Loading...
*  Catechol-O-methyl transferase
... and various drugs and substances having a catechol structure. In humans, catechol-O-methyltransferase protein is encoded by the ... Fan JB, Zhang CS, Gu NF, Li XW, Sun WW, Wang HY, Feng GY, St Clair D, He L (January 2005). "Catechol-O-methyltransferase gene ... Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines (such as dopamine, ... Catechol O-Methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ...
*  Methoxy group
... whose formation is catalyzed by O-methyltransferases that act on phenols, e.g., Catechol-O-methyl transferase (COMT). A large ... number of natural products in plants, e.g. lignins, are generated via catalysis by caffeoyl-CoA O-methyltransferase. Organic ...
*  3-O-Methyldopa
... is a major metabolite of L-3,4-dihydroxyphenylalanin (L-DOPA) and is formed by catechol O-methyltransferase ( ... This process is catalyzed by catechol O-methyltransferase methylates (COMT). The action of the enzyme makes it possible the ... Tai, C. H.; Wu, R. M. (2002). "Catechol-O-methyltransferase and Parkinson's disease". Acta medica Okayama. 56 (1): 1-6. PMID ... L-DOPA Entacapone Tolcapone Catechol-O-methyl transferase Parkinson's disease Parkinson's Disease and movement disorders. ...
*  Pirbuterol
... is not metabolized by catechol-O-methyltransferase. The plasma half-life measured after oral administration is about ...
*  Aesculetin
... as a substrate for catechol-o-methyltransferase". Z. Naturforsch. C (in German). 31 (5-6): 280-284. PMID 134569. ... through incubation with rat liver catechol-O-methyltransferase. Umbelliferone "Aesculetin". Sigma-Aldrich. Dey, P. M.; Harborne ...
*  Tolcapone
2012). "Catechol-O-methyltransferase in complex with substituted 3′-deoxyribose bisubstrate inhibitors". Acta Crystallographica ... Manikumar, G.; Jin, C.; Rehder, K. S. (2008). "Convenient Synthesis of Tolcapone, a Selective Catechol‐O‐methyltransferase ... a novel inhibitor of catechol-O-methyltransferase". British Journal of Clinical Pharmacology. 48 (4): 513-520. doi:10.1046/j. ... potent and reversible nitrocatechol-type inhibitor of the enzyme catechol-O-methyltransferase (COMT). It has demonstrated ...
*  Entacapone
... is a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT). When taken together with ... Entacapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT). COMT eliminates biologically active ... entacapone stops catechol-O-methyltransferase from breaking down and metabolizing levodopa, resulting in an overall increase of ... catechols present in catecholamines (dopamine, norepinephrine, and epinephrine) and their hydroxylated metabolites. When ...
*  Quercetin
The meta-hydroxyl group of catechol is methylated by catechol-O-methyltransferase. Four of the five hydroxyl groups of ...
*  Placebo
... catechol-O-methyltransferase) gene related to dopamine release are found to be critical in the placebo effect among the ... "Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndrome". PLoS ONE. 7 (10): ...
*  Opicapone
... is a pharmaceutical drug acting as a catechol-O-methyltransferase (COMT) inhibitor. It is administered together with ... Opicapone blocks the enzyme catechol-O-methyltransferase (COMT) effectively (>90% at therapeutic doses), selectively and ...
*  Purpurogallin
It can inhibit 2-hydroxy and 4-hydroxyestradiol methylation by catechol-O-methyltransferase. It potently and specifically ...
*  LRTOMT
"A catechol-O-methyltransferase that is essential for auditory function in mice and humans". Proceedings of the National Academy ... which is a transmembrane catechol-O-methyltransferase and is called LRTOMT2, TOMT or COMT2. The COMT2 is essential for auditory ... Leucine rich transmembrane and O-methyltransferase domain containing is a protein that in humans is encoded by the LRTOMT gene ... Leucine rich transmembrane and O-methyltransferase domain containing". Riahi Z, Bonnet C, Zainine R, Louha M, Bouyacoub Y, ...
*  Nitecapone
"Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat". European Journal of ... Nitecapone (INN; OR-462) is a drug which acts as a selective inhibitor of the enzyme catechol O-methyl transferase (COMT). It ...
*  Bruce Beutler
"A catechol-O-methyltransferase that is essential for auditory function in mice and humans". Proceedings of the National Academy ...
*  Prepulse inhibition
Gogos, J. A; Morgan, M; Luine, V; Santha, M; Ogawa, S; Pfaff, D; Karayiorgou, M (1998). "Catechol-O-methyltransferase-deficient ...
*  Rs4680
It is a single nucleotide polymorphism (SNP) in the COMT gene that codes catechol-O-Methyltransferase. The single nucleotide ... "A possible association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and the personality trait ... "An association study of catechol-O-methyltransferase and monoamine oxidase A polymorphisms and personality traits in Koreans". ... "Association of the functional catechol-O-methyltransferase VAL158MET polymorphism with the personality trait of extraversion". ...
*  Genetics of posttraumatic stress disorder
Catechol-O-methyl transferase (COMT) is an enzyme that catalyzes the extraneuronal breakdown of catecholamines. The gene that ...
*  COMT inhibitor
A COMT inhibitor is a drug that inhibits the action of catechol-O-methyl transferase. This enzyme is involved in degrading ...
*  Dental material
2014). "Genetic polymorphisms of catechol-O-methyltransferase modify the neurobehabioral effects of mercury in children". J ... 2014). "Genetic polymorphisms of catechol-O-methltransferase modify the neurobehavioral effects of mercury in children". J ...
*  Norepinephrine transporter
Yavich L, Forsberg MM, Karayiorgou M, Gogos JA, Männistö PT (Sep 2007). "Site-specific role of catechol-O-methyltransferase in ...
*  Normetanephrine
... is a metabolite of norepinephrine created by action of catechol-O-methyl transferase on norepinephrine. It is ...
*  Rs6313
"Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility". ...
*  ALDH3B1
"Evidence of epistasis between the catechol-O-methyltransferase and aldehyde dehydrogenase 3B1 genes in paranoid schizophrenia ...
*  Carbidopa/levodopa/entacapone
Entacapone is a selective, reversible catechol-O-methyltransferase (COMT) inhibitor that increases the bioavailability of ...
*  Ritodrine
However, the 4-hydroxy group makes it susceptible to metabolism by catechol-O-methyl transferase (COMT). Since it is β2- ...
*  Homovanillic acid
... a major catecholamine metabolite that is produced by a consecutive action of monoamine oxidase and catechol-O-methyltransferase ...