There are two types of caspases: initiator caspases, caspase 2,8,9,10,11,12, and effector caspases, caspase 3,6,7. The ... caspase-8 and caspase-10. In some types of cells (type I), processed caspase-8 directly activates other members of the caspase ... The apoptosome cleaves the pro-caspase to its active form of caspase-9, which in turn cleaves and activates pro-caspase into ... A caspase 9 knock-out leads to a severe brain malformation[citation needed]. A caspase 8 knock-out leads to cardiac failure and ...

AD neurons have increased expression of upstream caspases 8 and 9 while keeping control levels of downstream caspases 3, 6, and ... AD neurons which exit G0 and enter G1 do not activate the full set of caspases required for neuronal apoptosis (Raina et al. ... Despite a growing number of studies underlying caspases and apoptosis involvement in AD, no direct role of apoptotic death in ... may be due to AD neurons receiving apoptotic signals but failing to propagate these signals to downstream caspase effectors ( ...

Mitochondrial activity or caspase: Resazurin and Formazan (MTT/XTT) can assay for various stages in the apoptosis process that ... Examples of this type of assay include propidium iodide, trypan blue, and 7-Aminoactinomycin D. ...

... induced caspase-dependent cleavage of p23. The cleavage could be catalyzed by either caspase-7 or caspase-3 and occurred at ... The Hsp90 inhibitor GA was found to enhance caspase activation, p23 cleavage and apoptosis induced by anthracyclines. Finally ... Gausdal G, Gjertsen BT, Fladmark KE, Demol H, Vandekerckhove J, Døskeland SO (December 2004). "Caspase-dependent, geldanamycin- ...

The HA-tag is not suitable for detection or purification of proteins from apoptotic cells since it is cleaved by Caspase-3 and ... or Caspase-7 after its sequence DVPD, causing it to lose its immunoreactivity. Labeling of endogenous proteins with HA-tag ... 165 (7): 1803-1817. doi:10.1016/j.cell.2016.04.044. PMC 4912470. PMID 27180908. Field J, Nikawa J, Broek D, MacDonald B, ...

Xu HL, Xu WH, Cai Q, Feng M, Long J, Zheng W, Xiang YB, Shu XO (2009). "Polymorphisms and haplotypes in the caspase-3, caspase- ... In another study, the MIP was used to identify the association between the polymorphisms and haplotypes in the caspase-3, ... caspase-7, and caspase-8 genes and the risk for endometrial cancer. A recent study has demonstrated the success of MIP for copy ... and caspase-8 genes and risk for endometrial cancer: a population-based, case-control study in a Chinese population". Cancer ...

... and a Caspase 3 and 7 cleavage site from amino acids 404-408 indicating possible translocation from the cell membrane to the ... have been confirmed and another 7 genes have been implicated with incomplete cDNAs, and the remaining hypothetical genes are ...

... stimulation of caspase-cascade (increasing activity of caspase-3, −6, −7 and −9). Moreover Huang found that JNK and PAK2 (both ... These results suggest that ROS is an upstream activator of JNK and can possibly control caspase-3 to trigger apoptosis when ... increase in ROS production and activation of apoptotic cell death via signal transduction pathways and the caspase-cascade ... and found a significant reduction in caspase-3 and apoptosis, but no effect on ROS generation. ...

TNF-related apoptosis-inducing ligand (TRAIL) activates caspase 3 (CASP3), which in turn interacts with caspases 6, 7, 8, 9, ... doi:10.1016/b978-0-12-801238-3.64395-7. ISBN 978-0-12-815145-7. Liu Z, Li F, Xue J, Wang M, Lai S, Bao H, He S (August 2020). " ... However, rarely a cyst will grow to be very large (greater than 7 cm), cause abdominal pain, or rupture, in which case pain ...

PGE2 is released by apoptotic cells in a caspase-dependent manner, which aids cancer stem cells and cancer progenitor cells in ... Boland, K; Flanagan, L; Prehn, J HM (July 2013). "Paracrine control of tissue regeneration and cell proliferation by Caspase-3 ... 4 (7): e725. doi:10.1038/cddis.2013.250. ISSN 2041-4889. PMC 3730423. PMID 23846227. Zimmerman, Mary A.; Huang, Qian; Li, Fang ... 81 (1): 7-19. doi:10.1002/bjs.1800810106. ISSN 0007-1323. PMID 8313126. S2CID 23957292. Ritoe, Savitri C.; Verbeek, André L. M ...

Stewart SA, Poon B, Song JY, Chen IS (April 2000). "Human immunodeficiency virus type 1 vpr induces apoptosis through caspase ... Retrieved 7 April 2020. Olson JK, Grose C (May 1997). "Endocytosis and recycling of varicella-zoster virus Fc receptor ... Retrieved 7 April 2020. Pornillos O, Garrus JE, Sundquist WI (December 2002). "Mechanisms of enveloped RNA virus budding". ... 74 (7): 3105-11. doi:10.1128/jvi.74.7.3105-3111.2000. PMC 111809. PMID 10708425. Payne, Susan (2017). "Virus Interactions With ...

Researchers at Columbia University report of reconstituted caspases combined from C. elegans and humans, which maintain a high ... Chelur, Dattananda S.; Chalfie, Martin (February 2007). "Targeted cell killing by reconstituted caspases". Proceedings of the ... 104 (7): 2283-8. Bibcode:2007PNAS..104.2283C. doi:10.1073/pnas.0610877104. PMC 1892955. PMID 17283333. Sheehan, Patrick ( ...

"Galectin-9 induces apoptosis through the calcium-calpain-caspase-1 pathway". Journal of Immunology. 170 (7): 3631-6. doi: ... 168 (4): 1961-7. doi:10.4049/jimmunol.168.4.1961. PMID 11823532. Kageshita T, Kashio Y, Yamauchi A, Seki M, Abedin MJ, Nishi N ... 7 (6): e38708. Bibcode:2012PLoSO...738708V. doi:10.1371/journal.pone.0038708. PMC 3369903. PMID 22685601. Jia J, Abudu YP, ... 19 (7-9): 593-600. doi:10.1023/B:GLYC.0000014090.63206.2f. PMID 14758084. S2CID 11006101. Maruyama K, Sugano S (January 1994 ...

"Antitumor effect of a transducible fusogenic peptide releasing multiple proapoptotic peptides by caspase-3". Molecular Cancer ... 7 (6): 1514-1522. doi:10.1158/1535-7163.MCT-07-2009. PMID 18566222. Lee, Y. -J.; Choi, H. -J.; Lim, J. -S.; Earm, J. -H.; Lee, ... ISBN 978-1-4614-7167-7. PMID 23765627. Bae, S. M.; Kim, J. H.; Chung, S. W.; Byun, Y.; Kim, S. Y.; Lee, B. H.; Kim, I. S.; Park ... doi:10.1016/0140-6736(90)91783-7. PMID 1973803. Hong, H. Y.; Lee, H. Y.; Kwak, W.; Yoo, J.; Na, M. H.; So, I. S.; Kwon, T. H.; ...

Apr 2002). "A caspase-related protease regulates apoptosis in yeast". Molecular Cell. 9 (4): 911-7. doi:10.1016/S1097-2765(02) ... In an analogous manner to caspases, metacaspases induce programmed cell death in both plants and fungi (yeast). Uren AG, ... Khan MA, Chock PB, Stadtman ER (Nov 2005). "Knockout of caspase-like gene, YCA1, abrogates apoptosis and elevates oxidized ... Metacaspases are members of the C14 class of cysteine proteases and thus related to caspases, orthocaspases and paracaspases. ...

"The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8". Proceedings of the National Academy of Sciences. ... 4 (7): 1095-1098. doi:10.1021/ol017275j. ISSN 1523-7060. PMID 11922791. Wrasidlo, Wolf; Mielgo, Ainhoa; Torres, Vicente A.; ... 105 (7): 2313-2318. Bibcode:2008PNAS..105.2313W. doi:10.1073/pnas.0712198105. ISSN 0027-8424. PMC 2268133. PMID 18268346. ... with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells". Molecular Pharmacology. 53 (1): 62-76. doi: ...

... is subject to both caspase cleavage and proteasomal degradation. In conditions of cell detachment, and particularly in ... NEDD9 is rapidly cleaved by caspases 3 and/or 7 at a DLVD site (residue 363), and at a DDYD site (residue 630) to form N- ... 7 (5): 2565-70. PMC 4069898. PMID 24966970. Xue YZ, Sheng YY, Liu ZL, Wei ZQ, Cao HY, Wu YM, Lu YF, Yu LH, Li JP, Li ZS (2013 ... 114 (7): 1606-15. doi:10.1002/jcb.24502. PMID 23355420. S2CID 31176818. Lu R, Ji Z, Li X, Zhai Q, Zhao C, Jiang Z, Zhang S, Nie ...

These caspases then activate the effector caspases 3, 6, and 7, leading to cleavage of death substrates such as lamin A, lamin ... granzymes enter the cytoplasm of the target cell and their serine protease function triggers the caspase cascade, which is a ... doi:10.1007/s00018-016-2350-7. PMC 5241346. PMID 27585956. Rudd-Schmidt JA, Hodel AW, Noori T, Lopez JA, Cho HJ, Verschoor S, ...

Alcivar A, Hu S, Tang J, Yang X (Jan 2003). "DEDD and DEDD2 associate with caspase-8/10 and signal cell death". Oncogene. 22 (2 ... Alcivar A, Hu S, Tang J, Yang X (2003). "DEDD and DEDD2 associate with caspase-8/10 and signal cell death". Oncogene. 22 (2): ... Schickling O, Stegh AH, Byrd J, Peter ME (2002). "Nuclear localization of DEDD leads to caspase-6 activation through its death ... DEDD has been shown to interact with: CFLAR, Caspase 8, and FADD. GRCh38: Ensembl release 89: ENSG00000158796 - Ensembl, May ...

p53 binds to the third intron of the caspase 6 gene, and promotes the activation of the gene. Caspase 6 in turn activates HIPK2 ... The activity of HIPK2 is increased through the action of caspase 6. Caspase 6 cleaves HIPK2 at residue D916 and D977. As a ... MacLachlan TK, El-Deiry WS (July 2002). "Apoptotic threshold is lowered by p53 transactivation of caspase-6". Proceedings of ... CREB binding protein p53 p300 SKI protein TP53INP1 ATM kinase PIN1 HMGA1 SIAH1 WSB1 caspase 6 Tachykinin receptor 3 Mdm2 CtBP ...

Some evidence suggests that this may result from abnormal expression of Bcl-2 and increased expression of caspase-3. Antibodies ... Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES (April 2002). "Caspase-2 induces apoptosis by releasing ... Caspases Noxa Microphthalmia-associated transcription factor Protein mimetic p53 upregulated modulator of apoptosis (PUMA) ... 277 (16): 13430-7. doi:10.1074/jbc.M108029200. PMID 11832478. Pathan N, Aime-Sempe C, Kitada S, Basu A, Haldar S, Reed JC (2001 ...

"Sodium Salicylate Activates Caspases and Induces Apoptosis of Myeloid Leukemia Cell Lines". Blood. 93 (7): 2386-94. doi:10.1182 ... "ChemIDplus - 54-21-7 - ABBQHOQBGMUPJH-UHFFFAOYSA-M - Sodium salicylate [USP:JAN] - Similar structures search, synonyms, ...

While in vitro cleavage by caspase occurs throughout the caspase family, preliminary data suggest that caspase-3 and caspase-7 ... This mechanism appears to be caspase-independent. Cleavage of PARP, by enzymes such as caspases or cathepsins, typically ... PARP is composed of four domains of interest: a DNA-binding domain, a caspase-cleaved domain (see below), an auto-modification ... This is integral in a programmed cell death model based on caspase cleavage inhibition of PARP. The auto-modification domain is ...

It recognizes bacterial molecules and stimulates an immune reaction . NOD1 protein contains a caspase recruitment domain (CARD ... an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB". The Journal of Biological Chemistry. 274 (21): 14560-7. doi: ... "A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis". The Journal of ... enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1". Biochemical and Biophysical Research ...

2007). "Cells with defective p53-p21-pRb pathway are susceptible to apoptosis induced by p84N5 via caspase-6". Cancer Res. 67 ( ... 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. Li Y, Wang X, Zhang X, Goodrich DW (2005). "Human hHpr1/ ... 19 (13): 1512-7. doi:10.1101/gad.1302205. PMC 1172058. PMID 15998806. Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a ... 16): 7631-7. doi:10.1158/0008-5472.CAN-07-0334. PMID 17699767. v t e (Articles with short description, Short description ...

Her group also characterized redundancies between caspase-1 and caspase-8 and between NLRP3 and caspase-8 in autoinflammatory ... Kanneganti's lab showed compensatory roles for NLRP3/caspase-1 and caspase-8 in the regulation of IL-1β production in ... Her lab identified caspase-8 and FADD as expression and activation regulators of both the canonical and non-canonical NLRP3 ... This finding went against the dogma that existed at that time that caspase-8 and FADD were involved only in apoptosis. ...

... induces a caspase-independent autophagic cell death". Cell Death and Differentiation. 10 (7): 798-807. doi:10.1038/sj.cdd. ... 87 (8): 3244-7. Bibcode:1990PNAS...87.3244F. doi:10.1073/pnas.87.8.3244. PMC 53872. PMID 2326282. Dang S, Sun L, Huang Y, Lu F ... 261 (2): 484-7. doi:10.1006/bbrc.1999.1060. PMID 10425211. Munroe PB, Mitchison HM, O'Rawe AM, Anderson JW, Boustany RM, Lerner ... 38 (4): 452-7. doi:10.1038/ng1764. hdl:11379/29243. PMID 16550171. S2CID 836017. Vázquez-Mellado J, Jiménez-Vaca AL, Cuevas- ...

"Suppression of caspase 8 activity by a coronin 1-PI3Kδ pathway promotes T cell survival independently of TCR and IL-7 signaling ... 13 (7): 510-518. doi:10.1038/nri3465. PMID 23765056. S2CID 38179365. Mueller, Philipp; Massner, Jan; Jayachandran, Rajesh; ... 13 (7): 510-518. doi:10.1038/nri3465. PMID 23765056. S2CID 38179365. Jayachandran, Rajesh; Gumienny, Aleksandra; Bolinger, ...

Büki, A.; Okonkwo, D. O.; Wang, K. K.; Povlishock, J. T. (2000). "Cytochrome c release and caspase activation in traumatic ... and caspase activation". FASEB Journal. 14 (7): 847-858. doi:10.1096/fasebj.14.7.847. PMID 10783138. S2CID 2089247. Nicholls, D ... 1368 (1): 7-18. doi:10.1016/s0005-2736(97)00175-2. PMID 9459579. Stavrovskaya, I. G.; Kristal, B. S. (2005). "The powerhouse ...

... the lambda-holin protein causes caspase-independent non-apoptotic cell death of eukaryotic cells". Cellular Microbiology. 9 (7 ...