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*  Anxiety disorder
Sensory information enters the amygdala through the nuclei of the basolateral complex (consisting of lateral, basal, and ... The most common manifestations in individuals with anxiety disorder are avoidance of intercourse, premature ejaculation or ... racing heartbeat due to cardiac arrhythmia) as signs of anxiety. GAD runs in families and is six times more common in the ... accessory basal nuclei). The basolateral complex processes sensory-related fear memories and communicates their threat ...
*  Ageing
For example, a waste product called lipofuscin is formed by a complex reaction in cells that binds fat to proteins. This waste ... A chronically high cortisol level compromises the immune system, causes cardiac damage/arterosclerosis and is associated with ... Pandhi, D; Khanna, D (2013). "Premature graying of hair". Indian journal of dermatology, venereology and leprology. 79 (5): 641 ... While the effects on society are complex, there is a concern about the impact on health care demand. The large number of ...
*  Central sleep apnea
Premature infants with immature brains and reflex systems are at high risk for central sleep apnea syndrome, even if these ... Correlation with cardiac disorders: Atrial fibrillation (AF): A study in the medical journal Sleep found that the prevalence of ... located in the region of the human brain known as the pre-Botzinger complex, are imbalanced during sleep and fail to give the ... Premature babies who have the syndrome will generally outgrow it as they mature, provided that they receive careful enough ...
*  Elizabeth Nabel
She began clinical studies of endothelial and vascular smooth muscle function in the cardiac catheterization lab, and carried ... premature aging in Hutchinson Gilford progeria syndrome. Nabel delineated the mechanisms by which cell cycle and growth factor ... prevention and cures for five of the world's most complex neurologic diseases, including multiple sclerosis (MS), Alzheimer's ... due to her care of cardiac patients coupled with her strong interest in interventional cardiology. ...
*  Binding immunoglobulin protein
This creates a low off rate for high-affinity substrate binding and protects the bound substrate from premature folding or ... Brodsky JL, Schekman R (Dec 1993). "A Sec63p-BiP complex from yeast is required for protein translocation in a reconstituted ... Roe ND, Ren J (March 2013). "Oxidative activation of Ca(2+)/calmodulin-activated kinase II mediates ER stress-induced cardiac ... Upregulation of BiP has been associated with ER stress-induced cardiac dysfunction and dilated cardiomyopathy. BiP also has ...
*  Cardiac contractility modulation
... and the duration of the QRS complex seen in the electrocardiogram (ECG). Most clinical studies on Cardiac contractility ... Other irregular rhythms, including frequent premature ventricular contractions (ventricular extra systoles) or a distinct ... Since Cardiac contractility modulation signals are delivered during the absolute refractory period of the cardiac cycle, they ... In Cardiac contractility modulation therapy, electrical stimulation is applied to the cardiac muscle during the absolute ...
*  Sudden infant death syndrome
Premature birth increases the risk of SIDS death roughly fourfold. From 1995 to 1998, the U.S. SIDS rate for births at 37-39 ... Hunt CE (November 2007). "Small for gestational age infants and sudden infant death syndrome: a confluence of complex ... Behere, SP; Weindling, SN (2014). "Inherited arrhythmias: The cardiac channelopathies". Annals of Pediatric Cardiology. 8 (3): ...
*  Oxidative stress
Recently the focus has shifted to some of the more complex lesions. Tandem DNA lesions are formed at substantial frequency by ... "Oxidative stress mediates cardiac infarction aggravation induced by intermittent hypoxia". Fundam Clin Pharmacol. 27 (3): 252- ... biochemical implications in atherosclerosis and the problems of premature neonates". Essays Biochem. 29: 39-63. PMID 9189713. ... The presence of such metals in biological systems in an uncomplexed form (not in a protein or other protective metal complex) ...
*  Infant formula
These complex formulas recommended that parents mix cow's milk, water, cream, and sugar or honey in specific ratios to achieve ... Babies who consumed the formula were hospitalized with cardiac and neurological symptoms. Three of them died, and at least ... Specialized formulas are also available for premature infants and those with specific medical conditions. Manufacturers and ...
*  Senescence
Since complex and interacting systems of maintenance and repair comprise the homeodynamic space of a biological system, aging ... The claim that Dolly's early death involved premature senescence has been vigorously contested, and Dolly's creator, Dr. Ian ... enhance cardiac function and improve vascular reactivity in old mice, alleviate gait disturbance caused by radiation in mice, ... The process of senescence is complex, and may derive from a variety of different mechanisms and exist for a variety of ...
*  Heparin-binding EGF-like growth factor
It has been shown to play a role in wound healing, cardiac hypertrophy, and heart development and function. First identified in ... Louie GV, Yang W, Bowman ME, Choe S (1998). "Crystal structure of the complex of diphtheria toxin with an extracellular ... a disease affecting premature newborns. Associated with a breakdown in gut barrier function, necrotizing enterocolitis may be ... HB-EGF binding and activation of EGF receptors plays a critical role during cardiac valve tissue development and the ...
*  Ventricular fibrillation
It is a type of cardiac arrhythmia. Ventricular fibrillation results in cardiac arrest with loss of consciousness and no pulse ... Diagnosis is by an electrocardiogram (ECG) showing irregular unformed QRS complexes without any clear P waves. An important ... who brought to attention the concept of the danger of premature ventricular beats occurring on a T wave. Another definition of ... Ventricular fibrillation is a cause of cardiac arrest and sudden cardiac death. The ventricular muscle twitches randomly rather ...
*  Asperger syndrome
Abnormalities in metabolism, cardiac conduction times, and an increased risk of type 2 diabetes have been raised as concerns ... They include hand movements such as flapping or twisting, and complex whole-body movements. These are typically repeated in ... ISBN 978-0-08-044675-2. Schopler E (1998). "Premature popularization of Asperger syndrome". In Schopler E, Mesibov GB, Kunce LJ ... Some autistic people have advocated a shift in perception of autism spectrum disorders as complex syndromes rather than ...
*  Atherosclerosis
A complex set of biochemical reactions regulates the oxidation of LDL, involving enzymes (such as Lp-LpA2) and free radicals in ... Werner syndrome (WS) is a premature aging condition in humans. WS is caused by a genetic defect in a RecQ helicase that is ... If this is the myocardium (heart muscle) angina (cardiac chest pain) or myocardial infarction (heart attack) develops. The ... The buildup of an atheromatous plaque is a slow process, developed over a period of several years through a complex series of ...
*  Proteasome
The assembly of the proteasome is a complex process due to the number of subunits that must associate to form an active complex ... the proteasome maintains cardiac protein homeostasis and thus plays a significant role in cardiac Ischemic injury, ventricular ... In vertebrate cells, "slippage" through the mitotic checkpoint leading to premature M phase exit can occur despite the delay of ... The APC and the Skp1/Cul1/F-box protein complex (SCF complex) are the two key regulators of cyclin degradation and checkpoint ...
*  VLDL receptor
VLDLR has also been shown to reduce the chances of premature heart disease and stroke because VLDLR clears out lipoprotein A ( ... Zhang G, Assadi AH, McNeil RS, Beffert U, Wynshaw-Boris A, Herz J, Clark GD, D'Arcangelo G (2007). "The Pafah1b complex ... VLDLR is a peripheral lipoprotein receptor that functions in lipoprotein metabolism, cardiac fatty acid metabolism, and fat ... A third known mutation is caused by a homozygous 1-base pair deletion in exon 17 that causes a frameshift and premature ...
*  Animal model of ischemic stroke
However, in various settings global ischemia is also relevant, e.g. in global anoxic brain damage due to cardiac arrest. ... Ischemic stroke has a complex pathophysiology involving the interplay of many different cells and tissues such as neurons, glia ... evidence of inadvertent premature reperfusion and subarachnoid hemorrhage in rats by laser-Doppler flowmetry". Stroke. 29 (10 ... Complete global ischemia Decapitation Aorta/vena cava occlusion External neck torniquet or cuff Cardiac arrest Incomplete ...
*  Birth defect
According to the CDC, most birth defects are believed to be caused by a complex mix of factors including genetics, environment ... Exposure to carbon monoxide or polluted ozone exposure can also lead to cardiac defects of the ventrical septal, pulmonary ... Vitamine A and similar substances can induce spontaneous abortions, premature births, defects of eyes (microphthalmia), ears, ... For 20-25% of anomalies there seems to be a "multifactorial" cause, meaning a complex interaction of multiple minor genetic ...
*  Miscarriage
The fetus may or may not have cardiac activity. A complete miscarriage is when all products of conception have been expelled; ... It is identified after a premature birth has occurred at about 16-18 weeks into the pregnancy. During the second trimester, ... review) Acién, Pedro; Acién, Maribel (2016-01-01). "The presentation and management of complex female genital malformations". ... These conditions also may contribute to premature birth. Unlike first-trimester miscarriages, second-trimester miscarriages are ...
*  Beckwith-Wiedemann syndrome
... cardiac anomalies, musculoskeletal abnormalities, and hearing loss. Also, some premature newborns with BWS do not have ... Wiedemann HR (September 1964). "Familial malformation complex with umbilical hernia and macroglossia - a "new syndrome"?". ... Advances in treating neonatal complications and premature infants in the last twenty years have significantly improved the true ...
*  Henry Head
Head's 'complex personality', the vibrant mix between scientist and artist and his enthusiasm for all that he loved is ... After Rivers's premature death in 1922, Head adopted the mentoring role that he had once occupied, comforting a distraught ... Donald Hunter) recorded him as teaching on the difference between bronchial and cardiac asthma. Head first showed his talent ...
*  Titin
The exception is the small cardiac novex-3 isoform which is only 5,604 amino acid residues in length. The following table lists ... and MURF1 Mutations anywhere within the unusually long sequence of this gene can cause premature stop codons or other defects. ... "Solution scattering suggests cross-linking function of telethonin in the complex with titin". The Journal of Biological ... Variations in the sequence of titin between different types of muscle (e.g., cardiac or skeletal) have been correlated with ...
*  Heart rate
The cardiac centers monitor baroreceptor firing to maintain cardiac homeostasis, a mechanism called the baroreceptor reflex. ... Specifically, a resting heart rate above 65 beats per minute has been shown to have a strong independent effect on premature ... The relationship between electrolytes and HR is complex, but maintaining electrolyte balance is critical to the normal wave of ... Since HRmax varies by individual, the most accurate way of measuring any single person's HRmax is via a cardiac stress test. In ...
*  Serpin
This covalent complex between enzyme and substrate is called an acyl-enzyme intermediate. For standard substrates, the ester ... Serp1 suppresses the TLR-mediated innate immune response and allows indefinite cardiac allograft survival in rats. Crma and ... Serpin B9 may protect against inadvertent release of granzyme B and premature or unwanted activation of cell death pathways. ... In these cases, a serpin that has formed a complex with its target protease, is then recognised by a receptor. The binding ...
*  Anxiety
Cardiac, as palpitations, tachycardia, or chest pain. Muscular, as fatigue, tremors, or tetany. Cutaneous, as perspiration, or ... Depression as an adaptation for analyzing complex problems". Psychological Review. 116 (3): 620-54. doi:10.1037/a0016242. PMC ... "The pathophysiology of acquired premature ejaculation". Translational Andrology and Urology. 5 (4): 434-449. doi:10.21037/tau. ...
*  Hemolytic-uremic syndrome
Failure of neurologic, cardiac, renal, and gastrointestinal (GI) organs, as well as death, can occur unpredictably at any time ... The arterioles and capillaries of the body become obstructed by the resulting complexes of activated platelets, which have ... other severe complications and premature death. Historically, treatment options for aHUS were limited to plasma exchange or ...