... a unifying sequence format for carbohydrates". Carbohydrate Research. 343 (12): 2162-2171. doi:10.1016/j.carres.2008.03.011. ... CSDB provides access to several carbohydrate-related research tools: Simulation of 1D and 2D NMR spectra of carbohydrates ( ... Egorova K.S.; Toukach Ph.V. (2013). "Expansion of coverage of Carbohydrate Structure Database (CSDB)". Carbohydrate Research. ... Bacterial Carbohydrate Structure Database (BCSDB) and Plant&Fungal Carbohydrate Structure Database (PFCSDB) databases existed ...
Sequence and structural conservation in families CBM17 and CBM28 suggests that they have evolved through gene duplication and ... Carbohydrate-binding module family 20 (CBM20) binds to starch. Carbohydrate-binding module family 21 (CBM21), found in many ... Carbohydrate-binding module family 5 (CBM5) binds chitin. CBM5 and CBM12 are distantly related. Carbohydrate-binding module ... In molecular biology, a carbohydrate-binding module (CBM) is a protein domain found in carbohydrate-active enzymes (for example ...
CarbohydratesSequences and topology. 44: 39-47. doi:10.1016/j.sbi.2016.11.011. PMID 27940408. Crispin M, Stuart DI, Jones EY ... Around 20% of the deposited carbohydrate structures are in unjustified energy minima. A number of carbohydrate validation web ... carbohydrate validation) Privateer (carbohydrate validation) OOPS2, part of the Uppsala Software Factory ProSA web service ... see for recommendations on carbohydrate model building and refinement and for reviews on general errors in carbohydrate ...
January 1990). "Conformer populations of L-iduronic acid residues in glycosaminoglycan sequences". Carbohydrate Research. 195 ( ... Heparin binds to AT via a specific pentasaccharide sulfation sequence contained within the heparin polymer: GlcNAc/NS(6S)-GlcA- ... It is a synthetic pentasaccharide, whose chemical structure is almost identical to the AT binding pentasaccharide sequence that ... Heparin is a member of the glycosaminoglycan family of carbohydrates (which includes the closely related molecule heparan ...
"Discrimination of epimeric glycans and glycopeptides using IM-MS and its potential for carbohydrate sequencing". Nature ... "Advancing Solutions to the Carbohydrate Sequencing Challenge". Journal of the American Chemical Society. 141 (37): 14463-14479 ... carbohydrates and their conjugates using mass spectrometry-based methods[citation needed]. Eyers' work in biological mass ...
... sequencing' carbohydrates through chemical and conformational means. Detailed studies of enzyme reactions have also provided ... "Discrimination of epimeric glycans and glycopeptides using IM-MS and its potential for carbohydrate sequencing". Nature ... "Advancing Solutions to the Carbohydrate Sequencing Challenge". Journal of the American Chemical Society. 141 (37): 14463-14479 ... Flitsch's research is focussed on glycobiotechnology - the study of carbohydrates in applied science and biocatalysis - the ...
Protein sequence alignment studies indicate that this lysine is conserved in cytosolic sulfotransferases as well. In addition ... Carbohydrate sulfotransferases are sulfotransferase enzymes that transfer sulfate to carbohydrate groups in glycoproteins and ... Sulfation, performed by carbohydrate sulfotransferases, generates carbohydrate sulfate esters. These sulfate esters are only ... Carbohydrate sulfotransferases are transmembrane enzymes in the Golgi that modify carbohydrates on glycolipids or glycoproteins ...
Protein-Carbohydrate Complexes and Glycosylation ● Sequences and Topology. 68: 175-183. doi:10.1016/j.sbi.2020.11.010. ISSN ... randomly explore the sequence space to find transition sequences (switches) to new networks. His work also showed that errors ... Nucleic acids / Sequences and topology. 20 (3): 390-396. doi:10.1016/j.sbi.2010.02.005. ISSN 0959-440X. PMID 20347587. Wissler ... Bornberg-Bauer has been involved in the initial genome sequencing and annotation of Eucalyptus grandis, Nasonia vitripennis, ...
Carbohydrates: A feast of structural glycobiology • Sequences and topology: Computational studies of protein-protein ... modification and breakdown of carbohydrates. His chemical and structural insight into protein-carbohydrate interactions and his ... He has made fundamental additions to our understanding of enzyme mechanism and carbohydrate biochemistry. As a direct result of ... Agirre, Jon; Davies, Gideon J; Wilson, Keith S; Cowtan, Kevin D (June 2017). "Carbohydrate structure: the rocky road to ...
Davies GJ, Sinnott ML (2008). "Sorting the diverse: The sequence‑based classifications of carbohydrate‑active enzymes" (PDF). ... CAZy was established in 1999 in order to provide online and constantly updated access to the protein sequence-based family ... The rapid evolution of high-throughput DNA sequencing has resulted in the continuing exponential growth of the CAZy database, ... "CAZy - Carbohydrate-Active enZYmes Database". Architecture et Fonction des Macromolécules Biologiques, CNRS, Université de ...
A carbohydrate sequence markup language (CabosML) is a description of carbohydrate structures using XML. Many glycobiologists ... "GlycoCT-a unifying sequence format for carbohydrates". Carbohydrate Research. 343 (12): 2162-2171. doi:10.1016/j.carres.2008.03 ... "The carbohydrate sequence markup language (CabosML): an XML description of carbohydrate structures". Bioinformatics. 21 (8): ... LInear Notation for Unique description of Carbohydrate Sequences". Carbohydrate Research. 336 (1): 1-11. doi:10.1016/S0008-6215 ...
The protein name derives from the protein's interaction with carbohydrate response element sequences of DNA. This gene encodes ... Carbohydrate-responsive element-binding protein (ChREBP) also known as MLX-interacting protein-like (MLXIPL) is a protein that ... This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response ... "Entrez Gene: MLXIPL MLX interacting protein-like". Ortega-Prieto P, Postic C (2019). "Carbohydrate Sensing Through the ...
Lectins recognise and bind particular sugar sequences in carbohydrates; peanut agglutinin binds the carbohydrate sequence Gal-β ... Available Structures of peanut agglutinin Because peanut agglutinin specifically binds a particular carbohydrate sequence it ... GalNAc carbohydrate sequence. The protein is 273 amino acids in length with the first 23 residues acting as a signal peptide ... the binding specificity of peanut agglutinin is used to isolate glycosylated molecules which have the sugar sequence Gal-β(1-3 ...
"A practical guide to structural analysis of carbohydrates". https://www.nature.com/subjects/sequencing (Articles with short ... Exome sequencing Full genome sequencing Genetic code Pathogenomics RNA-Seq MicroRNA sequencing Sequence motif Wheeler, David A ... While sequencing DNA gives a genetic profile of an organism, sequencing RNA reflects only the sequences that are actively ... for low-throughput sequencing) and 454 Life Sciences (for high-throughput sequencing). The latter platform sequences roughly ...
Such structural studies, such as sequence determination or identification of new monosaccharides, benefit the most from the NMR ... Common chemical shift ranges for nuclei within carbohydrate residues are: Typical 1H NMR chemical shifts of carbohydrate ring ... Modern high field NMR instruments used for carbohydrate samples, typically 500 MHz or higher, are able to run a suite of 1D, 2D ... Carbohydrate NMR spectroscopy is the application of nuclear magnetic resonance (NMR) spectroscopy to structural and ...
Its sequence contains two regions of tandem 19-residue repeats, where the repeat motif consists of short beta-strands separated ... This domain is suggested to be a carbohydrate-dependent haemagglutination activity site. In Bordetella pertussis, the ... Members generally have a signal sequence, then an intervening region, then the region described in this entry. Following this ...
... or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence ... Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'. As of ... Cantarel BL, Coutinho PM, Rancurel C, Bernard T, Lombard V, Henrissat B (January 2009). "The Carbohydrate-Active EnZymes ... Henrissat B, Bairoch A (June 1996). "Updating the sequence-based classification of glycosyl hydrolases". Biochem. J. 316 (2): ...
Because 3-D structures are better conserved than sequences, several of the families defined on the basis of sequence ... This classification is available on the CAZy (Carbohydrate-Active EnZymes) web site. The same three-dimensional fold is ... Henrissat B, Coutinho PM (1999). "Carbohydrate-Active Enzymes server". {{cite journal}}: Cite journal requires ,journal= (help ... "A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities". Biochem. J. 326 ...
Because 3-D structures are better conserved than sequences, several of the families defined on the basis of sequence ... This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. The same three-dimensional fold is ... Sialyltransferase may be responsible for the synthesis of the sequence NEUAC-Alpha-2,3-GAL-Beta-1,3-GALNAC-, found on sugar ... Henrissat B, Coutinho PM (1998-2022). "Carbohydrate-Active Enzymes server". Marseille: Université d'Aix. Dall'Olio F, Chiricolo ...
Sulfation of tyrosines and carbohydrates occurs within the TGN. Other general post-translational modifications of proteins ... depending upon the signal sequence they carry. In this model, the Golgi is viewed as a set of stable compartments that work ... Protein modifications may form a signal sequence that determines the final destination of the protein. For example, the Golgi ... include the addition of carbohydrates (glycosylation) and phosphates (phosphorylation). ...
The system activates as a signal sequence HlyA binds HlyB on the cell membrane. This signal sequence is an ABC transporter. The ... T1SS transports various molecules including ions, carbohydrates, drugs, proteins. The secreted molecules vary in size from the ... In SecA pathway, a chaperone trigger factor (TF) first bind to the exposed N-terminal signal sequence of the peptide chain. As ... In this pathway, SRP competes with TF and binds to the N-terminal signal sequence. Proteins from inner membrane stops the ...
The bacteria contain an adhesion protein for the carbohydrate sequence Gal-1,4Gal. After incubation with various amounts of the ... The genome of S. suis isolates from the outbreak were examined to see whether its DNA sequence could explain why these ...
Sequence-based classifications are one of the most powerful predictive methods for suggesting function for newly sequenced ... Henrissat, B. and Coutinho P.M. "Carbohydrate-Active Enzymes server". 1999. CAZypedia, an online encyclopedia of carbohydrate- ... the carbohydrate-active enzymes and binding proteins involved in the synthesis and degradation of complex carbohydrates ... Glycoside hydrolases are found in the intestinal tract and in saliva where they degrade complex carbohydrates such as lactose, ...
The sequence of the amino acids in the polypeptide backbone is known as the primary structure of the protein. Like almost all ... Generally, carbohydrates which our bodies break down are alpha-linked (example: glycogen) and those which have structural ... Carbohydrates arise by condensation of monosaccharides such as glucose. The polymers can be classified into oligosaccharides ( ... the carbohydrate is designated as beta and if the linkage is on the opposite side it is designated as alpha. In a traditional " ...
The enzymes contain ~250-300 residues, which encode putative signal sequences and carbohydrate attachment sites. In addition, ...
Owing to the lack of a genetic blue print, carbohydrates do not have a "fixed" sequence. Instead, the sequence is largely ... as well as carbohydrate interactions. Conventional usage of the term does not currently include the treatment of carbohydrates ... 2004). Carbohydrate Polymers 55:171-177. Helenius A, Aebi M (2001) Intracellular functions of N-linked glycans. Science 291: ... For instance, just four sugars can be strung together to form more than 5 million different types of carbohydrates or nine ...
The major carbohydrate sequence linked to glycodelin-A also profusely coats the surface of schistosomes. The profile of the ... For example, human gametes are coated with carbohydrate sequences that have been implicated in the suppression of NK cell ... There are some notable examples of this mimicry or acquisition of the same carbohydrate sequences implicated in this protective ... The eu-FEDS model further suggests that specific carbohydrate sequences (oligosaccharides) are covalently linked to these ...
It has two noncovalently associated polypeptide chains: an A chain sequence with 44 amino acid residues, and a B chain with 50 ... it was first reported as a carbohydrate. The protein was named in 1972 after the Monell Chemical Senses Center in Philadelphia ... GEWEIIDIGP FTQNLGKFAV DEENKIGQYG RLTFNKVIRP CMKKTIYEEN Amino acid sequence of the sweet protein monellin adapted from Swiss- ...
The sequencing of marker genes of entire microbial communities, referred to as metagenomics, sheds light on the phylogenetic ... In return, the fungi obtain carbohydrates and lipids from host plants. Recent studies of arbuscular mycorrhizal fungi using ... Kumaravel, Sowmya; Thankappan, Sugitha; Raghupathi, Sridar; Uthandi, Sivakumar (2018). "Draft Genome Sequence of Plant Growth- ... and carbohydrates to the microorganisms. The association of AM fungi with plants has been known since 1842, and over 80% of ...
It contains a conserved sequence that is the reverse complement of the Shine-Dalgarno sequence of many transport and metabolic ... Broadly, it is suggested that tsRNAs regulate carbohydrate and amino acid metabolism in Burkholderia. They are more highly ... Likely targets include many genes that regulate carbohydrate transport and the degradation of aromatic amino acids. Specific ... it has been suggested that tsRNAs regulate gene expression by binding the ribosome binding sequence of multiple mRNAs. The low ...