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*  Caspase 3
Caspase substrate specificity has been widely used in caspase based inhibitor and drug design. Caspase-3, in particular, (also ... caspase activity would kill cells indiscriminately. As an executioner caspase, the caspase-3 zymogen has virtually no activity ... Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive ... This protein cleaves and activates caspases 6 and 7; and the protein itself is processed and activated by caspases 8, 9, and 10 ...
*  Phytaspase
... which resembles that of the animal caspases. Similarly to the animal caspases, the phytaspase is a cell death promoting ... In contrast with the animal caspases, that exist in the cytoplasm in a form of pre-synthesized precursors, the activation of ... Porter, A. G.; Jänicke, R. U. (1999-02-01). "Emerging roles of caspase-3 in apoptosis". Cell Death and Differentiation. 6 (2): ... The phytaspase displays a strict substrate specificity, which resembles that of the animal caspase-3. It recognizes a ...
*  TNS4
Lo SS, Lo SH, Lo SH (2005). "Cleavage of cten by caspase-3 during apoptosis". Oncogene. 24 (26): 4311-4. doi:10.1038/sj.onc. ... 2007). "A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration". Nat. Cell Biol. 9 (8): 961-9. doi: ... 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6 ...
*  Nerve tissue protein
In caspase-3 the 'hook' and 'sinker' attach. Both the BIR2 and BIR3 have a groove that is predominately negatively charged. ... This is done through the binding to caspases directly. Similar to the functionality of NAIP, the BIR3 domain of XAIP binds to ... This is unexpected because in nerve growth factor withdrawal, caspase-3 and -9 are activated, causing cell death, which are the ... When overexpressed, XAIP is able to block caspases extremely well and prevents cell death of sympathetic neurons when nerve ...
*  Clostridium difficile toxin A
Rho inactivation can activate caspase-3 and caspase-9; two key components of the apoptotic pathway. TcdA has been linked to ... 56 (3): 582-8. PMC 259330 . PMID 3343050. Lyras D, O'Connor JR, Howarth PM, Sambol SP, Carter GP, Phumoonna T, Poon R, Adams V ... 467 (7316): 711-3. doi:10.1038/nature09397. PMID 20844489. Dove CH, Wang SZ, Price SB, Phelps CJ, Lyerly DM, Wilkins TD, ... 35 (3): 1032-40. PMC 351151 . PMID 7068210. von Eichel-Streiber C, Laufenberg-Feldmann R, Sartingen S, Schulze J, Sauerborn M ( ...
*  HCLS1
Chen, Y R; Kori R; John B; Tan T H (Nov 2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins ... Chen YR, Kori R, John B, Tan TH (2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins ... HCLS1 has been shown to interact with Caspase 3. GRCh38: Ensembl release 89: ENSG00000180353 - Ensembl, May 2017 GRCm38: ... induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells". ...
*  Caspase-activated DNase
"Entrez Gene: DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)". Davidson College. "Caspase ... Caspase-activated DNase, and Inhibitor of Caspase-activated DNase to the Nuclear Phenotype and DNA Degradation during Apoptosis ... "Specific chaperone-like activity of inhibitor of caspase-activated DNase for caspase-activated DNase". The Journal of ... "Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome". ...
*  Caspase 7
... has been shown to interact with: Caspase 8, Survivin and XIAP. The Proteolysis Map Caspase GRCh38: Ensembl release 89 ... Caspases exist as inactive proenzymes that undergo proteolytic processing by upstream caspases (caspase-8, -9) at conserved ... Caspase-7 is a member of the caspase (cysteine aspartate protease) family of proteins, and has been shown to be an executioner ... The precursor of this caspase is cleaved by caspase 3, caspase 10, and caspase 9. It is activated upon cell death stimuli and ...
*  DFFA
2000). "Frequent nuclear localization of ICAD and cytoplasmic co-expression of caspase-8 and caspase-3 in human lymphomas". J. ... 1998). "A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD". Nature. 391 (6662): 43-50. doi: ... Liu X, Zou H, Slaughter C, Wang X (May 1997). "DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger ... DNA fragmentation factor subunit alpha (DFFA), also known as Inhibitor of caspase-activated DNase (ICAD), is a protein that in ...
*  XIAP
Caspases are the enzymes primarily responsible for cell death. XIAP binds to and inhibits caspase 3, 7 and 9. The BIR2 domain ... This allows normal caspase activity to proceed. The binding process of Smac/DIABLO to XIAP and caspase release requires a ... 2 region that is thought to contain the only element that comes into contact with the caspase molecule to form the XIAP/Caspase ... Caspase 7, Caspase-9, Diablo homolog HtrA serine peptidase 2, MAGED1, MAP3K2, MAP3K7IP1, and XAF1. GRCm38: Ensembl release 89: ...
*  Interleukin 16
Caspase 3 is reported to be involved in the proteolytic processing of this protein. Two alternatively spliced transcript ... This cytokine is produced as a precursor peptide (pro-IL-16) that requires processing by an enzyme called caspase-3 to become ... 1998). "Processing and activation of pro-interleukin-16 by caspase-3". J. Biol. Chem. 273 (2): 1144-9. doi:10.1074/jbc.273.2. ... doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Zhang Y, Center DM, Wu DM, et al. ( ...
*  RABEP1
Swanton E, Bishop N, Woodman P (Dec 1999). "Human rabaptin-5 is selectively cleaved by caspase-3 during apoptosis". The Journal ... 346 (3): 593-601. doi:10.1042/0264-6021:3460593. PMC 1220890 . PMID 10698684. Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, ... 83 (3): 423-32. doi:10.1016/0092-8674(95)90120-5. PMID 8521472. "Entrez Gene: RABEP1 rabaptin, RAB GTPase binding effector ... 508 (2): 201-9. doi:10.1016/s0014-5793(01)02993-3. PMID 11718716. Xiao GH, Shoarinejad F, Jin F, Golemis EA, Yeung RS (Mar 1997 ...
*  PARG
Affar, E. B.; Germain, M.; Winstall, E.; Vodenicharov, M.; Shah, R. G.; Salvesen, G. S.; Poirier, G. G. (2000). "Caspase-3- ... 392 (3): 499-509. doi:10.1042/BJ20050792. PMC 1316289 . PMID 16117724. This article incorporates text from the United States ...
*  Oleandrin
... increases caspase 3 activity in radiodamaged tumor cells and, therefore, increases radiation-induced apoptosis. It is ... Nasu, S; Milas, L; Kawabe, S; Raju, U; Newman, R (2002). "Enhancement of radiotherapy by oleandrin is a caspase-3 dependent ... 14 (4): 350-3. doi:10.1016/S0196-0644(85)80103-7. PMID 4039113. Bandara, V; Weinstein, SA; White, J; Eddleston, M (2010). "A ... 179 (2-3): e31-6. doi:10.1016/j.forsciint.2008.05.002. PMID 18602779. "Nerium oleander L.(PIM 366)". IPCS Inchem. 2005. . ...
*  Repinotan
... is able to suppress caspase-3 through MAPK and PKCalpha. Apoptosis as a result of anoxia/reoxygenation and H(2)O(2) ... "The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha". Biochimica et ... 284 (3): 1082-1094. PMID 9495870. Dong, J.; De Montigny, C.; Blier, P. (1998). "Full agonistic properties of BAY x 3702 on ... 3 (6): 924-7. PMID 12137415. Teal, P; Davis, S; Hacke, W; Kaste, M; Lyden, PD; Modified Randomized Exposure Controlled Trial ...
*  HLA-B associated transcript 3
Wu YH, Shih SF, Lin JY (2004). "Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3". J. Biol. ... 3 (10): E237-41. doi:10.1038/ncb1001-e237. PMID 11584289. Cross SJ, Tonks S, Trowsdale J, Campbell RD (1992). "Novel detection ... "Entrez Gene: BAT3 HLA-B associated transcript 3". Takayama S, Reed JC (2001). "Molecular chaperone targeting and regulation by ...
*  Fumonisin B1
The main factors could be DNA fragmentation and caspase-3 activation. FB1 has also immunotoxic effects, but much more research ... 301 (1-3): 21-32. doi:10.1016/j.tox.2012.06.012. PMID 22749975. Riley, R.T.; Voss, K.A. (2006). "Differential sensitivity of ... The proposed mechanism of action is depicted in figure 3. Fumonisin B1 occupies the space and electrostatic interactions of ... 3): 83-84. PMID 6346521. Wild CP, Gong YY (29 October 2009). "Mycotoxins and human disease: a largely ignored global health ...
*  Formaldehyde dehydrogenase
Mitchell DA, Marletta MA (August 2005). "Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine". Nat. ... Nitrosylated thioredoxin, via directed protein-protein interaction, trans-nitrosylates the active site cysteine of caspase-3 ... 129 (3): 511-22. doi:10.1016/j.cell.2007.02.046. PMID 17482545. Que LG, Liu L, Yan Y, Whitehead GS, Gavett SH, Schwartz DA, ... thus inactivating caspase-3 and preventing induction of apoptosis. As might be expected of an enzyme involved in regulating NO ...
*  LINGO1
However among the four WNK family members, only WNK3 has been shown to regulate and increase cell survival in a caspase-3- ... Veríssimo F, Silva E, Morris JD, Pepperkok R, Jordan P (Jul 2006). "Protein kinase WNK3 increases cell survival in a caspase-3- ... 7 (3): 221-8. doi:10.1038/nn1188. PMID 14966521. Llorens F, Gil V, Iraola S, Carim-Todd L, Martí E, Estivill X, Soriano E, del ... 7 (3): 221-8. doi:10.1038/nn1188. PMID 14966521. Shao Z, Browning JL, Lee X, Scott ML, Shulga-Morskaya S, Allaire N, Thill G, ...
*  Apoptosome
In each case, caspase 9 activation leads to the activation of a full caspase cascade and subsequent cell death. It has been ... 2002). "Caspase-8 and Apaf-1-independent Caspase-9 Activation in Sendai Virus-infected Cells". The Journal of Biological ... This functional apoptosome then can provide a platform activation of caspase 9. Caspase 9 exists as a zymogen in the cytosol ... Another targeted molecule for cancer therapy involves the caspase family and their regulators. The inhibition of caspase ...
*  Atrophin 1
"Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the ... protein is cleaved by caspase-3 during apoptosis". The Journal of Biological Chemistry. 272 (46): 29238-42. doi:10.1074/jbc. ... 16 (3): 572-9. doi:10.1006/geno.1993.1232. PMID 8325628. Ansari-Lari MA, Muzny DM, Lu J, Lu F, Lilley CE, Spanos S, Malley T, ... 5 (3): 373-9. doi:10.1093/hmg/5.3.373. PMID 8852663. Margolis RL, Li SH, Young WS, Wagster MV, Stine OC, Kidwai AS, Ashworth RG ...
*  Nuclear dots
Quignon F, De Bels F, Koken M, Feunteun J, Ameisen JC, de Thé H (1998). "PML induces a novel caspase-independent death process ... Retinoic acid induces a caspase-3 mediated degradation of the same chimera. In HHV, ICP0 disrupts nuclear dots in the early ... 1998). "Caspases mediate retinoic acid-induced degradation of the acute promyelocytic leukemia PML/RARalpha fusion protein". ... 198 (1-3): 307-31. doi:10.1016/s0171-2985(97)80051-4. PMID 9442402. Pawlotsky JM, Andre C, Metreau JM, Beaugrand M, Zafrani ES ...
*  Protein kinase N1
Takahashi M, Mukai H, Toshimori M, Miyamoto M, Ono Y (1998). "Proteolytic activation of PKN by caspase-3 or related protease ... The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal ... 378 (3): 281-5. doi:10.1016/0014-5793(95)01454-3. PMID 8557118. Amano M, Mukai H, Ono Y, Chihara K, Matsui T, Hamajima Y, Okawa ... 234 (3): 621-5. doi:10.1006/bbrc.1997.6669. PMID 9175763. Goedert M, Hasegawa M, Jakes R, Lawler S, Cuenda A, Cohen P (1997). " ...
*  ACIN1
Sahara S, Aoto M, Eguchi Y, Imamoto N, Yoneda Y, Tsujimoto Y (Sep 1999). "Acinus is a caspase-3-activated protein required for ... 2001). "Caspase activation is required for terminal erythroid differentiation". J. Exp. Med. 193 (2): 247-54. doi:10.1084/jem. ... 2003). "Specific involvement of caspases in the differentiation of monocytes into macrophages". Blood. 100 (13): 4446-53. doi: ... 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. Shu Y, Iijima T, Sun W, et al. (2007). "The ACIN1 gene is ...
*  FOXO3
"The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 ... "The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 ... "Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases". Oncogene. 22 (29): 4557-68. doi: ... 21 (3): 952-65. doi:10.1128/MCB.21.3.952-965.2001. PMC 86685 . PMID 11154281. Schuur ER, Loktev AV, Sharma M, Sun Z, Roth RA, ...
*  Proto-oncogene tyrosine-protein kinase Src
Src (gene) has been shown to interact with the following signaling pathways: PI3K Akt IKK NFkB Caspase 9 STAT3 p38 MAPK VEGF IL ... 262 (3): 118-128. doi:10.1016/j.neuroscience.2013.12.060. PMC 3943922 . PMID 24412374. Zhao X, Wu T, Chang CF, et al. (2015). " ... 10 (3): 1000-9. doi:10.1128/mcb.10.3.1000. PMC 360952 . PMID 1689455. Dehm SM, Bonham K (April 2004). "SRC gene expression in ...