Clapham DE (2007). "Calcium signaling". Cell. 131 (6): 1047-58. doi:10.1016/j.cell.2007.11.028. PMID 18083096.. ... Calcium is, therefore, a cell signaling molecule, and not usually considered a cofactor of the enzymes it regulates.[16] ... Niki I, Yokokura H, Sudo T, Kato M, Hidaka H (October 1996). "Ca2+ signaling and intracellular Ca2+ binding proteins". Journal ... Calcium is another special case, in that it is required as a component of the human diet, and it is needed for the full ...
Shahidul (ed.). Calcium Signaling. Advances in Experimental Medicine and Biology. 740. pp. 1219-47. doi:10.1007/978-94-007-2888 ... Antiepileptic drugs can control absence seizures by inhibiting the T-type calcium channels which prevents low-voltage calcium ... T-type calcium channels have been known to play a role in the spike-and-wave discharges of absence seizures. ... The T-type calcium channel is found in neurons throughout the brain. These channels produce particularly large currents in ...
GHS signal word Danger GHS hazard statements. H314, H318, H335, H402 GHS precautionary statements ... which decomposes calcium hydroxide into calcium oxide and water.[7] Ca(OH)2 → CaO + H2O. Structure, preparation, occurrence[ ... Calcium hydroxide (traditionally called slaked lime) is an inorganic compound with the chemical formula Ca(OH)2. It is a ... "MSDS Calcium hydroxide" (PDF). Archived from the original (PDF) on 25 March 2012. Retrieved 21 June 2011.. Cite uses deprecated ...
Calcium Signaling Protocols. Humana Press, 2006. ... Cheng, H.; Lederer, W.J.; Cannell, M.B. (1993). "Calcium Sparks ... Fluo-3 is a fluorescence indicator of intracellular calcium (Ca2+). It is used to measure Ca2+ inside living cells in flow ... Once inside the cell, unspecific esterases cleave the ester effectively trapping fluo-3. As calcium is a key second messenger ... Molecular Probes, 2010 Gamsjäger, T. Flow Cytometry of Intracellular Calcium in Platelets. Grin, 2012 Lambert, DG. ...
... is a positive modulator of calcium flux mediated by the STIM-ORAI signaling in vertebrates. STIMATE can physically ... Oh-hora, Masatsugu; Rao, Anjana (2008-01-01). "Calcium signaling in lymphocytes". Current Opinion in Immunology. 20 (3): 250- ... reduces the puncta formation of STIM1 at ER-PM junctions and remarkably inhibits the calcium/calcineurin/NFAT signaling axis. ... thereby coupling to and gating the ORAI calcium channels on the plasma membrane. Depletion of TMEM110 with RNAi knockdown or ...
Marambaud P, Dreses-Werringloer U, Vingtdeux V (2009). "Calcium signaling in neurodegeneration". Mol Neurodegeneration. 4 (1): ... The activated motor neurons then transmit their signals, via action potential, to motor neurons in the legs. However, when a ... During this time, microglia generate reactive oxygen species and release signals to recruit peripheral immune cells for an ... Alpha-synuclein activates ATM (ataxia-telangiectasia mutated), a major DNA damage repair signaling kinase. Alpha-synuclein ...
Nicholls DG (2005). "Mitochondria and calcium signaling". Cell Calcium. 38 (3-4): 311-7. doi:10.1016/j.ceca.2005.06.011. PMID ... load and oxidative stress The mitochondrial calcium uniporter which transports calcium from the cytosol of the cell into the ... Sam50 and Sam35 are responsible for the binding of precursors of β-barrel proteins, which contain conserved β-signal that is ... Yamano K, Yatsukawa Y, Esaki M, Hobbs AE, Jensen RE, Endo T (February 2008). "Tom20 and Tom22 share the common signal ...
Dodd, Antony N.; Kudla, Jörg; Sanders, Dale (2010). "The language of calcium signaling". Annual Review of Plant Biology. 61: ... He also molecularly characterised calcium permeable channels and is interested in how calcium fluxes are initiated and respond ... Sanders' research explores the transport of ions across plant cell membranes and the roles of ions in signalling and nutrient ... Allen, G. J.; Sanders, D. (1 May 1994). "Two Voltage-Gated, Calcium Release Channels Coreside in the Vacuolar Membrane of Broad ...
Finch, Elizabeth A.; Augustine, George J. (1998). "Local Calcium Signalling by Inositol-1,4,5-trisphosphate in Purkinje Cell ... doi:10.1016/0166-2236(88)90199-3. Augustine, George J.; Santamaria, Fidel; Tanaka, Keiko (2003). "Local Calcium Signaling in ... showing that it is triggered by a remarkably local calcium signal. He has been influential in discovering the role of several ... ISBN 978-1-60535-380-7. Augustine, George J.; Charlton, Milton P.; Smith, Stephen J. (1987). "Calcium Action in Synaptic ...
2012.) Calcium Signaling in Dendritic Spines. Cold Spring Harbor Perspectives in Biology. Retrieved from http://cshperspectives ... Therefore, heterosynaptic dopamine signaling in mammals can be best represented by dopamine's biological functions of mediating ...
2012.) Calcium Signaling in Dendritic Spines. Cold Spring Harbor Perspectives in Biology. Retrieved from http://cshperspectives ... Ca2+ is one signaling ion that causes this AMPA receptor density change by inducing a cascade of biological changes within the ... According to Hebb, these two cells are strengthened because their signaling occurs together in space and/or time, also known as ... In order to create input-specific changes in synaptic strength, the Ca2+ signal must be restricted to specific dendritic spines ...
This work eventually led to the identification of key channel proteins involved in calcium signaling in immune and other non- ... While continuing to investigate Fc𝛆RI biology, his lab also began to study calcium signaling in immune cells. ... Vig, Monika; Kinet, Jean-Pierre (January 2009). "Calcium signaling in immune cells". Nature Immunology. 10 (1): 21-27. doi: ... is a French-American immunologist known for his work studying the role of calcium signaling in the immune response. He is a ...
Brini, Marisa; Calì, Tito; Ottolini, Denis; Carafoli, Ernesto (2013). "Intracellular Calcium Homeostasis and Signaling". ... Chlorine, potassium, magnesium, calcium and phosphorus have important roles due to their ready ionization and utility in ... "Calcium". Linus Pauling Institute, Oregon State University, Corvallis, Oregon. 1 September 2017. Retrieved 31 August 2019. CS1 ... Miriyala, Sumitra; K. Holley, Aaron; St Clair, Daret K. (1 February 2011). "Mitochondrial Superoxide Dismutase - Signals of ...
Verkhratsky A, Orkand RK, Kettenmann H (1998). "Glial calcium: homeostasis and signaling function". Physiol. Rev. 78: 99-141. ... Xenopus oocyte calcium waves, and glial calcium waves in cortical tissue culture. Play media Winfree AT. (2001). The Geometry ... Lechleiter J, Girard S, Peralta E, Clapham D (1991). "Spiral calcium wave propagation and annihilation in Xenopus laevis ...
... has a suppressive effect on calcium signaling from the cytoplasm to the nucleus in the proliferative cells. Also, ... Yamaguchi M (March 2000). "Role of regucalcin in calcium signaling". Life Sciences. 66 (19): 1769-80. doi:10.1016/S0024-3205(99 ... Yamaguchi M (August 2012). "Role of regucalcin in brain calcium signaling: involvement in aging". Integrative Biology. 4 (8): ... Yamaguchi M (May 2014). "Regulatory role of regucalcin in heart calcium signaling: Insight into cardiac failure (Review)". ...
NFAT activation depends on calcium signaling. IP3 produced by PLC-γ is no longer bound to the membrane and diffuses rapidly in ... Signal 1 is provided by the T-cell receptor when recognising a specific antigen on a MHC molecule. Signal 2 comes from co- ... The signalling motifs involved in TCR signalling are tyrosine residues in the cytoplasmic tail of these adaptor proteins that ... Binding of IP3 to calcium channel receptors on the endoplasmic reticulum (ER) induces the release of calcium (Ca2+) into the ...
... is a small, stable protein containing EF-hand type calcium binding sites. It is involved in calcium signaling. ... Therefore, calcium-binding proteins must distinguish calcium in the presence of high concentrations of other metal ions. The ... Calcium binding proteins like parvalbumin play a role in many physiological processes, namely cell-cycle regulation, second ... Other calcium-binding protein markers are calretinin (most abundant subtype in DLPFC, about 50%) and calbindin. Interneurons ...
... an essential step in calcium signaling to regulate intracellular processes. There are four major classes, termed A, B, C and D ... "Role of protons in calcium signaling". The Biochemical Journal. 478 (4): 895-910. doi:10.1042/BCJ20200971. ISSN 1470-8728. PMID ... Acids trigger the release of bound calcium from cellular stores and the consequent increase in free cytosolic Ca2+, ... Phospholipase Cs play a central role in signal transduction, releasing the second messenger inositol triphosphate. ...
Verkhratsky, Alexei; Untiet, Verena; Rose, Christine R. (7 February 2019). "Ionic signalling in astroglia beyond calcium". The ... Verkhratsky, Alexej; Orkand, Richard K.; Kettenmann, Helmut (1998). "Glial calcium: homeostasis and signaling function". ... calcium signalling, and brain ageing. He is an elected member and vice-president of Academia Europaea, of the German National ... which create ionic signals coordinated in space and time; these ionic signals control the activity of astroglial homeostatic ...
Bazargani, N; Attwell, D (February 2016). "Astrocyte calcium signaling: the third wave". Nature Neuroscience. 19 (2): 182-9. ... A current theory of how such survival signals are sent from axon endings to the soma includes the idea that NGF receptors are ... 2004). Trafficking the NGF signal: implications for normal and degenerating neurons. Prog. Brain Res. Progress in Brain ... and this produces a signal that must be transported up the length of the axon to the nucleus. ...
Cantiello HF (2004). "Regulation of calcium signaling by polycystin-2". Am. J. Physiol. Renal Physiol. 286 (6): F1012-29. doi: ... and may modulate intracellular calcium homeostasis and other signal transduction pathways. This protein interacts with ...
Perea, Gertrudis (September 2005). "Glial calcium signaling and neuron-glia communication". Cell Calcium. 38 (3-4): 375-382. ... Perea, Gertrudis (16 March 2005). "Properties of Synaptically Evoked Astrocyte Calcium Signal Reveal Synaptic Information ... Through changes in their calcium concentration excitability, astrocytes are able to detect neurotransmitters and other signals ... astrocytes are capable of producing transient changes in their intracellular calcium concentrations through release of calcium ...
"Chapter 5 Intracellular Calcium Homeostasis and Signaling". In Banci, Lucia (Ed.). Metallomics and the Cell. Metal Ions in Life ... Contents: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z See also References Calcium - Calcium ions (Ca2+) contribute to ... Many enzymes require calcium ions as a cofactor, those of the blood-clotting cascade being notable examples. Extracellular ... It occurs when an odor binds to a receptor within the nose, transmitting a signal through the olfactory system. Olfaction has ...
Rock MT, Brooks WH, Roszman TL (1997). "Calcium-dependent signaling pathways in T cells. Potential role of calpain, protein ... Reverter D, Sorimachi H, Bode W (2001). "The structure of calcium-free human m-calpain: implications for calcium activation and ... "The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium". ... Chua BT, Guo K, Li P (2000). "Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases". ...
Today the IP3 signaling pathway is well mapped out, and is known to be important in regulating a variety of calcium-dependent ... Berridge, M. J. (2016). "The Inositol Trisphosphate/Calcium Signaling Pathway in Health and Disease". Physiological Reviews. 96 ... Bezprozvanny, I.; Hayden, M.R. (2004). "Deranged neuronal calcium signaling and Huntington disease". Biochemical and ... When IP3 binds its receptor, calcium is released into the cytosol, thereby activating various calcium regulated intracellular ...
They are also involved in calcium signaling. SK channel activation can mediate neuroprotection in various models of cell death ... Calcium enters the cell via voltage activated calcium channels as well as through NMDA receptors. Calcium does not directly ... In addition to being activated by calcium flow through voltage-gated calcium channels, SK channels can be activated by calcium ... by an increase in the concentration of intracellular calcium through N-type calcium channels. Their activation limits the ...
His work highlighted the spatial aspects of calcium signals and in particular the importance of nuclear calcium in governing ... His work on neuronal calcium signaling and gene regulation in the nervous system has been widely cited. He described the role ... Hilmar Bading is noted for his work on neuronal calcium signaling and gene regulation in the nervous system. He identified ... Hagenston, Anna M.; Bading, Hilmar (2011-11-01). "Calcium signaling in synapse-to-nucleus communication". Cold Spring Harbor ...
Carbachol-dependent release involves PKC and calcium signaling. Some lacritin is produced by the meibomian gland, and also by ... Lacritin mitogenic, survival and secretion signaling have been studied. Lacritin mitogenic signaling follows two pathways: Gαi ... Targeted cells signal to NFAT and mTOR if conditions are suitable for proliferation, or to AKT and FOXO3 under conditions of ... Here, it forms a complex with PKCα and PLCγ2 from which downstream mTOR and NFAT signaling is initiated. The upstream Gαi or G ...
ISBN 978-0-393-97767-7. García, AG; García de Diego, AM; Gandía, L; Borges, R; García Sancho, J (2006). "Calcium signaling and ... Hoeflich A, Bielohuby M (2009). "Mechanisms of adrenal gland growth: signal integration by extracellular signal regulated ... Cortisol reduces the capacity of osteoblasts to produce new bone tissue and decreases the absorption of calcium in the ... When activated, it evokes the release of catecholamines from the storage granules by stimulating the opening of calcium ...
... on calcium signalling and regulated secretion in PC12 cells". Biochem. J. 413 (1): 71-80. doi:10.1042/BJ20080441. PMC 2474559. ... "Calsenilin reverses presenilin-mediated enhancement of calcium signaling". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8590-3. doi: ... "Calsenilin enhances apoptosis by altering endoplasmic reticulum calcium signaling". Mol. Cell. Neurosci. 19 (4): 552-9. doi: ... which belong to the neuronal calcium sensor family of proteins. Members of this family are small calcium binding proteins ...
Kobayashi M, Takamatsu K, Saitoh S, Noguchi T (1993). "Myristoylation of hippocalcin is linked to its calcium-dependent ... formation can occur if the matrix domain of human immunodeficiency virus type 1 Gag is substituted by a myristylation signal". ...
The official start to its development started in December 1986 when Merck's president, Edward Scolnick, announced that they would start a comprehensive AIDS research program. They started a laboratory dedicated to AIDS research in West Point, Pennsylvania and placed Emilio Emini in charge of the laboratory.[11] A couple months later on January, 1987, a team of researchers consisting of Emilio Emini, Joel Huff, and Irving Sigal, kickstarted their studies by basing their project off of earlier research on the protease enzyme, renin.[5] They were the ones who started the process of research and development into protease inhibitors and its relation to the virus. Over a year later, in July 1988, Nancy Kohl, Emilio Emini, et al., published in the Proceedings of the National Academy of the Science about the idea of inhibiting the protease.[11] On February, 1989, Manuela Navia, Paula Fitzgerald, et al., published a paper that showed the three-dimensional structure of HIV's protease enzyme.[5] Other ...
The sGP forms a dimeric protein that interferes with the signalling of neutrophils, another type of white blood cell. This ... or calcium hypochlorite (bleaching powder), and other suitable disinfectants may be used at appropriate concentrations.[81][115 ... the signalling proteins STAT1 and STAT2 are activated and move to the cell's nucleus.[51] This triggers the expression of ... Viral replication triggers high levels of inflammatory chemical signals and leads to a septic state.[38] ...
Calcium-sensitive dyes have shown that internal concentrations of calcium increase during bursts. The activation of different ... The pre-BötC complex operates in animals as part of a larger network that receives critical information and signaling inputs ... Other research has also suggested that calcium flow through N-type calcium channels is essential for normal breathing, and is ... voltage gated calcium channels become activated and calcium is able to flow into the cell which usually leads to the release of ...
... both for camouflage and for signalling, in his Historia animalium: "The octopus ... seeks its prey by so changing its colour as ... and an enzyme in the toxic saliva is used to dissolve the calcium carbonate of the shell. It takes about three hours for O. ... signaling, mate defending and eviction of individuals from dens. This is likely the result of abundant food supplies combined ...
"Monitoring FDA MedWatch Reports: Signals for Dabigatran and Metoclopramide" (PDF). QuarterWatch. Institute for Safe Medication ...
Chronic hyperstimulation of opioid receptors results in altered homeostasis of pain signalling pathways in the body with ... "Venom from the platypus, Ornithorhynchus anatinus, induces a calcium-dependent current in cultured dorsal root ganglion cells" ... endotoxins and other signals of infection also increases pain sensitivity as part of sickness behavior, the evolved response to ...
See also: Receptor/signaling modulators • Ion channel modulators. Taxon identifiers. *Wikidata: Q146217 ...
The signal transduction pathway is the mechanism by which the energy of a photon signals a mechanism in the cell that leads to ... This leads to a decrease in the influx of calcium ions into the cell and thus the intracellular calcium ion concentration falls ... Photoreceptors do not signal color; they only signal the presence of light in the visual field. ... Early Notch signaling maintains progenitor cycling. Photoreceptor precursors come about through inhibition of Notch signaling ...
Receptor/signaling modulators. Androgens and antiandrogens. Estrogen receptor modulators. Progesterone receptor modulators. ... aluminum, calcium, gadolinium, magnesium, strontium, zinc). *Dehydroandrosterone. *Dihydrotestosterone. *Estradiol. *L-α-Amino ... Receptor/signaling modulators. Progestogens and antiprogestogens. Androgen receptor modulators. Estrogen receptor modulators. ...
Marine organisms which possess calcium carbonate shells or exoskeletons experience physiological pressure as the carbonate ... "Biological annihilation via the ongoing sixth mass extinction signaled by vertebrate population losses and declines". PNAS ...
Receptor/signaling modulators. Androgens and antiandrogens. Estrogen receptor modulators. Progesterone receptor modulators. ... NMDA induces a calcium flux that allows for synaptic plasticity which is crucial for AHN. ... Bennett NC, Gardiner RA, Hooper JD, Johnson DW, Gobe GC (2010). "Molecular cell biology of androgen receptor signalling". Int. ... Recent results indicate androgens inhibit the ability of some fat cells to store lipids by blocking a signal transduction ...
Foraminifera shells are composed of calcium carbonate (CaCO3) and are found in many common geological environments. The ratio ... Based on the simplifying assumption that the signal can be attributed to temperature change alone, with the effects of salinity ... and δ is δ18O for a calcium carbonate sample). ...
The link was a single nucleotide polymorphism of two genes involved in calcium channel signaling with neurons. One of these ... The underlying mechanism is genes that code for a product that is either used by various cells or has a cascade-like signaling ... Both males and females with larger combs have higher bone density and strength, which allows females to deposit more calcium ... In mating, for many animals the signals and receptors of sexual communication may have evolved simultaneously as the expression ...
See also: Receptor/signaling modulators. Retrieved from "https://en.wikipedia.org/w/index.php?title=Coomassie_Brilliant_Blue& ...
Calcium dipicolinate, the calcium salt of dipicolinic acid, is incorporated into the forespore during this time. The ... this signals to the bacteria that it has reached the end of the animal, and an inactive dispersable morphology is useful. ... Up to 20% of the dry weight of the endospore consists of calcium dipicolinate within the core, which is thought to stabilize ... Dipicolinic acid could be responsible for the heat resistance of the spore, and calcium may aid in resistance to heat and ...
T cell receptor signaling pathway. • segmentation. • positive regulation of receptor recycling. • calcium ion transmembrane ... Wnt signaling pathway[edit]. Wnt signaling pathway has been shown to be involved in several critical steps in embryogenesis and ... negative regulation of apoptotic signaling pathway. • neuron development. • memory. • endoplasmic reticulum calcium ion ... Notch signaling pathway[edit]. In Notch signaling, critical proteolytic reactions takes place during maturation and activation ...
At the hypothalamus, fear-signaling impulses activate both the sympathetic nervous system and the modulating systems of the HPA ... a social signal in salmonoid fish), activation of the HPA axis, and inhibition of aggression. Inclusion of the amino acid L- ...
Kühn, H. and Curran, M., Strontium, Barium and Calcium Chromates, in Artists' Pigments. A Handbook of Their History and ... GHS Signal word Danger GHS hazard statements. H272, H301, H302, H317, H332, H350, H400, H410 ... Kühn, H. and Curran, M., Strontium, Barium and Calcium Chromates, in Artists' Pigments. A Handbook of Their History and ...
See also: Receptor/signaling modulators • Ion channel modulators. Taxon identifiers. *Wikidata: Q35625 ...
"The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell ... protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium ...
"Vitamin D, calcium and prevention of breast cancer: a review". Weill Medical College of Cornell University, Strang Cancer ... "Vitamin D signaling in immune-mediated disorders: Evolving insights and therapeutic opportunities". Laboratory for Experimental ... "Vitamin D and calcium intake in relation to risk of endometrial cancer: a systematic review of the literature". Epidemiology ...
calcium-mediated signaling using extracellular calcium source. • transmembrane transport. • calcium ion transport. • regulation ... This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ... calcium ion transmembrane transport. • camera-type eye development. • cardiac conduction. • calcium ion import. ... high voltage-gated calcium channel activity. • voltage-gated calcium channel activity involved in AV node cell action potential ...
"Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling". Molecular ... CARHSP1: Calcium-regulated heat stable protein 1. *CASP16P: encoding protein Caspase 16, pseudogene ...
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling ... G-protein coupled receptor signaling pathway. • adenylate cyclase-activating G-protein coupled receptor signaling pathway. • ... dopamine receptor signaling pathway. • conditioned taste aversion. • cerebral cortex GABAergic interneuron migration. • glucose ... positive regulation of release of sequestered calcium ion into cytosol. • mating behavior. • behavioral fear response. • ...
... , together with calcium phosphide, is used in floating, self-igniting naval signal flares, such as those ... calcium oxide), Ca3P2 (calcium phosphide), CaS (calcium sulfide), Ca3N2 (calcium nitride), SiC (silicon carbide), etc.). In the ... Production of calcium cyanamideEdit. Calcium carbide reacts with nitrogen at high temperature to form calcium cyanamide:[5] ... Calcium carbide, also known as calcium acetylide, is a chemical compound with the chemical formula of CaC2. Its main use ...
signal transduction. • Wnt signaling pathway, calcium modulating pathway. • Wnt signaling pathway, planar cell polarity pathway ... Wnt signaling pathway involved in dorsal/ventral axis specification. • canonical Wnt signaling pathway. • synapse assembly. • ... signal transducer activity. • Wnt-protein binding. • protein binding. • protein kinase binding. • ubiquitin protein ligase ... Wnt signaling pathway. • embryonic camera-type eye development. • multicellular organism development. • cell surface receptor ...
For instance, serum calcium concentration affects parathyroid hormone synthesis; bluid succar (serum glucose concentration) ... Signal transduction. Skauk't categeries: *Pages wi citations uisin unsupportit parameters. *Airticles conteenin Auncient Greek- ...
See also: Receptor/signaling modulators • Nicotinic acetylcholine receptor modulators • Acetylcholine metabolism/transport ...
The increased calcium availability binds to the calmodulin subunit and activates glycogen phosphorylase kinase. Glycogen ... Upon eating a meal, there is a release of insulin, signaling glucose availability in the blood. Insulin indirectly activates PP ... An increase in AMP concentration, which occurs during strenuous exercise, signals energy demand. AMP activates glycogen ... PLC indirectly causes the release of calcium from the hepatocytes' endoplasmic reticulum into the cytosol. ...