase, a high amount of CD4 T- cells and a few IgM-positive B-cells were observed. Immunosuppression ... Within the synovium collected, plasma cells and T-lymphocytes were the primary inflammatory cells present. During the acute- ... and T and B-lymphocytes were observed to determine its effects on cellular infiltrates during the development of reovirus ...
*  Protein disulfide-isomerase
... has been found to be involved in the breaking of bonds on the HIV gp120 protein during HIV infection of CD4 positive cells, and ... is required for HIV infection of lymphocytes and monocytes. Some studies have shown it to be available for HIV infection on the ... surface of the cell clustered around the CD4 protein. Yet conflicting studies have shown that it is not available on the cell ...
*  IRF1
... specifically decreased CD8-positive T cell and NK cell numbers and an increase in CD4-positive T cells. The mice also had an ... Homozygous mutant animals had abnormal peripheral blood lymphocytes, ...
*  Hypereosinophilia
... e.g increased numbers of CD4 negative, CD7 positive T cells, CD3 negative, CD4 positive T cells, or CD3 positive, CD4 negative ... In on study of 16 lymphocyte-variant hypereosinophilia patients with the aberrant CD3 negative, CD41 positive immunophenotype, ... in T-cells or the proliferation of lymphocytes with the CD3 negative, CD41 positive immunophenotype may occur during the ... Lymphocyte-variant hypereosinophilia is a disorder attributed to the expansion of a cytokine-producing, aberrant population of ...
*  Human leukocyte antigen
These particular antigens stimulate the multiplication of T-helper cells (also called CD4 positive T cells), which in turn ... HLAs corresponding to MHC class II (DP, DM, DOA, DOB, DQ, and DR) present antigens from outside of the cell to T-lymphocytes. ... A representative cellular assay is the mixed lymphocyte culture (MLC) and used to determine the HLA class II types. The ... also called CD8 positive- or cytotoxic T-cells) that destroy cells. MHC class I proteins associate with β2-microglobulin, which ...
*  HLA-DP
A few TCR variants that recognize these DQ/antigen complexes are on CD4 positive T-cells. These T-cells, called T-helper (Th) ... Alternatively, macrophages and other cytotoxic lymphocytes consume or destroy cells by apoptotic signaling and present self- ... and B-lymphocytes). Normally, these APC 'present' class II receptor/antigens to a great many T-cells, each with unique T-cell ...
*  HLA-DQ
A few TCR variants that recognize these DQ/antigen complexes are on CD4 positive (CD4+) T-cells. These T-cells, called T-helper ... and B-lymphocytes). Normally, these APC 'present' class II receptor/antigens to a great many T-cells, each with unique T-cell ... Regional Evolution Many HLA DQ were under positive selection of 10,000s potentially 100,000s of years in some regions. As ... of Celiac Disease patients are positive for DQ2 or DQ8. Klitz W, Maiers M, Spellman S, et al. (October 2003). "New HLA ...
*  Magnetic-activated cell sorting
This method is useful for isolation of a particular cell type, for instance CD4 lymphocytes. In negative selection the antibody ... With this method, the cells can be separated positively or negatively with respect to the particular antigen(s). In positive ...
*  Thymocyte
... positive for both CD4 and CD8). The final stage in maturation is the single positive stage (positive for either CD4 or CD8). In ... Thymopoiesis is the process in the thymus by which thymocytes differentiate into mature T lymphocytes. The primary function of ... At this stage thymocytes upregulate both CD4 and CD8, becoming double positive cells. Double positive thymocytes that have a T ... Expression of both CD4 and CD8 makes them double positive, and matures into either CD4+ or CD8+ cells. Thymocytes are ...
*  HIV-associated neurocognitive disorder
... patients with a longer history of chronic HIV and higher CD4 nadir loss present with greater cerebral atrophy. CD4 lymphocyte ... A recent longitudinal study of a small representative cohort of HIV-positive patients on stable medication regiments suggests ... 1981), "Effects of nadir CD4 count and duration of human immunodeficiency virus infection on brain volumes in highly active ... Cerebral brain volume is associated with factors related to duration of the disease and CD4 nadir; ...
*  VISTA (protein)
The increased VISTA levels correlated with an increase in immune activation and a decrease in CD4-positive T cells. There is an ... VISTA is produced at high levels in tumor-infiltrating lymphocytes, such as myeloid-derived suppressor cells and regulatory T ... "Coinhibitory receptor PD-1H preferentially suppresses CD4⁺ T cell-mediated immunity". Journal of Clinical Investigation. 124 (5 ...
*  T-cell prolymphocytic leukemia
T-PLL has the immunophenotype of a mature (post-thymic) T-lymphocyte, and the neoplastic cells are typically positive for pan-T ... The immunophenotype CD4+/CD8- is present in 60% of cases, the CD4+/CD8+ immunophenotype is present in 25%, and the CD4-/CD8+ ... A high lymphocyte count (> 100 x 109/L) along with low amounts of red blood cells and platelets in the blood are common ... In the peripheral blood, T-PLL consists of medium-sized lymphocytes with single nucleoli and basophilic cytoplasm with ...
*  Thymic nurse cell
Also, almost 90% of all thymocytes extracted from the female TNCs were found to be double positives (CD4+CD8+), whereas no such ... "The importance of the nurse cells and regulatory cells in the control of T lymphocyte responses." BioMed research international ... al., 2010) triple positive T cells, αβTCRlowCD4+CD8+ within the spaces formed by the interlocking of the membrane. Some of ... found in their study that one-fourth of the nurse cells isolated from mice were double-positives for K5 and K8, while the rest ...
*  Lymphoma
Lymphocyte-rich Lymphocyte depleted or not depleted Nodular lymphocyte-predominant Hodgkin lymphoma Immunodeficiency-associated ... creating Pautrier microabscesseses CD4 5-year survival 75% Localized or more generalized skin symptoms, generally indolent, in ... aggressive Diffuse large B-cell lymphoma associated with chronic inflammation Epstein-Barr virus-positive DLBCL of the elderly ... Lymphoma is a group of blood cancers that develop from lymphocytes (a type of white blood cell). The name often refers to just ...
*  McDonald criteria
... and different lymphocyte subtypes, reacting to CD3, CD4, CD8, CD20 and CD138. The sensitivity of McDonald criteria is low with ... In order to reduce false positives, McDonald et al. propose that their criteria should be applied only after any other disease ... ", "dissemination" and a "positive MRI", etc. Later they were revised again in 2010. McDonald's criteria are the standard ...
*  HLA-DPB1
1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121-8. doi:10.1007/BF00211424. ... 1991). "Positive correlation between oligonucleotide typing and T-cell recognition of HLA-DP molecules". Immunogenetics. 34 (1 ... Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain ... Clayton LK, Sieh M, Pious DA, Reinherz EL (1989). "Identification of human CD4 residues affecting class II MHC versus HIV-1 ...
*  GNLY
2003). "CD8 T cell-mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T cells and IL-15". ... Granulysin is present in cytolytic granules of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Granulysin is made ... Recombinant 9 kD granulysin is broadly cytolytic against tumors and microbes, including gram positive and gram negative ... Donlon TA, Krensky AM, Clayberger C (1990). "Localization of the human T lymphocyte activation gene 519 (D2S69E) to chromosome ...