... and camptothecin: base sequence analysis and activity against camptothecin-resistant topoisomerases I.". Cancer Res. 63 (21): ... Camptothecin-derived TopI inhibitors function by forming a ternary complex with TopI-DNA and are able to stack between the base ... Camptothecin (CPT) was first derived from the tree Camptotheca acuminata, native to southern China. It was isolated in a United ... Pommier Y (2004). "Camptothecins and topoisomerase I: a foot in the door. Targeting the genome beyond topoisomerase I with ...
"Discovery of Camptothecin and Taxol". National Historic Chemical Landmarks. American Chemical Society. Retrieved 2012-10-28. " ... of frozen foods conducted at the USDA-ARS Western Regional Research Center between 1948 and 1965 The discovery of Camptothecin ...
Camptothecin · Topotecan · Irinotecan · Rubitecan · Belotecan); 2. Podophyllum (Etoposide · Teniposide); 3a. Anthracyclines ( ...
The article Camptothecin lists other analogues of camptothecin and the article Topoisomerase inhibitor lists other compounds ... Camptothecin analogues irinotecan and topotecan, which inhibit TOP1, are among the most effective FDA-approved anticancer ... Irinotecan is an analogue of the cytotoxic natural alkaloid camptothecin, obtained from the Chinese tree Camptotheca acuminata ... "A kinetic clutch governs religation by type IB topoisomerases and determines camptothecin sensitivity". Proc. Natl. Acad. Sci. ...
... is a semi-synthetic derivative of camptothecin. Camptothecin is a natural product extracted from the bark of the tree ... It is a synthetic, water-soluble analog of the natural chemical compound camptothecin. It is used in the form of its ... Pommier Y (October 2006). "Topoisomerase I inhibitors: camptothecins and beyond". Nature Reviews. Cancer. 6 (10): 789-802. doi: ... "The mechanism of topoisomerase I poisoning by a camptothecin analog". Proceedings of the National Academy of Sciences of the ...
... is a semi-synthetic analog of camptothecin with antineoplastic activity. Liposomal lurtotecan was in clinical trials ... "Convergent catalytic asymmetric synthesis of camptothecin analog GI147211C". Tetrahedron. 53 (32): 10953. doi:10.1016/S0040- ...
He discovered Taxol and camptothecin with Monroe Eliot Wall. Chetan E. Chitnis - worked on molecular parasitology and ...
The direct nitration of camptothecin results in regioselectivity problems. One way that has been used to synthesize Rubitecan ...
"Antifungal Activity of Camptothecin, Trifolin, and Hyperoside Isolated fromCamptotheca acuminata". Journal of Agricultural and ...
... camptothecin". Biochemistry. 25 (6): 1216-21. doi:10.1021/bi00354a004. PMID 3008823. Vasudevachari, M; Antony, A (1982). " ...
... the first established anticancer agent as camptothecin derivatives. 2014 - Hiroshi Nagase [ja]. Design and synthesis of opioid ...
Type 1 topoisomerase is inhibited by irinotecan, topotecan and camptothecin. The human topoisomerase type IB enzyme forms a ...
Li, S.; Zhang, Z.; Cain, A.; Wang, B.; Long, M.; Taylor, J. (2005). "Antifungal Activity of Camptothecin, Trifolin, and ...
Albihn A, Mo H, Yang Y, Henriksson M (2007). "Camptothecin-induced apoptosis is enhanced by Myc and involves PKCdelta signaling ...
... lowreyana S.Y.Li The bark and stems of C. acuminata contain the alkaloid camptothecin. Several chemical derivatives ... Li, S.; Zhang, Z.; Cain, A.; Wang, B.; Long, M.; Taylor, J. (2005). "Antifungal Activity of Camptothecin, Trifolin, and ... of camptothecin are under investigation for or used as drugs for cancer treatment, including irinotecan, topotecan, rubitecan. ...
... "p21-activated kinase 5 inhibits camptothecin-induced apoptosis in colorectal carcinoma cells". Tumour Biology. 31 (6): 575-82. ...
... contains alkaloids, such as 'camptothecin' (or CPT), 'chonemorphine', and 'funtumafrine'. 'Camptothecin' ... Anuradha Camptothecin and Camptothecin Producing Plants: Botany, Chemistry, Anticancer Activity, and Biotechnology (2020), p. ...
Fungi can synthesize podophyllotoxin and camptothecin, precursors to etoposide, teniposide, topotecan, and irinotecan. Lentinan ...
His group conjugated cyclodextrin to the anti-cancer compound camptothecin to improve the bio-availability and exhibit efficacy ... Schluep, T. (1 March 2006). "Preclinical Efficacy of the Camptothecin-Polymer Conjugate IT-101 in Multiple Cancer Models". ...
Several groups have encapsulated anti-cancer medications such as: Camptothecin, Methotrexate, and Doxorubicin. Results from ...
2010). Correlation of camptothecin-producing ability and phylogenetic relationship in the genus Ophiorrhiza. Planta Med. in pub ... 2004). Camptothecin production by in vitro cultures of Ophiorrhiza liukiuensis and O. kuroiwai. Plant Biotechnology 21:4 275. ... Ophiorrhiza is a genus of flowering plants in the coffee family (Rubiaceae). Species of the genus contain camptothecin, an ... 2007). Organogenesis from leaf and internode explants of Ophiorrhiza prostrata, an anticancer drug (camptothecin) producing ...
Curran, D. P.; Liu, H., New 4+1 radical annulations - a formal total synthesis of (+/-)-camptothecin. J. Am. Chem. Soc. 1992, ... A 1991 synthesis of the important anti-cancer agent camptothecin illustrates many of these features. The synthesis takes place ...
Wall ME, Wani MC (February 1995). "Camptothecin and taxol: discovery to clinic--thirteenth Bruce F. Cain Memorial Award Lecture ... Wall ME, Wani MC (February 1995). "Camptothecin and taxol: discovery to clinic--thirteenth Bruce F. Cain Memorial Award Lecture ...
"Aspirin inhibits camptothecin-induced p21CIP1 levels and potentiates apoptosis in human breast cancer cells". International ...
... is a drug which is a structural analog of camptothecin with antineoplastic activity. A derivative is used in ...
Futami K, Takagi M, Shimamoto A, Sugimoto M, Furuichi Y (2007). "Increased chemotherapeutic activity of camptothecin in cancer ... "Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease". ...
Camptothecin-encapsulated BSA-PMMA nanoparticles revealed enhanced anti-tumor activity both in vitro and in animals. Beyond the ... conjugated denatured bovine serum albumin micelles for effective delivery of camptothecin". Polymer Chemistry. 3 (8): 1958. doi ... composed of BSA-PMMA with diameters of around 100 nm were obtained and the water insoluble chemotherapeutic drug camptothecin ...
Another drug class originating from the NCI was the camptothecins. Camptothecin, derived from a Chinese ornamental tree, ... and camptothecins (in 1966). Both classes of drug were isolated and characterized by the laboratory of Monroe Wall at the ...
... a natural source of the anti-cancer compound camptothecin". GigaScience. 6 (9): 1-7. doi:10.1093/gigascience/gix065. PMC ...
Breakage is reduced after treatment with CPT (camptothecin) (without APH), signifying that CPT also has a necessary role in ... camptothecin (CPT), reduces APH-induced breakage. CFS regions are highly conserved in mouse and other species, including ...