Caspase-activated DNase Nicoletti assay Apoptotic DNA fragmentation TUNEL assay Kressel, M.; Groscurth, P. (1994-12-01). " ... caspase-3 activity by zinc supplementation in cultured HeLa cells". The Indian Journal of Medical Research. 129 (5): 579-586. ... DNA laddering is a distinctive feature of DNA degraded by caspase-activated DNase (CAD), which is a key event during apoptosis ...

McDonald ER, El-Deiry WS (2004). "Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ... 2005). "Crystal structure of a FYVE-type zinc finger domain from the caspase regulator CARP2". Structure. 12 (12): 2257-63. doi ...

... caspase-8 and caspase-10. In some types of cells (type I), processed caspase-8 directly activates other members of the caspase ... The apoptosome cleaves the pro-caspase to its active form of caspase-9, which in turn cleaves and activates pro-caspase into ... There are two types of caspases: initiator caspases, caspase 2,8,9,10,11,12, and effector caspases, caspase 3,6,7. The ... caspase-3 and caspase-7 pathway; and by external signals (FAS and TNF), along the caspase 8 pathway. Accessed 25 March 2007. ...

gp120 induces mitochondrial-death proteins like caspases which may influence the upregulation of the death receptor Fas leading ... "Tubular cell HIV-1 gp120 expression induces caspase 8 activation and apoptosis". Ren Fail. 31 (4): 303-12. doi:10.1080/ ... "Tubular Cell HIV-1 gp120 Expression Induces Caspase 8 Activation and Apoptosis". Renal Failure. 31 (4): 303-312. doi:10.1080/ ... 14 (12): 1229-1246. doi:10.1093/glycob/cwh106. ISSN 0959-6658. PMID 15175256. Liu Y, Curlin ME, Diem K, Zhao H, Ghosh AK, Zhu H ...

... induced caspase-dependent cleavage of p23. The cleavage could be catalyzed by either caspase-7 or caspase-3 and occurred at ... The Hsp90 inhibitor GA was found to enhance caspase activation, p23 cleavage and apoptosis induced by anthracyclines. Finally ... Gausdal G, Gjertsen BT, Fladmark KE, Demol H, Vandekerckhove J, Døskeland SO (December 2004). "Caspase-dependent, geldanamycin- ... 18 (12): 1989-96. doi:10.1038/sj.leu.2403508. PMID 15483679. Piper PW, Millson SH, Mollapour M, Panaretou B, Siligardi G, Pearl ...

8 deficiency in mice exacerbates inflammatory arthritis through delayed neutrophil apoptosis and reduced caspase 11 expression ... 62 (12): 3645-3655. doi:10.1002/art.27757. PMID 21120997.{{cite journal}}: CS1 maint: multiple names: authors list (link) ... 12 (5): e1001869. doi:10.1371/journal.pbio.1001869. PMC 4035269. PMID 24865846.{{cite journal}}: CS1 maint: multiple names: ...

The protein Sf caspase-1 is the insect ortholog of the human effector caspases CASP3 (CPP32) and CASP7 (MCH3) in the species ... Like other caspases, Sf caspase-1 is an aspartate-specific cysteine protease that is produced as an inactive proenzyme and ... The Sf caspase-1 proenzyme is cleaved after the amino acid residues Asp-28 and Asp-195, resulting in a smaller 12 kDa fragment ... Some experiments also showed cleavage of Sf caspase-1 at the residue Asp-184, resulting in an 18 kDa instead of 19 kDa fragment ...

It recognizes bacterial molecules and stimulates an immune reaction . NOD1 protein contains a caspase recruitment domain (CARD ... an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB". The Journal of Biological Chemistry. 274 (21): 14560-7. doi: ... "A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis". The Journal of ... enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1". Biochemical and Biophysical Research ...

The NLRP1 protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to ... responsible for the recruitment and activation of pro-caspase-1 in the active form of caspase-1. Human NLRP1 activation can be ... NLRP1 has been shown to interact with caspase 9 and APAF1. Via its FIIND domain, NLRP1 interacts directly with DPP9 and DPP8 ... Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The ...

Activated caspase-9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results ... hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner". The Journal of Cell Biology. ... Hu Y, Benedict MA, Wu D, Inohara N, Núñez G (Apr 1998). "Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 ... Hu Y, Benedict MA, Wu D, Inohara N, Núñez G (Apr 1998). "Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 ...

Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity". Cell Death and Differentiation. 9 (1): 20-6. ... reducing the cell's inhibition to caspase activation. In summary, HTRA2/Omi contributes to apoptosis through both caspase- ... This protein is involved in caspase-dependent apoptosis and in Parkinson's disease. The gene HTRA2 encodes a serine protease. ... Suzuki Y, Takahashi-Niki K, Akagi T, Hashikawa T, Takahashi R (Feb 2004). "Mitochondrial protease Omi/HtrA2 enhances caspase ...

Meyer U, Benghezal M, Imhof I, Conzelmann A (2000). "Active site determination of Gpi8p, a caspase-related enzyme required for ... 39 (12): 3461-71. doi:10.1021/bi992186o. PMID 10727241. Ohishi K, Inoue N, Maeda Y, et al. (2000). "Gaa1p and gpi8p are ... 14 (5): 1780-9. doi:10.1091/mbc.E02-12-0794. PMC 165076. PMID 12802054. Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The ...

Excess progenitor cell proliferation that leads to gross brain abnormalities is often lethal, as seen in caspase-3 or caspase-9 ... Kuida, K (1998). "Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9". Cell. 94 (3): 325- ... Pyroptosis, an inflammatory type of cell death, is uniquely mediated by caspase 1, an enzyme not involved in apoptosis, in ... to cells (such as feedback from neighbors, stress or DNA damage), mitochondria release caspase activators that trigger the cell ...

Sadasivam S, Gupta S, Radha V, Batta K, Kundu TK, Swarup G (Jan 2005). "Caspase-1 activator Ipaf is a p53-inducible gene ... Thalappilly S, Sadasivam S, Radha V, Swarup G (Jun 2006). "Involvement of caspase 1 and its activator Ipaf upstream of ... Damiano JS, Newman RM, Reed JC (Nov 2004). "Multiple roles of CLAN (caspase-associated recruitment domain, leucine-rich repeat ... a human caspase-1-activating protein related to Apaf-1". The Journal of Biological Chemistry. 276 (30): 28309-13. doi:10.1074/ ...

"Cytotoxicity of calotropin is through caspase activation and downregulation of anti-apoptotic proteins in K562 cells". Cell ... 33 (12): 1230-1236. doi:10.1016/j.cellbi.2009.08.013. PMID 19732845. S2CID 29139887. Jacinto, Sonia D.; Chun, Eunice Alexis C ... 13 (12): 3033-3039. doi:10.3390/molecules13123033. PMC 6244834. PMID 19052526. "Butterfly Society of Hawaii". Archived from the ... The fatal period is 6 to 12 hours.[citation needed] Treatment includes stomach wash, demulcents, and symptomatic treatment.[ ...

Nakagawa, Akihisa; Sullivan, Kelly D.; Xue, Ding (2014). "Caspase-activated phosphoinositide binding by CNT-1 promotes ... 12 (2): 235-246. doi:10.1016/j.devcel.2006.12.002. PMID 17276341. Takahashi, Yuta; Daitoku, Hiroaki; Hirota, Keiko; Tamiya, ... 21 (12): 1082-1090. doi:10.1038/nsmb.2915. PMC 4256149. PMID 25383666. Boucher, Jérémie; Kleinridders, André; Kahn, C. Ronald ( ... 102 (12): 4494-4499. Bibcode:2005PNAS..102.4494O. doi:10.1073/pnas.0500749102. PMC 555525. PMID 15767565. Wolf, Marc; Nunes, ...

2004). "Labile zinc and zinc transporter ZnT4 in mast cell granules: role in regulation of caspase activation and NF-kappaB ... 22 (38): 6005-12. doi:10.1038/sj.onc.1206797. PMID 12955079. Beck FW, Prasad AS, Butler CE, et al. (2004). "Differential ... 172 (12): 7750-60. doi:10.4049/jimmunol.172.12.7750. PMID 15187159. Smith JL, Xiong S, Markesbery WR, Lovell MA (2006). " ...

1999). "Identification of caspases that cleave presenilin-1 and presenilin-2. Five presenilin-1 (PS1) mutations do not alter ... Archived from the original on 2020-12-03. Retrieved 2019-12-14. van de Craen M, de Jonghe C, van den Brande I, et al. ( ... the sensitivity of PS1 to caspases" (PDF). FEBS Lett. 445 (1): 149-54. doi:10.1016/S0014-5793(99)00108-8. hdl:10067/ ... v t e (Articles with short description, Short description matches Wikidata, Genes on human chromosome 12, All stub articles, ...

"Frequent nuclear localization of ICAD and cytoplasmic co-expression of caspase-8 and caspase-3 in human lymphomas". The Journal ... Liu X, Zou H, Slaughter C, Wang X (April 1997). "DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger ... Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S (January 1998). "A caspase-activated DNase that degrades DNA ... Liu X, Zou H, Widlak P, Garrard W, Wang X (May 1999). "Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase ...

Apoptosis Apoptosome Bcl-2 Bcl-2-associated X protein (BAX) BH3 interacting domain death agonist (BID) Caspases Cytochrome c ... Phorbol-12-myristate-13-acetate-induced protein 1 is a protein that in humans is encoded by the PMAIP1 gene, and is also known ... 12 (3): 613-22. doi:10.1007/s10495-006-0020-1. PMID 17216584. S2CID 41674871. Doffo J, Bamopoulos SA, Köse H, Orben F, Zang C, ... "Entrez Gene: PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1". Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, ...

In macrophages, HIGD1A prevents apoptosis by inhibiting cytochrome C release and caspase activity. HIGD1A is also involved in ... "The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase ... 1813 (12): 2088-98. doi:10.1016/j.bbamcr.2011.07.017. PMID 21856340. Ameri K, Rajah AM, Nguyen V, Sanders TA, Jahangiri A, ...

2000). "Caspase-2 Is Localized at the Golgi Complex and Cleaves Golgin-160 during Apoptosis". J. Cell Biol. 149 (3): 603-12. ... Maag RS, Mancini M, Rosen A, Machamer CE (Jun 2005). "Caspase-resistant Golgin-160 Disrupts Apoptosis Induced by Secretory ... Sbodio JI, Hicks SW, Simon D, Machamer CE (2006). "GCP60 preferentially interacts with a caspase-generated golgin-160 fragment ... 7 (12): 1666-77. doi:10.1111/j.1600-0854.2006.00504.x. PMID 17118120. S2CID 6554179. Sbodio JI, Machamer CE (2007). " ...

Wang M, Qanungo S, Crow MT, Watanabe M, Nieminen AL (2005). "Apoptosis repressor with caspase recruitment domain (ARC) is ... NOL3 has been shown to interact with SFRS9 and Caspase 8. GRCh38: Ensembl release 89: ENSG00000140939 - Ensembl, May 2017 ... Ekhterae D, Platoshyn O, Zhang S, Remillard CV, Yuan JX (2003). "Apoptosis repressor with caspase domain inhibits cardiomyocyte ... "Apoptosis repressor with caspase recruitment domain (ARC) is expressed in cancer cells and localizes to nuclei". FEBS Lett. 579 ...

Hadji A, Clybouw C, Auffredou MT, Alexia C, Poalas K, Burlion A, Feraud O, Leca G, Vazquez A (December 2010). "Caspase-3 ... PUMA levels are downregulated through the activation of caspase-3 and a protease inhibited by the serpase inhibitor N-tosyl-L- ... Apoptosis Apoptosome Bcl-2 Bcl-2-associated X protein (BAX) BH3 interacting domain death agonist (BID) Caspases Cytochrome c ... Following mitochondrial dysfunction, the caspase cascade is activated ultimately leading to cell death. The PUMA protein is ...

The caspase-independence of necroptosis allows the cell to bypass caspase activation, decreasing the time during which the ... in a caspase-independent fashion in the presence of viral caspase inhibitors to restrict virus replication. In addition to ... Conversely, caspase 8 inhibition of necroptosis can be bypassed by the necroptotic machinery through the anti-apoptotic protein ... The best characterized example of this co-regulation is the ability of caspase 8 to inhibit the formation of the necrosome by ...

... and Caspase Activation". Chemical Research in Toxicology. 34 (12): 2579-2591. doi:10.1021/acs.chemrestox.1c00347. PMC 8853703. ... 12 September 2019. Retrieved 25 February 2020. "Cisplatin". The American Society of Health-System Pharmacists. Archived from ... 12 (5): 1063. doi:10.3390/cancers12051063. PMC 7281743. PMID 32344838. Dhara SC (1970). "Cisplatin". Indian J. Chem. 8: 123-134 ...

The initiation of the caspases cascade may lead to the activation of endonucleases such as caspase-activated DNAase (CAD). ... Caspases are produced as inactive proenzymes, which are proteolytically processed to their active forms. These proteases can ... In neuroectodermal tumor cells, betulinic acid-induced apoptosis is accompanied by caspase activation, mitochondrial membrane ... caspase activation. Betulinic acid bypasses resistance to CD95 and doxorubicin-mediated apoptosis, due to different molecular ...

Some evidence suggests that this may result from abnormal expression of Bcl-2 and increased expression of caspase-3. Antibodies ... Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES (April 2002). "Caspase-2 induces apoptosis by releasing ... Caspases Noxa Microphthalmia-associated transcription factor Protein mimetic p53 upregulated modulator of apoptosis (PUMA) ... 12 (9): 1432-40. doi:10.1210/mend.12.9.0166. PMID 9731710. Liang XH, Kleeman LK, Jiang HH, Gordon G, Goldman JE, Berry G, ...

"Restoration of TFPI-2 in a Human Glioblastoma Cell Line Triggers Caspase Mediated Pathway and Apoptosis". Clin. Cancer Res. 13 ... 12): 3507-3517. doi:10.1158/1078-0432.CCR-06-3023. PMC 1905856. PMID 17575213. Rao CN, Segawa T, Navari JR, et al. (2003). " ...

Zhou BB, Li H, Yuan J, Kirschner MW (Jun 1998). "Caspase-dependent activation of cyclin-dependent kinases during Fas-induced ... 12 (5): 706-20. doi:10.1101/gad.12.5.706. PMC 316589. PMID 9499405. Lu PJ, Zhou XZ, Shen M, Lu KP (Feb 1999). "Function of WW ... 10 (12): 1411-20. doi:10.1038/ncb1799. PMC 2635557. PMID 18997788. Zhou Y, Ching YP, Ng RW, Jin DY (Sep 2003). "Differential ... 95 (12): 6785-90. Bibcode:1998PNAS...95.6785Z. doi:10.1073/pnas.95.12.6785. PMC 22635. PMID 9618490. Wassmann K, Benezra R (Sep ...