*ERCC1

In Non-small cell lung carcinoma (NSCLC), surgically removed tumors that receive no further therapy have a better survival if ... Facista A, Nguyen H, Lewis C, Prasad AR, Ramsey L, Zaitlin B, Nfonsam V, Krouse RS, Bernstein H, Payne CM, Stern S, Oatman N, ... Busch D, Greiner C, Lewis K, Ford R, Adair G, Thompson L (Sep 1989). "Summary of complementation groups of UV-sensitive CHO ... Soria JC (Jul 2007). "ERCC1-tailored chemotherapy in lung cancer: the first prospective randomized trial". Journal of Clinical ...

*Lewis lung carcinoma

... is a tumor discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated ... In 1975, Munson discovered that cannabinoids suppress Lewis lung carcinoma cell growth. The mechanism of this action was shown ... Friedman MA (1977). "In vivo effects of cannabinoids on macromolecular biosynthesis in Lewis lung carcinomas". Cancer Biochem ... spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority ...

*Proteases in angiogenesis

"Growth and dissemination of lewis lung carcinoma in plasminogen-deficient mice". Blood. 90 (11): 4522-4531. PMID 9373263. ... techniques demonstrated an increase in cathepsin activity in the angiogenic blood vessels and invasive fronts of carcinoma in ...

*Tumour heterogeneity

"Mechanical heterogenization of Lewis lung carcinoma cells can improve antimetastatic effect of dendritic cells". J. Journal of ... This active phosphorylation may serve as a biomarker in clear-cell carcinoma. Mechanochemical heterogeneity is a hallmark of ... lung cancer). A more common source is genomic instability, which often arises when key regulatory pathways are disrupted in the ... bladder and gynecological carcinomas, liposarcoma, and multiple myeloma. There are two models used to explain the heterogeneity ...

*Tropomyosin

A study compared isoform expression between a low- and highly-metastatic Lewis lung carcinoma cell line. It is interesting to ... and high-metastatic Lewis lung carcinoma cells". Mol Cell Biol. 8 (9): 3934-3937. PMC 365453 . PMID 3221870. Takenaga, K; ... "Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder". Int J Cancer. 110 ( ...

*Yihai Cao

... is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice". The Journal of Experimental Medicine ... a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma". Cell. 79 (2): 315-328. ...

*Angiostatin

... a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma". Cell. 79 (2): 315-28. ... Study of rhAngiostatin Administered in Combination With Paclitaxel and Carboplatin to Patients With Non-Small-Cell Lung Cancer ...

*Methaneseleninic acid

... reduces spontaneous metastasis of Lewis lung carcinoma in mice". Int. J. Cancer. 131: 1260-1266. doi:10.1002/ijc.27355. Ip, C ... that methaneseleninic acid restricts tumor growth in the nude mouse model of metastatic breast cancer and Lewis lung carcinoma ...

*Dicer

"Intravenous injection of siRNA directed against hypoxia-inducible factors prolongs survival in a Lewis lung carcinoma cancer ... In analysis of lung and ovarian cancer, poor prognosis and decreased patient survival times correlate with decreased dicer and ...

*Dichlorotetrakis(dimethylsulfoxide)ruthenium(II)

... in mice bearing Lewis lung carcinoma". Chemico-Biological Interactions. 45 (1): 1-6. doi:10.1016/0009-2797(83)90037-6. Coluccia ... Based Compounds with Encouraging Antiproliferative Activity against Non-small-Cell Lung Cancer". Chemistry: A European Journal ...

*T-cadherin

... expression was found to be altered in tumor vessels: in Lewis carcinoma lung metastasis the expression of T-cadherin ... Thus, tumor progression in basal cell carcinoma, cutaneous squamous carcinoma, non-small cell lung carcinoma (NSCLC), ovarian ... In primary lung tumors the loss of T-cadherin was not attributed to the presence of metastasis in lymph nodes, and in ... 1998). "The H-cadherin (CDH13) gene is inactivated in human lung cancer". Hum. Genet. 103 (1): 96-101. doi:10.1007/ ...

*Margaret Reed Lewis

Lewis isolated a spontaneous epidermoid carcinoma in a mouse lung, which became known as a Lewis lung carcinoma. This carcinoma ... Their children were Margaret Nast Lewis, who became a physicist, Warren R. Lewis, who worked as an engineer and atomic ... In the Locke-Lewis solution, the more robust cells, such as fibroblasts and macrophages, had a tendency to migrate out of the ... Lewis also found no evidence of vacuoles forming fibrils as was believed to be the case by other researchers. In 1951, ...

*Arachidonate 5-lipoxygenase

Alox5 gene knockout mice exhibit an increase in the lung tumor volume and liver metastasis of Lewis lung carcinoma cells that ... reduces growth and progression of the Lewis carcinoma by recruiting cancer-inhibiting CD4+ T helper cells and CD8+ T Cytotoxic ... Avis IM, Jett M, Boyle T, Vos MD, Moody T, Treston AM, Martínez A, Mulshine JL (February 1996). "Growth control of lung cancer ... Setileuton (MK-0633) has completed a Phase II clinical trial for the treatment of asthma, chronic obstructive lung disease, and ...

*Versican

... is required for Lewis lung carcinoma in mice to metastasize to lung, liver and adrenal glands, acting via TLR2 to ... Kim S, Takahashi H, Lin WW, Descargues P, Grivennikov S, Kim Y, Luo JL, Karin M (Jan 2009). "Carcinoma-produced factors ... Versican is increased in the changing tissue extracellular matrix in inflammatory lung disorders such as chronic obstructive ... the impact on lung disorders". Glycobiol. 25 (3): 243-251. doi:10.1093/glycob/cwu120. PMC 4310351 . PMID 25371494. Jumper N, ...

*Prostaglandin EP3 receptor

The growth and metastasis of implanted Lewis lung carcinoma cells, a mouse lung cancer cell line, is suppressed in EP33 ... Claar D, Hartert TV, Peebles RS (February 2015). "The role of prostaglandins in allergic lung inflammation and asthma". Expert ...

*Patrick Edward McGovern

... including Lewis lung carcinoma, colon cancer (adenocarcinoma), Kaposi's sarcoma (connective tissue), uveal melanoma, hepatoma, ...

*Duocarmycin

... implanted Lewis lung carcinoma, i.p. or s.c. implanted B16 melanoma, s.c. implanted colon 38 carcinoma, and five s.c. implanted ... lung LX-1 tumor, ovarian 2780 carcinoma, and prostatic DU-145 carcinoma. Carzelesin treatment produced 100% complete remissions ... and adozelesin caused marked tumor shrinkage in mice bearing human lung LX-1 or advanced-stage human ovarian 2780 carcinoma; ... Cyclopropylpyrroloindole Drugs Adozelesin and Bizelesin Induce Different DNA Damage Response Pathways in Human Colon Carcinoma ...

*Kurt Hellmann

Following Karrer, Goldin and Humphreys' description of the Lewis lung (3LL) carcinoma as a model for metastases Hellmann set up ...

*List of MeSH codes (C04)

... carcinoma, lewis lung MeSH C04.557.470.200.300 --- carcinoma, non-small-cell lung MeSH C04.557.470.200.360 --- carcinoma, ... carcinoma, non-small-cell lung MeSH C04.588.894.797.520.235 --- carcinoma, small cell MeSH C04.588.894.797.520.240 --- coin ... carcinoma, ehrlich tumor MeSH C04.557.470.200.220 --- carcinoma, giant cell MeSH C04.557.470.200.240 --- carcinoma in situ MeSH ... carcinoma, acinar cell MeSH C04.557.470.200.025.220 --- carcinoma, adenoid cystic MeSH C04.557.470.200.025.232 --- carcinoma, ...

*P16

Strong and diffuse cytoplasmic and nuclear expression of p16 in squamous cell carcinomas (SCC) of the female genital tract is ... Sinha P, Thorstad WT, Nussenbaum B, Haughey BH, Adkins DR, Kallogjeri D, Lewis JS (January 2014). "Distant metastasis in p16- ... Carriers of germline mutations in CDKN2A have besides their high risks of melanoma also increased risks of pancreatic, lung, ... Tissue samples of primary oral squamous cell carcinoma (OSCC) display hypermethylation in the promoter regions of p16. Cancer ...

*MMP2

Furthermore, increased expression and activity of MMP-2 has been tied to increased vascularization of lung carcinoma metastases ... McQuibban GA, Gong JH, Tam EM, McCulloch CA, Clark-Lewis I, Overall CM (August 2000). "Inflammation dampened by gelatinase A ... "Expression of MMP-2 correlates with increased angiogenesis in CNS metastasis of lung carcinoma". International Journal of ... Bronchiectasis patients with P. aeruginosa infection have a more rapid decline in lung function. Altered expression and ...

*Health effects of tobacco

Doll R, Hill AB (Sep 1950). "Smoking and carcinoma of the lung; preliminary report". British Medical Journal. 2 (4682): 739-748 ... Carter BD, Abnet CC, Feskanich D, Freedman ND, Hartge P, Lewis CE, Ockene JK, Prentice RL, Speizer FE, Thun MJ, Jacobs EJ (Feb ... "Benefits of Quitting - American Lung Association". Stop Smoking. American Lung Association. Retrieved 2012-05-06. "Light ... "Smoking and Carcinoma of the Lung" which appeared in the British Medical Journal. This paper reported that "heavy smokers were ...

*Figitumumab

Krauskopf, Lewis (29 December 2009). "Pfizer ends late-stage lung-cancer study". Reuters. Clinical trial number NCT00976508 for ... for example adrenocortical carcinoma and non-small cell lung cancer (NSCLC). This drug was being developed by Pfizer, but they ... for the treatment of patients with non-small-cell lung cancer". Clinical Lung Cancer. 10 (4): 273-80. doi:10.3816/CLC.2009.n. ... and pharmacokinetics of the anti-IGF-1R monoclonal antibody figitumumab in patients with refractory adrenocortical carcinoma". ...

*YWHAZ

Lung Cellular and Molecular Physiology. 309 (2): L147-57. doi:10.1152/ajplung.00088.2015. PMC 4504974 . PMID 26001776. Lewis J ... However, no statistically significant relationship was determined in hepatocellular carcinoma. In addition to cancers, 14-3-3ζ ... So far, it stands to become a prognostic marker for breast cancer, lung cancer, head and neck cancer, and possibly gastric ... The protein has been implicated in many cancers, including lung cancer, breast cancer, lymphoma, and head and neck cancer, ...

*Hedgehog signaling pathway

Basal cell carcinoma, the most common form of cancerous malignancy, has the closest association with hedgehog signaling. Loss- ... In 1995, they shared the Nobel Prize with Edward B. Lewis for their work studying genetic mutations in Drosophila embryogenesis ... Activation of the hedgehog pathway has been implicated in the development of cancers in various organs, including brain, lung, ... Diseases associated with the malfunction of this pathway include basal cell carcinoma. The Hedgehog signaling pathway is one of ...

*Cervical cancer

Jones WB, Mercer GO, Lewis JL, Rubin SC, Hoskins WJ (1993). "Early invasive carcinoma of the cervix". Gynecol. Oncol. 51 (1): ... In advanced disease, metastases may be present in the abdomen, lungs, or elsewhere. Symptoms of advanced cervical cancer may ... adenosquamous carcinoma small cell carcinoma neuroendocrine tumour glassy cell carcinoma villoglandular adenocarcinoma ... Histologic subtypes of invasive cervical carcinoma include the following: Though squamous cell carcinoma is the cervical cancer ...

*Tumor-associated macrophage

Bingle, L.; Brown, N. J.; Lewis, C. E. (2002). "The role of tumour-associated macrophages in tumour progression: Implications ... better prognosis in colon and stomach cancers and both poor and better prognoses in lung and prostate cancers. As one route to ... New insights into the role of the immune microenvironment in breast carcinoma. Dev Immunol 2013; 2013: 785317. Williams, Carly ... Vaccine-induced tumor regression requires a dynamic cooperation between T cells and myeloid cells at the tumor site Lewis, C. E ...