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*  Brain ischemia
Focal brain ischemia occurs when a blood clot has occluded a cerebral vessel. Focal brain ischemia reduces blood flow to a ... During brain ischemia, the brain cannot perform aerobic metabolism due to the loss of oxygen and substrate. The brain is not ... The causes of brain ischemia vary from sickle cell anemia to congenital heart defects. Symptoms of brain ischemia can include ... Brain ischemia (a.k.a. cerebral ischemia, cerebrovascular ischemia) is a condition in which there is insufficient blood flow to ...
*  Primary and secondary brain injury
Other factors in secondary damage are breakdown of the blood-brain barrier, edema, ischemia and hypoxia. Ischemia is one of the ... Primary and secondary brain injury are ways to classify the injury processes that occur in brain injury. In traumatic brain ... These include ischemia (insufficient blood flow); cerebral hypoxia (insufficient oxygen in the brain); hypotension (low blood ... It occurs after a variety of brain injury including subarachnoid hemorrhage, stroke, and traumatic brain injury and involves ...
*  Cerebral infarction
The more rapidly blood flow is restored to the brain, the fewer brain cells die. In increasing numbers of primary stroke ... Thrombotic ischemia can occur in large or small blood vessels. In large vessels, the most common causes of thrombi are ... If the infarction occurs on the left side brain, speech will be slurred. Reflexes may be aggravated as well. Major risk factors ... A cerebral infarction is an area of necrotic tissue in the brain resulting from a blockage or narrowing in the arteries ...
*  Reperfusion injury
... plays a part in the brain's ischemic cascade, which is involved in stroke and brain trauma. Similar failure ... Repeated bouts of ischemia and reperfusion injury also are thought to be a factor leading to the formation and failure to heal ... "Brain Failure and Brain Death: Introduction". Scientific American Surgery, Critical Care, April 2005. Retrieved 2007-01-09. ... In prolonged ischemia (60 minutes or more), hypoxanthine is formed as a breakdown product of ATP metabolism. The enzyme ...
*  Neurooncology
4. Brain Stem Gliomas Brain stem glioma is a distinct category of central nervous system tumor because of its unique location ... Mechanisms of pain include spinal cord ischemia and traction on the periosteum, dura, nearby soft tissues, and nerve roots. ... Brain metastasis can be single or multiple and involve any portion of the brain. Metastasis to dural structures generally ... 1. Brain Tumor Presentations In general, patients with primary brain tumors or single metastatic tumors can present with any of ...
*  Licostinel
36-. ISBN 978-0-306-48644-9. Eugene I. Gusev; Veronika I. Skvortsova (30 April 2003). Brain Ischemia. Springer Science & ... It was under investigation by Acea Pharmaceuticals as a neuroprotective agent for the treatment of cerebral ischemia associated ...
*  Camilo R. Gomez
Nonthrombolytic approach to acute brain ischemia". Critical Care Clinics. 15 (4): 755-776. doi:10.1016/s0749-0704(05)70086-5. ... In the early 1990s he coined the phrase Time is Brain!, as an argument for the need to expedite the treatment of stroke victims ... additional History Gomez CR: Time is Brain! J Stroke and Cerebrovasc Dis 3:1-2. 1993, additional Time Gomez CR, Malkoff MD, ... He has written in his specialty and is credited with having coined the phrase Time is Brain! to denote the urgency required in ...
*  D-Deprenyl
... d-Deprenyl attenuates apoptosis in experimental brain ischaemia". European Journal of Pharmacology. 430 (2-3): 235-241. doi: ... Molecular Brain Research. 49 (1-2): 127-136. doi:10.1016/S0169-328X(97)00135-6. PMID 9387872. Srinivasan ThyagaRajan; Kelley S ...
*  Cosimo Mele
On 7 October 2017, Mele died, aged 60, of a brain ischemia. "Morto l'ex parlamentare Udc Cosimo Mele". La Stampa (in Italian). ...
*  Carbon monoxide poisoning
This causes reduced cardiac output and hypotension, which may result in brain ischemia. A delayed return of symptoms have been ... which can lead to edema and necrosis within the brain. This brain damage occurs mainly during the recovery period. This may ... Brain damage is confirmed following MRI or CAT scans. Extensive follow up and supportive treatment is often required for ... In the brain this causes further mitochondrial dysfunction, capillary leakage, leukocyte sequestration, and apoptosis. The ...
*  Cushing reflex
These symptoms can be indicative of insufficient blood flow to the brain (ischemia) as well as compression of arterioles. In ... Compression then results in diminished blood supply to the brain, a condition known as cerebral ischemia. alpha-1 adrenergic ... 2005). "Value of Cushing Reflex as warning sign for brain ischemia during neuroendoscopy". Br J Anaes. 94 (6): 791-9. doi: ... Brain plateau wave changes are also associated with the Cushing reflex. These waves are characterized by acute rises of the ICP ...
*  Citicoline
This is especially important after an ischemia, when arachidonic acid levels are elevated. The brain prefers to use choline to ... "Does CDP-choline modulate phospholipase activities after transient forebrain ischemia?". Brain Research. 893 (1-2): 268-72. doi ... "Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport". ... Once these cross the blood-brain barrier it is reformed into citicoline by the rate-limiting enzyme in phosphatidylcholine ...
*  Emil Bobu
Bobu died in 2014 in a Bucharest hospital, as the result of a brain ischemia. He married Maria Cristian in 1957; she served as ...
*  MMP9
Elevated MMP9 levels can be found in the cases of rheumatoid arthritis and focal brain ischemia. One of MMP9's most widely ... activities in human brain after focal ischemia". Neuroscience Letters. 238 (1-2): 53-6. doi:10.1016/s0304-3940(97)00859-8. PMID ... Brain. 128 (Pt 7): 1622-33. doi:10.1093/brain/awh489. PMID 15800021. Vandooren J, Van den Steen PE, Opdenakker G (2013). " ... "Time course of upregulation of inflammatory mediators in the hemorrhagic brain in rats: correlation with brain edema". ...
*  Dapsone
November 2008). "Antioxidant, antiinflammatory and antiapoptotic effects of dapsone in a model of brain ischemia/reperfusion in ...
*  Mitochondrial apoptosis-induced channel
"Bax Channel Inhibitors Prevent Mitochondrion-mediated Apoptosis and Protect Neurons in a Model of Global Brain Ischemia". J. ...
*  Ischemic preconditioning
"Astrocytic Toll-like receptor 3 is associated with ischemic preconditioning-induced protection against brain ischemia in ... The second window begins at 24 hours lasting up to 72 hours post the ischaemia and reperfusion stimulus. In an experimental ... In the heart, IPC is an intrinsic process whereby repeated short episodes of ischaemia protect the myocardium against a ... Murry, CE; Jennings, RB; Reimer, KA (November 1986). "Preconditioning with ischemia: a delay of lethal cell injury in ischemic ...
*  TLR3
... and activation of TLR3 signaling is associated with ischemic preconditioning-induced protection against brain ischemia and ... "Astrocytic Toll-like receptor 3 is associated with ischemic preconditioning-induced protection against brain ischemia in ... "TLR3 ligand Poly IC Attenuates Reactive Astrogliosis and Improves Recovery of Rats after Focal Cerebral Ischemia". CNS Neurosci ... "TLR3 ligand Poly IC Attenuates Reactive Astrogliosis and Improves Recovery of Rats after Focal Cerebral Ischemia". CNS ...
*  RE1-silencing transcription factor
REST is also responsible for ischaemia induced neuronal cell death, in mouse models of brain ischaemia. Ischaemia, which ... Brain Research. Molecular Brain Research. 72 (1): 30-9. doi:10.1016/S0169-328X(99)00196-5. PMID 10521596. Naruse Y, Aoki T, ... Brain Research. Molecular Brain Research. 90 (2): 174-86. doi:10.1016/S0169-328X(01)00107-3. PMID 11406295. Battaglioli E, ... REST levels are highest in the brains of people who lived up to be 90 - 100s and remained cognitively intact. Levels stayed ...
*  Quinolinic acid
Brain ischemia is characterized by insufficient blood flow to the brain. Studies with ischaemic gerbils indicate that, after a ... Quinolinic acid has also been found in HAND patients' brains. In fact, the amount of quinolinic acid found in the brain of HAND ... Quinolinic acid is unable to pass through the blood-brain barrier (BBB) and must be produced within the brain microglial cells ... there are microglia containing quinolinic acid within the brain. Following cerebral ischaemia, delayed neuronal death may occur ...
*  Butylphthalide
... attenuated neuronal autophagy and amyloid-beta expression in diabetic mice subjected to brain ischemia". Neurological research ... In 2002, NBP was approved in China for the treatment of cerebral ischemia. NBP undergoes extensive metabolism in humans. The ...
*  Mechanism of anoxic depolarization in the brain
Neurons are more susceptible to brain ischemia than the supporting glial cells, because neurons have higher energy demand, ... Anoxic depolarization is a progressive and uncontrollable depolarization of neurons during stroke or brain ischemia in which ... During brain ischemia, glutamate is released in excess from the presynaptic terminal, leading to the uncontrollable opening of ... Brain ischemia Penumbra Weilinger NL, Maslieieva V, Bialecki J, Sridharan SS, Tang PL, Thompson RJ (2013). "Ionotropic ...
*  Gelatinase B
Elevated gelatinase B levels can also be found in the cases of rheumatoid arthritis and focal brain ischemia. However, one of ... activities in human brain after focal ischemia". Neuroscience Letters. 238 (1-2): 53-6. doi:10.1016/s0304-3940(97)00859-8. PMID ...
*  Pulse
Doing so may limit the flow of blood to the head, possibly leading to fainting or brain ischemia. It can be felt between the ...
*  EIF2S1
After reperfusion following brain ischemia, there is inhibition of neuron protein synthesis due to phosphorylation of eIF2α. ... cytochrome c in vulnerable hippocampal neurons after 4 hours of reperfusion following 10-minute complete brain ischemia". Acta ...
*  Proto-oncogene tyrosine-protein kinase Src
2015). "Toxic role of prostaglandin E2 receptor EP1 after intracerebral hemorrhage in mice". Brain Behav Immun. 46: 293-310. ... It also regulates angiogenic factors and vascular permeability after focal cerebral ischemia-reperfusion, and regulates matrix ... and angiogenic factors after focal cerebral ischemia: correlations with angiogenesis and cerebral edema". Neurochem Int. 58 (8 ... "Src regulates angiogenic factors and vascular permeability after focal cerebral ischemia-reperfusion". Neuroscience. 262 (3): ...
*  Aleksandr Vinogradov (writer)
In the late 2000s he started to develop brain ischemia, leading to problems with memory, judgment and gait. Possibly affected ...