... carboxylesterase 1 carboxylesterase 2 carboxylesterase 3 esterase A, esterase B, esterase D, methylbutyrase, methylbutyrate ... has a role as a human carboxylesterase inhibitor. The carboxylesterase family of evolutionarily related proteins (those with ... The enzyme carboxylesterase (or carboxylic-ester hydrolase, EC 3.1.1.1; systematic name carboxylic-ester hydrolase) catalyzes ... Humans genes that encode carboxylesterase enzymes include: CES1 CES2 CES3 CES4 CES7 CES8 An approved nomenclature has been ...
... is an enzyme that in humans is encoded by the CES3 gene. Carboxylesterase 3 is a member of a large multigene ... "Entrez Gene: CES3 carboxylesterase 3 (brain)". Lee CV, Hymowitz SG, Wallweber HJ, et al. (2006). "Synthetic anti-BR3 antibodies ... Aida K, Moore R, Negishi M (1993). "Cloning and nucleotide sequence of a novel, male-predominant carboxylesterase in mouse ... and a newly expressed carboxylesterase isoenzyme, CES3". Drug Metab Dispos. 32 (5): 505-11. doi:10.1124/dmd.32.5.505. PMID ...
Liver carboxylesterase 1 also known as carboxylesterase 1 (CES1, hCE-1 or CES1A1) is an enzyme that in humans is encoded by the ... Carboxylesterase 1 is a serine esterase and member of a large multigene carboxylesterase family. It is also part of the alpha/ ... "Entrez Gene: CES1 carboxylesterase 1 (monocyte/macrophage serine esterase 1)". Imai T (Jun 2006). "Human Carboxylesterase ... Carboxylesterase 1 deficiency may be associated with non-Hodgkin lymphoma or B-cell lymphocytic leukemia. Inhibition of CES1 by ...
"Entrez Gene: CES2 carboxylesterase 2 (intestine, liver)". Imai T (June 2006). "Human carboxylesterase isozymes: catalytic ... Carboxylesterase 2 is an enzyme that in humans is encoded by the CES2 gene. It is a member of the alpha/beta fold hydrolase ... Carboxylesterase 2 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the ... Charasson V, Bellott R, Meynard D, Longy M, Gorry P, Robert J (December 2004). "Pharmacogenetics of human carboxylesterase 2, ...
Carboxylesterase, type B is a family of evolutionarily related proteins that belongs to the superfamily of proteins with the ... ACHE ARACHE BCHE CEL CES1 CES2 CES3 CES4 CES7 CES8 NLGN1 NLGN2 NLGN3 NLGN4X NLGN4Y TG Carboxylesterase Nachon F, Asojo OA, ... IPR000997 Human genes that encode proteins containing the carboxylesterase domain include: ...
Notum, palmitoleoyl-protein carboxylesterase is a protein that in humans is encoded by the NOTUM gene. GRCh38: Ensembl release ... "Entrez Gene: Notum, palmitoleoyl-protein carboxylesterase". Retrieved 2018-06-15. Torisu Y, Watanabe A, Nonaka A, Midorikawa Y ... provides an overview of all the structure information available in the PDB for Human Palmitoleoyl-protein carboxylesterase ...
It belongs to the carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such ...
The hydrolysis was found to be catalyzed by carboxylesterase 1 (CES1). Etymologically, ritalinic acid shares its roots with ... August 2004). "Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1". The Journal of Pharmacology ...
August 2004). "Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1". The Journal of Pharmacology ...
Wang BZ, Guo P, Hang BJ, Li L, He J, Li SP (September 2009). "Cloning of a novel pyrethroid-hydrolyzing carboxylesterase gene ... The enzyme pyrethroid hydrolase (EC 3.1.1.88, pyrethroid-hydrolyzing carboxylesterase, pyrethroid-hydrolysing esterase, ... and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes". The Journal of Biological Chemistry ...
... is a carboxylesterase that is excreted in large amounts in cat urine. There is also evidence that it can serve as a ... It is also the first carboxylesterase to be found in urine. Cauxin has been shown to hydrolyze 3-methylbutanol-cysteinylglycine ... "Characterisation of the carboxylesterase enzyme cauxin in the seminal fluid of the cat". The Veterinary Journal. 190 (3): 378- ... a Carboxylesterase-Like Enzyme, Is Present and Active in Mammalian Male Reproductive Fluids1". Biology of Reproduction. 74 (2 ...
Metabolism of pethidine to pethidinic acid is carried out mainly by the carboxylesterase enzyme hCE-1 in the liver, and since ... Zhang J, Burnell JC, Dumaual N, Bosron WF (July 1999). "Binding and hydrolysis of meperidine by human liver carboxylesterase ...
Moroi K, Kuga T (April 1982). "Inhibitory effect of leptophos on carboxylesterase (isocarboxazid amidase) in rat liver". ...
Cunnac S, Wilson A, Nuwer J, Kirik A, Baranage G, Mudgett MB (February 2007). "A conserved carboxylesterase is a SUPPRESSOR OF ...
Potential Regulatory Role of Human-Carboxylesterase-1 Glycosylation in Liver Cancer Cell Growth. Y., K. Paik; J., E. Graham; M ... "Human liver carboxylesterase 1 outperforms alpha-fetoprotein as biomarker to discriminate hepatocellular carcinoma from other ... "Potential Regulatory Role of Human-Carboxylesterase-1 Glycosylation in Liver Cancer Cell Growth". Journal of Proteome Research ...
In rodent models, butyl acrylate is metabolized by carboxylesterase or reactions with glutathione; this detoxification produces ...
Selim, Samy; Hagagy, Nashwa (2016-03-01). "Genome sequence of carboxylesterase, carboxylase and xylose isomerase producing ... and carboxylesterase. Other genes coding for biosynthesis of peptides and secondary metabolites were also detected. ...
Furthermore, cauxin is a carboxylesterase enzyme which hydrolyzes 3-methylbutanol-cysteinylglycine (MBCG) into felinine. Thus, ... a majority of MBCG is hydrolyzed to felinine and glycine by carboxylesterase 5A, or cauxin. Cauxin specifically works by ...
The enzyme cocaine esterase (EC 3.1.1.84, CocE, hCE2, hCE-2, human carboxylesterase 2; systematic name cocaine benzoylhydrolase ... "Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine ...
Thomsen R, Rasmussen HB, Linnet K (January 2014). "In vitro drug metabolism by human carboxylesterase 1: focus on angiotensin- ... Ramipril, a prodrug or precursor drug, is converted to the active metabolite ramiprilat by carboxylesterase 1. Ramiprilat is ...
Prilocaine, an amino amide-type local anesthetic, yields o-toluidine when metabolized by carboxylesterase enzymes. Large ... and Lidocaine-Induced Methemoglobinemia Is Caused by Human Carboxylesterase-, CYP2E1-, and CYP3A4-Mediated Metabolic Activation ...
... a new carboxylesterase from Escherichia coli". The Journal of Biological Chemistry. 278 (28): 26039-45. doi:10.1074/jbc. ...
"Identification of the Catalytic Residues of Carboxylesterase from by Diisopropyl Fluorophosphate-Labeling and Site-Directed ...
White KN, Hope DB (1984). "Partial purification and characterization of a microsomal carboxylesterase specific for salicylate ...
... resistance is thought to always be due to either increased carboxylesterase concentrations or altered ...
"Molecular cloning of the carboxylesterase gene and biochemical characterization of the encoded protein from Pseudomonas ...
This carboxylesterase-dependent transesterification process is also known to occur when cocaine and alcohol are consumed ... Bourland JA, Martin DK, Mayersohn M (December 1997). "Carboxylesterase-mediated transesterification of meperidine (Demerol) and ...
2013). OATP1A/1B Transporters Affect Irinotecan and SN-38 Pharmacokinetics and Carboxylesterase Expression in Knockout and ...
... while organophosphate resistance most commonly is carboxylesterase metabolization. While the carbamate acetylcholinesterase ...
August 2014). "Structural insights into the low pH adaptation of a unique carboxylesterase from Ferroplasma: altering the pH ...