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*  Caveolae
High levels of caveolin Cav1 are expressed in adipocytes. Caveolin associates with cholesterol, fatty acids and lipid droplets ... The presence of caveolin leads to a local change in morphology of the membrane. Cavin proteins emerged in the late 2000s to be ... Formation and maintenance of caveolae was initially thought to be primarily due to caveolin, a 21 kD protein. There are three ... However, some bacteria do not use typical caveolae but only caveolin-rich areas of the plasma membrane. The pathogens ...
*  Caveolin 1
All these interactions are through a caveolin-scaffolding domain (CSD) within caveolin-1 molecule. Molecules that interact with ... caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases". J. Biol. Chem. 271 (46): 29182-90 ... Caveolin-1 is a protein that in humans is encoded by the CAV1 gene. The scaffolding protein encoded by this gene is the main ... Feng, X; Gaeta M L; Madge L A; Yang J H; Bradley J R; Pober J S (March 2001). "Caveolin-1 associates with TRAF2 to form a ...
*  MALL
It interacts with caveolin-1. GRCh38: Ensembl release 89: ENSG00000144063 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... 2001). "BENE, a novel raft-associated protein of the MAL proteolipid family, interacts with caveolin-1 in human endothelial- ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and ... "A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1". Nat Genet. 17 (2): 149-53. doi:10.1038/ ...
*  Androgen receptor
Lu ML, Schneider MC, Zheng Y, Zhang X, Richie JP (April 2001). "Caveolin-1 interacts with androgen receptor. A positive ... Caveolin 1, CDK9, COX5B, CREB-binding protein, Cyclin D1, Cyclin-dependent kinase 7, DACH1, Death associated protein 6, L-DOPA ... 275 (1): 571-9. doi:10.1074/jbc.275.1.571. PMID 10617653. Liu Y, Kim BO, Kao C, Jung C, Dalton JT, He JJ (May 2004). "Tip110, ... 16 (1): 85-99. doi:10.1210/mend.16.1.0753. PMID 11773441. Pero R, Lembo F, Palmieri EA, Vitiello C, Fedele M, Fusco A, Bruni CB ...
*  TLR5
Data from Caveolin-1 knockout mice demonstrated that TLR5 expression significantly decreases in the absence of Caveolin-1 ... It is hypothesized that the Caveolin-1 directly interacts with TLR5 to stabilize it and hence increases the level of TLR5. TLR5 ... Lim JS, Nguyen KC, Han JM, Jang IS, Fabian C, Cho KA (Dec 2015). "Direct Regulation of TLR5 Expression by Caveolin-1". ... Recent study has identified Caveolin-1 as a potential regulator of TLR5 expression. In contrast to the decreased TLR4 level in ...
*  Prostaglandin-endoperoxide synthase 2
PTGS2 has been shown to interact with Caveolin 1. Arachidonic acid Cyclooxygenase Cyclooxygenase 1 NSAID Discovery and ... "Colocalization and interaction of cyclooxygenase-2 with caveolin-1 in human fibroblasts". J. Biol. Chem. 276 (37): 34975-82. ... 88 (1-2): 24-30. doi:10.1016/j.lfs.2010.10.017. PMC 3046773 . PMID 21035466. Wang D, Patel VV, Ricciotti E, Zhou R, Levin MD, ... PTGS1 (COX-1) is constitutively expressed in many tissues and is the predominant form in gastric mucosa and in the kidneys. ...
*  SPRY1
Cabrita MA, Jäggi F, Widjaja SP, Christofori G (2006). "A functional interaction between sprouty proteins and caveolin-1". J. ... Protein sprouty homolog 1 is a protein that in humans is encoded by the SPRY1 gene. Neurofibromin 1 SPRED1 GRCh38: Ensembl ... 342 (1,2): 57-62. doi:10.1007/s11010-010-0468-8. PMC 2923832 . PMID 20461448. SPRY1 human gene location in the UCSC Genome ... "Entrez Gene: SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)". Lim J, Wong ES, Ong SH, et al. (2000). " ...
*  SPRY4
Cabrita MA, Jäggi F, Widjaja SP, Christofori G (Sep 2006). "A functional interaction between sprouty proteins and caveolin-1". ... 287 (1): L52-9. doi:10.1152/ajplung.00430.2003. PMID 14977631. Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, ...
*  SPRY3
Cabrita MA, Jäggi F, Widjaja SP, Christofori G (2006). "A functional interaction between sprouty proteins and caveolin-1". J. ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and ...
*  Endothelin B receptor
Endothelin receptor type B has been shown to interact with Caveolin 1. Agonists IRL-1620 Antagonists A-192,621 BQ-788 Bosentan ... Yamaguchi T, Murata Y, Fujiyoshi Y, Doi T (Apr 2003). "Regulated interaction of endothelin B receptor with caveolin-1". ... 178 (1): 248-55. doi:10.1016/0006-291X(91)91806-N. PMID 1648908. Cyr C, Huebner K, Druck T, Kris R (Nov 1991). "Cloning and ... 181 (1): 184-90. doi:10.1016/S0006-291X(05)81399-3. PMID 1659806. "Entrez Gene: EDNRB endothelin receptor type B". Sato-Jin K, ...
*  Mir-802 microRNA precursor family
Caveolin-1 conversely inhibits ROMK channel activity, and expression of the two shows a clear inverse relationship. Co- ... MicroRNA Lin DH, Yue P, Pan C, Sun P, Wang WH (2011). "MicroRNA 802 stimulates ROMK channels by suppressing caveolin-1". J Am ... miR-802 expression in the kidney is stimulated by a high potassium intake, along with caveolin-1 expression, one of the many ... Lin, D. -H.; Yue, P.; Pan, C.; Sun, P.; Wang, W. -H. (2011). "MicroRNA 802 Stimulates ROMK Channels by Suppressing Caveolin-1 ...
*  STRN
... directly binds caveolin-1". FEBS Letters. 508 (1): 49-52. doi:10.1016/S0014-5793(01)03020-4. PMID 11707266. Huang Y, Tang R, ... 8 (1): 157-71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004 . PMID 18782753. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S ... 51 (1): 136-9. doi:10.1006/geno.1998.5342. PMID 9693043. Castets F, Bartoli M, Barnier JV, Baillat G, Salin P, Moqrich A, ... Dai J, Gu S, Zhao W, Cheng C, Xu M, Zhou Z, Ying K, Xi Y, Mao Y (2002). "A novel human hydroxysteroid dehydrogenase like 1 gene ...
*  STRN4
... directly binds caveolin-1". FEBS Lett. 508 (1): 49-52. doi:10.1016/S0014-5793(01)03020-4. PMID 11707266. Suzuki Y, Yoshitomo- ... 8 (1): 157-71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004 . PMID 18782753. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S ... 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, ... 200 (1-2): 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Maruyama K, Sugano S (1994). "Oligo-capping: a simple ...
*  EMP2
2007). "The tetraspan protein EMP2 regulates expression of caveolin-1". J. Biol. Chem. 282 (36): 26542-51. doi:10.1074/jbc. ... 183 (1-2): 69-75. doi:10.1016/S0378-1119(96)00475-1. PMID 8996089. Liehr T, Kuhlenbaumer G, Wulf P, Taylor V, Suter U, Van ... 58 (1): 106-8. doi:10.1006/geno.1999.5803. PMID 10331954. Wadehra M, Forbes A, Pushkarna N, Goodglick L, Gordon LK, Williams CJ ... 175 (1-2): 115-20. doi:10.1016/0378-1119(96)00134-5. PMID 8917086. Street VA, Goldy JD, Golden AS, et al. (2002). "Mapping of ...
*  Antagomir
Thus, micro103/107 may affect insulin sensitivity by targeting Caveolin-1. The blockmir CD5-2 has been shown to inhibit the ... It has been shown that Caveolin-1-deficient mice show insulin resistance. MicroRNA-103/107 inhibition in Caveolin-1-deficient ... This may be achieved by designing a Blockmir that matches seed 1. microRNA-33a/b MicroRNA-33a/b inhibition in mice leads to ...
*  Bruton's tyrosine kinase
"Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx". J. Biol. Chem. 277 (11): 9351-7. doi:10.1074/jbc. ... 228 (1): 42-53. doi:10.1016/j.cellimm.2004.03.004. PMID 15203319. Yasuda T, Tezuka T, Maeda A, Inazu T, Yamanashi Y, Gu H, ... Phase 2: Phase 1: ONO-4059 for Non-Hodgkin's Lymphoma and/or CLL. Renamed GS-4059 and now in trial NCT02457598. spebrutinib ( ... 461 (1-2): 68-72. doi:10.1016/S0014-5793(99)01424-6. PMID 10561498. Matsushita M, Yamadori T, Kato S, Takemoto Y, Inazawa J, ...
*  HEPACAM
"Interaction of the immunoglobulin-like cell adhesion molecule hepaCAM with caveolin-1". Biochemical and Biophysical Research ... 37 (1): 155-65. doi:10.3892/ijo_00000663. PMID 20514407. Moh MC, Shen S (2009). "The roles of cell adhesion molecules in tumor ... In cell signaling, HEPACAM directly interacts with F-actin and calveolin 1, and is capable of inducing senescence-like growth ...
*  Ductal carcinoma in situ
June 2009). "Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer". Cancer Biology & Therapy. 8 ( ... 2015: 1-7. doi:10.1155/2015/104231. "Ductal Carcinoma In Situ: Treatment Options for Patients With DCIS". National Cancer ... 185): 1-549. PMC 4781639 . PMID 20629475. Raphael Rubin; David S. Strayer, eds. (2008). Rubin's Pathology: clinicopathologic ... the risk of recurrence is 1% for women undergoing mastectomy. There is no evidence that mastectomy decreases the risk of death ...
*  Phospholipase D1
... regulation by protein kinase Calpha and caveolin-1". Biochemistry. 38 (12): 3763-9. doi:10.1021/bi982478+. PMID 10090765. Kim Y ... 302 (1): 127-32. doi:10.1016/s0006-291x(03)00112-8. PMID 12593858. Cai S, Exton JH (May 2001). "Determination of interaction ... "Activation of phospholipase D1 by direct interaction with ADP-ribosylation factor 1 and RalA". FEBS Lett. 430 (3): 231-5. doi: ... "Activation of phospholipase D1 by direct interaction with ADP-ribosylation factor 1 and RalA". FEBS Lett. 430 (3): 231-5. doi: ...
*  BMX (gene)
2002). "Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx". J. Biol. Chem. 277 (11): 9351-7. doi: ... doi:10.1016/S1570-9639(02)00524-1. PMID 12573241. Zhang R, Xu Y, Ekman N, et al. (2004). "Etk/Bmx transactivates vascular ...
*  SCP2
... has been shown to interact with Caveolin 1 and peroxisomal receptor PEX5. GRCh38: Ensembl release 89: ENSG00000116171 - ... "Sterol carrier protein-2 directly interacts with caveolin-1 in vitro and in vivo". Biochemistry. United States. 43 (23): 7288- ... 76 (1): 73-84. doi:10.1016/0009-3084(95)02436-M. PMID 7788802. Vesa J, Hellsten E, Barnoski BL, et al. (1994). "Assignment of ... 265 (1): 151-7. PMID 2294101. Ohba T, Holt JA, Billheimer JT, Strauss JF (1995). "Human sterol carrier protein x/sterol carrier ...
*  Congenital generalized lipodystrophy
This gene codes for the Caveolin protein, which is a scaffolding membrane protein. This protein plays a role in lipid ... April 2008). "Association of a Homozygous Nonsense Caveolin-1 Mutation with Berardinelli-Seip Congenital Lipodystrophy". ... In type 1 patients, they still have mechanical adipose tissue, but type 2 patients do not have any adipose tissue, including ... The gene for type 1 CGL was identified as AGPAT2 at chromosome 9q34, and later the gene for type 2 CGL was identified as BSCL2 ...
*  PTPRM
Caveolin 1 is dephosphorylated on tyrosine 14 in response to shear stress and PTPmu is hypothesized to catalyze this reaction. ... Caveolin 1 is a scaffolding protein enriched in endothelial cell junctions that is also linked to shear stress regulated ... Shin J, Jo H, Park H (2006). "Caveolin-1 is transiently dephosphorylated by shear stress-activated protein tyrosine phosphatase ... 248 (1): 329-38. doi:10.1006/excr.1999.4428. PMID 10094839. Koop EA, Lopes SM, Feiken E, Bluyssen HA, van der Valk M, Voest EE ...
*  GJA1
Caveolin 1, Tight junction protein 1 CSNK1D, and PTPmu (PTPRM). Mitochondria portal Connexin Hypoplastic left heart syndrome ... "Connexin family members target to lipid raft domains and interact with caveolin-1". Biochemistry. 41 (18): 5754-64. doi:10.1021 ... Gap junction alpha-1 protein (GJA1), also known as connexin 43 (Cx43), is a protein that in humans is encoded by the GJA1 gene ... 58 (1): 34-40. doi:10.1006/geno.1999.5814. PMID 10331943. Fishman GI, Eddy RL, Shows TB, Rosenthal L, Leinwand LA (May 1991). " ...
*  GJA3
"Connexin family members target to lipid raft domains and interact with caveolin-1". Biochemistry. 41 (18): 5754-64. doi:10.1021 ... ISBN 978-1-934115-46-6. Hsieh CL, Kumar NM, Gilula NB, Francke U (1991). "Distribution of genes for gap junction membrane ... GJA3 has been shown to interact with Tight junction protein 1. GRCh38: Ensembl release 89: ENSG00000121743 - Ensembl, May 2017 ... 2004). "Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1)". Mol. Biol. Cell. 14 (6): ...
*  Rocky Mountain spotted fever
Clathrin and Caveolin 2-Dependent Manner". Cellular Microbiology. 11 (4): 629-644. doi:10.1111/j.1462-5822.2008.01279.x. Walker ... ISBN 84-345-1106-1. Masters EJ, Olson GS, Weiner SJ, Paddock CD (2003). "Rocky Mountain spotted fever: a clinician's dilemma". ...