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*  Calcitonin gene-related peptide
... (CGRP) is a member of the calcitonin family of peptides, which in humans exists in two forms, α ... Regulation of the calcitonin gene-related peptide (CGRP) gene is in part controlled by the expression of the mitogen-activated ... The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors". Pharmacol Rev. 54 (2): 233- ... 1992). "Calcitonin gene-related peptide in the regulation of cardiac function". Ann NY Acad Sci. 657: 194-203. doi:10.1111/j. ...
*  Calcitonin gene-related peptide receptor antagonist
Calcitonin gene-related peptide (CGRP) receptor antagonists are a class of drugs that act as antagonists of the calcitonin gene ... Mitsikostas, DD; Reuter, U. "Calcitonin gene-related peptide monoclonal antibodies for migraine prevention: comparisons across ... an Oral Calcitonin Gene Related Peptide Receptor Antagonist". British Journal of Clinical Pharmacology. 79 (5): 831-7. doi: ... Nakasa, T; Ishikawa, M; Takada, T; Miyaki, S; Ochi, M (2015). "Attenuation of cartilage degeneration by calcitonin gene-related ...
*  S100A12
Maayan C, Becker Y, Gesundheit B, Girgis SI (2002). "Calcitonin gene related peptide in familial dysautonomia". Neuropeptides. ... 1996). "Human CAAF1 gene--molecular cloning, gene structure, and chromosome mapping". Biochem. Biophys. Res. Commun. 221 (2): ... gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium. 20 (6): 459-64. doi:10.1016/S0143-4160(96)90087- ... S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be ...
*  Neurotransmission
ACh-vasoactive intestinal peptide (VIP) co-release. ACh-calcitonin gene-related peptide (CGRP) co-release. Glutamate-dynorphin ... For example, striatal "GABAergic neurons" utilize opioid peptides or substance P as their primary cotransmitter. Some neurons ...
*  RCP9
"Entrez Gene: RCP9 calcitonin gene-related peptide-receptor component protein". Yallampalli C, Chauhan M, Thota CS, et al. (2003 ... 2002). "Characterization of calcitonin gene-related peptide (CGRP) receptors and their receptor-activity-modifying proteins ( ... Balkan W, Oates EL, Howard GA, Roos BA (Mar 1999). "Testes exhibit elevated expression of calcitonin gene-related peptide ... 2000). "CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin ...
*  Debbie Lucy Hay
"Regulation of signal transduction by calcitonin gene-related peptide receptors." Trends in pharmacological sciences 31, no. 10 ... "Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes." Molecular pharmacology ... Investigation of the calcitonin receptor-like receptor and receptor activity modifying proteins' at Imperial College London. ...
*  Rimegepant
... is a calcitonin gene-related peptide (CGRP) receptor antagonist. "Drug Profile: Rimegepant". Adis Insight. " ...
*  AKTIP
"A cDNA encoding the calcitonin gene-related peptide type 1 receptor". J Biol Chem. 271 (19): 11325-9. doi:10.1074/jbc.271.19. ... Lesche R, Peetz A, van der Hoeven F, Rüther U (1998). "Ft1, a novel gene related to ubiquitin-conjugating enzymes, is deleted ... AKT-interacting protein is a protein that in humans is encoded by the AKTIP gene. The mouse homolog of this gene produces fused ... This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell ...
*  Neurogenic inflammation
In turn, histamine evokes the release of substance P and calcitonin gene-related peptide; thus, a bidirectional link between ... Durham, PL; Vause, CV (2010). "Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine". CNS ... Calcitonin Gene-Related Peptide (CGRP), neurokinin A (NKA), and endothelin-3 (ET-3). TRPA1 channels stimulated by ... "decrease expression of the proinflammatory neuropeptides calcitonin gene-related peptide and substance P in sensory neurons," ...
*  Development of the endocrine system
This stage is regulated by androgens, the genitofemoral nerve, and calcitonin gene-related peptide. During the second and third ... Studies of gene expression show that a specific complement of genes, such as follistatin and multiple cyclin kinase inhibitors ... Studies in mice have shown that interfering with the HOX15 gene can cause parathyroid gland aplasia, which suggests the gene ... Malformations in the GCM2 gene have resulted in hypoparathyroidism. Studies on SOX3 gene mutations have demonstrated that it ...
*  Alternative splicing
... calcitonin gene related peptide). Examples of alternative splicing in immunoglobin gene transcripts in mammals were also ... The gene encoding the thyroid hormone calcitonin was found to be alternatively spliced in mammalian cells. The primary ... 1982). "Calcitonin mRNA polymorphism: peptide switching associated with alternative RNA splicing events". Proc. Natl. Acad. Sci ... Rosenfeld MG, Amara SG, Roos BA, Ong ES, Evans RM (1981). "Altered expression of the calcitonin gene associated with RNA ...
*  Telcagepant
... acts as a calcitonin gene-related peptide receptor (CRLR) antagonist and blocks this peptide. It is believed to ... The calcitonin gene-related peptide (CGRP) is a strong vasodilator primarily found in nervous tissue. Since vasodilation in the ... Telcagepant (INN) (code name MK-0974) is a calcitonin gene-related peptide receptor antagonist which was an investigational ... December 2008). "Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide ...
*  Parafollicular cell
Kameda Y (1987). "Localization of immunoreactive calcitonin gene-related peptide in thyroid C dells from various mammalian ... Calcitonin lowers blood levels of calcium by inhibiting the resorption of bone by osteoclasts, and its secretion is increased ... Parafollicular cells secrete calcitonin, a hormone that participates in the regulation of calcium metabolism. It is important ... Gkonos, PJ; Tavianini, MA; Liu, CC; Roos, BA (December 1989). "Thyrotropin-releasing hormone gene expression in normal thyroid ...
*  CALCRL
2004). "Calcitonin gene-related peptide and its role in migraine pathophysiology". Eur J Pharmacol. 500 (1-3): 315-30. doi: ... calcitonin gene-related peptide receptor antagonists are under investigation for the treatment of migraine. GRCh38: Ensembl ... 2003). "Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity". Trends Endocrinol. Metab. 13 (6 ... 1996). "A cDNA encoding the calcitonin gene-related peptide type 1 receptor". J. Biol. Chem. 271 (19): 11325-9. doi:10.1074/jbc ...
*  EMA401
AgnII co-localization with substance P and calcitonin gene-related peptide implies its role in nociception. AT2R, the receptor ... 26 (8): 1401-9. doi:10.1016/j.peptides.2005.03.010. PMID 16042980. Alterman M. (2010). "Development of selective non-peptide ... Peptides. 26 (8): 1401-9. doi:10.1016/j.peptides.2005.03.010. PMID 16042980. Sumners C, Horiuchi M, Widdop RE, McCarthy C, ... 26 (8): 1401-9. doi:10.1016/j.peptides.2005.03.010. PMID 16042980. Maree T. Smith, P. & P. Bruce D. Wyse, P. Stephen R. Edwards ...
*  Sankar Ghosh
Inhibition of NF-kappaB activity and enhancement of apoptosis by the neuropeptide calcitonin gene-related peptide. J Biol Chem ... Budde, L.M. and S. Ghosh, Cloning and characterisation of the gene encoding mouse IkappaBbeta. Gene, 2000. 247(1-2): p. 279-86 ... Genes Dev. 2005 Nov 15 Jimi, E. and S. Ghosh. Role of nuclear factor-kappaB in the immune system and bone. Immunol Rev. 2005 ... Genes Dev, 2004. 18(18): p. 2195-224. Zhang, D., et al., A toll-like receptor that prevents infection by uropathogenic bacteria ...
*  Eptinezumab
It is a monoclonal antibody that targets calcitonin gene-related peptides (CGRP) alpha and beta. It is in Phase III clinical ... an antibody to calcitonin gene-related peptide, for the prevention of frequent episodic migraine: A randomised, double-blind, ...
*  RAMP3
2004). "Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like ... CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or ... 2008). "Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide ... 2004). "Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity- ...
*  RAMP2
CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or ... 2008). "Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide ... 2004). "Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity- ... of the cytoplasmic tails of the human receptor activity-modifying protein components of calcitonin gene-related peptide and ...
*  Amylin
1991). "Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin". ... Amylin also acts in bone metabolism, along with the related peptides calcitonin and calcitonin gene related peptide. Rodent ... Westermark P, Wernstedt C, Wilander E, Sletten K (1986). "A novel peptide in the calcitonin gene related peptide family as an ... A non-fibril forming peptide (1-19 residues of human amylin) is toxic like the full-length peptide but the respective segment ...
*  Veterinary acupuncture
These neuropeptides include calcitonin gene-related peptide (CGRP), nerve growth factor, substance P, and vasoactive intestinal ... Gene Bruno and John Ottaviano. In the process of treating thousands of small animals and several hundred horses, Bruno and ... there are several related methods which do not use these, or may use a modified type of needle or stimulator. ... immune-related dysfunction and visceral dysfunction. In 2015, the American Animal Hospital Association (AAHA) and American ...
*  Circumventricular organs
... peptide histidine isoleucine, calcitonin gene-related peptide, substance P and somastotin. However, these probably accumulate ... Peptides. 31 (4): 757-76. doi:10.1016/j.peptides.2010.01.003. PMID 20093161. Morita S.; Miyata S. (2012). "Different vascular ... Other peptides aside from melatonin have been detected in the pineal. They are most likely associated with a type of ... The lack of a blood brain barrier allows the CVOs to act as an alternative route for peptides and hormones in the neural tissue ...
*  RAMP1
"Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like ... CALCRL, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor ... 2008). "Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide ... 2004). "Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity- ...
*  Parabrachial nuclei
"Calcitonin gene-related peptide immunoreactivity in the visceral sensory cortex, thalamus, and related pathways in the rat". ... of neurons in the external lateral parabrachial subnucleus that contain the neurotransmitter calcitonin gene-related peptide ( ... Peptides. 8 (2): 267-283. ISSN 0196-9781. PMID 2884646. Kaur, Satvinder; Pedersen, Nigel P.; Yokota, Shigefumi; Hur, Elizabeth ... "Respiratory-related outputs of glutamatergic, hypercapnia-responsive parabrachial neurons in mice". The Journal of Comparative ...
*  Capsinolol
It is the first beta blocker with an associated calcitonin gene-related peptide releasing activity in the heart. Chen IJ, Yeh ... the first beta-adrenoceptor blocker with an associated calcitonin gene-related peptide releasing activity in the heart". Br J ...
*  Sumatriptan
... 's primary therapeutic effect, however, is in its inhibition of the release of Calcitonin gene-related peptide (CGRP ... "Sumatriptan Causes Parallel Decrease in Plasma Calcitonin Gene-Related Peptide (CGRP) Concentration and Migraine Headache ...