... from a cow heart is used as an antigen in the Wassermann test for syphilis. Anti-cardiolipin antibodies can also be ... 2009;23(4):210-2. Cardiolipin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Cardiolipin ( ... Phospholipase D (PLD) in the mitochondrion hydrolyses cardiolipin to phosphatidic acid. Because of cardiolipin's unique ... The enzyme can operate in reverse under some physiological conditions to remove cardiolipin. Catabolism of cardiolipin may ...

... (ACA) are antibodies often directed against cardiolipin and found in several diseases, including ... Anti-cardiolipin antibodies can be classified in two ways: As IgM, IgG or IgA As β2-glycoprotein dependent or independent In ... In SLE, anti-DNA antibodies and anti-cardiolipin antibodies may be present individually or together; the two types of ... Only a subset of autoimmune anti-cardiolipin antibodies bind Apo-H, these anti-apolipoprotein antibodies are associated with ...

Cardiolipins are a subclass of glycerophospholipids containing four acyl chains and three glycerol groups that are particularly ... Nowicki M, Müller F, Frentzen M (April 2005). "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161-2165 ... Hoch FL (March 1992). "Cardiolipins and biomembrane function" (PDF). Biochimica et Biophysica Acta (BBA) - Reviews on ...

Cardiolipin contains four fatty acids rather than two, and may help to make the inner membrane impermeable, and its disruption ... McMillin JB, Dowhan W (December 2002). "Cardiolipin and apoptosis". Biochimica et Biophysica Acta (BBA) - Molecular and Cell ... Additionally, the inner membrane is rich in an unusual phospholipid, cardiolipin. This phospholipid was originally discovered ... "Advances in methods to analyse cardiolipin and their clinical applications". Trends in Analytical Chemistry. 157: 116808. doi: ...

It uses cardiolipin. The inhibitory IF1 also binds differently, in a way shared with trypanosomatida. Archaea do not generally ... Mühleip A, McComas SE, Amunts A (November 2019). "Structure of a mitochondrial ATP synthase with bound native cardiolipin". ...

A role for cardiolipin". The Journal of Biological Chemistry. 278 (34): 31861-31870. doi:10.1074/jbc.m300190200. PMID 12805375 ...

Nowicki M (2006). Characterization of the Cardiolipin Synthase from Arabidopsis thaliana (Ph.D. Thesis thesis). RWTH-Aachen ... "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161-5. doi:10.1016/j.febslet.2005.03.007. PMID 15811335 ... of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin ...

Other members of this family are able hydrolyze other phospholipid substrates, such as cardiolipin, or even the phosphodiester ... Nowicki M, Müller F, Frentzen M (April 2005). "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161-5. ... Nowicki M (2006). Characterization of the Cardiolipin Synthase from Arabidopsis thaliana (Ph.D. thesis). RWTH-Aachen University ... PLD5 PC-hydrolyzing PLD is a homologue of cardiolipin synthase, phosphatidylserine synthase, bacterial PLDs, and viral proteins ...

Nowicki M (2006). "Characterization of the Cardiolipin Synthase from Arabidopsis thaliana". Ph.D. Thesis, RWTH-Aachen ... "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161-5. doi:10.1016/j.febslet.2005.03.007. PMID 15811335 ... of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin ...

... and its overexpression in cultured cells resulted in increased cardiolipin synthase activity. As cardiolipin is synthesized in ... The active t-Bid fragment is shown to localize to mitochondria through a positive interaction with cardiolipin. This activated ... M. Nowicki (2006). "Characterization of the Cardiolipin Synthase from Arabidopsis thaliana". Ph.D. Thesis, RWTH-Aachen ... Recent findings suggest that PLSCR3 is involved in regulation of biosynthesis of cardiolipin in mitochondria, ...

... and cardiolipin is oxidized by a peroxidase function of the cardiolipin-cytochrome c complex. The hemoprotein is then detached ... Cytochrome c binds to cardiolipin in the inner mitochondrial membrane, thus anchoring its presence and keeping it from ... While the initial attraction between cardiolipin and cytochrome c is electrostatic due to the extreme positive charge on ... Orrenius S, Zhivotovsky B (September 2005). "Cardiolipin oxidation sets cytochrome c free". Nature Chemical Biology. 1 (4): 188 ...

Ye C, Shen Z, Greenberg ML (April 2016). "Cardiolipin remodeling: a regulatory hub for modulating cardiolipin metabolism and ... Barth syndrome patients exhibit defects in cardiolipin metabolism, including aberrant cardiolipin fatty acyl composition, ... After its synthesis, cardiolipin cannot exert its proper functions until it is actively remodeled. Tafazzin, an acyl-specific ... Cardiolipin is a complex glycerophospholipid which contains four acyl groups linked to three glycerol moietie localized in the ...

Erythrocyte sedimentation rate was elevated at 35 mm/hour; cardiolipin IgM was weakly positive at 16.3; C4 was decreased at 10 ...

A membrane lipid cardiolipin is exclusively found in the inner mitochondrial membrane and bacterial cell membranes. Some ... Mileykovskaya, E.; Dowhan, W. (October 2009). "Cardiolipin membrane domains in prokaryotes and eukaryotes". Biochimica et ... that cardiolipin is found only in the inner mitochondrial membrane and bacterial cell membranes; and that some mitochondria and ...

It can stain cardiolipin content of mitochondria. North Atlantic oscillation, a climatic phenomenon Nao (robot), a humanoid ...

Mileykovskaya, E; Dowhan, W (2009). "Cardiolipin Membrane Domains in Prokaryotes and Eukaryotes". Biochimica et Biophysica Acta ...

One of its functions is to bind cardiolipin. When bound, the structure of cardiolipin and β2-GP1 both undergo large changes in ... Borchman D, Harris EN, Pierangeli SS, Lamba OP (1995). "Interactions and molecular structure of cardiolipin and beta 2- ... systemic lupus erythematosus (SLE)). Positivity for anti-cardiolipin antibodies in diagnostic tests for autoimmune ... beta 2-glycoprotein I identifies a cluster of lysine residues that are critical for phospholipid binding and anti-cardiolipin ...

The main phospholipids are phosphatidylethanolamine, phosphatidylglycerol, and cardiolipin. Ectoine, glutamate, and, to a ...

Identify via agglutination with cardiolipin sensitive chicken erythrocytes. RCN infected Strain 143 human osteosarcoma cells ...

In addition it contains cardiolipin and phosphatidylcholine as the major phospholipids, while sterols are absent. Cardiolipin ...

... combines with CDP-DAG forming cardiolipin releasing CMP by the action of cardiolipin synthase. Two ... The mechanism of cardiolipin biosynthesis in liver mitochondria. Biochim Biophys Acta. 1972 Mar 23;260(3):507-13. doi: 10.1016/ ... The mechanism of cardiolipin biosynthesis in liver mitochondria. Biochim Biophys Acta. 1972 Mar 23;260(3):507-13. doi: 10.1016/ ... In eukaryotic mitochondria phosphatidylglycerol is converted to cardiolipin by reacting with a molecule of cytidine diphosphate ...

Alpha helices 2 and 3 bind to cardiolipin. The UQCC3 gene encodes a protein that functions in complex III assembly, downstream ... Desmurs M, Foti M, Raemy E, Vaz FM, Martinou JC, Bairoch A, Lane L (April 2015). "C11orf83, a mitochondrial cardiolipin-binding ... Depletion of this protein alters cardiolipin composition, causing cellular and mitochondrial defects. The UQCC3 gene is located ... Depleted levels of the UQCC3 protein cause impaired respiration and subtle yet significant alterations in cardiolipin ...

Yadav, Pradeep Kumar; Rajasekharan, Ram (2017). "Cardiolipin deficiency causes triacylglycerol accumulation in Saccharomyces ...

Pan, Ronghui; Jones, A. Daniel; Hu, Jianping (2014-02-28). "Cardiolipin-Mediated Mitochondrial Dynamics and Stress Response in ...

Cardiolipin is intimately connected with the electron transport chain proteins and the membrane structure of the mitochondrion ... Kulik found that every patient with Barth Syndrome that he tested had abnormalities in their cardiolipin, a lipid found inside ... Claypool SM, Boontheung P, McCaffery JM, Loo JA, Koehler CM (December 2008). "The cardiolipin transacylase, tafazzin, ... December 2000). "Defective remodeling of cardiolipin and phosphatidylglycerol in Barth syndrome". Biochemical and Biophysical ...

Phosphatidylcholine makes up about 26.5%, cardiolipin 25.4%, and phosphatidylinositol 4.5%. In S. cerevisiae mitochondria, ... cardiolipin 16.1%, phosphatidylserine 3.8%, and phosphatidic acid 1.5%. In the inner mitochondrial membrane, the protein-to- ...

Although MLCL AT-1 and MTP are different proteins, in 2012 the same lab discovered that MTP did indeed have cardiolipin ... This suggests a possible link between mitochondrial membrane cardiolipin content and beta oxidation. Disorders associated MTP ... "Human Trifunctional Protein Alpha Links Cardiolipin Remodeling to Beta-Oxidation". PLOS ONE. 7 (11): e48628. Bibcode:2012PLoSO ... linking MTP to the remodeling of cardiolipin from monolysocardiolipin. ...

... into cardiolipin. In 1990, biologists Michael Schlame and Bernd Rustow observed the deacylation of cardiolipin into MLCL, which ... producing cardiolipin. This lipid remodeling is separate from the cardiolipin synthesis pathway, and is essential to maintain ... Since cardiolipin content is significantly diminished in the inner mitochondrial membrane during apoptosis, the increase of ... Taylor WA, Mejia EM, Mitchell RW, Choy PC, Sparagna GC, Hatch GM (2012). "Human trifunctional protein alpha links cardiolipin ...

Corcelli, Angela; Schlame, Michael (2016-06-01). "Cardiolipin as key lipid of mitochondria in health and disease. 2nd Edition, ...

This composition of fatty acyl is also known as tetralinoleoyl cardiolipin (TLCL). However, newly synthesized cardiolipin, also ... leading to cardiolipins with not only non-optimal functionality compared to that of tetralinoleoyl cardiolipin (TLCL), but also ... leading to tetralinoleoyl cardiolipins (TLCL) depletion. That renders cardiolipins high sensitivity to oxidative damage by ... Cao J, Liu Y, Lockwood J, Burn P, Shi Y (July 2004). "A novel cardiolipin-remodeling pathway revealed by a gene encoding an ...