1-Aminocyclopropane-1-carboxylate synthase
This enzyme belongs to the family of lyases, specifically carbon-sulfur lyases. The systematic name of this enzyme class is S- ... Tyrosine attacks the sulfur bound carbon, allowing S(CH3)(Ado) to leave, and during ring formation, Tyrosine leaves. Note ... increasing the acidity of the alpha carbon by stabilizing the conjugate base. The PLP-stabilized carbanion intermediate formed ... "Slow-binding inhibition of Escherichia coli cystathionine beta-lyase by L-aminoethoxyvinylglycine: a kinetic and X-ray study". ...
S-alkylcysteine lyase
This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme ... alkylcysteine lyase, S-alkyl-L-cysteine sulfoxide lyase, S-alkyl-L-cysteine lyase, S-alkyl-L-cysteinase, alkyl cysteine lyase, ... In enzymology, a S-alkylcysteine lyase (EC 4.4.1.6) is an enzyme that catalyzes the chemical reaction an S-alkyl-L-cysteine + ... and S-alkyl-L-cysteine alkylthiol-lyase (deaminating). It employs one cofactor, pyridoxal phosphate. Nomura J, Nishizuka Y, ...
Methionine gamma-lyase
This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme ... methionine lyase, methioninase, methionine dethiomethylase, L-methionine γ-lyase, and L-methionine methanethiol-lyase ( ... The enzyme methionine γ-lyase (EC 4.4.1.11, MGL) is in the γ-family of PLP-dependent enzymes. It degrades sulfur-containing ... Stipanuk MH (2004). "Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine". Annual ...
Alliinase
This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme ... cysteine sulfoxide lyase, alkylcysteine sulfoxide lyase, S-alkylcysteine sulfoxide lyase, L-cysteine sulfoxide lyase, S-alkyl-L ... and alliin itself was the first natural product found to have both carbon- and sulfur-centered stereochemistry. However, the ... In enzymology, an alliin lyase (EC 4.4.1.4) is an enzyme that catalyzes the chemical reaction an S-alkyl-L-cysteine S-oxide ...
Dimethylpropiothetin dethiomethylase
This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme ... Portal: Biology v t e (EC 4.4.1, Enzymes of unknown structure, All stub articles, Lyase stubs). ... S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase. ANDERSON DG, CANTONI GL (1956). "Enzymatic cleavage of ... class is S,S-dimethyl-β-propiothetin dimethyl-sulfide-lyase (acrylate-forming). Other names in common use include desulfhydrase ...
Cystathionine beta-lyase
The enzyme also belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this ... Other members include cystathionine gamma-synthase, cystathionine gamma-lyase, and methionine gamma lyase. Additionally, these ... and sulfur metabolism. Cystathionine beta-lyase is a tetramer composed of identical subunits, and is constructed as a dimer of ... Cystathionine beta-lyase (EC 4.4.1.8), also commonly referred to as CBL or β-cystathionase, is an enzyme that primarily ...
citrate (pro-3S)-lyase) ligase
... lyase(acetyl form). This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ... Antranikian G, Gottschalk G (1982). "Copurification of citrate lyase and citrate lyase ligase from Rhodopseudomonas gelatinosa ... lyase(acetyl form) The 3 substrates of this enzyme are ATP, acetate, and citrate (pro-3S)-lyase(thiol form), whereas its 3 ... HS-citrate lyase ligase, and acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming). This enzyme participates in two- ...
Cystathionine gamma-lyase
... the gamma carbon is attacked by a sulfur nucleophile, resulting in the formation of a new sulfur-gamma carbon bond. ... To reform the aldimine, this lone pair pushes back down, cleaving the sulfur-gamma carbon bond, resulting in the release of ... Cystathionase uses pyridoxal phosphate to facilitate the cleavage of the sulfur-gamma carbon bond of cystathionine, resulting ... Other members include cystathionine γ synthase, cystathionine β lyase, and methionine γ lyase. It is also a member of the ...
Lactoylglutathione lyase
Glyoxalase I is classified as a carbon-sulfur lyase although, strictly speaking, the enzyme does not form or break a carbon- ... sulfur bond. Rather, the enzyme shifts two hydrogen atoms from one carbon atom of the methylglyoxal to the adjacent carbon atom ... Lactoylglutathione lyase in humans is encoded by the GLO1 gene. Several structures of glyoxalase I have been solved. Four ... The enzyme lactoylglutathione lyase (EC 4.4.1.5, also known as glyoxalase I) catalyzes the isomerization of hemithioacetal ...
Isethionate sulfite-lyase
... enzyme that catalyzes the degradation of isethionate into acetaldehyde and sulfite through the cleavage of a carbon-sulfur bond ... rSAM is formed by the one-electron reduction of an iron-sulfur cluster, and the resulting radical is stabilized by amino acid ... Deng WH, Lu Y, Liao RZ (December 2021). "Revealing the Mechanism of Isethionate Sulfite-Lyase by QM/MM Calculations". Journal ... September 2021). "Molecular basis of C-S bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase". Cell Chemical ...
Phosphosulfolactate synthase
... sulfite This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of ... O-phospho-3-sulfolactate sulfo-lyase. As of late 2007, only one structure has been solved for this class of enzymes, with the ... this enzyme class is (2R)-2-O-phospho-3-sulfolactate hydrogen-sulfite-lyase (phosphoenolpyruvate-forming). Other names in ...
S-ribosylhomocysteine lyase
3-dione This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of ... The enzyme S-ribosylhomocysteine lyase (EC 4.4.1.21) catalyzes the reaction S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L- ... this enzyme class is S-(5-deoxy-D-ribos-5-yl)-L-homocysteine L-homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming ...
Selenocysteine lyase
... acceptor This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of ... While selenocysteine lyases generally catalyze the removal of both selenium or sulfur from selenocysteine or cysteine, ... The enzyme selenocysteine lyase (SCL) (EC 4.4.1.16) catalyzes the chemical reaction L-selenocysteine + reduced acceptor ⇌ {\ ... Esaki N, Nakamura T, Tanaka H, Soda K (April 1982). "Selenocysteine lyase, a novel enzyme that specifically acts on ...
Homocysteine desulfhydrase
This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme ... L-homocysteine hydrogen-sulfide-lyase (deaminating). This enzyme participates in nitrogen and sulfur metabolism. It employs one ... class is L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming). Other names in common use include ...
Cysteine-S-conjugate beta-lyase
This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme ... Other names in common use include cysteine conjugate β-lyase, glutamine transaminase K/cysteine conjugate β-lyase, and L- ... The enzyme cysteine-S-conjugate β-lyase (EC 4.4.1.13) catalyzes the chemical reaction an L-cysteine-S-conjugate + H2O = a thiol ... Tateishi M, Suzuki S, Shimizu H (1978). "Cysteine conjugate β-lyase in rat liver. A novel enzyme catalyzing formation of thiol- ...
Cysteine lyase
... specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is L-cysteine hydrogen-sulfide-lyase ( ... CL genes are found only in Sauropsida where they are involved in a metabolic pathway for sulfur metabolism in the chicken egg. ... Genes encoding cysteine lyase (CL) originated around 300 million years ago by a tandem gene duplication and ... Malatesta M, Mori G, Acquotti D, Campanini B, Peracchi A, Antin PB, Percudani R (2020). "Birth of a pathway for sulfur ...
Leukotriene-C4 synthase
... glutathione This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of ... 14-tetraenoate glutathione-lyase (epoxide-forming). This enzyme participates in arachidonic acid metabolism. As of late 2007, 3 ... this enzyme class is leukotriene-C4 glutathione-lyase (leukotriene-A4-forming). Other names in common use include leukotriene ...
S-(hydroxymethyl)glutathione synthase
... formaldehyde This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name ... glutathione formaldehyde-lyase. This enzyme participates in methane metabolism. Goenrich M, Bartoschek S, Hagemeier CH, ... of this enzyme class is S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming). Other names in common use ...
Glucobrassicin
... which is then cleaved off by a carbon-sulfur lyase (like the SUR1 enzyme found in Arabidopsis) to create a free thiol. A single ... "Arabidopsis Mutants in the C-S Lyase of Glucosinolate Biosynthesis Establish a Critical Role for Indole-3-acetaldoxime in Auxin ...
Holocytochrome-c synthase
... heme This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this ... Cytochrome c heme-lyase (CCHL) and cytochrome Cc1 heme-lyase (CC1HL) are mitochondrial enzymes that catalyze the covalent ... Dumont ME, Ernst JF, Hampsey DM, Sherman F (1987). "Identification and sequence of the gene encoding cytochrome c heme lyase in ... Other names in common use include cytochrome c heme-lyase, holocytochrome c synthetase, and holocytochrome-c apocytochrome-c- ...
L-cysteate sulfo-lyase
This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme ... The enzyme L-cysteate sulfo-lyase (EC 4.4.1.25) catalyzes the reaction L-cysteate + H2O = hydrogensulfite + pyruvate + NH3 ( ... Denger K, Smits TH, Cook AM (2006). "L-Cysteate sulpho-lyase, a widespread pyridoxal 5′-phosphate-coupled desulphonative enzyme ... class is L-cysteate bisulfite-lyase (deaminating; pyruvate-forming). Other names in common use include L-cysteate sulfo-lyase ( ...
Sulfolactate sulfo-lyase
... hydrogensulfite This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic ... The enzyme (2R)-sulfolactate sulfo-lyase (EC 4.4.1.24) catalyzes the reaction (2R)-3-sulfolactate ⇌ {\displaystyle \ ... and 3-sulfolactate bisulfite-lyase. Graham DE, White RH (April 2002). "Elucidation of methanogenic coenzyme biosyntheses: from ... "Dissimilation of cysteate via 3-sulfolactate sulfo-lyase and a sulfate exporter in Paracoccus pantotrophus NKNCYSA". ...
Lyase
... cleave carbon-nitrogen bonds EC 4.4 includes lyases that cleave carbon-sulfur bonds EC 4.5 includes lyases that cleave carbon- ... Lyases can be further classified into seven subclasses: EC 4.1 includes lyases that cleave carbon-carbon bonds, such as ... oxo acid lyases (EC 4.1.3), and others (EC 4.1.99) EC 4.2 includes lyases that cleave carbon-oxygen bonds, such as dehydratases ... this reaction was first classified as a lyase (EC 4.2.99.9), but was then reclassified as a transferase (EC 2.5.1.48). Lyases ...
D-cysteine desulfhydrase
... pyruvate This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of ... Other names in common use include D-cysteine lyase, and D-cysteine sulfide-lyase (deaminating). This enzyme participates in ... Portal: Biology v t e (EC 4.4.1, Enzymes of unknown structure, All stub articles, Lyase stubs). ... this enzyme class is D-cysteine sulfide-lyase (deaminating; pyruvate-forming). ...
L-3-cyanoalanine synthase
... specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is L-cysteine hydrogen-sulfide-lyase ( ... and L-cysteine hydrogen-sulfide-lyase (adding HCN). This enzyme participates in cyanoamino acid metabolism. Akopyan TN, ... hydrogen sulfide This enzyme belongs to the family of lyases, ...
List of EC numbers (EC 3)
... carbon disulfide hydrolase EC 3.13.1.6: [CysO sulfur-carrier protein]-S-L-cysteine hydrolase * EC 3.13.1.7: Carbonyl sulfide ... EC 3.1.27.6: Now EC 4.6.1.21, Enterobacter ribonuclease, since the primary reaction is that of a lyase EC 3.1.27.7: ... EC 3.1.25.1: deoxyribonuclease (pyrimidine dimer) EC 3.1.25.2: Now EC 4.2.99.18, DNA-(apurinic or apyrimidinic site) lyase EC ... citrate lyase deacetylase EC 3.1.2.17: (S)-methylmalonyl-CoA hydrolase EC 3.1.2.18: ADP-dependent short-chain-acyl-CoA ...
Biosynthesis
In the case of methionine, the methyl carbon is derived from serine and the sulfur group, but in most organisms, it is derived ... SAICAR lyase removes the carbon skeleton of the added aspartate, leaving the amino group and forming 5-aminoimidazole-4- ... For all standard amino acids, except glycine, the α-carbon is a chiral center. In the case of glycine, the α-carbon has two ... Proline has a functional group on the α-carbon that forms a ring with the amino group. One major step in amino acid ...
Citrate-CoA ligase
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The ... "Isolation of enzymically active fragments formed by limited proteolysis of ATP citrate lyase". Eur. J. Biochem. 125 (3): 645-50 ...
Radical SAM
... enzymes that can catalyze sulfur-to-alpha carbon thioether cross-linked peptides (sactipeptides) are important to ... Benjdia A (December 2012). "DNA photolyases and SP lyase: structure and mechanism of light-dependent and independent DNA lyases ... "The Radical S-Adenosyl-L-methionine Enzyme QhpD Catalyzes Sequential Formation of Intra-protein Sulfur-to-Methylene Carbon ... The active site of Mo nitrogenase is the M-cluster, a metal-sulfur cluster containing a carbide at its core. Within the ...
Cystathionine beta synthase
This enzyme belongs to the family of lyases, to be specific, the hydro-lyases, which cleave carbon-oxygen bonds. CBS is a ... CBS occupies a pivotal position in mammalian sulfur metabolism at the homocysteine junction where the decision to conserve ... Puranik M, Weeks CL, Lahaye D, Kabil O, Taoka S, Nielsen SB, Groves JT, Banerjee R, Spiro TG (May 2006). "Dynamics of carbon ... The systematic name of this enzyme class is L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming). Other names in ...