One novel protein (ProAgio) has been designed to bind at an unusual site, and then induces apoptosis by recruiting caspase 8. ... Fibronectin domain 10 contains the RGD motif that αVβ3 recognizes. A high-affinity, pure antagonist mutant has been discovered ...

Sadasivam S, Gupta S, Radha V, Batta K, Kundu TK, Swarup G (Jan 2005). "Caspase-1 activator Ipaf is a p53-inducible gene ... Thalappilly S, Sadasivam S, Radha V, Swarup G (Jun 2006). "Involvement of caspase 1 and its activator Ipaf upstream of ... Damiano JS, Newman RM, Reed JC (Nov 2004). "Multiple roles of CLAN (caspase-associated recruitment domain, leucine-rich repeat ... a human caspase-1-activating protein related to Apaf-1". The Journal of Biological Chemistry. 276 (30): 28309-13. doi:10.1074/ ...

Initiator caspases: responsible for the activation of effector caspases. These caspases are activated through oligomerization ... FLIPL's pseudo-caspase has two tandem DEDs that are very similar to the N-terminus of capase-8, but in which there is an ... Studying caspases is important since they don't only control apoptosis but also inhibit it, depending on the necessity of the ... This type of apoptosis depends on the pDED of the HIP-1, and it consists in the activation of caspase-3, an enzyme that is ...

Caspase recruitment domain-containing protein 11 also known as CARD-containing MAGUK protein 1 (Carma 1) is a protein in the ... "Entrez Gene: CARD11 caspase recruitment domain family, member 11". Holliday MJ, Witt A, Rodriguez Gama A, Walters B, Arthur C, ... This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated ... "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and ...

Kim SJ, Zhang Z, Lee YC, Mukherjee AB (2006). "Palmitoyl-protein thioesterase-1 deficiency leads to the activation of caspase-9 ... 15 (10): 1580-6. doi:10.1093/hmg/ddl078. PMID 16571600. Ahtiainen L, Luiro K, Kauppi M, et al. (2006). "Palmitoyl protein ...

"Galectin-9 induces apoptosis through the calcium-calpain-caspase-1 pathway". Journal of Immunology. 170 (7): 3631-6. doi: ... 169 (10): 5912-8. doi:10.4049/jimmunol.169.10.5912. PMID 12421975. Kashio Y, Nakamura K, Abedin MJ, Seki M, Nishi N, Yoshida N ... 207 (10): 2187-94. doi:10.1084/jem.20100643. PMC 2947065. PMID 20819927. Liu FT (April 2005). "Regulatory roles of galectins in ... 272 (10): 6416-22. doi:10.1074/jbc.272.10.6416. PMID 9045665. "Entrez Gene: LGALS9 lectin, galactoside-binding, soluble, 9 ( ...

Chen, Y R; Kori R; John B; Tan T H (Nov 2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins ... Chen YR, Kori R, John B, Tan TH (2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins ... HCLS1 has been shown to interact with Caspase 3. GRCm38: Ensembl release 89: ENSMUSG00000022831 - Ensembl, May 2017 "Human ... induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells". ...

... are directly responsible for the expression of anergy associated genes such as ubiquitin ligase GRAIL or a protease caspase 3. ... 10 (6): 640-645. doi:10.1016/s0952-7915(98)80082-4. PMID 9914222. Tone Y, Furuuchi K, Kojima Y, Tykocinski ML, Greene MI, Tone ... 10 (7): 1535-1541. doi:10.1183/09031936.97.10071535. PMID 9230243. Jenkins MK (February 1992). "The role of cell division in ... Anergized cells tend to produce antiinflammatory IL-10 instead. There are 3 NFAT proteins in the T-cell, NFAT1, NFAT2 and NFAT4 ...

The caspase-independence of necroptosis allows the cell to bypass caspase activation, decreasing the time during which the ... in a caspase-independent fashion in the presence of viral caspase inhibitors to restrict virus replication. In addition to ... Conversely, caspase 8 inhibition of necroptosis can be bypassed by the necroptotic machinery through the anti-apoptotic protein ... The best characterized example of this co-regulation is the ability of caspase 8 to inhibit the formation of the necrosome by ...

June 2004). "PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1". Int. Immunol. 16 (6): 777-86. doi: ... 2004). "PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1". Int. Immunol. 16 (6): 777-86. doi: ... 2005). "PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta ... caspase-1 and PYCARD. ENSG00000281166, ENSG00000182261 GRCh38: Ensembl release 89: ENSG00000276780, ENSG00000281166, ...

"Substituted titanocenes induce caspase-dependent apoptosis in human epidermoid carcinoma cells in vitro and exhibit antitumour ... 10 (8): 675-682. doi:10.2174/15701808113100890027. Tacke M (2008). "The Interaction of Titanocene Y with Double-Stranded DNA: A ... 8 (10): 904-910. doi:10.2174/157018011797655241.{{cite journal}}: CS1 maint: multiple names: authors list (link) Bannon JH, ... 16 (10): 1091-1098. doi:10.1097/00001813-200511000-00008. PMID 16222151. S2CID 44409481. Oberschmidt O, Hanauske AR, Pampillón ...

Following the exposure of PC12 cells to monocrotophos, the levels of protein and mRNA expression of caspase-3, caspase-9, BAX, ... Mitochondria mediated apoptosis induction was confirmed by the increased activity of caspase cascade. These apoptotic changes ... Retrieved 2013-10-31. The poison pill in India's search for cheap food Children Die from Tainted Lunches at Indian School ... 10−5 M) decreases the number of apoptotic events due to an increase in the number of necrotic cells. Monocrotophos-induced ...

Caspase 3. Caspase 7, Caspase-9, Diablo homolog HtrA serine peptidase 2, MAGED1, MAP3K2, TAB1, and XAF1. GRCm38: Ensembl ... Caspases are the enzymes primarily responsible for cell death. XIAP binds to and inhibits caspase 3, 7 and 9. The BIR2 domain ... When inhibiting caspase-3 and caspase-7 activity, the BIR2 domain of XIAP binds to the active-site substrate groove, blocking ... This allows normal caspase activity to proceed. The binding process of Smac/DIABLO to XIAP and caspase release requires a ...

Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants ... that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase- ... 116 (Pt 10): 1937-48. doi:10.1242/jcs.00403. ISSN 0021-9533. PMID 12668730. Andersson B, Wentland MA, Ricafrente JY, et al. ( ... 8 (10): 2003-15. doi:10.1091/mbc.8.10.2003. PMC 25662. PMID 9348539. Kadlec L, Pendergast AM (1997). "The amphiphysin-like ...

Because cleavage by caspase 3 also cleaves off MST2's nuclear export signal, the MST2 kinase fragment can diffuse into the ... Recent studies have shown that when caspase 3 is activated during apoptosis, MST2 is cleaved, resulting in removal of the ... Lee KK, Ohyama T, Yajima N, Tsubuki S, Yonehara S (June 2001). "MST, a physiological caspase substrate, highly sensitizes ... De Souza PM, Kankaanranta H, Michael A, Barnes PJ, Giembycz MA, Lindsay MA (May 2002). "Caspase-catalyzed cleavage and ...

TNF-α then triggers apoptotic pathways through the activation of caspases, resulting in cell death. Cirrhosis is a late stage ... Between 10% and 35% of heavy drinkers develop alcoholic hepatitis (NIAAA, 1993). While development of hepatitis is not directly ... 76 (10): 1021-9. doi:10.4065/76.10.1021. PMID 11605686. Longstreth, George F.; Zieve, David, eds. (18 October 2009). "Alcoholic ... Despite cessation of alcohol use, only 10% will have normalization of histology and serum liver enzyme levels. As previously ...

Before cleavage by caspase 1, pro-IL-1β has a molecular weight of 37 kDa. The molecular weight of the proteolytically processed ... NLRP3 inflammasome activate caspase-1 which catalyze cleavage of inactive cytosolic precursor pro-IL-1β to its mature form IL-1 ... Pyroptosis is mediated via caspase-1 and is characterized by cell lysis and the secretion of IL-1β causing inflammation and ... Additionally, it has been shown that caspase-1 is upregulated in the retina of diabetic patients, causing a higher production ...

Yuan J, Murrell GA, Trickett A, Wang MX (June 2003). "Involvement of cytochrome c release and caspase-3 activation in the ... "HIV-1 Vpr induces apoptosis through caspase 9 in T cells and peripheral blood mononuclear cells". The Journal of Biological ... "Adenovirus encoding HIV-1 Vpr activates caspase 9 and induces apoptotic cell death in both p53 positive and negative human ... 111 (10): 1455-7. doi:10.1172/JCI18609. PMC 155055. PMID 12750393. Lum JJ, Cohen OJ, Nie Z, Weaver JG, Gomez TS, Yao XJ, Lynch ...

... wanted to apply Aurora's assay expertise to its programs in kinase inhibitors and caspase inhibitors, and wanted access to ... July 10, 2000. At the Speed of Light Tom Abate for the San Francisco. October 30, 2000 IMAGE is everything: Automated tools ... In 2003 Vertex sold PanVera to Invitrogen for $95 million in cash and $10 million in assumption of debt and other costs. Later ... Retrieved 2020-09-10. Wells, WA (July 1997). "Shine a light, Aurora Biosciences Corporation". Chemistry & Biology. 4 (7): 537-8 ...

"Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with ... "Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with ... 10 (12): 1287-98. doi:10.1093/hmg/10.12.1287. PMID 11406610. Brosh RM, Li JL, Kenny MK, Karow JK, Cooper MP, Kureekattil RP, ... 10 (12): 1287-98. doi:10.1093/hmg/10.12.1287. PMID 11406610. Freire R, d'Adda Di Fagagna F, Wu L, Pedrazzi G, Stagljar I, ...

During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of ... by caspase-3 occurs at a noncanonical cleavage site". J. Biol. Chem. 275 (7): 5031-6. doi:10.1074/jbc.275.7.5031. PMID 10671544 ... 19 (10): 6833-44. doi:10.1128/MCB.19.10.6833. PMC 84680. PMID 10490622. Eggert M, Michel J, Schneider S, Bornfleth H, Baniahmad ... 19 (10): 6833-44. doi:10.1128/MCB.19.10.6833. PMC 84680. PMID 10490622. Kipp M, Schwab BL, Przybylski M, Nicotera P, ...

"Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with ... "Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with ... 10 (12): 1287-98. doi:10.1093/hmg/10.12.1287. PMID 11406610. von Kobbe C, Karmakar P, Dawut L, Opresko P, Zeng X, Brosh RM, ... 10 (12): 1287-98. doi:10.1093/hmg/10.12.1287. PMID 11406610. Freire R, d'Adda Di Fagagna F, Wu L, Pedrazzi G, Stagljar I, ...

137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells". Scientific Reports. 5: 12448. ... 464 (3): 705-10. doi:10.1016/j.bbrc.2015.07.004. PMID 26166821. Liu SM, Lu J, Lee HC, Chung FH, Ma N (October 2014). "miR-524- ... 15 (10): 1138-47. doi:10.1093/eurjhf/hft078. PMID 23696613. S2CID 8373858. Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, ... 10 (5): 246-53. doi:10.1016/j.gpb.2012.07.005. PMC 3611977. PMID 23200134. Schouten M, Fratantoni SA, Hubens CJ, Piersma SR, ...

Quignon F, De Bels F, Koken M, Feunteun J, Ameisen JC, de Thé H (November 1998). "PML induces a novel caspase-independent death ... Retinoic acid induces a caspase-3 mediated degradation of the same chimera. In HHV, ICP0 disrupts nuclear dots in the early ... October 1998). "Caspases mediate retinoic acid-induced degradation of the acute promyelocytic leukemia PML/RARalpha fusion ... 13 (10): 6170-9. doi:10.1128/MCB.13.10.6170. PMC 364676. PMID 8413218. Chelbi-Alix MK, Quignon F, Pelicano L, Koken MH, de Thé ...

The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to activate NF-κB. This ... Costanzo A, Guiet C, Vito P (1999). "c-E10 is a caspase-recruiting domain-containing protein that interacts with components of ... Srinivasula SM, Ahmad M, Lin JH, Poyet JL, Fernandes-Alnemri T, Tsichlis PN, Alnemri ES (1999). "CLAP, a novel caspase ... Yan M, Lee J, Schilbach S, Goddard A, Dixit V (1999). "mE10, a novel caspase recruitment domain-containing proapoptotic ...

... a key factor of caspase-independent apoptosis". J. Biol. Chem. 282 (42): 30920-8. doi:10.1074/jbc.M706870200. PMID 17709377. ... 372 (1): 10-23. doi:10.1016/j.virol.2007.10.012. PMID 18006034. Collingwood TS, Smirnova EV, Bogush M, et al. (2007). "T-cell ...

2003). "Nuclear localization of a Non-caspase Truncation Product of Atrophin-1, with an Expanded Polyglutamine Repeat, ... 272 (16): 4202-10. doi:10.1111/j.1742-4658.2005.04832.x. PMID 16098201. S2CID 27027519. Hayashi, Y; et al. (1998). "Hereditary ... 10 (1): 99-103. doi:10.1038/ng0595-99. PMID 7647802. S2CID 5850726. Nucifora, F; et al. ( ... doi:10.1016/S0002-9440(10)63025-8. PMC 1867069. PMID 11696439. Yamada, M; et al. (2001). "Widespread occurrence of intranuclear ...

... induces apoptosis by increasing caspase-3 and PARP cleavage. These proteins induce programmed cell death when ... Convallatoxin can donate a hydrogen bond at five places and it can accept a hydrogen bond on ten accounts. Its melting point ... In MCF-7 derived breast cancer cells an IC50 dose of 10 nM over a long time (exposure 24 h) show 27.65 ± 8.5 or over an even ... When using 10 grams of strophanthidin, 13.6 grams of convallatoxin can be produced. Convallatoxin is a digitalis like compound ...

The initiation of the caspases cascade may lead to the activation of endonucleases such as caspase-activated DNAase (CAD). ... Caspases are produced as inactive proenzymes, which are proteolytically processed to their active forms. These proteases can ... In neuroectodermal tumor cells, betulinic acid-induced apoptosis is accompanied by caspase activation, mitochondrial membrane ... caspase activation. Betulinic acid bypasses resistance to CD95 and doxorubicin-mediated apoptosis, due to different molecular ...

da Costa CA (2006). "Recent insights on the pro-apoptotic phenotype elicited by presenilin 2 and its caspase and presenilinase- ... "Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C- ... 4 (10): 1177-81. doi:10.1038/2673. PMID 9771752. S2CID 10799492. Choi EK, Zaidi NF, Miller JS, Crowley AC, Merriam DE, ...