Lewis lung carcinoma
... is a tumor that spontaneously developed as an epidermoid carcinoma in the lung of a C57BL mouse. It was ... Lewis lung carcinoma is the only reproducible syngeneic lung cancer model, meaning that it is the only reproducible lung cancer ... In fact, a 1996 study found that the carcinoma predominantly metastasized into the lungs after tail vein injections. Lewis lung ... implanting a Lewis lung carcinoma into the lung of another C57BL mouse). Because of this fidelity to mimicking the tumor ...
Proteases in angiogenesis
"Growth and dissemination of lewis lung carcinoma in plasminogen-deficient mice". Blood. 90 (11): 4522-4531. doi:10.1182/blood. ... techniques demonstrated an increase in cathepsin activity in the angiogenic blood vessels and invasive fronts of carcinoma in ...
Margaret Reed Lewis
Lewis isolated a spontaneous epidermoid carcinoma in a mouse lung, which became known as a Lewis lung carcinoma. This carcinoma ... "A highly metastatic Lewis lung carcinoma orthotopic green fluorescent protein model". Clinical & Experimental Metastasis. 18 (1 ... Lewis was among the first scientists to observe the dynamics of mitochondria in living cells. In 1915 Margaret and Warren Lewis ... Their children were Margaret Nast Lewis, who became a physicist, Warren R. Lewis, who worked as an engineer and atomic ...
Zbtb7
"FBI1/Akirin2 promotes tumorigenicity and metastasis of Lewis lung carcinoma cells". Biochemical and Biophysical Research ... As an oncogene, Zbtb7 is overexpressed in many types of cancer, including lung, liver, prostate, and oral. In initial studies ... Zbtb7 has also been studied in association with renal carcinoma. The study indicated that Zbtb7 was present in abundance in ... "The expression and clinical significance of ZBTB7 in transitional cell carcinoma of the bladder". Oncology Letters. 14 (4): ...
MMP2
Furthermore, increased expression and activity of MMP-2 has been tied to increased vascularization of lung carcinoma metastases ... McQuibban GA, Gong JH, Tam EM, McCulloch CA, Clark-Lewis I, Overall CM (August 2000). "Inflammation dampened by gelatinase A ... "Expression of MMP-2 correlates with increased angiogenesis in CNS metastasis of lung carcinoma". International Journal of ... Bronchiectasis patients with P. aeruginosa infection have a more rapid decline in lung function. Disease-causing mutations in ...
Tumour heterogeneity
"Mechanical heterogenization of Lewis lung carcinoma cells can improve antimetastatic effect of dendritic cells". Journal of ... This active phosphorylation may serve as a biomarker in clear-cell carcinoma. Mechanochemical heterogeneity is a hallmark of ... lung cancer). A more common source is genomic instability, which often arises when key regulatory pathways are disrupted in the ... bladder and gynecological carcinomas, liposarcoma, and multiple myeloma. There are two models used to explain the heterogeneity ...
Tropomyosin
A study compared isoform expression between a low- and highly-metastatic Lewis lung carcinoma cell line. The study found that ... and high-metastatic Lewis lung carcinoma cells". Mol Cell Biol. 8 (9): 3934-3937. doi:10.1128/MCB.8.9.3934. PMC 365453. PMID ... "Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder". Int J Cancer. 110 ( ...
Yihai Cao
... is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice". The Journal of Experimental Medicine ... a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma". Cell. 79 (2): 315-328. ...
Angiostatin
... a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma". Cell. 79 (2): 315-28. ... Study of rhAngiostatin Administered in Combination With Paclitaxel and Carboplatin to Patients With Non-Small-Cell Lung Cancer ...
Marsha Moses
... a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma". Cell. 79 (2): 315-28. ... Lewis A.; Moses, Marsha A. (2022-10-11). "Escape from breast tumor dormancy: The convergence of obesity and menopause". ...
Methaneseleninic acid
... reduces spontaneous metastasis of Lewis lung carcinoma in mice". Int. J. Cancer. 131 (6): 1260-1266. doi:10.1002/ijc.27355. ... that methaneseleninic acid restricts tumor growth in the nude mouse model of metastatic breast cancer and Lewis lung carcinoma ...
Dicer
"Intravenous injection of siRNA directed against hypoxia-inducible factors prolongs survival in a Lewis lung carcinoma cancer ... In analysis of lung and ovarian cancer, poor prognosis and decreased patient survival times correlate with decreased dicer and ...
Photodynamic therapy
Lewis lung carcinoma in mice) with a tetrabenzamido analogue. Complexes of silicon (IV) NCs with two axial ligands in ... are an efficient photosensitiser against Lewis lung carcinoma in mice. SiNC[OSi(i-Bu)2-n-C18H37]2 is effective against Balb/c ... Of six patients with a facial basal cell carcinoma, treated with a 1% eosin solution and long-term exposure either to sunlight ... A methyl ALA ester (Metvix) is now available for basal cell carcinoma and other skin lesions. Benzyl (Benvix) and hexyl ester ( ...
Semustine
Lewis lung tumours, cancers of the digestive tract, lymphoma, malignant melanoma, and epidermoid carcinoma of the lung. It has ... There was an increase found in peritoneal sarcoma and lung tumours, indicating a different toxicity to animals. Kramer RA, ... in advanced bronchogenic carcinoma". Cancer Letters. 1 (2): 97-102. doi:10.1016/S0304-3835(75)95630-X. PMID 65213. Guo Y, Lu JJ ...
Dichlorotetrakis(dimethylsulfoxide)ruthenium(II)
... in mice bearing Lewis lung carcinoma". Chemico-Biological Interactions. 45 (1): 1-6. doi:10.1016/0009-2797(83)90037-6. PMID ... Based Compounds with Encouraging Antiproliferative Activity against Non-small-Cell Lung Cancer". Chemistry: A European Journal ...
P16
Strong and diffuse cytoplasmic and nuclear expression of p16 in squamous cell carcinomas (SCC) of the female genital tract is ... Sinha P, Thorstad WT, Nussenbaum B, Haughey BH, Adkins DR, Kallogjeri D, Lewis JS (January 2014). "Distant metastasis in p16- ... Carriers of germline mutations in CDKN2A have, besides their high risks of melanoma, also increased risks of pancreatic, lung, ... Tissue samples of primary oral squamous cell carcinoma (OSCC) often display hypermethylation in the promoter regions of p16. ...
Anticancer gene
Current apoptin therapeutic agents have been used to treat Lewis lung carcinomas, and osteosarcomas with future implications in ... lung carcinoma) exhibit preferential cytotoxicity towards it in comparison to primary cells such T cells, human lung ... Mutations in the p53 pathway have been observed in almost all cancer types including breast cancer, bladder cancer, lung cancer ... "Characterization of an 800 kb region at 3p22-p21.3 that was homozygously deleted in a lung cancer cell line". Human Molecular ...
Deaths in December 2007
Keshav Meshram, 70, Indian writer and critic, lung cancer. Lord Bloody Wog Rolo, 62, Australian activist, renal cell carcinoma ... "Professor David Maybury-Lewis". The Times. January 1, 2008. Archived from the original on May 24, 2010. Retrieved June 23, 2018 ... David Maybury-Lewis, 78, British anthropologist. Eleonora Rossi Drago, 82, Italian actress, cerebral haemorrhage. Les Shannon, ... Murray Klein, 84, American businessman, co-owner of New York City's Zabar's food emporium, lung cancer. Shelley Rohde, 74, ...
Arachidonate 5-lipoxygenase
Alox5 gene knockout mice exhibit an increase in the lung tumor volume and liver metastasis of Lewis lung carcinoma cells that ... reduces growth and progression of the Lewis carcinoma by recruiting cancer-inhibiting CD4+ T helper cells and CD8+ T cytotoxic ... Avis IM, Jett M, Boyle T, Vos MD, Moody T, Treston AM, MartÃnez A, Mulshine JL (February 1996). "Growth control of lung cancer ... These metabolites may also contribute to the progression of certain cancers such as those of the prostate, breast, lung, ovary ...
Versican
... is required for Lewis lung carcinoma in mice to metastasize to lung, liver and adrenal glands, acting via TLR2 to ... Kim S, Takahashi H, Lin WW, Descargues P, Grivennikov S, Kim Y, Luo JL, Karin M (Jan 2009). "Carcinoma-produced factors ... Versican is increased in the changing tissue extracellular matrix in inflammatory lung disorders such as chronic obstructive ... the impact on lung disorders". Glycobiology. 25 (3): 243-251. doi:10.1093/glycob/cwu120. PMC 4310351. PMID 25371494. Jumper N, ...
T-cadherin
... expression was found to be altered in tumor vessels: in Lewis carcinoma lung metastasis the expression of T-cadherin ... Thus, tumor progression in basal cell carcinoma, cutaneous squamous carcinoma, non-small cell lung carcinoma (NSCLC), ovarian ... In primary lung tumors the loss of T-cadherin was not attributed to the presence of metastasis in lymph nodes, and in ... 1998). "The H-cadherin (CDH13) gene is inactivated in human lung cancer". Hum. Genet. 103 (1): 96-101. doi:10.1007/ ...
Prostaglandin EP3 receptor
The growth and metastasis of implanted Lewis lung carcinoma cells, a mouse lung cancer cell line, is suppressed in EP3 receptor ... Claar D, Hartert TV, Peebles RS (February 2015). "The role of prostaglandins in allergic lung inflammation and asthma". Expert ...
Bruguiera gymnorhiza
Sarcoma 180 and Lewis lung carcinoma). The bark is used for dying, with colours ranging from red-brown to black (requires ...
Patrick Edward McGovern
... including Lewis lung carcinoma, colon cancer (adenocarcinoma), Kaposi's sarcoma (connective tissue), uveal melanoma, hepatoma, ...
Stromal cell
... emphasis on carcinoma-associated fibroblasts and non-small cell lung cancer". Journal of Thoracic Oncology. 6 (1): 209-17. doi: ... Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter (2002). "T Cells and MHC ... Certain types of skin cancers (basal cell carcinomas) cannot spread throughout the body because the cancer cells require nearby ... These changes include the formation of carcinoma-associated fibroblasts (CAFs) which comprises a major portion of the reactive ...
Macrophage polarization
February 2017). "Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ ... Lewis CE, Pollard JW (January 2006). "Distinct role of macrophages in different tumor microenvironments". Cancer Research. 66 ( ...
CBR96-doxorubicin immunoconjugate
... of carcinoma-reactive BR96-doxorubicin conjugate against human carcinomas in athymic mice and rats and syngeneic rat carcinomas ... Multiple tumor models including lung, breast and colon were evaluated, and cBR96-Dox was found to have broad and potent anti- ... The payload is the chemotherapy drug doxorubicin which is connected with a hydrazone linker to cysteine residues of the Lewis-Y ... directed to the Lewis-Y antigen designed for the treatment of cancer. ...
CXCL1
... gastric and colorectal carcinoma or lung cancer. Also, CXCL1 is secreted by human melanoma cells, has mitogenic properties and ... Schumacher C, Clark-Lewis I, Baggiolini M, Moser B (November 1992). "High- and low-affinity binding of GRO alpha and neutrophil ... Moser B, Clark-Lewis I, Zwahlen R, Baggiolini M (May 1990). "Neutrophil-activating properties of the melanoma growth- ... Chen X, Jin R, Chen R, Huang Z (2018-02-01). "Complementary action of CXCL1 and CXCL8 in pathogenesis of gastric carcinoma". ...
Secretory carcinoma
Desai MA, Mehrad M, Ely KA, Bishop JA, Netterville J, Aulino JM, Lewis JS (December 2019). "Secretory Carcinoma of the Thyroid ... Huang T, McHugh JB, Berry GJ, Myers JL (April 2018). "Primary mammary analogue secretory carcinoma of the lung: a case report ... The formerly termed secretory carcinomas include: Mammary secretory carcinoma, also termed secretory carcinoma of the breast, ... Salivary gland-type carcinoma of the thyroid appears to be a more aggressive disease than mammary secretory carcinoma or MASCSG ...
Psammoma body
Psammoma bodies are commonly seen in certain tumors such as: Papillary thyroid carcinoma Papillary renal cell carcinoma Ovarian ... Lewis RB (2010). "Pancreatic Endocrine Tumors: Radiologic-Clinicopathologic Correlation". RadioGraphics. 30 (6): 1445-1464. doi ... Prolactinoma of the pituitary Glucagonoma Micropapillary subtype of Lung Adenocarcinoma Psammoma bodies may be seen in: ... "Renal Cell Carcinoma". The Lecturio Medical Concept Library. Retrieved 1 October 2021. Ovarian papillary serous ...