Neuroectodermal neoplasm
... neuroendocrine carcinomas. These show predominantly epithelial differentiation. They include pituitary adenoma and carcinoid ... "Neuroectodermal Neoplasms of the Head and Neck with Emphasis on Neuroendocrine Carcinomas". Modern Pathology. 15 (3): 264-278. ...
Melanoma
"Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas". Modern Pathology. 15 (3): 264-78. ... Sunscreen also protects against squamous cell carcinoma, another skin cancer. Concerns have been raised that sunscreen might ...
Chromophobe cell
While renal cell carcinoma is one of the most frequently diagnosed cancers, chromophobe renal cancer only accounts for five ... Melanotroph Chromophil Acidophil cell Basophil cell Oxyphil cell Oxyphil cell (parathyroid) Pituitary gland Neuroendocrine cell ... "Chromophobe Renal Cell Carcinoma: A Review of an Uncommon Entity." International Journal of Urology 19.10 (2012): 894-900. Web ... also refers to a type of renal cell carcinoma (distinct from "clear cell"). Chromophobe renal cancer is part of a rare, genetic ...
Thymic carcinoma
... thymic carcinoma, and thymic neuroendocrine tumor in the United States". PLOS ONE. 14 (12): e0227197. Bibcode:2019PLoSO.. ... After thymoma, thymic carcinoma is the second most common type of thymus cancer. Early-stage thymic carcinoma is generally ... Superior vena cava syndrome may be associated with thymic carcinoma. Thymic carcinoma is rarely associated with paraneoplastic ... Both thymoma and thymic carcinoma originate from thymic epithelial cells; however, the epithelial cells in thymic carcinoma ...
Atypical pulmonary carcinoid tumour
... "moderately differentiated neuroendocrine carcinoma". It is a more aggressive than typical carcinoid tumors: nodal metastases in ...
Deaths in December 2016
... neuroendocrine carcinoma. John Nike, 81, English businessman. Miriam Pirazzini, 98, Italian opera singer. NĂºria Pompeia, 85, ... William Christopher, 84, American actor (M*A*S*H, Gomer Pyle, U.S.M.C., The Smurfs), small-cell carcinoma. Henning ...
SIR-Spheres
These are mostly patients with hepatocellular carcinoma (HCC), metastatic colorectal cancer (mCRC), or metastatic ... neuroendocrine tumours (mNET). Therapy goals are local disease control, downstaging to resection, bridging to transplantation, ...
Health effects of tobacco
Small-cell carcinoma (SCLC) is the most closely associated with almost 100% of cases occurring in smokers. This form of cancer ... SCLC may originate from neuroendocrine cells located in the bronchus called Feyrter cells. The risk of dying from lung cancer ... The strongest results were found by "Smoking and carcinoma of the lung. Preliminary report", by Richard Doll and Austin ... 4-5. ISBN 978-0-19-530067-3. Doll R, Hill AB (September 1950). "Smoking and carcinoma of the lung; preliminary report". British ...
Small-cell carcinoma
In addition, because of their neuroendocrine cell origin, small-cell carcinomas will often secrete substances that result in ... Small-cell carcinoma is most often more rapidly and widely metastatic than non-small-cell lung carcinoma (and hence staged ... Due to its high grade neuroendocrine nature, small-cell carcinomas can produce ectopic hormones, including adrenocorticotropic ... April 2011). "Combined small-cell carcinoma of the lung with quadripartite differentiation of epithelial, neuroendocrine, ...
DLK1
... a Putative Mammalian Homeotic Gene Differentially Expressed in Small Cell Lung Carcinoma and Neuroendocrine Tumor Cell Line". ... Helman, L. J. (1987). "Molecular Markers of Neuroendocrine Development and Evidence of Environmental Regulation". Proceedings ... A Novel Circulating Human Epidermal-Growth-Factor-Like Protein Expressed in Neuroendocrine Tumors and its Relation to the Gene ...
Parafollicular cell
... s, also called C cells, are neuroendocrine cells in the thyroid. The primary function of these cells is to ... When parafollicular cells become cancerous, they lead to medullary carcinoma of the thyroid.[citation needed] List of human ... Parafollicular cells are also known to secrete in smaller quantities several neuroendocrine peptides such as serotonin, ...
Seminal vesicles
Even rarer neoplasms include sarcoma, squamous cell carcinoma, yolk sac tumor, neuroendocrine carcinoma, paraganglioma, ...
SOX2
In squamous cell carcinoma, gene amplifications frequently target the 3q26.3 region. The gene for Sox2 lies within this region ... Overexpression causes an increase in neuroendocrine, gastric/intestinal and basal cells. Under normal conditions, Sox2 is ... Sox2 is a key upregulated factor in lung squamous cell carcinoma, directing many genes involved in tumor progression. Sox2 ... January 2010). "SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas". PLOS ...
Salt-and-pepper chromatin
... is typically seen in endocrine tumours such as medullary thyroid carcinoma, neuroendocrine tumours ... Neuroendocrine tumour of the lung with salt-and-pepper chromatin. H&E stain. Neuroendocrine tumour of the small intestine with ...
Transdifferentiation
No standard of care exists for these patients, and those diagnosed with treatment induced neuroendocrine carcinoma are ... Davies, AH; Beltran, H; Amina Zoubeidi (May 2018). "Cellular plasticity and the neuroendocrine phenotype in prostate cancer". ... Aggarwal, R; Zhang, T; Small, EJ; Armstrong, AJ (May 2014). "Neuroendocrine prostate cancer: subtypes, biology, and clinical ... In prostate cancer, treatment with androgen receptor targeted therapies induces neuroendocrine transdifferentiation in a subset ...
Cancer of unknown primary origin
... or squamous cell carcinomas (5%). Rarely, CUP may appear as neuroendocrine tumors, or mixed tumors, such as sarcomatoid, ... A PET CT scan should be done for squamous cell carcinoma involving lymph nodes of the neck region. For other types of cancer of ... Krishnatreya M, Sharma JD, Kataki AC, Kalita M (2014). "Survival in carcinoma of unknown primary to neck nodes treated with ... Varadhachary, Gauri R. (2007). "Carcinoma of Unknown Primary Origin". Gastrointestinal Cancer Research. 1 (6): 229-235. ISSN ...
National Institute of Arthritis and Musculoskeletal and Skin Diseases
One area of focus is skin sensory neuroendocrine cells, Merkel cells, and the pathogenesis and treatment of Merkel cell ... carcinoma (MCC). An important area of research for the Branch includes investigation of the skin microbiome in health and ...
Brian Catling
Catling died from small cell neuroendocrine carcinoma, a rare form of cancer, on 26 September 2022, at the age of 73. He was ...
Merkel cell polyomavirus
... polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomas". ... cutaneous squamous cell carcinoma, Bowen's disease, basal cell skin carcinoma, extrapulmonary small cell carcinoma, and EGFR ... Merkel cell carcinoma is a highly aggressive type of skin cancer that was first described by Cyril Toker in 1972 as "trabecular ... Merkel cell carcinoma is mainly seen in older individuals. It is known to occur at increased frequency in people with ...
Lung cancer
NSCLCs comprise a group of three cancer types: adenocarcinoma, squamous-cell carcinoma, and large-cell carcinoma. Nearly 40% of ... SCLCs bear the markers of neuroendocrine cells, such as chromogranin, synaptophysin, and CD56. Adenocarcinomas tend to express ... squamous-cell carcinomas, and large-cell carcinomas. After diagnosis, further imaging and biopsies are done to determine the ... Lung cancer, also known as lung carcinoma, is a malignant tumor that begins in the lung. Lung cancer is caused by genetic ...
Polyomaviridae
... polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomas". ... Feng H, Shuda M, Chang Y, Moore PS (February 2008). "Clonal integration of a polyomavirus in human Merkel cell carcinoma". ... Gross L (June 1953). "A filterable agent, recovered from Ak leukemic extracts, causing salivary gland carcinomas in C3H mice". ... "Merkel Cell Carcinomas Arising in Autoimmune Disease Affected Patients Treated with Biologic Drugs, Including Anti-TNF". ...
VPS24
"Neuroendocrine-like differentiation of non-small cell lung carcinoma cells: regulation by cAMP and the interaction of mac25/ ... neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells". J Clin Endocrinol ...
Keratin 8
Antibodies to CK8 (e.g. CAM 5.2) can be used to differentiate lobular carcinoma of the breast from ductal carcinoma of the ... It also reacts with neuroendocrine tumors. Keratin 8 is often used together with keratin 18 and keratin 19 to differentiate ... such as spindle cell carcinoma. It is considered useful in identifying microscopic metastases of breast carcinoma in lymph ... October 2004). "Tumor Cells Circulate in the Peripheral Blood of All Major Carcinomas but not in Healthy Subjects or Patients ...
Surface epithelial-stromal tumor
15-30% of endometrioid carcinomas occur in individuals with carcinoma of the endometrium, and these patients have a better ... Kaphan AA, Castro CM (2014-01-01). MPH rG, FRCPATH RH, MD JO, MD MJ (eds.). Small Cell and Neuroendocrine Cancers of the Ovary ... ISBN 978-0-07-147257-9. Smedley H, Sikora K. Age as a prognostic factor in epithelial ovarian carcinoma. Br J Obstet Gynaecol ... Bakhru A, Liu JR, Lagstein A (2012). "A case of small cell carcinoma of the ovary hypercalcemic variant in a teenager". ...
Ki-67 (protein)
The best-studied examples in this context are prostate, brain and breast carcinomas, as well as nephroblastoma and ... in this case in a neuroendocrine tumor of the small intestine. To count as positive, a nucleus should be at least half within ... chromosomal copy number and protein overexpression in breast carcinoma tissues for diagnostic use". Histopathology. 37 (5): 411 ... neuroendocrine tumors. For these types of tumors, the prognostic value for survival and tumor recurrence have repeatedly been ...
ASCL1
... a marker for small cell lung carcinomas with neuroendocrine features". Clinical Cancer Research. 8 (4): 1082-6. PMID 11948117. ... June 1993). "Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors". Proceedings of the ... April 1997). "An achaete-scute homologue essential for neuroendocrine differentiation in the lung". Nature. 386 (6627): 852-5. ... "Tissue-specific expression of human achaete-scute homologue-1 in neuroendocrine tumors: transcriptional regulation by dual ...
Paraganglioma
... neuroendocrine carcinoma, and medullary carcinoma of the thyroid.[citation needed] With immunohistochemistry, the chief cells ... A paraganglioma is a rare neuroendocrine neoplasm that may develop at various body sites (including the head, neck, thorax and ... Wick MR (March 2000). "Neuroendocrine neoplasia. Current concepts". American Journal of Clinical Pathology. 113 (3): 331-5. doi ... the differential diagnosis includes related neuroendocrine tumors, such as carcinoid tumor, ...
Erythema ab igne
... there is a possibility that a squamous cell carcinoma or a neuroendocrine carcinoma such as a Merkel cell carcinoma may form. ...
Histopathologic diagnosis of prostate cancer
"Poorly Differentiated Small-Cell-Type Neuroendocrine Carcinoma of the Prostate: A Case Report and Literature Review". Case ... Zhou, Ming (2018). "High-grade prostatic intraepithelial neoplasia, PIN-like carcinoma, ductal carcinoma, and intraductal ... Intraductal carcinoma of the prostate gland (IDCP), which is now categorised as a distinct entity by WHO 2016, includes two ... Intraductal carcinoma of the prostate with an infiltrative growth pattern may be morphologically difficult to distinguish from ...
Alpha-enolase
... thyroid carcinoma, lung cancer, hepatocellular carcinoma, and breast cancer. In many of these tumors, ENO1 promoted cell ... ENO1 overexpression has been associated with multiple tumors, including glioma, neuroendocrine tumors, neuroblastoma, ... Hepatocellular carcinoma and Cholangiocarcinoma. The co-deletion of ENO1 is a passenger event with the resultant tumor cells ...