Wada O, Oishi H, Takada I, Yanagisawa J, Yano T, Kato S (Aug 2004). "BRCA1 function mediates a TRAP/DRIP complex through direct ... Rachez C, Suldan Z, Ward J, Chang CP, Burakov D, Erdjument-Bromage H, Tempst P, Freedman LP (Jun 1998). "A novel protein ... "Entrez Gene: THRAP4 thyroid hormone receptor associated protein 4". Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, ... MED24 has been shown to interact with Estrogen receptor alpha, Cyclin-dependent kinase 8, Calcitriol receptor and BRCA1. GRCh38 ...
"A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): ... Ray H, Suau F, Vincent A, Dalla Venezia N (January 2009). "Cell cycle regulation of the BRCA1/acetyl-CoA-carboxylase complex". ... Shen Y, Tong L (May 2008). "Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho- ... "Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas ...
DNA repair protein XRCC2 is a protein that in humans is encoded by the XRCC2 gene. This gene encodes a member of the RecA/Rad51 ... Chun J, Buechelmaier ES, Powell SN (2013). "Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2- ... EZH2 protein is up-regulated in numerous cancers. EZH2 mRNA is up-regulated, on average, 7.5-fold in breast cancer, and between ... The XRCC2 protein is one of five human paralogs of RAD51, including RAD51B (RAD51L1), RAD51C (RAD51L2), RAD51D (RAD51L3), XRCC2 ...
DNA repair protein XRCC3 is a protein that in humans is encoded by the XRCC3 gene. This gene encodes a member of the RecA/Rad51 ... Chun J, Buechelmaier ES, Powell SN (2013). "Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2- ... of breast cancers have over-expressed EZH2 protein. Click on genes, proteins and metabolites below to link to respective ... EZH2 protein is up-regulated in numerous cancers. EZH2 mRNA is up-regulated, on average, 7.5-fold in breast cancer, and between ...
Nuclear transcription factor Y subunit alpha is a protein that in humans is encoded by the NFYA gene. The protein encoded by ... Fan W, Jin S, Tong T, Zhao H, Fan F, Antinore MJ, Rajasekaran B, Wu M, Zhan Q (March 2002). "BRCA1 regulates GADD45 through its ... NFYA+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) FactorBook NF-YA This article ... Maity SN, de Crombrugghe B (May 1998). "Role of the CCAAT-binding protein CBF/NF-Y in transcription". Trends in Biochemical ...
EZH2 protein is up-regulated in numerous cancers. EZH2 mRNA is up-regulated, on average, 7.5-fold in breast cancer, and between ... "Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway". ... The RAD51C protein is one of five paralogs of RAD51, including RAD51B (RAD51L1), RAD51C (RAD51L2), RAD51D (RAD51L3), XRCC2 and ... Since the RAD51C protein is involved in repairing double strand chromosome breaks, this chromosomal rearrangement could be ...
The CHEK2 protein encoded by the CHEK2 gene is a serine threonine kinase. The protein consists of 543 amino acids and the ... Unlike BRCA1 and BRCA2 mutations, CHEK2 mutations do not appear to cause an elevated risk for ovarian cancer. However, a large- ... Furthermore, the CHK2 protein interacts with several other proteins including p53 (p53). Stabilization of p53 by CHK2 leads to ... produces a nonfunctional version of the CHK2 protein, truncated at the kinase domain. The loss of normal CHK2 protein function ...
Jin H, Selfe J, Whitehouse C, Morris JR, Solomon E, Roberts RG (Dec 2004). "Structural evolution of the BRCA1 genomic region in ... Leucine rich repeat containing 37A is a protein in humans that is encoded by the LRRC37A gene. "Human PubMed Reference:". ...
BRCA1 and BRCA2 polymorphic variants can increase the risk of breast cancer, and these cancers tend to express a pr ofile of ... HER2-low has some HER2 proteins on the cell surface, but not enough to be classified as HER2-positive. Trastuzumab deruxtecan ... Jerevall PL, Jansson A, Fornander T, Skoog L, Nordenskjöld B, Stål O (2010). "Predictive relevance of HOXB13 protein expression ... Tumors overexpressing the Wnt signaling pathway co-receptor low-density lipoprotein receptor-related protein 6 (LRP6) may ...
Vogel has studied the mechanisms involved with protein signalling. The creation of proteins involve messenger RNA molecules ... Mutations on the BRCA1 means that damage to DNA cannot be repaired, such that cells mutate and cause cancer. Vogel believes ... Both the generation of RNA and formation of proteins are coupled to one another, akin to the coupling of a moving escalator ... Vogel has shown that both processes, the generation of RNA and the arrangement of RNA into proteins, are important. She ...
"MAP4K4 - Mitogen-activated protein kinase kinase kinase kinase 4 - Homo sapiens (Human) - MAP4K4 gene & protein". www.uniprot. ... Rodriguez M, Yu X, Chen J, Songyang Z (December 2003). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) ... facilitates protein-protein interactions. Although it has been identified, its structural components and functionality are ... Luan Z, Zhang Y, Liu A, Man Y, Cheng L, Hu G (October 2002). "A novel GTP-binding protein hGBP3 interacts with NIK/HGK". FEBS ...
This leads to a premature stop codon, shortening the protein that is supposed to be transcribed. When the protein is able to ... are over 500 mutations on chromosome 17 that seem to play a role in the development of breast and ovarian cancer in the BRCA1 ... aligns a protein against a DNA sequence allowing frameshifts and introns FastY - compare a DNA sequence to a protein sequence ... An incorrectly made protein can have detrimental effects on cell viability and in most cases cause the higher organism to ...
... is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, ... C-jun has been shown to interact with: ATF2 AR ASCC3 ATF3 BCL3 BCL6 BRCA1 C-Fos CSNK2A1 COPS5 CREBBP CSNK2A2 DDX21, DDIT3 ERG ... The human JUN encodes a protein that is highly similar to the viral protein, which interacts directly with specific target DNA ... Na SY, Choi JE, Kim HJ, Jhun BH, Lee YC, Lee JW (October 1999). "Bcl3, an IkappaB protein, stimulates activating protein-1 ...
Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (2001). "Protein-protein ... Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (1997). "BRCA1 is a component of the RNA ... Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA (Oct 1997). "CA150, a nuclear protein associated with the RNA ... Chao DM, Gadbois EL, Murray PJ, Anderson SF, Sonu MS, Parvin JD, Young RA (Apr 1996). "A mammalian SRB protein associated with ...
HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein ... Cabart P, Chew HK, Murphy S (July 2004). "BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II ... The protein encoded by this gene is a member of the cyclin-dependent kinase (CDK) family. CDK family members are highly similar ... This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. ...
Cyclin-T1 is a protein that in humans is encoded by the CCNT1 gene. The protein encoded by this gene belongs to the highly ... Cabart P, Chew HK, Murphy S (July 2004). "BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II ... Gibellini D, Vitone F, Schiavone P, Re MC (2005). "HIV-1 tat protein and cell proliferation and survival: a brief review". New ... Pugliese A, Vidotto V, Beltramo T, Petrini S, Torre D (2005). "A review of HIV-1 Tat protein biological effects". Cell Biochem ...
Metastasis-associated protein MTA1 is a protein that in humans is encoded by the MTA1 gene. MTA1 is the founding member of the ... Molli PR, Singh RR, Lee SW, Kumar R (Mar 2008). "MTA1-mediated transcriptional repression of BRCA1 tumor suppressor gene". ... Kleene R, Zdzieblo J, Wege K, Kern HF (Aug 1999). "A novel zymogen granule protein (ZG29p) and the nuclear protein MTA1p are ... "Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase ...
The DNA-PKcs protein is the critical element in the center of NHEJ. Using DNA-PKcs KO cell lines or inhibition of DNA-PKcs does ... Ku70/80 DNA-PKcs DNA Ligase IV XRCC4 XLF Artemis DNA polymerase mu DNA polymerase lambda PNKP Aprataxin APLF BRCA1 BRCA2 CYREN ... Ku may function as a docking site for other NHEJ proteins, and is known to interact with the DNA ligase IV complex and XLF. End ... In yeast, Sir2 was originally identified as an NHEJ protein, but is now known to be required for NHEJ only because it is ...
"of C22orf15 Protein Sequence (SAPS)Statistical Analysis". EMBL-EBI. "Uncharacterized protein C22orf15 AlphaFold structure ... DNA region 22q11.23 is also significantly more prevalent in basal-like BRCA1-mutated tumors compared to nonmutated wild-type ... facilitates the creation of the common gamma chain protein. This protein is a component of various receptors that aid in immune ... "Protein BLAST". Basic Local Alignment Search Tool. U.S National Library of Medicine. Kawauchi S, Furuay T, Uchiyama T, Adachi A ...
The PARPs have many protein targets at the site of DNA damage. KU protein and DNA-PKcs are both double-stranded break repair ... is to enhance the damage done by chemotherapy on the cancerous DNA by disallowing the reparative function of PARP1 in BRCA1/2 ... It is also involved in transcriptional regulation through its facilitation of protein-protein interactions. PARP1 uses NAD+ in ... in multi-protein complexes with A and B domains bound by non-covalent interactions; and, third, in multi-protein complexes with ...
Dual specificity protein phosphatase 3 is an enzyme that in humans is encoded by the DUSP3 gene. The protein encoded by this ... This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... 2003). "Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to ...
Kinesin-like protein KIF1B is a protein that in humans is encoded by the KIF1B gene. It is associated with Charcot-Marie-Tooth ... Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. ... Bunn RC, Jensen MA, Reed BC (1999). "Protein Interactions with the Glucose Transporter Binding Protein GLUT1CBP That Provide a ... synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins". J. Neurosci. 22 ...
Na SY, Choi JE, Kim HJ, Jhun BH, Lee YC, Lee JW (October 1999). "Bcl3, an IkappaB protein, stimulates activating protein-1 ... BRCA1, CDX2, CEBPB, CITED1, CITED2, DDX5, DTX1, EID1, ELK1, ESR1, FEN1, GPS2, HIF1A, HNF1A, HNRPU, ING4, ING5, IRF2, LEF1, MAF ... Ko L, Cardona GR, Chin WW (May 2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions ... "Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with ...
Interferon-induced 35 kDa protein is a protein that in humans is encoded by the IFI35 gene. IFI35 has been shown to interact ... and identification of genes within a 500-kb region containing BRCA1". Proceedings of the National Academy of Sciences of the ... Zhang L, Tang Y, Tie Y, Tian C, Wang J, Dong Y, Sun Z, He F (May 2007). "The PH domain containing protein CKIP-1 binds to IFP35 ... IFI35+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short ...
This protein binds to anti-apoptotic proteins resulting in these proteins' inhibition. As a p53 inducible gene, NOXA is ... Cancers BRCA1 and BRCA2 are the two BRCA recognized cancer-causing gene alterations. The likelihood that a woman may develop ... NS1 is considered a regulatory protein due to its activity in transcription, translation, and protein-protein interactions, ... This protein, also known as viral protein 3 (VP3) was isolated from chickens, and has been shown to cause PCD in transformed ...
Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA ... GTF2F1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) FactorBook GTF2F1 This article ... Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (1997). "BRCA1 is a component of the RNA ... General transcription factor IIF subunit 1 is a protein that in humans is encoded by the GTF2F1 gene. GTF2F1 has been shown to ...
YTH domain-containing protein 1 is a protein that in humans is encoded by the YTHDC1 gene. YTHDC1 is a nuclear protein involved ... BRCA1) and hormonal growth driver; the progesterone receptor (PGR). In prostate cancer, YTHDC1 has also been shown to interact ... Imai Y, Matsuo N, Ogawa S, Tohyama M, Takagi T (1998). "Cloning of a gene, YT521, for a novel RNA splicing-related protein ... Stoss O, Olbrich M, Hartmann AM, Konig H, Memmott J, Andreadis A, Stamm S (2001). "The STAR/GSG family protein rSLM-2 regulates ...
"Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair". Molecular and Cellular Biology. 24 (2): 708-18. doi: ... "The interaction of p53 with replication protein a mediates suppression of homologous recombination". Oncogene. 23 (56): 9025-33 ...
The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase ... Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. ... HDAC8+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text ... Lee H, Rezai-Zadeh N, Seto E (2004). "Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein ...
"The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation". Oncogene ... RELA has been shown to interact with: APBA2, AHR, ASCC3, BRCA1, BTRC, c-Fos, c-Jun, C22orf25, CDK9, CEBPB, CEBPE, CREBBP, ... Seven proteins encoded by five genes are involved in the NF-κB complex, namely p105, p100, p50, p52, RELA, c-REL and RELB. Like ... RELA protein has four isoforms, the longest and the predominant one being 551 amino acids. RELA is expressed alongside p50 in ...