The compound 13-cis retinoic acid was first studied in the 1960s at Roche Laboratories in Switzerland by Werner Bollag as a treatment for skin cancer. Experiments completed in 1971 showed that the compound was likely to be ineffective for cancer and, surprisingly, that it could be useful to treat acne. However, they also showed that the compound was likely to cause birth defects, so in light of the events around thalidomide, Roche abandoned the product. In 1975, Gary Peck and Frank Yoder independently rediscovered the drug's use as a treatment of cystic acne while studying it as a treatment for lamellar ichthyosis, and published that work. Roche resumed work on the drug. In clinical trials, subjects were carefully screened to avoid including women who were or might become pregnant. Roche's New Drug Application for isotretinoin for the treatment of acne included data showing that the drug caused birth defects in rabbits. The FDA approved the application in 1982. Scientists involved in the ...
"calcinosis_cutis_2_060122". Derm Atlas. Archived from the original on 5 February 2007. Retrieved 13 March 2012.. ...
"Gastric mucosal calcinosis: clinicopathologic considerations". Advances in Anatomic Pathology. 14 (3): 224-8. doi:10.1097/PAP. ... Drowsiness Headache Gastric mucosal calcinosis Heart valve calcification Hypercalcemia Increased intracranial pressure ...
... calcinosis (calcium deposits in blood vessels); atherosclerosis (blockage of blood vessels); type 2 diabetes; loss of bone mass ...
Enzootic Calcinosis Archived 2014-07-28 at the Wayback Machine. Gruenberg MS, PhD, DECAR DECBHM. W.G., April 2014. Enzootic ... Calcinosis. The Merck Veternary Manual. Merck Sharp & Dohme, Whitehouse Station, NJ, USA. Topical Agents (Toxicity) Archived ...
TSC2 Tumoral calcinosis, familial, normophosphatemic; 610455; SAMD9 Tumoral calcinosis, hyperphosphatemic; 211900; KL Tumoral ... calcinosis, hyperphosphatemic, familial; 211900; FGF23 Tumoral calcinosis, hyperphosphatemic, familial; 211900; GALNT3 Tyrosine ...
"calcinosis_cutis_2_060122". Derm Atlas. Retrieved 13 March 2012. "Calcium Pyrophosphate Dihydrate Deposition Disease: Synovial ...
Calcinosis cutis is condition in which there are irregular nodular deposits of calcium salts in skin and subcutaneous tissue. ... Calcinosis Monckeberg's arteriosclerosis "Cell Injury". Bertazzo, Sergio; Gentleman, Eileen; Cloyd, Kristy L.; Chester, Adrian ...
Dystrophic calcinosis cutis has also been reported. Other serious sequelae include sialolithiasis of the submandibular gland ... Oga, A.; Kadowaki, T.; Hamanaka, S.; Sasaki, K. (1998). "Dystrophic calcinosis cutis in the skin below the mandible of a ...
Dereure O (May 2007). "[SAMD9 mutation in normophosphatemic familial tumoral calcinosis]". Annales De Dermatologie Et De ... "A deleterious mutation in SAMD9 causes normophosphatemic familial tumoral calcinosis". American Journal of Human Genetics. 79 ( ...
Gorospe M, Fadare O (May 2007). "Gastric mucosal calcinosis: clinicopathologic considerations". Advances in Anatomic Pathology ...
2007). "Tumoral calcinosis presenting with eyelid calcifications due to novel missense mutations in the glycosyl transferase ... 2006). "Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O- ... cause familial tumoral calcinosis". Nat Genet. 36 (6): 579-81. doi:10.1038/ng1358. PMID 15133511. "Entrez Gene: GALNT3 UDP-N- ... "Two novel nonsense mutations in GALNT3 gene are responsible for familial tumoral calcinosis". J. Hum. Genet. 52 (5): 464-8. doi ...
It is a part of CREST syndrome, referring to the five main features: calcinosis, Raynaud syndrome, esophageal dysmotility, ... Winterbauer RH (1964). "Multiple telangiectasia, Raynaud's phenomenon, sclerodactyly, and subcutaneous calcinosis: a syndrome ...
Calcinosis Fahr's syndrome Muscular atrophy "OMIM Entry - # 259050 - PRIMROSE SYNDROME; PRIMS". omim.org. Retrieved 6 August ...
Kalani, MY; Martirosyan, NL; Little, AS; Kakarla, UK; Theodore, N (Dec 2011). "Tumoral calcinosis presenting as a deformity of ...
Bonazza S, La Morgia C, Martinelli P, Capellari S (August 2011). "Strio-pallido-dentate calcinosis: a diagnostic approach in ... Loeb JA (March 1998). "Functional improvement in a patient with cerebral calcinosis using a bisphosphonate". Mov. Disord. 13 (2 ...
Some children develop calcinosis, which are calcium deposits under the skin. The rash is the source of the "dermato-" part of ... calcinosis and neopterin. Once a diagnosis of JDMS is made, the treatment is often a 3-day course of Intravenous ("pulse") ... calcinosis, dysphonia and nailfold capillaroscopy. Other useful criteria include myositis-specific or -related antibodies, ...
Calcinosis cutis Skin lesion List of cutaneous conditions James, William D.; Berger, Timothy G.; et al. (2006). Andrews' ...
Other: facial pain due to trigeminal neuralgia, hand paresthesias, headache, stroke, fatigue, calcinosis and weight loss. ...
2000). Enzootic calcinosis in 16 cows from 6 dairy farms in Unterengadin. Schweiz Arch Tierheilkd. 142:6 333-8. Braun, U., et ... 2000). Enzootic calcinosis in goats caused by golden oat grass (Trisetum flavescens). Veterinary Record 146 161-2. Grabner, A ... 1985). Enzootic calcinosis in the horse. Tierarztl Prax Suppl. 1 84-93. Ess. Agrostogr. 88, 153. 1812 GrassBase entry: Trisetum ... This grass is noted for being toxic to livestock, causing calcinosis, the deposition of calcium in soft tissues including ...
Lesions may also appear on the ear and eyelid.[citation needed] Calcinosis cutis Skin lesion List of cutaneous conditions ... Subepidermal calcified nodule (also known as a "solitary congenital nodular calcification", and "Winer's nodular calcinosis") ...
CREST causes thickening and tightening of the skin with deposition of calcific nodules ("calcinosis"). Raynaud's phenomenon is ... The acronym "CREST" refers to the five main features: calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, ... Scleroderma Winterbauer RH (1964). "Multiple telangiectasia, Raynaud's phenomenon, sclerodactyly, and subcutanious calcinosis: ...
Typical clinical features include jaundice, elevated blood levels of alkaline phosphatase, calcinosis cutis, telangiectasias, ...
... renal insufficiency and calcinosis. Calcium forms complexes with a number of pharmaceutical drugs, reducing their ...
Loss of FGF23 activity is thought to lead to increased phosphate levels and the clinical syndrome of familial tumor calcinosis ...
... additional calcium used as a phosphate binder may cause hypercalcemia and tissue-damaging calcinosis. One may avoid these ...