Carbapenems are the treatment of choice for serious infections due to ESBL-producing organisms, yet carbapenem-resistant ( ... monobactams and carbapenems (ertapenem), although carbapenems are relatively resistant to beta-lactamase. Beta-lactamase ... OXA carbapenemases hydrolyse carbapenems very slowly in vitro, and the high MICs seen for some Acinetobacter hosts (>64 mg/L) ... Carbapenems are famously stable to AmpC β-lactamases and extended-spectrum-β-lactamases. Carbapenemases are a diverse group of ...

Carbapenem antibiotics (heretofore often the treatment of last resort for resistant infections) are generally not effective ... As of 2013 hard-to-treat or untreatable infections of carbapenem-resistant Enterobacteriaceae (CRE), also known as ... C. difficile colitis is most strongly associated with fluoroquinolones, cephalosporins, carbapenems, and clindamycin. Some ...

... (formerly CS-023) is a carbapenem β-lactam antibiotic. Efficacy of human-simulated exposures of tomopenem (formerly ...

Carbapenems are a class of beta-lactam antibiotics that are capable of killing most bacteria by inhibiting the synthesis of one ... The carbapenems were developed to overcome antibiotic resistance mediated by bacterial beta-lactamase enzymes. However, the ... In March 2010, a study in a hospital in Mumbai found that most carbapenem-resistant bacteria isolated from patients carried the ... These include the antibiotics of the carbapenem family, which are a mainstay for the treatment of antibiotic-resistant ...

They are: cephalosporins, carbapenems, aztreonam, clindamycin, erythromycin, nitrofurantoin, bacitracin, doxycycline, ...

However, HugA does not affect cephamycins or carbapenems and is inhibited by clavulanic acid. Similar to other Proteus species ... carbapenems, aztreonam, quinolones, sulphamethoxazole, and co-trimoxazole. Isolates of P. penneri have been found to be ...

... acts synergistically with many other antibiotics, including aminoglycosides, carbapenems, cephalosporins, daptomycin ...

Imipenem/relebactam: carbapenem/ β-lactamase inhibitor combination (cell wall synthesis inhibitor). FDA approved on 16 July ... Meropenem/vaborbactam: carbapenem/ β-lactamase inhibitor combination (cell wall synthesis inhibitor). FDA approved on 29 August ... and the carbapenems. Compounds that are still isolated from living organisms are the aminoglycosides, whereas other ...

"Nosocomial bloodstream infection and the emerging carbapenem-resistant pathogen Ralstonia insidiosa". BMC Infectious Diseases. ...

... (INN) is a carbapenem antibiotic used in combination with betamipron. It is not used in the United States.[citation ... Carbapenem antibiotics, Pyrrolidines, Daiichi Sankyo, All stub articles, Antibiotic stubs). ...

Orchid's main products are active pharmaceutical ingredients, including cephalosporins (oral and injectable), carbapenems and ...

... carbapenem)) This membrane-bound, zinc enzyme has broad specificity. Inhibitors include bestatin and cilastatin. Dipeptidase 1 ... "Metabolism of thienamycin and related carbapenem antibiotics by the renal dipeptidase, dehydropeptidase". Antimicrobial Agents ...

It also demonstrates potent in vitro activity versus carbapenem-resistant Acinetobacter baumannii. Plazomicin was found to be ... October 2015). "Can Plazomicin Alone or in Combination Be a Therapeutic Option against Carbapenem-Resistant Acinetobacter ...

"Acinetobacter radioresistens as a Silent Source of Carbapenem Resistance for Acinetobacter spp". Antimicrobial Agents and ...

A carbapenam is a β-lactam compound that is a saturated carbapenem. They exist primarily as biosynthetic intermediates on the ... Carbapenem antibiotics, All stub articles, Heterocyclic compound stubs). ... way to the carbapenem antibiotics. Dalhoff, A.; Janjic, N.; Echols, R. (2006). "Redefining penems". Biochemical Pharmacology. ...

Cefepime, a fourth-generation cephalosporin from the β-Lactam antibiotic class.[more detail needed] Imipenem (a carbapenem) is ...

First-choice drugs for E. corrodens infections should be third-generation cephems, carbapenems, or new quinolones. It is ...

Some of the antibiotic resistance occurs when the bacterium is introduced to carbapenems, cephalosporins, and aminoglycosides. ...

Those medications that may cause a cross sensitivity reaction are: carbapenems, ampicillin, cefazolin, cephalosporins and ...

... is contraindicated in those with a previous history of allergy to penicillins, cephalosporins, or carbapenems. ...

2012). "Increase of carbapenem-resistant Acinetobacter baumannii infection in acute care hospitals in Taiwan: Association with ... Traditionally, infections were treated with imipenem or meropenem, but a steady rise in carbapenem-resistant A. baumannii has ... carbapenem resistance evolution through heteroresistance as an intermediate stage in Acinetobacter baumannii after carbapenem ... and various carbapenems. Many other efflux pumps have been implicated in A. baumannii resistant strains. Bacterial small RNAs ...

In a study where cultures of these bacteria were grown, tests showed that all the isolates were susceptible to carbapenem ... While there are several kinds of medicines that can treat P. oryzihabitans, the carbapenem displayed the best results against ... The antibiotics that the infectious disease responded to are gentamicin, ciprofloxacin, carbapenems, cephalosprins, ...

Recommendations for hospital-acquired pneumonia include third- and fourth-generation cephalosporins, carbapenems, ...

"Definition of the common and divergent steps in carbapenem β-lactam antibiotic biosynthesis". ChemBioChem. 12 (14): 2159-65. ...

nov., isolated from hospital sewage and capable of acquisition of carbapenem resistance genes". Systematic and Applied ...

"Tracking a Hospital Outbreak of Carbapenem-Resistant Klebsiella pneumoniae with Whole-Genome Sequencing". Science Translational ...

... and carbapenems. Hydrolysis of the antibiotics by blaCMY-2 results in the resistance. This enzyme is present and expressed in ...

... (PTZ-601) is a broad spectrum injectable antibiotic, from the carbapenem subgroup of beta-lactam antibiotics. It was ... Livermore DM, Mushtaq S, Warner M (August 2009). "Activity of the anti-MRSA carbapenem razupenem (PTZ601) against ...

Continuing her research and discovery efforts in antibiotic chemotherapy where she led teams that discovered a new carbapenem ... An unusual E. coli PBP3 insertion sequence identified from a collection of carbapenem-resistant Enterobacteriaceae (CRE) tested ... SME-type carbapenem-hydrolyzing class A beta-lactamases from geographically diverse Serratia marcescens strains. Antimicrobial ... "SME-Type Carbapenem-Hydrolyzing Class A β-Lactamases from Geographically Diverse Serratia marcescens Strains". Antimicrobial ...

"Chemical genetic identification of peptidoglycan inhibitors potentiating carbapenem activity against methicillin-resistant ...