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... induces apoptosis by increasing caspase-3 and PARP cleavage. These proteins induce programmed cell death when ... Convallatoxin can donate a hydrogen bond at five places and it can accept a hydrogen bond on ten accounts. Its melting point ... In MCF-7 derived breast cancer cells an IC50 dose of 10 nM over a long time (exposure 24 h) show 27.65 ± 8.5 or over an even ... When using 10 grams of strophanthidin, 13.6 grams of convallatoxin can be produced. Convallatoxin is a digitalis like compound ...

The initiation of the caspases cascade may lead to the activation of endonucleases such as caspase-activated DNAase (CAD). ... Caspases are produced as inactive proenzymes, which are proteolytically processed to their active forms. These proteases can ... In neuroectodermal tumor cells, betulinic acid-induced apoptosis is accompanied by caspase activation, mitochondrial membrane ... caspase activation. Betulinic acid bypasses resistance to CD95 and doxorubicin-mediated apoptosis, due to different molecular ...

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In CTL-targeted cells, it activates caspase-independent programmed cell death pathways that are unique and parallel to that of ... 2001). "Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA ... "Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death". Cell. 133 (4): 681-692. doi: ... 10 (7): 527-34. doi:10.1038/nsb944. PMID 12819769. S2CID 9608837. Granzyme+A at the U.S. National Library of Medicine Medical ...

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... and promote an increase in caspase-3 activity. These effects appear to contribute to the apoptosis of cancer cells and a ... inactivates Akt to trigger mitochondrial translocation of BAD and caspase-mediated apoptosis in human prostate cancer cells". ... 84 (10): 1241-1250. doi:10.1016/j.bcp.2012.08.024. PMID 22981381. Xiao, Dong; Singh, Shivendra V (2006). "Diallyl trisulfide, a ...

Her group also characterized redundancies between caspase-1 and caspase-8 and between NLRP3 and caspase-8 in autoinflammatory ... Kanneganti's lab showed compensatory roles for NLRP3/caspase-1 and caspase-8 in the regulation of IL-1β production in ... Her lab identified caspase-8 and FADD as expression and activation regulators of both the canonical and non-canonical NLRP3 ... This finding went against the dogma that existed at that time that caspase-8 and FADD were involved only in apoptosis. ...

"The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8". Proceedings of the National Academy of Sciences. ... 10 (20): 4449-4452. doi:10.1021/ol8016947. ISSN 1523-7060. PMC 3227555. PMID 18788741. Verdier-Pinard, P.; Lai, J. Y.; Yoo, H. ... 10 (12): 1417-1437. doi:10.2174/1381612043384853. ISSN 1381-6128. PMID 15134491. Taylor, Kimberly S.; Zhang, Chen; Glukhov, ... Suyama, Takashi L.; Gerwick, William H. (2008-10-16). "Stereospecific Total Synthesis of Somocystinamide A". Organic Letters. ...

... an investigational drug targeting caspases and caspase-like proteases: the clinical trials in sight and recent anti- ... May 2016). "The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute ... The substance acts as a pan-caspase inhibitor and has antiapoptotic and antiinflammatory effects. It was developed for the ... November 2005). "First-in-class pan caspase inhibitor developed for the treatment of liver disease". Journal of Medicinal ...

Caspase recruitment domains, or caspase activation and recruitment domains (CARDs), are interaction motifs found in a wide ... Hong GS, Junk YK (2002). "Caspase recruitment domain (CARD) as a bi-functional switch of caspase regulation and NF-kappaB ... caspase recruitment domain family, member 8 [21][permanent dead link] CARD9: caspase recruitment domain family, member 9 [22][ ... caspase recruitment domain family, member 11 (also called CARMA1) [24][permanent dead link] CARD14: caspase recruitment domain ...

... thereby allowing aggregation and activation of Caspase 8 and subsequent activation of the Caspase cascade. However, Caspase 8 ... December 2012). "A caspase cascade regulating developmental axon degeneration". The Journal of Neuroscience. 32 (49): 17540- ... LNGFR also activates a caspase-dependent signaling pathway that promotes developmental axon pruning, and axon degeneration in ... Jax-like proteins and caspase activation). This effect can be counteracted by anti-apoptotic signaling by TrkA. Neurotrophin ...

AD neurons have increased expression of upstream caspases 8 and 9 while keeping control levels of downstream caspases 3, 6, and ... AD neurons which exit G0 and enter G1 do not activate the full set of caspases required for neuronal apoptosis (Raina et al. ... Despite a growing number of studies underlying caspases and apoptosis involvement in AD, no direct role of apoptotic death in ... may be due to AD neurons receiving apoptotic signals but failing to propagate these signals to downstream caspase effectors ( ...

... caspase-2 EC 3.4.22.56: caspase-3 EC 3.4.22.57: caspase-4 EC 3.4.22.58: caspase-5 EC 3.4.22.59: caspase-6 EC 3.4.22.60: caspase ... EC 3.4.22.61: caspase-8 EC 3.4.22.62: caspase-9 EC 3.4.22.63: caspase-10 EC 3.4.22.64: caspase-11 EC 3.4.22.65: peptidase 1 ( ... caspase-1 EC 3.4.22.37: Gingipain R EC 3.4.22.38: Cathepsin K EC 3.4.22.39: adenain EC 3.4.22.40: bleomycin hydrolase EC 3.4. ... 10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase EC 3.7.1.18: 6-oxocamphor hydrolase EC 3.7.1.19: 2,6- ...

2003: Discovered that apoptosis and caspase activation induces beta-amyloid deposition. 2005: Discovered ubiquilin 1 to be an ... Nanos, Janelle (2017-10-13). "Forging a better connection between the brain and the mind". The Boston Globe. Retrieved 2017-10- ... Retrieved 2017-10-16. Tanzi, Rudy; Mann, Chris (2017-03-03). "Curing Alzheimer's with Science and Song". TEDxNatick. Retrieved ... 383 (10): 919-930. doi:10.1056/NEJMoa1916945. ISSN 1533-4406. PMC 9134321. PMID 32877582. Moir, Robert D.; Lathe, Richard; ...

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... the Inhibitor of Caspase Activated DNase (ICAD). During apoptosis, the apoptotic effector caspase, caspase-3, cleaves ICAD and ... Caspase-activated DNase DNA laddering Sakahira, H; Enari, M; Nagata, S (January 1998). "Cleavage of CAD inhibitor in CAD ... When cells are induced to undergo apoptosis, caspase 3 cleaves ICAD to dissociate the CAD:ICAD complex, allowing CAD to cleave ... Cells that lack ICAD or that express caspase-resistant mutant ICAD thus do not show DNA fragmentation during apoptosis, ...

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"Involvement of anion exchanger-2 in apoptosis of endothelial cells induced by high glucose through an mPTP-ROS-Caspase-3 ... 284 (10): 6126-6139. doi:10.1074/jbc.M802051200. PMC 2649077. PMID 19103596. Huang QR, Li Q, Chen YH, Li L, Liu LL, Lei SH, et ... A loop between transmembrane (TM) helices 10 and 11 extends from TM domain into its cytoplamic domain, forming a "trigger" ...

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However among the four WNK family members, only WNK3 has been shown to regulate and increase cell survival in a caspase-3- ... Veríssimo F, Silva E, Morris JD, Pepperkok R, Jordan P (Jul 2006). "Protein kinase WNK3 increases cell survival in a caspase-3- ... 2015-10-26. Retrieved 2015-10-30. Delay C, Tremblay C, Brochu E, Paris-Robidas S, Emond V, Rajput AH, Rajput A, Calon F (Nov ... Retrieved 2015-10-28. Flynn SW, Lang DJ, Mackay AL, Goghari V, Vavasour IM, Whittall KP, Smith GN, Arango V, Mann JJ, Dwork AJ ...

... binds to the death receptors DR4 (TRAIL-RI) and DR5 (TRAIL-RII). The process of apoptosis is caspase-8-dependent. Caspase ... 1] Apoptosis, Trail & Caspase 8 - The Proteolysis Map-animation PDB: 1D2Q​ TRAIL+Protein at the U.S. National Library of ... Feb 2016 Song JJ, Lee YJ (May 2008). "Differential cleavage of Mst1 by caspase-7/-3 is responsible for TRAIL-induced activation ... activates downstream effector caspases including procaspase-3, -6, and -7, leading to activation of specific kinases. TRAIL ...

Sinha SK, Chaudhary PM (2004). "Induction of apoptosis by X-linked ectodermal dysplasia receptor via a caspase 8-dependent ... 13 (10): 2265-70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. Strausberg RL, Feingold EA, Grouse LH, et al. (2003). " ...

In residue 321, the change of aspartic acid (D) to Asparagine (N) reveals as loss of proteolytic cleavage by caspases. Those ... STK24 operates on serine and threonine residues and, as a response to oxidative stress and caspase activity, develops cell ... "Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis". The Journal ... "Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis". The Journal ...

It can also prevent the formation of Apaf-1 and Caspase 9 complex by acting directly upon Apaf-1 rather than Caspase 9, as ... Fiebig AA, Zhu W, Hollerbach C, Leber B, Andrews DW (August 2006). "Bcl-XL is qualitatively different from and ten times more ... Hu Y, Benedict MA, Wu D, Inohara N, Núñez G (April 1998). "Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 ... Bcl-xL is about ten times more functional than Bcl-2 when induced by the chemotherapy drug, Doxorubicin and can specifically ...

... "miR-212-3p attenuates neuroinflammation of rats with Alzheimer's disease via regulating the SP1/BACE1/NLRP3/Caspase-1 signaling ... "miR-212-3p attenuates neuroinflammation of rats with Alzheimer's disease via regulating the SP1/BACE1/NLRP3/Caspase-1 signaling ... 10 (2): 9-29. doi:10.3384/ijal.1652-8670.16302. Weber MM (1997). "Aloys Alzheimer, a coworker of Emil Kraepelin". Journal of ... 10 (16): 1665-1671. doi:10.1093/hmg/10.16.1665. PMID 11487570. Johansson AS, Berglind-Dehlin F, Karlsson G, Edwards K, ...

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In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIFM1 also ... a novel caspase-independent death effector released from mitochondria". Biochimie. 84 (2-3): 215-22. doi:10.1016/S0300-9084(02) ... "Mitochondrial release of caspase-2 and -9 during the apoptotic process". The Journal of Experimental Medicine. 189 (2): 381-94 ... "The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway". Cell Death and ...