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*  WormBase
The annotated genomes of Caenorhabditis elegans, Caenorhabditis briggsae, Caenorhabditis remanei, Caenorhabditis brenneri, ... elegans protein-coding genes and ~16,000 C. elegans non-coding genes; Gene families; Orthologies; Genomic transcription factor ... WormBase is an online biological database about the biology and genome of the nematode model organism Caenorhabditis elegans ... The protein products of gene are created by translating the CDS sequences. Each unique protein sequence is given a unique ...
*  FERM domain
Protein-tyrosine phosphatases PTPN14 and PTP-D1, PTP-RL10 and PTP2E. Caenorhabditis elegans protein phosphatase ptp-1. Chishti ... Ezrin, moesin, and radixin are highly related proteins (ERM protein family), but the other proteins in which the FERM domain is ... In molecular biology, the FERM domain (F for 4.1 protein, E for ezrin, R for radixin and M for moesin) is a widespread protein ... Non-receptor tyrosine-protein kinase TYK2. Protein-tyrosine phosphatases PTPN3 and PTPN4, enzymes that appear to act at ...
*  Protein unc-119 homolog
... a mammalian ortholog of the Caenorhabditis elegans protein unc119, to synaptic ribbons of photoreceptor synapses". J. Biol. ... The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans ... Protein unc-119 homolog A is a protein that in humans is encoded by the UNC119 gene. This gene is enriched in the ... 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi: ...
*  CTNS (gene)
Non-human protein homologs for cystinosin include ERS1 in Saccharomyces cerevisiae (yeast cells) and the Caenorhabditis elegans ... CTNS is the gene that encodes the protein cystinosin in humans. Cystinosin is a lysosomal seven-transmembrane protein that ... The protein obeys Michaelis-Menton kinetics and has an associated KM of 278 ± 49 µM. Cystinosin functions as a symporter which ... Variation in the encoded cystinosin protein results in an inhibition or loss in its ability to transport cysteine out of the ...
*  Crustacean neurohormone family
Caenorhabditis elegans uncharacterised protein ZC168.2. These neurohormones are peptides of 70 to 80 amino acid residues which ... In molecular biology, the crustacean neurohormone family of proteins is a family of neuropeptides expressed by arthropods. The ...
*  XMAP215-Dis1 family
The second group consists of only the Caenorhabditis elegans protein zyg-9, which has three TOG domains. It is similar, though ... Matthews, Lisa; Philip Carter; Danielle Thierry-Mieg; Ken Kemphues (June 1998). "ZYG-9, A Caenorhabditis elegans Protein ... This protein was discovered in 1999. DdCP224: Dictyostelium discoideum Centrosomal Protein. This protein's size is ... This special property classifies this protein family as plus-end tracking proteins (+TIPs). The basic structure of the protein ...
*  IMD domain
Caenorhabditis elegans M04F3.5 protein. The vertebrate IRSp53/MIM family is divided into two major groups: the IRSp53 subfamily ... Vertebrate brain-specific angiogenesis nhibitor 1-associated protein 2-like proteins 1 and 2 (BAI1-associated protein 2-like ... Vertebrate ABBA-1 (MTSS1L), a MIM-related protein. Vertebrate brain-specific angiogenesis inhibitor 1-associated protein 2 ( ... a multifunctional adaptor protein that links Rac1 with a Wiskott-Aldrich syndrome family verprolin-homologous protein 2 (WAVE2/ ...
*  UNC93B1
This gene encodes a protein with similarity to the Caenorhabditis elegans unc93 protein. The Unc93 protein is involved in the ... Unc-93 homolog B1 (C. elegans), also known as UNC93B1, is a protein which in humans is encoded by the UNC93B1 gene. ... This protein is an intrinsic membrane protein that spans the membrane twelve times. It is found in the endoplasmic reticulum ... Unc93B1 protein appears to be involved in the innate immune response. Defects in the protein predispose to hypersensitity to ...
*  Immunoglobulin C2-set domain
Chothia C, Teichmann SA (2000). "Immunoglobulin superfamily proteins in Caenorhabditis elegans". J. Mol. Biol. 296 (5): 1367-83 ... "Protein-Protein Recognition: Juxtaposition of Domain and Interface Cores in Immunoglobulins and Other Sandwich-like Proteins". ... Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. ... CD2 displays structural and functional similarities with African swine fever virus (ASFV) LMW8-DR, a protein that is involved ...
*  KX blood-group antigen family
... a Caenorhabditis elegans protein implicated in controlling the kinetics of apoptosis and a homologue of the XK family proteins ... CED-8, the only Caenorhabditis elegans Xk-family homolog, also promoted apoptotic PtdSer exposure and cell-corpse engulfment. ... "Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization". Nature ... Two covalently linked proteins, Kell and XK, constitute the Kell blood group system. Kell, a 93-Kd type II glycoprotein, is ...
*  SMAD (protein)
A similar screen done in the Caenorhabditis elegans protein SMA (from gene sma for small body size) revealed three genes, Sma-2 ... Savage C, Das P, Finelli AL, Townsend SR, Sun CY, Baird SE, Padgett RW (January 1996). "Caenorhabditis elegans genes sma-2, sma ... Thus, the two proteins could be caught in a "vicious cycle" of regulation. Pin1 causes both itself and Smad2 to be associated ... Therefore, downregulating ID proteins is a pathway by which TGF-B signaling could arrest the cell cycle. In a DNA microarray ...
*  Ced-3
... is one of the major protein components of the programmed cell death (PCD) pathway for Caenorhabditis elegans. There are ... "ced-3 Cell death protein 3 [ Caenorhabditis elegans ]". The National Center for Biotechnology Information. 2017-10-12. Shaham S ... elegans but for mammals as well. One of the main roles of the ced-3 protein in C. elegans is to help the development and growth ... "Direct physical interaction between the Caenorhabditis elegans 'death proteins' CED-3 and CED-4". FEBS Letters. 406 (1-2): 189- ...
*  Synaptic vesicle
"The Caenorhabditis elegans JIP3 Protein UNC-16 Functions As an Adaptor to Link Kinesin-1 with Cytoplasmic Dynein". Journal of ... Trafficking proteins are more complex. They include intrinsic membrane proteins, peripherally bound proteins, and proteins such ... In C. elegans the major motor for synaptic vesicles is UNC-104. There is also evidence that other proteins such as UNC-16/ ... however none of the identified protein interactions between the vesicle proteins and release site proteins can account for the ...
*  BED zinc finger
Caenorhabditis elegans Dpy-20 protein, a predicted cuticular gene transcriptional regulator; Drosophila BEAF (boundary element- ... In molecular biology the BED-type zinc finger domain is a protein domain which was named after the Drosophila proteins BEAF and ... Some proteins known to contain a BED domain include animal, plant and fungi AC1 and Hobo-like transposases; ... Aravind L (September 2000). "The BED finger, a novel DNA-binding domain in chromatin-boundary-element-binding proteins and ...
*  Galactose binding lectin domain
The hypothetical B0457.1, F32A7.3A and F32A7.3B proteins from Caenorhabditis elegans. Ozeki Y, Matsui T, Suzuki M, Titani K ( ... In molecular biology, the galactose binding lectin domain is a protein domain. It is found in many proteins including the ... homologous to the SUEL protein has been identified in the following proteins: Plant beta-galactosidases EC 3.2.1.23 (lactases ... This protein is composed of three tandem repeat domains homologous to the SUEL lectin domain. All cysteine positions of each ...
*  RBFOX1
"Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals". Molecular and Cellular ... or hexaribonucleotide-binding protein 1 (HRNBP1) or RNA binding protein, fox-1 homolog (Rbfox1), is a protein that in humans is ... Rbfox1 has an RNA recognition motif that is highly conserved among RNA-binding proteins. Rbfox1, and the related protein Rbfox2 ... "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): ...
*  NeuN
Underwood JG, Boutz PL, Dougherty JD, Stoilov P, Black DL (2005). "Homologues of the Caenorhabditis elegans Fox-1 protein are ... Fox-3 is one of a family of mammalian homologues of the Fox-1 protein, originally discovered in the nematode worm C. elegans as ... a protein originally found in the nematode worm C. elegans. Western blotting shows that mAb A60 binds to two bands of apparent ... a homologue to sex-determining genes in Caenorhabditis elegans, is a neuronal nuclear antigen that is commonly used as a ...
*  EMI domain
"EMI domains are widespread and reveal the probable orthologs of the Caenorhabditis elegans CED-1 protein". Biochem. Biophys. ... Caenorhabditis elegans ced-1, a transmembrane receptor that mediates cell corpse engulfment. Doliana R, Bot S, Bonaldo P, ... It has been suggested that the EMI domain could be a protein-protein interaction module, as the EMI domain of EMILIN-1 was ... Vertebrate Emu proteins, which could interact with several different extracellular matrix components and serve to connect and ...
*  Cell nucleus
"Stress induced nuclear granules form in response to accumulation of misfolded proteins in Caenorhabditis elegans". BMC Cell ... The PML protein is the key organizer of these domains that recruits an ever-growing number of proteins, whose only common known ... The nuclear lamina is composed mostly of lamin proteins. Like all proteins, lamins are synthesized in the cytoplasm and later ... The composition by dry weight of the nucleus is approximately: DNA 9%, RNA 1%, Histone Protein 11%, Residual Protein 14%, ...
*  Cell polarity
... a Mammalian Homologue of Caenorhabditis elegans Polarity Protein PAR-3". J Cell Biol. 143 (1): 95-106. doi:10.1083/jcb.143.1.95 ... "Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans". Development. 125 ( ... proteins), 2) asymmetric localization of specific proteins or RNAs within cells (which is often mediated by the cytoskeleton), ... 3) concentration gradients of secreted proteins across the embryo such as Wnt, Nodal, and Bone Morphogenic Proteins (BMPs), and ...
*  Epithelial polarity
... a Mammalian Homologue of Caenorhabditis elegans Polarity Protein PAR-3". J Cell Biol. 143 (1): 95-106. doi:10.1083/jcb.143.1.95 ... These molecules are the proteins Cdc42, atypical protein kinase C (aPKC), Par6, Par3/Bazooka/ASIP. Crumbs, "Stardust" and ... Crumbs is the only transmembrane protein in this list and the Crumbs complex serves as an apical cue to keep the aPKC complex ... Apical membrane proteins are trafficked from the Golgi to the apical, rather than baso-lateral, membrane because apical ...
*  Shigeo Ohno
... a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3". The Journal of Cell Biology. 143 (1): 95-106. doi: ... which is mammalian homologue of Caenorhabditis elegans Par3. This led to the finding of a conserved Par3-Par6-atypical PKC ... In 1998, he and his colleagues found the atypical PKC-specific interacting protein (ASIP) ... known for his pioneer research on Protein Kinase C and cell polarity. Ohno was born in 1952 in Niigata prefecture, Japan, and ...
*  Gluconeogenesis
"Bifunctional glyoxylate cycle protein of Caenorhabditis elegans: a developmentally regulated protein of intestine and muscle". ... Transport of PEP across the mitochondrial membrane is accomplished by dedicated transport proteins; however no such proteins ... it triggers phosphorylation of enzymes and regulatory proteins by Protein Kinase A (a cyclic AMP regulated kinase) resulting in ... From breakdown of proteins, these substrates include glucogenic amino acids (although not ketogenic amino acids); from ...
*  Richard I. Morimoto
Neuronal Signaling Modulates Protein Homeostasis in Caenorhabditis elegans Postsynaptic Muscle Cells. Genes and Development: 21 ... Polyglutamine Proteins at the Pathogenic Threshold Display Neuron-Specific Aggregation in a Pan-Neuronal C. elegans Model. ... Polyglutamine Aggregates Alter Protein Folding Homeostasis in C. elegans. Proc. Natl. Acad. Sci. USA. 97: 5750-5755 (2000). Shi ... Neuronal Circuitry Regulates the Response of C. elegans to Misfolded Proteins. Proc. Natl. Acad. Sci. U.S.A. 108: 14204-14209, ...
*  UPF3A
... a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1". RNA. 9 (1 ... This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It ... Regulator of nonsense transcripts 3A is a protein that in humans is encoded by the UPF3A gene. This gene encodes a protein that ... Caenorhabditis elegans SMG-4)". Mol Cell Biol. 21 (1): 209-23. doi:10.1128/MCB.21.1.209-223.2001. PMC 88795 . PMID 11113196. ...
*  WIPI2
2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics". ... WD repeat domain phosphoinositide-interacting protein 2 is a protein that in humans is encoded by the WIPI2 gene. WD40 repeat ... 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs ... The Atg proteins regulate autophagy, which is a lysosomal degradation pathway required for maintaining cell health, surviving ...
*  UPF2
... a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1". Rna. 9 (1 ... This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are ... Regulator of nonsense transcripts 2 is a protein that in humans is encoded by the UPF2 gene. This gene encodes a protein that ... Caenorhabditis elegans SMG-4)". Molecular and Cellular Biology. 21 (1): 209-23. doi:10.1128/MCB.21.1.209-223.2001. PMC 88795 . ...