... homologous kinase associates with RAFTK/Pyk2 in breast cancer cells and negatively regulates its activation and breast cancer ... Yamashita, H; Avraham S; Jiang S; Dikic I; Avraham H (May 1999). "The Csk homologous kinase associates with TrkA receptors and ... 2002). "Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function ... This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants ...

... epidermal growth factor receptor, cathepsin-D, and p53 in saliva among women with breast carcinoma". Cancer Invest. 18 (2): 101 ... Streckfus C, Bigler L, Dellinger T, Dai X, Kingman A, Thigpen JT (June 2000). "The presence of soluble c-erbB-2 in saliva and ... compared saliva from breast cancer patients to that from healthy individuals and observed, notably, that breast cancer patients ... such as breast cancer, pancreatic cancer, and oral cancer), infectious conditions (such as HIV, viral hepatitis, amoebiasis, ...

... supports existence of molecular apocrine breast cancer with a role for androgen receptor and implies interactions with ErbB ... "Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours". Breast ... "Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours". Breast ... January 2012). "Differential oestrogen receptor binding is associated with clinical outcome in breast cancer". Nature. 481 ( ...

"Androgen receptor genotypes predict response to endocrine treatment in breast cancer patients". Br. J. Cancer. 105 (11): 1676- ... "Activation and function of the epidermal growth factor receptor and erbB-2 during mammary gland morphogenesis". Cell Growth ... implications for risk of early-onset breast cancer in young women from hereditary breast cancer families". Br. J. Cancer. 92 (5 ... Some factors of breast morphology, including their density, are clearly implicated in breast cancer. While breast size is ...

ErbB-3) and Her 4 (ErbB-4). In many cancer types, mutations affecting EGFR expression or activity could result in cancer. ... regulates cell spreading and motility in MDA-MB-231 human breast cancer cells downstream of epidermal growth factor receptor". ... The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor ... The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members ...

"Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor". The ... Receptor tyrosine-protein kinase erbB-4 is a receptor tyrosine kinase that is a member of the epidermal growth factor receptor ... Receptor tyrosine-protein kinase erbB-4 is an enzyme that in humans is encoded by the ERBB4 gene. Alternatively spliced ... Chang H, Riese DJ, Gilbert W, Stern DF, McMahan UJ (May 1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like ...

Hsu JL, Hung MC (2016). "The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer". Cancer and Metastasis ... The ErbB family consists of four individual plasma membrane-bound receptor tyrosine kinases. One of which is erbB-2, and the ... AACR Cancer Concepts Factsheet on HER2 Breast Friends for Life Network - A South African Breast Cancer Support Forum for HER2 ... Tan M, Yu D (2007). "Molecular Mechanisms of ErbB2-Mediated Breast Cancer Chemoresistance". Breast Cancer Chemosensitivity. ...

ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene. MIG6 is a Cytoplasmic protein ... "Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to ... Zhang YW, Vande Woude GF (March 2007). "Mig-6, signal transduction, stress response and cancer". Cell Cycle. 6 (5): 507-13. doi ... "Entrez Gene: ERRFI1 ERBB receptor feedback inhibitor 1". Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). " ...

... supports existence of molecular apocrine breast cancer with a role for androgen receptor and implies interactions with ErbB ... Analytic studies of human breast cancer tissues suggest that GATA3 is required for specific type of low risk breast cancer (i.e ... "Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours". Breast ... "GATA3 inhibits breast cancer growth and pulmonary breast cancer metastasis". Oncogene. 28 (29): 2634-42. doi:10.1038/onc. ...

... signaling pathway in breast cancer cells". Cancer Lett. 314 (2): 147-54. doi:10.1016/j.canlet.2011.09.024. PMID 22033246. " ... Recent insights into the activation of EGF/ErbB receptors". Mol. Cell. 12 (3): 541-52. doi:10.1016/S1097-2765(03)00350-2. PMID ... EGF-induced MMP-9 expression enhances tumor invasion and metastasis in some kinds of tumor cells such as breast cancer and ... It is a TGFβ type 1 receptor antagonist. It blocks TGFβ1 and activin associating with the receptor, blocking access to SMAD2. ...

... are infrequent in breast cancer but Ras may be pathologically activated in breast cancer by overexpression of ErbB receptors. ... The ErbB protein family consists of 4 members ErbB-1, also named epidermal growth factor receptor (EGFR) ErbB-2, also named ... Breast Cancer, 15: 57-64 doi: 10.1007/s12282-007-0014-z "Why Do Some HER2-Positive Breast Cancers Not Respond to Herceptin?". ... Research suggests that a low FISH test ratio in estrogen receptor positive breast cancers are less likely to respond to this ...

This protein is implicated in several cancers, including skin cancer, breast cancer, and colorectal cancer. It is a key player ... DNAJA3 has been shown to interact with: ErbB-2 receptor tyrosine kinase MK5 HSPA9 HSPA8, JAK2, and RASA1 ENSG00000103423 GRCh38 ... In neuromuscular junctions, only the short isoform clusters acetylcholine receptors for efficient synaptic transmission. The ... Edwards KM, Münger K (2004). "Depletion of physiological levels of the human TID1 protein renders cancer cell lines resistant ...

1993). "Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor ... Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound ... in HER2+ breast cancers anti-estrogen therapy in ER+ breast cancers EGFR inhibitors in lung and head and neck cancers hormones ... ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. The kinase-impaired ...

"ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis". ... July 2004). "Changes in the expression and cytological localization of betacellulin and its receptors (ErbB-1 and ErbB-4) in ... and the proteolytic release the soluble factors can bind and activate the homodimer or heterodimer of the ERBB receptors. The ... September 2004). "Differential activation of epidermal growth factor (EGF) receptor downstream signaling pathways by ...

"Ectopic expression of the ErbB-3 binding protein ebp1 inhibits growth and induces differentiation of human breast cancer cell ... mediated repression of androgen receptor signalling". British Journal of Cancer. 92 (1): 140-6. doi:10.1038/sj.bjc.6602257. PMC ... protein with ErbB-3 and regulation of this binding by heregulin". British Journal of Cancer. 82 (3): 683-90. doi:10.1054/bjoc. ... protein with ErbB-3 and regulation of this binding by heregulin". British Journal of Cancer. 82 (3): 683-90. doi:10.1054/bjoc. ...

The role of erbB2 signal transduction pathways in human breast cancer". Breast Cancer Res. Treat. 27 (1-2): 83-93. doi:10.1007/ ... The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through their displayed ... NRG-1 and its receptor family ErbB can play a beneficial role in the treatment of chronic heart failure (CHF) by promoting ... "The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor ...

... cell cycle and apoptosis in estrogen-receptor-positive breast cancer cells". The Journal of Nutritional Biochemistry. 21 (9): ... "Genistein induces enhanced growth promotion in ER-positive/erbB-2-overexpressing breast cancers by ER-erbB-2 cross talk and p27 ... drugs commonly used in breast cancer therapy. Genistein was found to inhibit immune response towards cancer cells allowing ... Genistein was found to increase the rate of proliferation of estrogen-dependent breast cancer when not cotreated with an ...

... and the role of Ki67 in predicting benefit of adjuvant docetaxel in patients with oestrogen receptor positive breast cancer". ... Bánkfalvi A (November 2000). "Comparative methodological analysis of erbB-2/HER-2 gene dosage, chromosomal copy number and ... In breast cancer Ki67 identifies a high proliferative subset of patients with ER-positive breast cancer who derive greater ... High Ki-67 expression in an invasive breast cancer, with cancer nuclei being stained (brown). There is tumor cell positivity in ...

HER2-positive breast cancer from 20.3 to 25.1 months. In early-stage HER2-positive breast cancer, it reduces the risk of cancer ... It is specifically used for cancer that is HER2 receptor positive. It may be used by itself or together with other chemotherapy ... an erb-B-related gene encoding a 185,000-Mr tumour antigen". Nature. 312 (5994): 513-516. Bibcode:1984Natur.312..513S. doi: ... for the treatment of early breast cancer, metastatic breast cancer and metastatic gastric cancer. Ontruzant is the first ...

"ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis". ... NRGs bind to the ERBB receptors to promote phosphorylation of specific tyrosine residues on the C-terminal link of the receptor ... Neuregulins are ligands of the ERBB-family receptors, while NRG1 and NRG2 are able to bind and activate both ERBB3 and ERBB4, ... Murphy S, Krainock R, Tham M (February 2002). "Neuregulin signaling via erbB receptor assemblies in the nervous system". ...

Burris HA (2004). "Dual kinase inhibition in the treatment of breast cancer: initial experience with the EGFR/ErbB-2 inhibitor ... treatment of postmenopausal women with hormone receptor positive metastatic breast cancer that overexpresses the HER2 receptor ... ER+/EGFR+/HER2+ breast cancer patients and in patients who have HER2-positive advanced breast cancer that has progressed after ... "Breast cancer drug approved for new indication". Women's Health. Cancer.gov. 6 (2): 173. March 2010. doi:10.2217/whe.10.11. ...

... colorectal cancer, ovarian carcinoma, breast cancer, lung cancer and glioblastoma. It has been estimated that approximately 10 ... "ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 ... This way receptor-bound axin will abolish mediating the phosphorylation of β-catenin. Since β-catenin is no longer marked for ... lung cancer, malignant breast tumors, ovarian and endometrial cancer. Alterations in the localization and expression levels of ...

PLA as described above has been used to study aspects of animal development and breast cancer among many other topics. In situ ... "HER-3 targeting alters the dimerization pattern of ErbB protein family members in breast carcinomas". Oncotarget. 7 (5): 5576- ... The two proteins of interest are a B cell receptor and MYD88. The finding of interaction in the cytoplasm was interesting ... 345 (1): 2-9. doi:10.1016/j.ab.2005.01.018. PMID 15950911. Staudt, Louis (February 2017). "Therapy of lymphoma inspired by ...

... and irreversible inhibitor of the catalytic domain of the erbB receptor subfamily of protein tyrosine kinases". Journal of ... EU in 2018 for the extended adjuvant treatment of adult patients with early-stage HER2-overexpressed/amplified breast cancer ... The drug elicited partial responses in half of evaluable patients with KRAS G12C-mutant non-small cell lung cancer, and led to ... The pan-ErbB inhibitor Neratinib was approved in the US in 2017 and in the ...

identified a previously unknown, complementary and potentially superior mechanism of inhibiting the ErbB receptor signaling ... "Dynamic modelling of oestrogen signalling and cell fate in breast cancer cells". Nat. Rev. Cancer. 11 (7): 523-532. doi:10.1038 ... "The Cancer Genome Atlas Home Page". The Cancer Genome Atlas - National Cancer Institute. 2018-06-13. Benson, DA; Clark, K; ... Cancer Systems Biology is steadily improving our ability to organize information on cancer, in order to fill these gaps. Key ...

... breast cancer in situ - breast density - breast duct endoscopy - Breast Imaging Reporting and Data System - breast implant - ... estrogen receptor - estrogen receptor negative - estrogen receptor positive - estrogen receptor test - estrogen replacement ... c-erbB-2 - c-kit - CA 19-9 assay - CA-125 - CA-125 test - cachexia - calcitonin - calcitriol - CAM - Campath-1H - camptothecin ... cancer induction - Cancer Information Service - cancer of unknown primary origin - cancer stem cell - cancer vaccine - Cancer. ...

... has been used to treat HER2 overexpression in breast cancer. + Table adapted from "Cell signalling by receptor-tyrosine kinases ... RTK class I (EGF receptor family) (ErbB family) RTK class II (Insulin receptor family) RTK class III (PDGF receptor family) RTK ... NGF receptor family) RTK class VIII (HGF receptor family) RTK class IX (Eph receptor family) RTK class X (AXL receptor family) ... RYK receptor family) RTK class XIII (DDR receptor family) RTK class XIV (RET receptor family) RTK class XV (ROS receptor family ...

"Low levels of Stat5a protein in breast cancer are associated with tumor progression and unfavorable clinical outcomes". Breast ... Schulze WX, Deng L, Mann M (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Mol. Syst. Biol. 1 (1): E1 ... Many studies have indicated a key role of STAT5a in leukemia, breast, colon, head and neck, and prostate cancer. Until recently ... In breast cancer, STAT5a signaling is important for maintain tumor differentiation and suppressing disease progression. Studies ...

... human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers ... Kanai Y, Ochiai A, Shibata T, Oyama T, Ushijima S, Akimoto S, Hirohashi S (Mar 1995). "c-erbB-2 gene product directly ... Hazan RB, Norton L (Apr 1998). "The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin ... Besco JA, Hooft van Huijsduijnen R, Frostholm A, Rotter A (Oct 2006). "Intracellular substrates of brain-enriched receptor ...

"ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis". ... Epiregulin can function as a ligand of epidermal growth factor receptor (EGFR), as well as a ligand of most members of the ERBB ... difference at the C-terminus may provide an explanation for the reduced binding affinity of epiregulin to the ERBB receptors. ... 2008). "Intratumoral epiregulin is a marker of advanced disease in non-small cell lung cancer patients and confers invasive ...