A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction". The ... an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a ... an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a ... and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions". The Journal of Cell Biology. 144 (5): ...
Thus, E-cadherin forms adherens junctions that connect the actin cytoskeletons of neighbouring cells. Adherens junctions are ... but polarized membranes are essential for maintaining E-cadherin at adherens junctions. Biology portal Cell polarity Bruce ... All epithelial cells express the transmembrane adhesion molecule E-cadherin, a cadherin which localises most prominently to the ... junction between the apical and lateral membranes. The extra-cellular domains of E-cadherin molecules from neighbouring cells ...
1999). "Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through ... This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant ... a Component of Cell-Cell Adherens Junctions". Mol. Cell. Biol. 20 (8): 2865-73. doi:10.1128/MCB.20.8.2865-2873.2000. PMC 85510 ...
α-catenin participates in the formation and stabilization of adherens junctions by binding to β-catenin-cadherin complexes in ... are known as adherens junctions and they typically include at least cadherin, β-catenin, and α-catenin. Catenins play roles in ... The exact mechanisms by which α-catenin acts in adherens junctions is still unclear; however, it is likely that α-catenin acts ... For instance, when an epithelial layer is complete and the adherens junctions indicate that the cell is surrounded, β-catenin ...
This transition occurs through the loss of epithelial cadherin, tight junctions, and adherens junctions on the cell membranes ... The EMT occurs as a result of Wnt signaling, the influence of Sox genes and the loss of E-cadherin from the cell surface. NCCs ... an oncogene associated with the down-regulation of epithelial cadherin. Both formation of the primitive streak and mesenchymal ... additionally require the repression of N-cadherin, and neural cell adhesion molecule. NCCs ingress into the embryo from the ...
"Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin ... Leckband has shown that the velcro-like cadherins are not only involved with holding cells together, but that they perform ... Under tensional stress, the cadherin growth factor interaction is disrupted, which switches on tissue growth signalling ... "Mechanical disruption of E-cadherin complexes with epidermal growth factor receptor actuates growth factor-dependent signaling ...
2007). "Type Igamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct ...
p0071 binds E-cadherin at adherens junctions, which are important for maintenance of cell architecture in epithelial tissues, ... interacts with the adherens junction protein p0071 to regulate cell-cell adhesion". PLOS ONE. 7 (11): e47842. Bibcode:2012PLoSO ... Additional supporting evidence includes reduction in E-cadherin expression and increased alveolar apoptosis in lungs from lung- ... April 2014). "Folliculin controls lung alveolar enlargement and epithelial cell survival through E-cadherin, LKB1, and AMPK". ...
An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a ... An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a ... Yoon M, Spear PG (2002). "Disruption of Adherens Junctions Liberates Nectin-1 To Serve as Receptor for Herpes Simplex Virus and ... is an adhesion molecule found in a wide range of tissues where it localizes in various junctions such as the adherens junction ...
Through SRC, EFS may also negatively regulate expression of E-cadherin at adherens junctions, a function that has been reported ...
... they localize to a cell adhesion structure such as focal adhesion or adherens junction. 2. they directly interact with one of ... Cell-cell adhesion is primarily mediated by cadherin receptors and therefore the adhesome of cell-cell adhesion is referred to ... functional modularity in the adherens junction". Current Opinion in Cell Biology. 36: 32-40. doi:10.1016/j.ceb.2015.06.008. ... Later, with the emergence of the cadherin-catenin-actin structure they were co-opted into the cadhesome. Whittaker, Charles A ...
Actin dynamics modulate mechanosensitive immobilization of E-cadherin at adherens junctions », Nature Cell Biol., (2014), 16, p ... Biochemical and biophysical origins of cadherin selectivity and adhesion strength », Current Op. Cell Biol., (2012), 24, p. 614 ...
... was shown to remove ubiquitin chains from VE-cadherin to prevent loss of VE-cadherin at the endothelial adherens junctions. ...
Conversely, cell-cell adhesion via tight and adherens junctions, along with anchoring to extra cellular matrix (ECM) via ... Myosin light chain pulls the actin stress fiber attached to the cadherin, resisting the force of the adjacent cell's cadherin. ... Cunningham KE, Turner JR (July 2012). "Myosin Light Chain Kinase: Pulling the Strings of Epithelial Tight Junction Function". ... regulates epithelial tight junction permeability". The Journal of Biological Chemistry. 279 (53): 55506-13. doi:10.1074/jbc. ...
... tight junctions, adherens junctions, desmosomes, hemidesmosomes, and gap junctions. Tight junctions are a pair of trans- ... They are made up of the integrin (a transmembrane protein) instead of cadherin. They attach the epithelial cell to the basement ... Adherens junctions are a plaque (protein layer on the inside plasma membrane) which attaches both cells' microfilaments. ... Gap junctions connect the cytoplasm of two cells and are made up of proteins called connexins (six of which come together to ...
... where it co-localizes with E-cadherin and β-catenin at cell-cell adherens junctions, suggesting FAM110A's involvement in the ...
α-catenin and β-catenin are integral components of adherens junctions, which bind together to produce cadherin-α-catenin-β- ... such as the formation of adherens junctions, tight junctions and focal adhesions. Adherens junctions are a type of cell-cell ... This may serve as a mechanism for how actin is recruited to adherens junctions. Tight junctions, or zona occludens, are the ... Hartsock, Andrea; Nelson, W. James (March 2008). "Adherens and tight junctions: Structure, function and connections to the ...
... is a major cytoplasmic component of both desmosomes and adherens junctions, and is the only known constituent ... Plakoglobin forms distinct complexes with cadherins and desmosomal cadherins. ... Shasby DM, Ries DR, Shasby SS, Winter MC (Jun 2002). "Histamine stimulates phosphorylation of adherens junction proteins and ... Plakoglobin is a cytoplasmic component of desmosomes and adherens junctions structures located within intercalated discs of ...
... tight junctions (including occludins and claudins), adherens junctions, and cadherins. January 25, 1955: Publication of the ... Furuse, M. (December 15, 1993). "Occludin: a novel integral membrane protein localizing at tight junctions". The Journal of ... Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin". The Journal of Cell ...
The GSCs are physically attached to the cap cells by Drosophila E-cadherin (DE-cadherin) adherens junctions and if this ... Song X, Zhu CH, Doan C, Xie T (June 2002). "Germline stem cells anchored by adherens junctions in the Drosophila ovary niches ... whereby differentiating spermatocytes must traverse the tight junctions. These tight junctions form the blood testis barrier ( ... E cadherin expression on SSCs in mice, unlike in Drosophila, have been shown to be dispensable as the transplantation of ...
... of the atypical myosin Dachs by the Fat and Dachsous cadherins is responsible for polarising tension at adherens junctions and ... Aguilar-Aragon, M.; Bonello, T.T.; Bell, G.P.; Fletcher, G.C; Thompson, B.J. (2015). "Adherens junction remodeling during ... remodelling of adherens junctions, and removal of the Lgl protein from the plasma membrane to allow spindle orienting factors ...
An autoinhibited structure of alpha-catenin and its implications for vinculin recruitment to adherens junctions. J Biol Chem. ... Simply put, in the cadherin-catenin complex, cadherin molecules are linked through beta-catenin to α-Catenin, which then binds ... Kobielak A, Pasolli HA, Fuchs E. Mammalian formin-1 participates in adherens junctions and polymerization of linear actin ... 9. Takeichi M. Dynamic contacts: rearranging adherens junctions to drive epithelial remodelling. Nature Reviews Molecular Cell ...
... at the plasma membrane in association with the cadherin/catenin complex is important for the maintenance of adherens junction ... α-catenin and β-catenin in pancreatic acinar cells prior to the dissolution of adherens junctions in a rat model of ... "Protein tyrosine phosphatase kappa and SHP-1 are involved in the regulation of cell-cell contacts at adherens junctions in the ... PTPRK has been shown to interact with: Beta-catenin, E-cadherin (CDH-1), Epidermal growth factor receptor (EGFR), HER2, ...
... "puncta adherens", which are similar to an adherens junction. Different classes of adhesion molecules, like SynCAM, cadherins ... An important family of adhesion molecules is constituted by the cadherins, whose different combination on targeting cells allow ... Arikkath, Jyothi; Reichardt, Louis F. (September 2008). "Cadherins and catenins at synapses: roles in synaptogenesis and ... where the N-cadherin molecule is present only in those layers that receive axons form the retina. Matrix factors and secreted ...
"A novel kind of tumor type-characteristic junction: plakophilin-2 as a major protein of adherens junctions in cardiac myxomata ... Plakophilin 2 is expressed in skin and cardiac muscle, where it functions to link cadherins to intermediate filaments in the ... Additionally, plakophilin-2 was found in adherens junctions of cardiac myxomata tumors analyzed, and absent in patients with ... couple the assembly of adherens junctions to the translocation of desmosome precursors in newly formed cell-cell junctions. ...
... in colonic enterocytes strengthens E-cadherin-based adherens junctions to maintain lateral cell-cell contacts and ... "Overexpression of CD97 in intestinal epithelial cells of transgenic mice attenuates colitis by strengthening adherens junctions ... Ectopic CD97 expression upregulates the expression of N-cadherin and β-catenin in HT1080 fibrosarcoma cells leading to enhanced ... "GPS autoproteolysis is required for CD97 to up-regulate the expression of N-cadherin that promotes homotypic cell-cell ...
Through its effects on E-cadherin and beta-catenin, which form the adherens junction and promote cell adhesion, NDRG1 also ... Is a Rab4a effector involved in vesicular recycling of E-cadherin". PLOS ONE. 2 (9): e844. Bibcode:2007PLoSO...2..844K. doi: ... E-cadherin, and mothers against decapentaplegic homolog 4 (SMAD4). ...
... are shifted to the periphery of the active zone and form the puncta adherens junction (PAJ). The PAJ functions much like the ... Many cadherins in the central nervous system exhibit distinct spatial and temporal expression patterns. For example, N-cadherin ... adherens junctions in epithelial tissues. The displacement of these CAMs and the formation of this junction provides the ... Cadherins are calcium- dependent, homophilic cell adhesion molecules that form complexes with cytosolic partners known as ...
In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the ... It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, ...
... αE-catenin is present in cell to cell regions known as adherens junctions which lie within intercalated discs; these junctions ... Aberle H, Schwartz H, Kemler R (Jun 1996). "Cadherin-catenin complex: protein interactions and their implications for cadherin ... αE-catenin is highly expressed in cardiac muscle and localizes to adherens junctions at intercalated disc structures where it ... αE-catenin also plays a role in epithelial tissue, both at adherens junctions and in signaling pathways. In cardiomyocytes, ...
Adherens junctions are composed primarily of E-cadherin, alpha and beta catenins and other proteins such as actin and myosin. ... E-cadherin is an important transmembrane molecule in creating and facilitating adherens junctions, particularly in epithelial ... Vezatin co-localises with E-cadherin at these cell-cell junctions suggesting that in fact it is involved within adherens ... The adherens junctions in the Sertoli cells is one of the only epithelial cell-cell junction that lacks the expression of ...