Layer II projects primarily to dentate gyrus and hippocampal region CA3; layer III projects primarily to hippocampal region CA1 ... Alterations in the neural activity across the brain region results in an observed "traveling wave" phenomena across the MEC ... An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. ... It is usually divided into medial and lateral regions with three bands with distinct properties and connectivity running ...

"Differential effects of PACAP-38 on synaptic responses in rat hippocampal CA1 region". Learning & Memory. 8 (5): 265-271. doi: ... "PACAP-38 enhances excitatory synaptic transmission in the rat hippocampal CA1 region". Learning & Memory. 7 (5): 303-311. doi: ... "The transient depression of hippocampal CA1 LTP induced by chronic intermittent ethanol exposure is associated with an ... a brain region critical in mediating the behavioral effects of alcohol consumption. In 2005, Roberto became an assistant ...

While this was a temporary case of amnesia, it still shows the importance of the CA1 region of the hippocampus in memory. ... This virus affected the hippocampal regions of the brain. Because of this damage, Wearing was unable to remember information ... One reason that patients could not form new episodic memories is likely because the CA1 region of the hippocampus has a lesion ... In addition, specific areas of the hippocampus (the CA1 region) are involved with memory. Research has also shown that when ...

"Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice". Nature. 375 ( ... However, recent research on hippocampal silent synapses shows that while they may indeed be a developmental landmark in the ... 193-5. Kullmann DM (May 1994). "Amplitude fluctuations of dual-component EPSCs in hippocampal pyramidal cells: implications for ... mediated by AMPARs and NMDARs in hippocampal neurons. More direct evidence came from experiments where only a few axons were ...

CA1), terminate on the pyramidal cells of the CA1 region. Damage to any of these hippocampal pathways is sufficient to cause ... "Blockade of long-term potentiation in rat hippocampal CA1 region by inhibitors of protein synthesis". J. Neurosci. 4 (12): 3080 ... Huerta P.T., Tonegawa S., Tsien J.Z. (1996). "The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity ... In summary, although the CA1 and DG regions are closely related physically and functionally, they react differently to insults ...

Hippocampal sulcus (sulc.) or fissure is a cell-free region that separates the CA1 field from the dentate gyrus. Because the ... They pass through hippocampal commissures to reach contralateral regions of hippocampus. Hippocampal commissures have dorsal ... from CA4 through CA1 (only CA3 and CA1 are labeled). The CA regions are also structured depthwise in clearly defined strata (or ... Region CA1 receives input from the CA3 subfield, EC layer III and the nucleus reuniens of the thalamus (which project only to ...

... severe neuronal cell loss in hippocampal subfield cornum Ammonis 1 (CA1) and some neuronal cell loss in hippocampal subfield ... Electroencephalographic and surgical studies show that temporal lobe seizures arise from hippocampal regions with severe ... Stauder linked mesial temporal lobe seizures to hippocampal sclerosis.: 566 Hippocampal sclerosis was later found to occur in ... 8-9 Pyramidal cell loss and gliosis occurs in the CA1 sector, subiculum, entorhinal cortex, and the amygdala. The hippocampal ...

"Etomidate Does Not Alter Recovery after Anoxia of Evoked Population from the CA1 Region of Rat Hippocampal Slices". ... Amorim, P; Cottrell, JE; Kass, IS (1999). "Effect of Small Changes in Temperature on CA1 Pyramidal Cells from Rat Hippocampal ... and Morphology in Rat Hippocampal Slice CA-1 Pyramidal Cells". Stroke. 30 (11): 2400-2407. doi:10.1161/01.str.30.11.2400. PMID ... "The Effect of Fentanyl on Electrophysiologic Recovery of CA1 Pyramidal Cells from Anoxia in the Rat Hippocampal Slice". ...

Kemp A, Manahan-Vaughan D (April 2008). "The hippocampal CA1 region and dentate gyrus differentiate between environmental and ... exhibits frequency-dependent properties in synaptic plasticity and behavioural metaplasticity in the hippocampal CA1 region in ... Her findings with regard to the role of hippocampal long-term depression in memory processing have contributed to a revised ... Lemon N, Manahan-Vaughan D (September 2012). "Dopamine D1/D5 receptors contribute to de novo hippocampal LTD mediated by novel ...

CA1 is the first region in the hippocampal circuit, from which a major output pathway goes to layer V of the entorhinal cortex ... The pyramidal cells in CA3 send some axons back to the dentate gyrus hilus, but they mostly project to regions CA2 and CA1 via ... Diagram of hippocampal regions in a rat brain. Jerome Engel TAP, ed. Epilepsy: A Comprehensive Textbook in Three Volumes. ... There are four hippocampal subfields, regions in the hippocampus proper which form a neural circuit called the trisynaptic ...

... blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro". Brain Research. 452 (1-2): 57-65. doi:10.1016/0006 ... An analysis of CA1 hippocampal synapses revealed that inhibitory avoidance training induced in vivo AMPA receptor ... Tonegawa found that by impairing the NMDA receptor, specifically by genetically removing the NR1 subunit in the CA1 region, the ... McHugh TJ, Blum KI, Tsien JZ, Tonegawa S, Wilson MA (December 1996). "Impaired hippocampal representation of space in CA1- ...

"Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor ... Korte, M; Carroll, P; Wolf, E; Brem, G; Thoenen, H; Bonhoeffer, T (September 1995). "Hippocampal long-term potentiation is ... Engert, F; Bonhoeffer, T (May 1999). "Dendritic spine changes associated with hippocampal long-term synaptic plasticity". ... the demonstration that hippocampal spines exhibit activity-dependent, bidirectional structural plasticity (Nägerl et al., ...

Hippocampal CA1 neurons have been shown to produce reliable dendritic spike propagation through spatial summation of multiple ... In the hippocampus, the CA1 neurons contain two distinctive regions that receive excitatory synaptic inputs: the perforant path ... Nav1.6 has been identified in the dendrites of hippocampal CA1 neurons that generate dendritic spikes; the density of Nav1.6 in ... Dendritic sodium spikes are variable triggers of axonal action potentials in hippocampal CA1 pyramidal neurons. Neuron 21:1189- ...

... blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro". Brain Research. 452 (1-2): 57-65. doi:10.1016/0006 ... Mayford, M.; Baranes, D.; Podsypanina, K.; Kandel, E. R. (1996). "The 3'-untranslated region of CaMKII alpha is a cis-acting ... Dendritic TEs have been identified in the untranslated region of several mRNAs, like MAP2 and alphaCaMKII. Synaptic tagging is ... untranslated region. Eukaryotic initiation factor 4 group (eIF4) members recruit ribosomal subunits to the mRNA terminus, and ...

The CA1 is the region within the hippocampus between the subiculum, the innermost area of the hippocampal formation, and region ... The CA1 is separated from the dentate gyrus by the hippocampal sulcus. Cells within the CA1 are mostly pyramidal cells, similar ... and pyramidal neurons in CA1. The hippocampal relay involves 3 main regions within the hippocampus which are classified ... Florian, C.; Roullet, P. (2004). "Hippocampal CA3-region is crucial for acquisition and memory consolidation in Morris water ...

Glucocorticoids that are released during stress cause damage to neurons that are located in the hippocampal region of the brain ... The CA1 neurons found in the hippocampus are destroyed due to glucocorticoids decreasing the release of glucose and the ... such as calcium within hippocampal neurons) in the cell. In the case of hippocampal cells, this release is dependent upon the ... Hippocampal damage may also cause memory loss and problems with memory storage. This memory loss includes retrograde amnesia ...

... s are the axons of the neurons in the CA3 regions of the hippocampus that form synapses in the CA1 regions. ... Christie, J. M.; Jahr, CE (4 January 2006). "Multivesicular release at Schaffer collateral-CA1 hippocampal synapses". Journal ... The Schaffer collateral is located between the CA3 region and CA1 region in the hippocampus. Schaffer collaterals are the axons ... The contralateral CA3 region sends information through Schaffer collateral to the CA1 pyramidal neurons. Plastic changes ...

... for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region". The ... In mouse hippocampal CA1 neurons, certain PI3Ks are complexed with AMPA receptors and compartmentalized at the postsynaptic ... Furthermore, PI3K inhibitors abolished the expression of LTP in rat hippocampal CA1, but do not affect its induction. Notably, ... of LTP in mouse hippocampal CA1. The PI3K pathway also recruits many other proteins downstream, including mTOR, GSK3β, and PSD- ...

More recent studies of FMRP-bound RNAs present in microdissected dendrites of CA1 hippocampal neurons revealed no changes in ... It then localizes this mRNA to the lamella region of several asymmetric cell types where it can then be translated. In 2008 it ... RBPs are critical in the localization of this mRNA that insures proteins are only translated in their intended regions. One of ... The majority of RNA editing occurs on non-coding regions of RNA; however, some protein-encoding RNA transcripts have been shown ...

The enzyme was also expressed at high levels in the activated microglia of the hippocampal CA1 region and in degenerating ... to human chromosome region 1q31 by in situ hybridization and analysis of somatic cell hybrids". Cytogenetics and Cell Genetics ... to human chromosome region 1q31 by in situ hybridization and analysis of somatic cell hybrids". Cytogenetics and Cell Genetics ... and all 3 have almost identical active site regions. The differences between them lie in the microenvironments that surround ...

They are both produced as the response of the CA1 region to inputs from the CA3 region. Ripples are only present when theta ... In spite of the fact that hippocampal ripples (140-220 Hz) and fast gamma (90-150 Hz) oscillations have similar mechanisms of ... Besides they are shown to be region dependent, ripples that are the fastest oscillations are present in the CA1 region ... Pyramidal cells of CA3 and CA1 dendritic layer region are important in generating these waves, and they affect the subiculum, ...

When interneurons are activated by metabotropic acetylcholine receptors in the CA1 region of rat hippocampal slices, a theta ... "Direct depolarization and antidromic action potentials transiently suppress dendritic IPSPs in hippocampal CA1 pyramidal cells ... DSIs can be blocked by ionotropic receptor calcium ion channel antagonists on the somata and proximal apical dendrites of CA1 ... in CA1 pyramidal cells and cerebellar Purkinje cells. In a laboratory setting step depolarizations the soma have been used to ...

TSA treatments in the hippocampal CA1 region of mice increased acetylation levels and enhanced long-term potentiation (LTP), a ... Studies done on Acetylation of histone H3 in the CA1 region of the hippocampus show that the activation of NMDA receptors ... Long term potentiation in CA1 neurons was not observed in HDAC2 OE mice but was easily induced in HDAC2 KO mice. LTP was not ... See Figure: Brain regions involved in memory formation, and also this reference.) When contextual fear conditioning is applied ...

... others hypothesize that AD patients have increased neurogenesis in the CA1 region of Ammon's horn (the principal region of AD ... increase hippocampal neurogenesis. It has been theorized that decreased hippocampal neurogenesis in individuals with major ... As discussed above, hippocampal cells are sensitive to stress which can lead to decreased neurogenesis. This area is being ... Seasonal changes in hippocampal densities have been described since 1994 where neuronal survival peaks during the fall (October ...

Hyman, JM; Wyble BP; Goyal V; Rossi CA; Hasselmo ME (December 17, 2003). "Stimulation in hippocampal region CA1 in behaving ... from electrophysiological studies showing that both synaptic plasticity and strength of inputs to hippocampal region CA1 vary ... Later, hippocampal oscillations of the same type were observed in rats; however, the frequency of rat hippocampal EEG ... Kirk IJ (1998). "Frequency modulation of hippocampal theta by the supramammillary nucleus, and other hypothalamo-hippocampal ...

... particularly the hippocampal CA1 region, pyramidal neurons in the cerebral cortex, and Purkinje cells in the cerebellum. There ...

... then CA1, and finally through to the subiculum. Information is then directed back to the para-hippocampal region and finally to ... that is projected from nearly all neocortical areas come together onto one or more subdivisions of the para-hippocampal region ... Similarly, hippocampal lesions severely impacted all three components (what, where, and when) suggesting that the hippocampus ... Eichenbaum, H. (2000). "A cortical-hippocampal system for declarative memory". Nature Reviews Neuroscience. 1 (1): 41-50. doi: ...

More specifically, only the CA1 region of the hippocampus seemed to demonstrate a significant reduction in size. The CA1 ... Because the region of the hippocampus affected by protein malnutrition is so specific, global hippocampal function is not ... Rats with the CA1 volume deficit were found to perform poorly in a tasks requiring behavioural inhibition and accurate response ... In another study using rats, it was found that the size of the hippocampus (the central region in memory functioning) was ...

Jeffreys, JGR; HL Hass (1982-12-02). "Synchronized bursting of CA1 hippocampal pyramidal cells in the absence of synaptic ... Smith, JC; HH Ellenberger; K Ballanyi; DW Richter; JL Feldman (November 1991). "Pre-Botzinger complex: a brainstem region that ... The subiculum, a component of the hippocampal formation, is thought to perform relaying of signals originating in the ... "An autoradiographic study of the organization of the efferent connections of the hippocampal formation in the rat". Journal of ...

The juvenile type also shows reactivity in the cerebral cortex, hippocampal CA1 area, and the reticular formation of the ... In regions lacking obvious neuronal depletion, atrophy of the neuropil is noted. The globus pallidus (lateral greater than ... In both the juvenile and adult forms, regions in which more than 40% of neurons became immunoreactive to 1C2 (a monoclonal ... The human genome contains two atrophin genes; DRPLA has been correlated to the expansion of the polyglutamine region of the ...