Wikimedia Commons has media related to Catechol O-methyltransferase, COMT. Catechol+O-Methyltransferase at the U.S. National ... and various drugs and substances having a catechol structure. In humans, catechol-O-methyltransferase protein is encoded by the ... December 2008). "The catechol-O-methyl transferase Val158Met polymorphism and experience of reward in the flow of daily life". ... Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines (neurotransmitters such ...

A catechol-O-methyltransferase (COMT) inhibitor is a drug that inhibits the enzyme catechol-O-methyltransferase. This enzyme ... Catechol-O-methyltransferase inhibitors, All stub articles, Nervous system drug stubs). ... "Identification of novel flavonoid inhibitor of Catechol-O-Methyltransferase enzyme by molecular screening, quantum mechanics/ ... diarrhea drowsiness urine discoloration dyskinesia Medication Management of Parkinson's disease catechol-O-methyltransferase ...

Examples include: Catechol-O-methyltransferase DNA methyltransferase Histone methyltransferase 5-Methyltetrahydrofolate- ... These types include protein methyltransferases, DNA/RNA methyltransferases, natural product methyltransferases, and non-SAM ... Catechol-O-methyltransferase (COMT) degrades a class of molecules known as catcholamines that includes dopamine, epinephrine, ... "COMT catechol-O-methyltransferase". NCBI Genetic Testing Registry. Retrieved 18 February 2014. Ragsdale, S.W. "Catalysis of ...

... is produced by the methylation of L-DOPA by the enzyme catechol-O-methyltransferase. The necessary cofactor for ... 3-O-methyldopa is a major metabolite of L-3,4-dihydroxyphenylalanine (L-DOPA) and is formed by catechol-O-methyltransferase ( ... This process is catalyzed by catechol O-methyltransferase methylates (COMT). The action of the enzyme makes it possible the ... Tai, C. H.; Wu, R. M. (2002). "Catechol-O-methyltransferase and Parkinson's disease". Acta Medica Okayama. 56 (1): 1-6. PMID ...

Catechol-O-methyltransferase inhibitors, Catechols, Diketones, Nitrophenols, All stub articles, Nervous system drug stubs). ... "Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat". European Journal of ... Nitecapone (INN; OR-462) is a drug which acts as a selective inhibitor of the enzyme catechol O-methyl transferase (COMT). It ... Catechol-O-methyltransferase inhibitor F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. p. 1635. ISBN 978 ...

... is not metabolized by catechol-O-methyltransferase. The plasma half-life measured after oral administration is about ...

... is a catechol-O-methyltransferase (COMT) inhibitor. The most common side effects are dyskinesia (difficulty ... Opicapone blocks an enzyme that is involved in the breakdown of levodopa in the body called catechol-O-methyltransferase (COMT ... Opicapone blocks the enzyme catechol-O-methyltransferase (COMT) effectively (>90% at therapeutic doses), selectively and ...

... allelic polymorphism of the catechol-O-methyltransferase (COMT) gene; increased adenosine receptor function; increased cortisol ...

Catechol-O-methyltransferase inhibitors, Catechols, Hydroquinones, Tetrahydroxyanthraquinones, All stub articles, Ketone stubs) ... It is also a potent catechol O-methyltransferase (COMT) inhibitor. 1,4-Dihydroxyanthraquinone (quinizarin) Alizarin, a related ...

Catechol-O-methyltransferase inhibitors, Estranes, Estrogens, Human metabolites, Steroid hormones). ... A catechol estrogen is a steroidal estrogen that contains catechol (1,2-dihydroxybenzene) within its structure. The catechol ... Similarly to estradiol and estrone, catechol estrogens possess estrogenic activity. 2-Hydroxylated catechol estrogens are weak ... and are metabolized by catechol O-methyltransferase (COMT) into methoxylated estrogens such as 2-methoxyestradiol and 4- ...

Catechol-O-methyltransferase inhibitors, Catechols, Hepatotoxins, Hoffmann-La Roche brands, Nitrophenols, Benzophenones, 4- ... March 2012). "Catechol-O-methyltransferase in complex with substituted 3'-deoxyribose bisubstrate inhibitors". Acta ... Manikumar G, Jin C, Rehder KS (2008). "Convenient Synthesis of Tolcapone, a Selective Catechol‐O‐methyltransferase Inhibitor". ... Manikumar G, Jin C, Rehder KS (2008). "Convenient Synthesis of Tolcapone, a Selective Catechol‐O‐methyltransferase Inhibitor". ...

Catechol-O-methyltransferase genotype modulates opioid release in decision circuitry. Clin Transl Sci. 2013 Oct; 6(5):400-3. ...

... as a substrate for catechol-o-methyltransferase". Z. Naturforsch. C (in German). 31 (5-6): 280-284. doi:10.1515/znc-1976-5-611 ... through incubation with rat liver catechol-O-methyltransferase. Aesculetin can be synthesized by condensation of ...

Catechols, Catechol-O-methyltransferase inhibitors, Novartis brands, Nitriles, Nitrobenzenes). ... Entacapone is a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT). When taken together with ... Entacapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT). COMT eliminates biologically active ... entacapone stops catechol-O-methyltransferase from breaking down and metabolizing levodopa, resulting in an overall increase of ...

Catechol-O-methyltransferase val158met: Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome'. PLoS One, 2012 Hall ...

A comparison of dopamine agonists and catechol-O-methyltransferase inhibitors in Parkinson's disease. Clinical ...

"A catechol-O-methyltransferase that is essential for auditory function in mice and humans". Proceedings of the National Academy ... which is a transmembrane catechol-O-methyltransferase and is called LRTOMT2, TOMT or COMT2. The COMT2 is essential for auditory ... Leucine rich transmembrane and O-methyltransferase domain containing is a protein that in humans is encoded by the LRTOMT gene ... "Entrez Gene: Leucine rich transmembrane and O-methyltransferase domain containing". Riahi Z, Bonnet C, Zainine R, Louha M, ...

"Genetic polymorphisms of catechol-O-methyltransferase modify the neurobehavioral effects of mercury in children". Journal of ...

In vitro, the meta-hydroxyl group of catechol is methylated by catechol-O-methyltransferase. Four of the five hydroxyl groups ... 3-dioxygenase Quercetin 3-O-methyltransferase Quercetin-3-sulfate 3'-sulfotransferase Quercetin-3-sulfate 4'-sulfotransferase ...

"A catechol-O-methyltransferase that is essential for auditory function in mice and humans". Proceedings of the National Academy ...

Gogos JA, Morgan M, Luine V, Santha M, Ogawa S, Pfaff D, Karayiorgou M (August 1998). "Catechol-O-methyltransferase-deficient ...

It is a single nucleotide polymorphism (SNP) in the COMT gene that codes catechol-O-Methyltransferase. The single nucleotide ... "SZGene". Martin Reuter & Juergen Hennig (July 2005). "Association of the functional catechol-O-methyltransferase VAL158MET ... "A possible association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and the personality trait ... "An association study of catechol-O-methyltransferase and monoamine oxidase A polymorphisms and personality traits in Koreans". ...

Barnett JH, Jones PB, Robbins TW, Müller U (May 2007). "Effects of the catechol-O-methyltransferase Val158Met polymorphism on ... Leung WW, McClure MM, Siever LJ, Barch DM, Harvey PD (December 2007). "Catechol-O-methyltransferase Val158Met genotype in ... Nolan KA, Bilder RM, Lachman HM, Volavka J (February 2004). "Catechol O-methyltransferase Val158Met polymorphism in ... July 2019). "Interrogating the Relationship Between Schizotypy, the Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism ...

Catechol-O-methyl transferase (COMT) is an enzyme that catalyzes the extraneuronal breakdown of catecholamines. The gene that ...

"Effects of Active-Site Modification and Quaternary Structure on the Regioselectivity of Catechol- O -Methyltransferase". ... Micklefield's lab also characterised various methyltransferases, demonstrating how these can be used in the regioselective ... His lab succeeded in engineering orthogonal methyltransferases creating alternative bioalkylation pathways and developed ... Methyltransferase". Angewandte Chemie International Edition. 57 (33): 10600-10604. doi:10.1002/anie.201805060. ISSN 1433-7851. ...

"Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum". The ...

... is a metabolite of norepinephrine created by action of catechol-O-methyl transferase on norepinephrine. It is ...

"Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility". ...

"Evidence of epistasis between the catechol-O-methyltransferase and aldehyde dehydrogenase 3B1 genes in paranoid schizophrenia ...

"Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility". ...