Loading...
*  Protein primary structure
This pyruvoyl group may be used as a covalently attached catalytic cofactor in some enzymes, especially decarboxylases such as ... "Normalization of nomenclature for peptide motifs as ligands of modular protein domains". FEBS Letters. 513 (1): 141-144. doi: ...
*  MMP3
... and the calcium ion are present in the catalytic domain approximately 12 Å away from the catalytic zinc. The catalytic zinc ion ... a catalytic domain; and a hemopexin-like domain at the carboxy-terminal. The propeptide consists of approximately 80-90 amino ... The catalytic domain contains two zinc ions and at least one calcium ion coordinated to various residues. One of the two zinc ... The catalytic domain of MMP-3 can be inhibited by tissue inhibitors of metalloproteinases (TIMPs). The n-terminal fragment of ...
*  Prostaglandin-endoperoxide synthase 2
... domain; an α-helical membrane-binding moiety; and a C-terminal catalytic domain. PTGS (COX, which can be confused with " ... The catalytic domain is homologous to mammalian peroxidases such as myeloperoxidase. It has been found that human PTGS2 (COX-2 ... Both the cyclooxygenase and the peroxidase active sites are located in the catalytic domain, which accounts for approximately ... Each subunit has three different structural domains: a short N-terminal epidermal growth factor (EGF) ...
*  PCSK9
... the catalytic domain (residues 153-425); and the C-terminal domain (residues 426-692), which is further divided into three ... A number of monoclonal antibodies that bind to and inhibit PCSK9 near the catalytic domain were in clinical trials as of 2014[ ... though the N-terminal prodomain retains its association with the catalytic domain. In particular, residues 61-70 in the N- ... domain of the LDLR. While previous studies indicated that the C-terminal domain was uninvolved in binding LDLR, a recent study ...
*  Juvenile hormone
This enzyme has 8 helical domains anchoring it in the Golgi membrane of the ER; the catalytic domain is in the cytosol. It is ...
*  B4GALNT1
Antiparallel orientation of the catalytic domains". J. Biol. Chem. 275 (52): 41476-86. doi:10.1074/jbc.M007480200. PMID ...
*  CYB5R3
The membrane-bound form has both membrane-binding and catalytic domains. The soluble form has only the catalytic domain. This ... Exon 2 contains the junction of the membrane-binding domain and the catalytic domain of b5R, which shows that there are two ... this isoform has one hydrophobic membrane-anchoring domain and one catalytic domain that is hydrophilic. The other isoform, a ... The NH2-terminal structure of the membrane-binding domain is CH3(CH2)12-CO-Gly-Ala-Gln-Leu-Ser-Thr-Leu-Gly-His-Met-Val-Leu-Phe- ...
*  Shikimate dehydrogenase
It is considered to be the catalytic domain. It has a structure of six beta strands forming a twisted beta sheet with four ... The domains of the monomer show a fair amount of flexibility suggesting that the enzyme can open in close to bind with the ... The C-terminal domain binds to NADPH. It has a special structure, a Rossmann fold, whereby six-stranded twisted and parallel ... The Structure of Shikimate dehydrogenase is characterized by two domains, two alpha helices and two beta sheets with a large ...
*  Dam methylase
"Universal Catalytic Domain Structure of AdoMet-dependent Methyltransferases". Journal of Molecular Biology. 247 (1): 16-20. doi ... The similarity in the catalytic domains of C5-cytosine methyltransferases and N6 and N4-adenine methyltransferases provided ... Motifs IV-VIII play a role in the catalytic activity, while motifs 1-III and X play a role in binding of the cofactor. For N6- ... based on the sequential order of certain 9 motifs and the Target Recognition Domain (TRD). Motif I consists of a Gly-X-Gly ...
*  Histone acetylation and deacetylation
HDAC10 has two catalytic domains as well. One active domain is located in the N-terminus and a putative catalytic domain is ... However, HDAC6's catalytic domain is most similar to HDAC9. A unique feature of HDAC6 is that it contains two catalytic domains ... 5 and 7 have their catalytic domains located in the C-terminus along with an NLS region while HDAC9 has its catalytic domain ... domain with a HAT domain in-between. The last is TAFII250 which has a Kinase domain at the N-terminus region, two bromodomains ...
*  ADAM33
"Crystal structure of the catalytic domain of human ADAM33". Journal of Molecular Biology. 335 (1): 129-37. doi:10.1016/j.jmb. ... Zou J, Zhu F, Liu J, Wang W, Zhang R, Garlisi CG, Liu YH, Wang S, Shah H, Wan Y, Umland SP (March 2004). "Catalytic activity of ... Disintegrin and metalloproteinase domain-containing protein 33 is an enzyme that in humans is encoded by the ADAM33 gene. This ... "Entrez Gene: ADAM33 ADAM metallopeptidase domain 33". Davies ER, Kelly JF, Howarth PH, Wilson DI, Holgate ST, Davies DE, ...
*  Phosphoinositide-dependent kinase-1
The structure of PDPK1 can be divided into two domains; the kinase or catalytic domain and the PH domain. The PH domain ... The kinase domain has three ligand binding sites; the substrate binding site, the ATP binding site, and the docking site (also ... The activation of PDPK1's main effector, AKT, is believed to require a proper orientation of the kinase and PH domains of PDPK1 ... "Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA". EMBO J. 19 (5 ...
*  HDAC9
The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of ... "Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5". Proceedings ... "Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5". Proceedings ... which is in the public domain. Molecular and Cellular Biology portal. ...
*  Animal heme-dependent peroxidases
... and a large C-terminal catalytic domain containing the cyclooxygenase and the peroxidase active sites. The catalytic domain ... Both MPO and the catalytic domain of PGHS are mainly alpha-helical, 19 helices being identified as topologically and spatially ... PGHS exists as a symmetric dimer, each monomer of which consists of 3 domains: an N-terminal epidermal growth factor (EGF) like ... The following is a list of human proteins containing this domain: DUOX1; DUOX2; EPX; LPO; MPO; PTGS1; PTGS2; PXDNL; TPO PDB: ...
*  MMP9
... a catalytic domain with inserted three repeats of fibronectin type II domain followed by a C-terminal hemopexin-like domain. ... The catalytic domain contains two zinc and three calcium atoms. The catalytic zinc is coordinated by three histidines from the ... The human MMP9 proenzyme consists of five domains. The amino-terminal propeptide, the zinc-binding catalytic domain and the ... Three type II fibronectin repeats are inserted in the catalytic domain, although these domains are omitted in most ...
*  Clostridium novyi
Busch C, Schömig K, Hofmann F, Aktories K (November 2000). "Characterization of the Catalytic Domain of Clostridium novyi Alpha ...
*  MMP1
MMP-1 has an archetypal structure consisting of a pre-domain, a pro-domain, a catalytic domain, a linker region and a hemopexin ... this entry will focus only on the structural features of MMP-1 Catalytic Domain. The Catalytic Domain of MMP-1 is composed of ... one of which with catalytic role. The Catalytic Domain (CAT) of MMP-1 starts with the F100 (non-truncated CAT) as the first ... The Catalytic Domain ends at Gly261 with α-helix hC. MMPs are involved in the breakdown of extracellular matrix in normal ...
*  Polyadenylation
Its catalytic domain is homologous to that of other polymerases. It is presumed that the horizontal transfer of bacterial CCA- ... Nuclease Interacts with the C-terminal Domain of Polyadenylate-binding Protein Domain from Poly(A)-binding Protein". Journal of ... However, the wide distribution of this modification and the fact that it is present in organisms from all three domains of life ... Yehudai-Resheff, S.; Portnoy, V; Yogev, S; Adir, N; Schuster, G (2003). "Domain Analysis of the Chloroplast Polynucleotide ...
*  Phospholipase A2
They include a C2 domain and a large catalytic domain. These phospholipases are involved in cell signaling processes, such as ... The suggested catalytic mechanism of pancreatic sPLA2 is initiated by a His-48/Asp-99/calcium complex within the active site. ... His-48 improves the nucleophilicity of the catalytic water via a bridging second water molecule, w6. It has been suggested that ... The calcium ion polarizes the sn-2 carbonyl oxygen while also coordinating with a catalytic water molecule, w5. ...
*  APOBEC3G
... resulting in 2 homologous catalytic domains, the N-terminal (CD1) and C-terminal (CD2) domains, each of which contains a Zn2+ ... The C-terminal domain of A3G renders catalytic activity, several NMR and crystal structures explain the substrate specificity ... APOBEC3G contains a unique alpha helix between two beta sheets in the catalytic domain that could be a cofactor binding site. ( ... "An extended structure of the APOBEC3G catalytic domain suggests a unique holoenzyme model". J. Mol. Biol. 389 (5): 819-32. doi: ...
*  PTK2
Between the amino and the carboxy regions lies the catalytic domain. Phosphorylation of the activation loop within this kinase ... Two of these domains, the N-terminal FERM domain and the Kinase domain form an auto-inhibitory interaction. This interaction- ... The amino-terminal domains of FAK share a significant sequence similarity with the band 4.1 domain first identified in ... "Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src ...
*  Chitinase A N-terminal domain
It is separated by a hinge region from the catalytic domain; this hinge region is probably mobile, allowing the N-terminal ... In molecular biology, the chitinase A N-terminal domain is found at the N-terminus of a number of bacterial chitinases and ... It is organised into a fibronectin III module domain-like fold, comprising only beta strands. Its function is not known, but it ... This article incorporates text from the public domain Pfam and InterPro IPR013540. ...
*  Lysin
The catalytic domain is responsible for the cleavage of peptidoglycan bonds. Functionally, five types of lysin catalytic domain ... which contains two catalytic domains. Catalytic domains are highly conserved in phage lysins of the same class. The cell- ... Usually, two or more different catalytic domains are linked to a single cell-binding domain. This is typical in many ... In contrast to the catalytic domain, the cell-binding domain is variable, which allows a great specificity and decreases ...
*  PI4K2A
"Analysis of the catalytic domain of phosphatidylinositol 4-kinase type II". The Journal of Biological Chemistry. 277 (46): ... The kinase domain can be divided into N-terminal and C-terminal lobes with the ATP binding groove and putative ... PI4K2A is composed of a proline-rich N-terminal region and a kinase domain located C-terminally. The proline-rich N-terminal ... The C-lobe of the kinase domain contains an additional lateral hydrophobic pocket with no distinct function assigned yet. ...
*  Phenylalanine hydroxylase
... a regulatory N-terminal domain (residues 1-117), the catalytic domain (residues 118-427), and a C-terminal domain (residues 428 ... and iron-coordinated catalytic domain to examine the active site. The structure of the N-terminal regulatory domain has also ... Erlandsen H, Fusetti F, Martinez A, Hough E, Flatmark T, Stevens RC (Dec 1997). "Crystal structure of the catalytic domain of ... Erlandsen H, Fusetti F, Martinez A, Hough E, Flatmark T, Stevens RC (Dec 1997). "Crystal structure of the catalytic domain of ...
*  Proto-oncogene tyrosine-protein kinase Src
SH4 domain), unique region, SH3 domain, SH2 domain, catalytic domain and short regulatory tail. When Src is inactive, the ... c-Src includes an SH2 domain, an SH3 domain, and a tyrosine kinase domain. c-Src stands for "cellular Src kinase" and should ... group at the 527 position interacts with the SH2 domain which helps the SH3 domain interact with the flexible linker domain and ... Arbesú M, Maffei M, Cordeiro TN, Teixeira JM, Pérez Y, Bernadó P, Roche S, Pons M (March 2017). "The Unique Domain Forms a ...
*  DUSP2
2003). "Solution structure of the MAPK phosphatase PAC-1 catalytic domain. Insights into substrate-induced enzymatic activation ... 2006). "New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding". J ...