... since β2-glycoprotein-I antibodies are a subset of anti-cardiolipin antibodies, an anti-cardiolipin assay can be performed as a ... Anti-cardiolipin IgG and/or IgM measured by standardized, non-cofactor dependent ELISA on 2 or more occasions, not less than 12 ... Anti-cardiolipin antibodies can be detected using an enzyme-linked immunosorbent assay (ELISA) immunological test, which ... Anti-ApoH and a subset of anti-cardiolipin antibodies bind to ApoH, which in turn inhibits Protein C, a glycoprotein with ...
Anti-cardiolipin. Anti-cytoplasm antibody. *Anti-neutrophil cytoplasmic *C-ANCA. *P-ANCA ...
Anti-cardiolipin. Anti-cytoplasm antibody. *Anti-neutrophil cytoplasmic *C-ANCA. *P-ANCA ...
Cardiolipins are a subclass of glycerophospholipids containing four acyl chains and three glycerol groups that are particularly ... Nowicki M, Müller F, Frentzen M (April 2005). "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161-5. ... Hoch FL (March 1992). "Cardiolipins and biomembrane function" (PDF). Biochimica et Biophysica Acta (BBA) - Reviews on ...
A role for cardiolipin". The Journal of Biological Chemistry. 278 (34): 31861-70. doi:10.1074/jbc.m300190200. PMID 12805375.. ...
Cardiolipin contains four fatty acids rather than two, and may help to make the inner membrane impermeable. Unlike the outer ... McMillin JB, Dowhan W (December 2002). "Cardiolipin and apoptosis". Biochimica et Biophysica Acta (BBA) - Molecular and Cell ... Additionally, the inner membrane is rich in an unusual phospholipid, cardiolipin. This phospholipid was originally discovered ...
It uses cardiolipin. The inhibitory IF1 also binds differently, in a way shared with trypanosomatida. Archaea do not generally ... Mühleip A, McComas SE, Amunts A (November 2019). "Structure of a mitochondrial ATP synthase with bound native cardiolipin". ...
... and cardiolipin is oxidized by a peroxidase function of the cardiolipin-cytochrome c complex. The hemoprotein is then detached ... Orrenius S, Zhivotovsky B (Sep 2005). "Cardiolipin oxidation sets cytochrome c free". Nature Chemical Biology. 1 (4): 188-9. ... Cytochrome c binds to cardiolipin in the inner mitochondrial membrane, thus anchoring its presence and keeping it from ... While the initial attraction between cardiolipin and cytochrome c is electrostatic due to the extreme positive charge on ...
Nowicki M (2006). Characterization of the Cardiolipin Synthase from Arabidopsis thaliana (Ph.D. Thesis thesis). RWTH-Aachen ... "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161-5. doi:10.1016/j.febslet.2005.03.007. PMID 15811335 ... of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin ...
Other members of this family are able hydrolyze other phospholipid substrates, such as cardiolipin, or even the phosphodiester ... Nowicki M, Müller F, Frentzen M (April 2005). "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161-5. ... Nowicki M (2006). Characterization of the Cardiolipin Synthase from Arabidopsis thaliana (Ph.D. thesis). RWTH-Aachen University ... PLD5 PC-hydrolyzing PLD is a homologue of cardiolipin synthase, phosphatidylserine synthase, bacterial PLDs, and viral proteins ...
... and its overexpression in cultured cells resulted in increased cardiolipin synthase, activity. As cardiolipin is synthesized in ... The active t-Bid fragment is shown to localize to mitochondria through a positive interaction with cardiolipin. This activated ... M. Nowicki (2006). "Characterization of the Cardiolipin Synthase from Arabidopsis thaliana". Ph.D. Thesis, RWTH-Aachen ... Recent findings suggest that PLSCR3 is involved in regulation of biosynthesis of cardiolipin in mitochondria, ...
A membrane lipid cardiolipin is exclusively found in the inner mitochondrial membrane and bacterial cell membranes.[58] ... that cardiolipin is found only in the inner mitochondrial membrane and bacterial cell membranes; and that some mitochondria and ... "Cardiolipin membrane domains in prokaryotes and eukaryotes". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1788 (10): ...
A membrane lipid cardiolipin is exclusively found in the inner mitochondrial membrane and bacterial cell membranes.[58] ... that cardiolipin is found only in the inner mitochondrial membrane and bacterial cell membranes; and that some mitochondria and ... "Cardiolipin membrane domains in prokaryotes and eukaryotes". Biochim Biophys Acta. 1788 (10): 2084-2091. doi:10.1016/j.bbamem. ...
Ye C, Shen Z, Greenberg ML (April 2016). "Cardiolipin remodeling: a regulatory hub for modulating cardiolipin metabolism and ... Barth syndrome patients exhibit defects in cardiolipin metabolism, including aberrant cardiolipin fatty acyl composition, ... After its synthesis, cardiolipin cannot exert its proper functions until it is actively remodeled. Tafazzin, an acyl-specific ... Cardiolipin is a complex glycerophospholipid which contains 4 acyl groups linked to three glycerol moietie localized in the ...
Mileykovskaya, E; Dowhan, W (2009). "Cardiolipin Membrane Domains in Prokaryotes and Eukaryotes". Biochimica et Biophysica Acta ...
One of its functions is to bind cardiolipin. When bound, the structure of cardiolipin and β2-GP1 both undergo large changes in ... Borchman D, Harris EN, Pierangeli SS, Lamba OP (1995). "Interactions and molecular structure of cardiolipin and beta 2- ... systemic lupus erythematosus (SLE)). Positivity for anti-cardiolipin antibodies in diagnostic tests for autoimmune ... beta 2-glycoprotein I identifies a cluster of lysine residues that are critical for phospholipid binding and anti-cardiolipin ...
Identify via agglutination with cardiolipin sensitive chicken erythrocytes. RCN infected Strain 143 human osteosarcoma cells ...
In addition it contains cardiolipin and phosphatidylcholine as the major phospholipids, while sterols are absent. Cardiolipin ...
Alpha helices 2 and 3 bind to cardiolipin. The UQCC3 gene encodes a protein that functions in complex III assembly, downstream ... Desmurs M, Foti M, Raemy E, Vaz FM, Martinou JC, Bairoch A, Lane L (April 2015). "C11orf83, a mitochondrial cardiolipin-binding ... Depletion of this protein alters cardiolipin composition, causing cellular and mitochondrial defects. The UQCC3 gene is located ... Depleted levels of the UQCC3 protein cause impaired respiration and subtle yet significant alterations in cardiolipin ...
Yadav, Pradeep Kumar; Rajasekharan, Ram (2017). "Cardiolipin deficiency causes triacylglycerol accumulation in Saccharomyces ...
Cardiolipin is intimately connected with the electron transport chain proteins and the membrane structure of the mitochondria ... Kulik found that all the BTHS individuals that he tested had abnormalities in their cardiolipin molecules, a lipid found inside ... Claypool SM, Boontheung P, McCaffery JM, Loo JA, Koehler CM (December 2008). "The cardiolipin transacylase, tafazzin, ... December 2000). "Defective remodeling of cardiolipin and phosphatidylglycerol in Barth syndrome". Biochemical and Biophysical ...
Phosphatidylcholine makes up about 26.5%, cardiolipin 25.4%, and phosphatidylinositol 4.5%. In S. cerevisiae mitochondria, ... cardiolipin 16.1%, phosphatidylserine 3.8%, and phosphatidic acid 1.5%. In the inner mitochondrial membrane, the protein-to- ...
Although MLCL AT-1 and MTP are different proteins, in 2012 the same lab discovered that MTP did indeed have cardiolipin ... This suggests a possible link between mitochondrial membrane cardiolipin content and beta oxidation. Disorders associated MTP ... "Human Trifunctional Protein Alpha Links Cardiolipin Remodeling to Beta-Oxidation". PLOS ONE. 7 (11): e48628. Bibcode:2012PLoSO ... linking MTP to the remodeling of cardiolipin from monolysocardiolipin. ...
... into cardiolipin. In 1990, biologists Michael Schlame and Bernd Rustow observed the deacylation of cardiolipin into MLCL, which ... producing cardiolipin. This lipid remodeling is separate from the cardiolipin synthesis pathway, and is essential to maintain ... Since cardiolipin content is significantly diminished in the inner mitochondrial membrane during apoptosis, the increase of ... Taylor WA, Mejia EM, Mitchell RW, Choy PC, Sparagna GC, Hatch GM (2012). "Human trifunctional protein alpha links cardiolipin ...
... and in particular requires the presence of cardiolipin, a unique mitochondrial lipid. In yeast mitochondria lacking cardiolipin ... Zhang, M. (2005). "Cardiolipin Is Essential for Organization of Complexes III and IV into a Supercomplex in Intact Yeast ... 2009), cardiolipin stabilizes the supercomplex formation by neutralizing the charges of lysine residues in the interaction ... CARDIOLIPIN IS REQUIRED FOR SUPERCOMPLEX FORMATION IN THE INNER MITOCHONDRIAL MEMBRANE". Journal of Biological Chemistry. 277 ( ...
This is a family of proteins that acts as a mitochondrial phosphatase in cardiolipin biosynthesis. Cardiolipin is a unique ... "A mitochondrial phosphatase required for cardiolipin biosynthesis: the PGP phosphatase Gep4". The EMBO Journal. 29 (12): 1976- ...
Nowicki M, Müller F, Frentzen M (April 2005). "Cardiolipin synthase of Arabidopsis thaliana". 》FEBS Letters》 579 (10): 2161-5. ... "Cardiolipins and biomembrane function" (PDF). 》Biochimica et Biophysica Acta》 1113 (1): 71-133. doi:10.1016/0304-4157(92)90035 ...
The envelope contains a variety of lipids including cardiolipins, phosphatidylglycerols, phosphatidylglycerophosphate methyl ...