Within caspase-9's active site, in order for catalytic activity to occur there has to be specific amino acids in the right ... Caspase 8, NLRP1, and XIAP. The Proteolysis Map Caspase Caspase-3 Apoptosome Apaf-1 GRCh38: Ensembl release 89: ENSG00000132906 ... Similar to other caspases, caspase-9 has three domains: N-terminal pro-domain, large subunit, and a small subunit. The N- ... The introduction of caspases may also have medical benefits. In the context of graft versus host disease, caspase-9 can be ...

... akin to caspase 9's behaviour, an adequate enzymatic activity might demand the formation of a holoenzyme complex involving ... In Drosophila melanogaster cells, caspase Dronc is ubiquitylated by Diap-1. Similarly, effector caspases Caspase-3 and Caspase- ... In humans, initiator caspases such as Caspase-2 and Caspase-9 have a prodomain that cleaves caspases to a holoenzyme complex in ... Although most human caspases are considered orthologs of caspase Dronc, the one that resembles it the most is Caspase-2. ...

Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9. It is encoded by the CASP3 gene. CASP3 orthologs ... As an executioner caspase, the caspase-3 zymogen has virtually no activity until it is cleaved by an initiator caspase after ... Caspase substrate specificity has been widely used in caspase based inhibitor and drug design. Caspase-3, in particular, (also ... During the caspase cascade, however, caspase-3 functions to inhibit XIAP activity by cleaving caspase-9 at a specific site, ...

The precursor of this caspase is cleaved by caspase 3, caspase 10, and caspase 9. It is activated upon cell death stimuli and ... Caspase 7 has been shown to interact with: Caspase 8, Survivin and XIAP. The Proteolysis Map Caspase GRCh38: Ensembl release 89 ... Caspases exist as inactive proenzymes that undergo proteolytic processing by upstream caspases (caspase-8, -9) at conserved ... Caspase-7 is a member of the caspase (cysteine aspartate protease) family of proteins, and has been shown to be an executioner ...

... -1, Caspase-4, Caspase-5 and Caspase-11 are considered 'Inflammatory Caspases'. Caspase-1 is key in activating pro- ... Caspase 10) Executioner Caspases (Caspase 3, Caspase 6 and Caspase 7) Once initiator caspases are activated, they produce a ... Apoptotic caspases are subcategorised as: Initiator Caspases (Caspase 2, Caspase 8, Caspase 9, ... Caspase-1, Caspase-4 and Caspase-5 in humans, and Caspase-1 and Caspase-11 in mice play important roles in inducing cell death ...

CAD release from ICAD inhibition is achieved by cleavage of ICAD at these Asp residues by the caspase-3. Caspase-3 is activated ... Larsen BD, Rampalli S, Burns LE, Brunette S, Dilworth FJ, Megeney LA (March 2010). "Caspase 3/caspase-activated DNase promote ... October 2005). "The contribution of apoptosis-inducing factor, caspase-activated DNase, and inhibitor of caspase-activated ... "Entrez Gene: DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)". Davidson College. "Caspase ...

... has a similar amino acid sequence to initiator caspases, including caspase 1, caspase 4, caspase 5, and caspase 9. It ... Overall, caspase 2 appears to be a very versatile caspase with multiple functions beyond cell death induction. Caspase 2 has ... Within this family, caspase 2 is part of the Ich-1 subfamily. It is one of the most conserved caspases in different species of ... Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive ...

... hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner". The Journal of Cell Biology. ... Hu Y, Benedict MA, Wu D, Inohara N, Núñez G (Apr 1998). "Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 ... Hu Y, Benedict MA, Wu D, Inohara N, Núñez G (Apr 1998). "Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 ... The protein was identified in the laboratory of Xiaodong Wang as an activator of caspase-3 in the presence of cytochromeC and ...

2005) XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs. EMBO J 24: 645-655 ... 2006) The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases. J Biol Chem 281: 3254-3260 Pop C, ... His research focuses on proteases and their inhibitors in humans, with particular emphasis on the caspases of the apoptotic ... 2006) The apoptosome activates caspase-9 by dimerization. Mol Cell 22: 269-275 Eckelman BP, Salvesen GS. ( ...

Caspase recruitment domain-containing protein 9 is an adaptor protein of the CARD-CC protein family, which in humans is encoded ... "Entrez Gene: CARD9 caspase recruitment domain family, member 9". Bertin J, Guo Y, Wang L, Srinivasula SM, Jacobson MD, Poyet JL ... CARD9 is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated ... Merriam S, Du MQ, Dyer MJ, Robison KE, DiStefano PS, Alnemri ES (December 2000). "CARD9 is a novel caspase recruitment domain- ...

Rho inactivation can activate caspase-3 and caspase-9; two key components of the apoptotic pathway. TcdA has been linked to ... 50 (7): 613-9. doi:10.1099/0022-1317-50-7-613. PMID 11444771. Kuehne SA, Cartman ST, Heap JT, Kelly ML, Cockayne A, Minton NP ( ... 62 (2): 384-9. doi:10.1128/IAI.62.2.384-389.1994. PMC 186119. PMID 8300199. Hecht G, Pothoulakis C, LaMont JT, Madara JL ( ... 458 (7242): 1176-9. Bibcode:2009Natur.458.1176L. doi:10.1038/nature07822. PMC 2679968. PMID 19252482. (Protein pages needing a ...

Caspase 3. Caspase 7, Caspase-9, Diablo homolog HtrA serine peptidase 2, MAGED1, MAP3K2, TAB1, and XAF1. GRCm38: Ensembl ... Caspases are the enzymes primarily responsible for cell death. XIAP binds to and inhibits caspase 3, 7 and 9. The BIR2 domain ... When inhibiting caspase-3 and caspase-7 activity, the BIR2 domain of XIAP binds to the active-site substrate groove, blocking ... This allows normal caspase activity to proceed. The binding process of Smac/DIABLO to XIAP and caspase release requires a ...

... is one of the most studied ligands for HAVCR2 (TIM-3) and is expressed on various tumor cells. However, it can also ... Human galectin-9 is encoded by the LGALS9 gene. The protein has N- and C- terminal carbohydrate-binding domains connected by a ... Zhang ZY, Dong JH, Chen YW, Wang XQ, Li CH, Wang J, Wang GQ, Li HL, Wang XD (2012). "Galectin-9 acts as a prognostic factor ... 272 (9): 6078-86. doi:10.1074/jbc.272.9.6078. PMID 9038233. Türeci O, Schmitt H, Fadle N, Pfreundschuh M, Sahin U (March 1997 ...

Weng C, Li Y, Xu D, Shi Y, Tang H (Mar 2005). "Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related ... Pan G, O'Rourke K, Dixit VM (Mar 1998). "Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex". The Journal of Biological ... "Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation". Proceedings of the National Academy of ... 12 (9): 1432-40. doi:10.1210/mend.12.9.0166. PMID 9731710. Ray R, Chen G, Vande Velde C, Cizeau J, Park JH, Reed JC, Gietz RD, ...

The NLRP1 protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to ... responsible for the recruitment and activation of pro-caspase-1 in the active form of caspase-1. Human NLRP1 activation can be ... NLRP1 has been shown to interact with caspase 9 and APAF1. Via its FIIND domain, NLRP1 interacts directly with DPP9 and DPP8 ... Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The ...

In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIFM1 also ... a novel caspase-independent death effector released from mitochondria". Biochimie. 84 (2-3): 215-22. doi:10.1016/S0300-9084(02) ... "Mitochondrial release of caspase-2 and -9 during the apoptotic process". The Journal of Experimental Medicine. 189 (2): 381-94 ... "The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway". Cell Death and ...

Pan G, O'Rourke K, Dixit VM (1998). "Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex". J. Biol. Chem. 273 (10): 5841-5. ... The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which ... 8 (2): 83-9. doi:10.1007/s101470300015. PMID 12720100. S2CID 24180107. Kang Y, Lee DC, Han J, et al. (2007). "NM23-H2 involves ... 87 (9): 923-40. doi:10.1007/s00109-009-0495-7. PMID 19551325. S2CID 23491033. BCL2L10 human gene location in the UCSC Genome ...

... is an initiator caspase, as are caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63). ... Caspase-2 (EC 3.4.22.55, ICH-1, NEDD-2, caspase-2L, caspase-2S, neural precursor cell expressed developmentally down-regulated ... Caspase-2 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 3.4.22). ... Li H, Bergeron L, Cryns V, Pasternack MS, Zhu H, Shi L, Greenberg A, Yuan J (August 1997). "Activation of caspase-2 in ...

Gly Caspase-10 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-9 (EC 3.4.22.62 ... Shikama Y, Yamada M, Miyashita T (July 2003). "Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha ... Fischer U, Stroh C, Schulze-Osthoff K (January 2006). "Unique and overlapping substrate specificities of caspase-8 and caspase- ... Caspase-10 (EC 3.4.22.63, FLICE2, Mch4, CASP-10, ICE-like apoptotic protease 4, apoptotic protease Mch-4, FAS-associated death ...

Murine caspase-11, and its human homologs caspase-4 and caspase-5, are mammalian intracellular receptor proteases activated by ... Caspase-11 activation by direct binding to LPS represents a novel and unprecedented mechanism for caspase activation. Caspase- ... "Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions". The Journal of Cell ... an inactive precursor to active caspase-11) expression and caspase-11-mediated pyroptosis. Once expressed, caspase-11 is only ...

Instead, it is thought to inhibit Caspase-1 activation by interfering with the interaction of Caspase-1 with other important ... and a caspase, in this case Caspase-1. In some cases, where the signaling proteins contain their own CARDs, like in NLRP1 and ... Caspase-1 is produced as a zymogen that can then be cleaved into 20 kDa (p20) and 10 kDa (p10) subunits that become part of the ... Active Caspase 1 contains two heterodimers of p20 and p10. It contains a catalytic domain with an active site that spans both ...

... antagonizes both the precursor and mature forms of Smac and caspase-9". J. Biol. Chem. 280 (1): 174-82. doi:10.1074/jbc. ... "Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function". Nat. Cell Biol. 6 (9): 849-60. doi: ... 6 (9): 791-806. doi:10.1101/gr.6.9.791. PMID 8889548. Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (2000). " ... 9 (3): 99-106. doi:10.1093/dnares/9.3.99. PMID 12168954. Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, ...

Bonfoco E, Li E, Kolbinger F, Cooper NR (August 2001). "Characterization of a novel proapoptotic caspase-2- and caspase-9- ... Proteomics-based identification of proapoptotic caspase adapter protein as a novel serum marker of non-small cell lung cancer ... 54 (9): 2368-80. doi:10.1007/s00125-011-2212-7. PMID 21688198. Flach H, Rosenbaum M, Duchniewicz M, Kim S, Zhang SL, Cahalan MD ... 99 (9): 6398-403. Bibcode:2002PNAS...99.6398V. doi:10.1073/pnas.082112699. PMC 122960. PMID 11972030. ...

In addition, several other molecules, most notably caspase-3, have been reported to co-purify with the apoptosome and caspase-3 ... Another targeted molecule for cancer therapy involves the caspase family and their regulators. The inhibition of caspase ... this initiator caspase can then activate effector caspases and trigger a cascade of events leading to apoptosis. The term ... "Caspase-8 and Apaf-1-independent caspase-9 activation in Sendai virus-infected cells". The Journal of Biological Chemistry. 277 ...

The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. », Nat Cell. Biol, 2009 Furne et al., « ...

"US Patent Application for COMBINATION THERAPIES USING CASPASE-1 DEPENDENT ANTICANCER AGENTS AND PGE2 ANTAGONISTS Patent ... 56 (9): 3467-3477. doi:10.1021/jm400351a. PMC 4059180. PMID 23594271. "National Academy of Inventors". (Articles with short ... More recently his work has shown that DPP8/9 inhibitors trigger an immune response. He also designed, synthesized, and ... "DPP8/9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis". Nature Chemical Biology. 13 (1): 46-53. ...

Marisol Soengas; Alarcón RM; Yoshida H; Giaccia AJ; Hakem R; Mak TW; Lowe SW (1 April 1999). "Apaf-1 and caspase-9 in p53- ...

"Beclin 1 augmented cis-diamminedichloroplatinum induced apoptosis via enhancing caspase-9 activity". Experimental Cell Research ... 61 (8): 3443-9. PMID 11309306. Weinmann AS, Bartley SM, Zhang T, Zhang MQ, Farnham PJ (October 2001). "Use of chromatin ... doi:10.1016/S0896-6273(02)00861-9. PMID 12372286. S2CID 10534933. Song H, Xia SL, Liao C, Li YL, Wang YF, Li TP, Zhao MJ ( ... doi:10.1016/S0896-6273(02)00861-9. PMID 12372286. S2CID 10534933. Chang, Chunmei; Young, Lindsey N.; Morris, Kyle L.; von Bülow ...

Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive ... Caspase 10 has been shown to interact with FADD, CFLAR, Caspase 8, Fas receptor, RYBP, TNFRSF1A and TNFRSF10B. The Proteolysis ... Wang, J; Chun H J; Wong W; Spencer D M; Lenardo M J (November 2001). "Caspase-10 is an initiator caspase in death receptor ... That protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene ...

... has been shown to interact with Caspase 8. The Proteolysis Map Caspase GRCh38: Ensembl release 89: ENSG00000138794 - ... Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive ... Caspase 6 can also undergo self-processing without other members of the caspase family. Alternative splicing of this gene ... "Entrez Gene: CASP6 caspase 6, apoptosis-related cysteine peptidase". Cowling V, Downward J (Oct 2002). "Caspase-6 is the direct ...