2002). "Evidence that E-box promoter elements and MyoD transcription factors play a role in the induction of cathepsin B gene ... They act by transactivating cathepsin B promotor activity and inducing its mRNA expression. E47 is produced by alternative ...

Furthermore, recent studies have also implied the protein's role in cathepsin D deficiency; the overexpression of the defective ... Only recently have studies of human patients shown deficiency of lysosomal aspartyl proteinase cathepsin D.[citation needed] ... protein appears to have significant effects on cathepsin D processing, with implications suggesting that accumulation of ATP ...

2006). "Overexpression of cathepsin F, matrix metalloproteinases 11 and 12 in cervical cancer". BMC Cancer. 5: 68. doi:10.1186/ ...

... is closely related to other cytotoxic immune serine proteases, such as the granzymes and cathepsin G. It is ... Korkmaz B, Horwitz MS, Jenne DE, Gauthier F (December 2010). "Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic ...

Cathepsin, Lectin. The Bathini Goud Brothers in Hyderabad, India, promote the swallowing of live murrel fish and herbs claimed ... cathepsin L: bioinformatics characterization, gene expression and proteolytic activity". Biologia. 39 (3): 395-406. doi:10.2478 ...

SDF stops the degradation of cysteine cathepsins, which are also responsible for dentine collagen degradation. A systematic ... "The inhibitory effects of silver diamine fluorides on cysteine cathepsins". primary. Journal of Dentistry. 42 (3): 329-35. doi: ...

Cathepsin S which is produced by most of the antigen- presenting cells along with mTECs is absent in cTECs. Cathepsin L not ... MHC II processing and presentation in cTECs took advantage of several proteolytic pathways including cathepsin L, encoded by ... Honey, Karen; Nakagawa, Terry; Peters, Christoph; Rudensky, Alexander (2002-05-20). "Cathepsin L Regulates CD4+ T Cell ... "Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus". Science. 280 (5362): 450-453. Bibcode: ...

The enzyme cathepsin K breaks down type-I collagen, an important constituent in bones. Prepared antibodies can recognize the ... "The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics". Adv. Drug Deliv. Rev. 57 ( ...

Several other cathepsins are expressed in osteoclasts including cathepsins B, C, D, E, G, and L. The function of these cysteine ... Of these hydrolytic enzymes, cathepsin K is of most importance. Cathepsin K is a collagenolytic papain-like cysteine protease ... characterised by a lack of functional cathepsin K expression. Knockout studies of cathepsin K in mice lead to an osteopetrotic ... Cathepsin K has an optimal enzymatic activity in acidic conditions. It is synthesized as a proenzyme with a molecular weight of ...

FTLD-GRN IPSC cortical Neurons have enlarged vesicles, lipofuscin accumulation and cathepsin D deficiency. Homozygous mutation ... and cathepsin D, the primary protease involved in protein aggregate break down. GRN mutation shares similar neuropathology and ...

"Early immunodiagnosis of fasciolosis in ruminants using recombinant Fasciola hepatica cathepsin L-like protease". International ...

Encoding of the mutated gene results in a defective form of the protein cathepsin A. When the structure of cathepsin A is ... Cathepsin A is required in this process because within the complex, it prevents neuraminidase-1 and beta-galactosidase from ... When the CTSA gene is mutated, the protein structure of cathepsin A is defected, making it incapable of binding to other ... 1996). "Cathepsin A deficiency in galactosialidosis: studies of patients and carriers in 16 families". Pediatr. Res. 39 (6): ...

A diagnosis can be made by a urine analysis for low/no activity of the enzyme cathepsin C. A full patient history and ... The teeth are involved in roughly the same order in which they erupt.[citation needed] Mutations in the cathepsin C gene (CTSC ... Wani A, Devkar N, Patole M, Shouche Y (2006). "Description of two new cathepsin C gene mutations in patients with Papillon- ... is an autosomal recessive genetic disorder caused by a deficiency in cathepsin C. PLS is characterized by periodontitis and ...

"Degradation of canine cardiac myosin and actin by cathepsin D isolated from homologous tissue". Cardiovasc Research. 13 (11): ...

The lysosome contains a large number of proteases such as cathepsins. The ubiquitin-mediated process is selective. Proteins ...

TGF-β activators include proteases such as plasmin, cathepsins, and calpains. Thrombospondin 1, a glycoprotein that inhibits ...

"Table 1: The Single Nucleotide Polymorphisms in cathepsin B protein mined from literature (PMID: 16492714)". doi:10.7717/peerj. ... "Table 1: The Single Nucleotide Polymorphisms in cathepsin B protein mined from literature (PMID: 16492714)". doi:10.7717/peerj. ...

Endocrinol., 2, (1988)., p. 186-192 H. Rogier et al., « Two-site immuno-enzymometric assay for the 52-kDa-cathepsin D cytosols ... Chem., 35, (1989), p. 81-85 S Thorpe, H. Rochefort et al., « Association between high concentrations of Mr 52,000 cathepsin-D ... Endocrinol., 3, (1989), p. 552-558 H. Rochefort et al., « Cathepsin D in breast cancer: From molecular and cellular biology to ... USA, 90, (1993), p. 203-207 P. Roger et al., « Dissociated overexpression of cathepsin D and estrogen receptor alpha in ...

The Single Nucleotide Polymorphisms in cathepsin B protein mined from literature (PMID: 16492714)". PeerJ. 7: e7425. doi: ...

2006). "Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases". Exp. Dermatol. 15 (2 ... 2003). "Inhibition of the cysteine proteinases cathepsins K and L by the serpin headpin (SERPINB13): a kinetic analysis". Arch ... 2003). "Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis ...

March 2017). "Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36γ". Proceedings of ... IL-36γ is specifically cleaved by the endogenous protease cathepsin S as well exogenous proteases derived from fungal and ...

... is an American pharmaceutical company which develops drugs using a proprietary cysteine cathepsin platform. House, ...

January 2020). "Disease-Modifying Effects of a Novel Cathepsin K Inhibitor in Osteoarthritis: A Randomized Controlled Trial". ...

"Table 1: The Single Nucleotide Polymorphisms in cathepsin B protein mined from literature (PMID: 16492714)". PeerJ. doi:10.7717 ... functional and molecular dynamics analysis of cathepsin B gene SNPs associated with tropical calcific pancreatitis, a rare ...

"Amentoflavone and its derivatives as novel natural inhibitors of human Cathepsin B". Bioorganic & Medicinal Chemistry. 13 (20 ...

Hentze, M.; Hasilik, A.; Figura, Kurt v. (1984). "Enhanced degradation of Cathepsin D synthesized in the presence of the ...

Blomgran R, Zheng L, Stendahl O (May 2007). "Cathepsin-cleaved Bid promotes apoptosis in human neutrophils via oxidative stress ...

These markers include angiotensin-converting enzyme, cathepsin S, chitotriosidase, and CCL18 in the blood plasma; and tumor ...

"Table 1: The Single Nucleotide Polymorphisms in cathepsin B protein mined from literature (PMID: 16492714)". doi:10.7717/peerj. ...

"Table 1: The Single Nucleotide Polymorphisms in cathepsin B protein mined from literature (PMID: 16492714)". doi:10.7717/peerj. ...