December 2007). "DNA accelerates the inhibition of human cathepsin V by serpins". The Journal of Biological Chemistry. 282 (51 ... June 2003). "Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced ... cathepsin G". Blood. 93 (6): 2089-2097. doi:10.1182/blood.V93.6.2089.406k10_2089_2097. PMID 10068683. Tan J, Prakash MD, ... antitrypsin to inhibit cathepsin proteases". Biochemistry. 41 (15): 4998-5004. doi:10.1021/bi0159985. PMID 11939796. Schick C, ...
BACE1, BACE2 Cathepsin D Cathepsin E Chymosin (or "rennin") Napsin-A Nepenthesin Pepsin Presenilin Renin BACE1; BACE2; CTSD; ... Eukaryotic aspartic proteases include pepsins, cathepsins, and renins. They have a two-domain structure, arising from ancestral ... Cathepsin D". In Rawlings ND, Salvesen G (eds.). Handbook of Proteolytic Enzymes (Third ed.). Academic Press. pp. 54-63. doi: ...
Cathepsin F: This is a digestive enzyme of parasitic flukes. Hormones or compounds produced by the stomach and their respective ...
... there are 11 cysteine cathepsins: B, C, F, H, K, L, O, S, V, X, and W. Most cathepsins are expressed throughout the body, but ... gene duplications have produced over 20 paralogs of a cathepsin L-like enzyme. Cysteine cathepsins are also part of the normal ... Cathepsin K has a role in bone resorption and has been studied as a drug target for osteoporosis. A number of parasites, ... Cysteine cathepsins have been associated with cancer and tumor progression, cardiovascular disease, autoimmune disease, and ...
2000). "Cathepsin G activates protease-activated receptor-4 in human platelets". J. Biol. Chem. 275 (10): 6819-23. doi:10.1074/ ...
In humans, the group of cathepsin cysteine proteases or cysteine cathepsins comprises 11 family members, cathepsins B, C, F, H ... Examination of cathepsin activity by using chemical probes and in vivo imaging techniques demonstrated an increase in cathepsin ... Cathepsins also can be secreted by cells, associate with the cell surface, and degrade the ECM. A study of all 11 members of ... Cathepsin L1 is active at neutral pH by associating with a p41 splice variant of the MHC class II-associated invariant chain ...
Yamashima T (2013). "Reconsider Alzheimer's disease by the 'calpain-cathepsin hypothesis'--a perspective review". Progress in ... which clearly distinguished it from the cathepsin family of proteases. The calcium-dependent activity, intracellular ...
... does not bind to human proteases, with the exception of cathepsin B (69% inhibition). Overexpression of cathepsin B ...
... also prevents tumor progression, partially by inhibiting cathepsin B activity. In particular, ulinastatin is ... It inactivates many serine proteases, including trypsin, chymotrypsin, kallikrein, plasmin, granulocyte elastase, cathepsin, ...
May 2019). "KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D". eLife. 8: 44478. doi:10.7554/eLife.44478. PMC 6588350. PMID ... This cleavage can be performed either by ADAMTS3, plasmin, KLK3/PSA or cathepsin D. With progressing maturation, the affinity ...
A plant aspartic proteinase resembling mammalian cathepsin D". European Journal of Biochemistry. 202 (3): 1021-7. doi:10.1111/j ...
The name cathelin itself is coined from cathepsin L inhibitor in 1989. The general rule of the mechanism triggering ...
"Entrez Gene: GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)". Waterhouse NJ, Trapani JA (2007). "H is for helper: ...
... has been shown to inhibit the enzymatic activity of cathepsin B. Cathepsin B degrades extra-cellular membrane ... Sosič I, Mirković B, Arenz K, Stefane B, Kos J, Gobec S (January 2013). "Development of new cathepsin B inhibitors: combining ... The mechanism of action by which nitroxoline inhibits cathepsin B may also suggest that further research of noncovalent, ... The Ki (dissociation constant) values it demonstrates are comparable to other reversible inhibitors of cathepsin B. This ...
They are also members of the cathepsin family and can digest lysosomes. Cry6Aa triggers a magnesium dependent adenylyl cyclase/ ...
... DB 2.0 - Database of histones and variants at NCBI Chromatin, Histones & Cathepsin; PMAP The Proteolysis Map-animation ( ...
This sequence can be cleaved by cathepsin C, removing 2 amino acids. Cathepsin H has also been reported to activate granzyme B ...
... has been shown to interact with Cathepsin B and CTSL1. Peptide Transporter Carbon Starvation (cstA) Family GRCh38: ... Characterization by kinetic and equilibrium methods of the interactions of cystatin A Gly-4 mutants with papain, cathepsin B, ... forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified ... and cathepsin L". Biochemistry. UNITED STATES. 37 (20): 7551-60. doi:10.1021/bi980026r. ISSN 0006-2960. PMID 9585570. Majerle, ...
May 2019). "KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D". eLife. 8: -44478. doi:10.7554/eLife.44478. PMC 6588350. PMID ...
Spizz G, Blackshear PJ (September 1997). "Identification and characterization of cathepsin B as the cellular MARCKS cleaving ...
Proteases included the invadolysin (host penetration) and cathepsin (blood-feeding) gene families. In 2012, an improved version ...
Hook G, Yu J, Toneff T, Kindy M, Hook V (2014). "Brain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the ... Kumar P, Nachagari D, Fields C, Franks J, Albritton LM (October 2007). "Host cell cathepsins potentiate Moloney murine leukemia ... reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not ... and Structure-Activity Relationship Study of Epoxysuccinyl-Peptide Derivatives as Cathepsin B Inhibitors". Biological & ...
Im E, Kazlauskas A (March 2007). "The role of cathepsins in ocular physiology and pathology". Experimental Eye Research. 84 (3 ... PMID 17322367.[dead link] Gacko M, Chyczewski L, Chrostek L (1999). "Distribution, activity and concentration of cathepsin B ...
M cells express the protease cathepsin E, similar to other antigen-presenting cells. This process takes place in a unique ...
It is also an inhibitor of human cathepsin B. Amentoflavone has a variety of in vitro activities including antimalarial ... "Amentoflavone and its derivatives as novel natural inhibitors of human Cathepsin B". Bioorg. Med. Chem. 13 (20): 5819-5825. doi ...
2002). "Evidence that E-box promoter elements and MyoD transcription factors play a role in the induction of cathepsin B gene ... They act by transactivating cathepsin B promotor activity and inducing its mRNA expression. E47 is produced by alternative ...
Furthermore, recent studies have also implied the protein's role in cathepsin D deficiency; the overexpression of the defective ... Only recently have studies of human patients shown deficiency of lysosomal aspartyl proteinase cathepsin D.[citation needed] ... protein appears to have significant effects on cathepsin D processing, with implications suggesting that accumulation of ATP ...
2006). "Overexpression of cathepsin F, matrix metalloproteinases 11 and 12 in cervical cancer". BMC Cancer. 5: 68. doi:10.1186/ ...
... is closely related to other cytotoxic immune serine proteases, such as the granzymes and cathepsin G. It is ... Korkmaz B, Horwitz MS, Jenne DE, Gauthier F (December 2010). "Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic ...
Cathepsin, Lectin. The Bathini Goud Brothers in Hyderabad, India, promote the swallowing of live murrel fish and herbs claimed ... cathepsin L: bioinformatics characterization, gene expression and proteolytic activity". Biologia. 39 (3): 395-406. doi:10.2478 ...