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The initiation of the caspases cascade may lead to the activation of endonucleases such as caspase-activated DNAase (CAD). ... Caspases are produced as inactive proenzymes, which are proteolytically processed to their active forms. These proteases can ... In neuroectodermal tumor cells, betulinic acid-induced apoptosis is accompanied by caspase activation, mitochondrial membrane ... caspase activation. Betulinic acid bypasses resistance to CD95 and doxorubicin-mediated apoptosis, due to different molecular ...

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Caspase activity that is triggered by the NLRP1 inflammasome activates caspase-6, which destroys the axons of neurons. Plants ... NOD-like receptors, in general, activate caspase-1 and assist in the maturation of the proinflammatory cytokines IL-1β and IL- ... However, not every NLRP forms an inflammasome and activates caspase-1; these NLRPs are referred to as non-canonical NLRPs. As ... including K+ efflux and caspase 1 activation. NLRPs are also known to be associated with a number of diseases. Research ...

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... initiating the caspase cascade. The activated caspases can go on to cleave intracellular proteins such as inhibitor of caspase- ... Activated caspase 8 cleaves these kinases, inhibiting necroptosis. Since activation of caspase 8 requires FADD in order to ... "Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8". Journal of ... Caspase 8 then cleaves RIPK1, leading to inhibition of this signalling, inhibiting cell death. FADD knockout in mouse embryos ...

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In residue 321, the change of aspartic acid (D) to Asparagine (N) reveals as loss of proteolytic cleavage by caspases. Those ... STK24 operates on serine and threonine residues and, as a response to oxidative stress and caspase activity, develops cell ... "Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis". The Journal ... "Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis". The Journal ...

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Plant cells do not have caspases. Plant disease resistance Phytopathogen Plant hormones Systemic acquired resistance ... the pore-forming activity arises from gasdermin B which is cleaved by caspases as a result of the oligomerisation of the NLRs. ... 22 (12): 662-70. doi:10.1016/j.tig.2006.09.011. PMID 17011664. Baggs E, Dagdas G, Krasileva KV (August 2017). "NLR diversity, ... 12 (9): 817-26. doi:10.1038/ni.2083. PMID 21852785. S2CID 205364432. Burdett H, Kobe B, Anderson PA (July 2019). "Animal NLRs ...

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A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular ... Graves JD, Gotoh Y, Draves KE, Ambrose D, Han DK, Wright M, Chernoff J, Clark EA, Krebs EG (June 1998). "Caspase-mediated ... Ura S, Masuyama N, Graves JD, Gotoh Y (August 2001). "Caspase cleavage of MST1 promotes nuclear translocation and chromatin ... Lee KK, Ohyama T, Yajima N, Tsubuki S, Yonehara S (2001). "MST, a physiological caspase substrate, highly sensitizes apoptosis ...

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