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*  Bradykinin receptor B1
BDKRB1 bradykinin receptor B1". Seabrook GR, Bowery BJ, Hill RG. "Bradykinin receptors in mouse and rat isolated superior ... "Two B1 and B2 bradykinin receptor antagonists fail to inhibit the Ca2+ response elicited by bradykinin in human skin ... Bradykinin receptor B1 (B1) is a G-protein coupled receptor encoded by the BDKRB1 gene in humans. Its principal ligand is ... The B1 receptor is one of two of G protein-coupled receptors that have been found which bind bradykinin and mediate responses ...
*  Bradykinin receptor B2
... is a G-protein coupled receptor for bradykinin, encoded by the BDKRB2 gene in humans. The B2 receptor is ... "Entrez Gene: BDKRB2 bradykinin receptor B2". "Bradykinin Receptors: B2". IUPHAR Database of Receptors and Ion Channels. ... "Two B1 and B2 bradykinin receptor antagonists fail to inhibit the Ca2+ response elicited by bradykinin in human skin ... 1993). "Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity". Mol. Pharmacol. 44 (2): 346- ...
*  Bradykinin
... is a 9-amino acid peptide chain. The amino acid sequence of bradykinin is: Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg ( ... Bradykinin also causes natriuresis, contributing to the drop in blood pressure. Bradykinin raises internal calcium levels in ... they discovered the powerful hypotensive effects of bradykinin in animal preparations. Bradykinin was detected in the blood ... Bradykinin is also thought to be the cause of the dry cough in some patients on angiotensin-converting enzyme (ACE) inhibitor ...
*  Bradykinin receptor
There are two Bradykinin receptors: the B1 receptor and the B2 receptor. Bradykinin receptor B1 (B1) is a G-protein coupled ... The bradykinin receptor family is a group of G-protein coupled receptors whose principal ligand is the protein bradykinin. ... The B1 receptor is one of two G protein-coupled receptors that have been found which bind bradykinin and mediate responses to ... "Bradykinin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. ...
*  Diphenhydramine
Histamine, Bradykinin, and Their Antagonists". In Brunton L. Goodman & Gilman's The Pharmacological Basis of Therapeutics (12e ...
*  Angioedema
Dampening or inhibiting bradykinin has been shown to relieve HAE symptoms. Various mechanisms that interfere with bradykinin ... ACE inhibitors block the enzyme ACE so it can no longer degrade bradykinin; thus, bradykinin accumulates and causes angioedema ... ACE inhibitors block ACE, the enzyme that among other actions, degrades bradykinin. In hereditary angioedema, bradykinin ... In those with bradykinin related disease a C1 esterase inhibitor, ecallantide, or icatibant may be used. Fresh frozen plasma ...
*  Lysine carboxypeptidase
It inactivates bradykinin and anaphylatoxins. Plummer, T.H. Jr.; Erdös, E.G. (1981). "Human plasma carboxypeptidase N". Methods ... bradykinin-decomposing enzyme, protaminase, CPase N, creatinine kinase convertase, peptidyl-L-lysine(-L-arginine) hydrolase, ...
*  Respiratory system
The converting enzyme also inactivates bradykinin. Circulation time through the alveolar capillaries is less than one second, ...
*  Sérgio Henrique Ferreira
Maurício Rocha e Silva, the discoverer of bradykinin. While working on this subject, he discovered a family of peptides present ... This factor was named bradykinin potentiating factor, BPF. In 1968, with the collaboration of Dr. Lewis Joel Greene, from the ... His group made a relevant contribution to the role of bradykinin and of cytokines in the development of inflammatory ... Bradykinin initiates cytokine mediated inflammatory hyperalgesia. Brazilian Journal of Pharmacological Sciences. vol. 110, p. ...
*  Carboxypeptidase U
"Pro-carboxypeptidase R cleaves bradykinin following activation". Int. Arch. Allergy Immunol. 103: 400-404. doi:10.1159/ ...
*  High-molecular-weight kininogen
HMWK is also a precursor of bradykinin; this vasodilator is released through positive feedback by kallikrein. HMWK is a strong ... and in the generation of the vasodilator bradykinin via the Kallikrein-kinin system. HMWK is inactive until it either adheres ... bradykinin generation Domain 5 - heparin and cell binding; antiangiogenic properties; binding to negatively charged surfaces ...
*  ACE inhibitor
The inactivation of bradykinin and the conversion of angiotensin I to angiotensin II in the lungs was thought to be caused by ... Elevated bradykinin level due to ACE inhibition can be a cause of dry cough, angioedema and/or rash, hypotension, and ... Bradykinin is rapidly inactivated in the circulating blood, and it disappears completely in a single pass through the pulmonary ... Fuller, RW; Warren, JB; McCusker, M; Dollery, CT (1987). "Effect of enalapril on the skin response to bradykinin in man". Br J ...
*  Calreticulin
Abd Alla J, Reeck K, Langer A, Streichert T, Quitterer U (Sep 2009). "Calreticulin enhances B2 bradykinin receptor maturation ...
*  Oh Uhtaek
2002). "Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia". Proc. Natl. Acad. Sci. USA. 99 (15): ... Nature (2008) 2002 : Shin J et al., Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia. Proc Natl ...
*  Dynorphin
The group found that it acts on the bradykinin receptor as well as KOR. The N-terminal tyrosine of dynorphin A is necessary to ... Blocking bradykinin receptors in the lumbar region of the spinal cord reversed persistent pain. A multiple pathway system might ... Lai J, Luo MC, Chen Q, Ma S, Gardell LR, Ossipov MH, Porreca F (December 2006). "Dynorphin A activates bradykinin receptors to ... Based on the results of dynorphin A2-13, the authors proposed a mechanism in which dynorphin A activates bradykinin receptors ...
*  Teprotide
Ferreira, Sergio (February 1965). "A bradykinin-potentiating factor (bpf) present in the venom of bothrops jararaca". British ... Ferreira, Sergio H.; Diana C. Bartelt; Lewis J. Greene (June 1970). "Isolation of bradykinin-potentiating peptides from ... inhibits the conversion of angiotensin I to angiotensin II and may potentiate some of the pharmacological actions of bradykinin ...
*  Hereditary angioedema
Icatibant inhibits the bradykinin B2 receptor, and was approved in Europe and the USA. In hereditary angioedema, specific ... This results in increased amounts of bradykinin which promotes swelling. The condition may be inherited from a person's parents ... Treatment with ACE inhibitors is contraindicated in this condition, as these drugs can lead to bradykinin accumulation, which ... Icatibant (marketed as Firazyr) is a selective bradykinin receptor antagonist, which has been approved in Europe and was ...
*  Combined oral contraceptive pill
Bradykinin lowers blood pressure by causing blood vessel dilation. Certain enzymes are capable of breaking down bradykinin ( ... Cilia La Corte AL, Carter AM, Turner AJ, Grant PJ, Hooper NM (2008). "The bradykinin-degrading aminopeptidase P is increased in ... thereby increasing the breakdown of bradykinin, which increases the risk of developing hypertension. Other side effects ...
*  Icatibant
... acts as a bradykinin inhibitor by blocking the binding of native bradykinin to the bradykinin B2 receptor. Icatibant ... Bradykinin plays an important role as the mediator of pain. Surplus bradykinin is responsible for the typical symptoms of ... Bradykinin is a peptide-based hormone that is formed locally in tissues, very often in response to a trauma. It increases ... It is a peptidomimetic consisting of ten amino acids, which is a selective and specific antagonist of bradykinin B2 receptors. ...
*  Angiotensin-converting enzyme
Other less known functions of ACE are degradation of bradykinin and amyloid beta-protein. ACE is also known by the following ... Thus, the same enzyme (ACE) that generates a vasoconstrictor (ANG II) also disposes of vasodilators (bradykinin). ACE is a zinc ... ACE is also part of the kinin-kallikrein system where it degrades bradykinin, a potent vasodilator, and other vasoactive ... That results in the decreased formation of angiotensin II and decreased metabolism of bradykinin, which leads to systematic ...
*  Kininogen
Kinins are biologically active peptides, the parent form is bradykinin. The two main kininogen types are: High-molecular-weight ... These high molecular weight kininogens are cleaved into bradykinin and kallidin by tissue and plasma kallikreins. Low-molecular ...
*  Blood-brain barrier
... biochemically by the use of vasoactive substances such as bradykinin; or even by localized exposure to high-intensity focused ... "Hyperfibrinolysis increases blood brain barrier permeability by a plasmin and bradykinin-dependent mechanism". Blood. 128: 2423 ...
*  Kallidin
It can be converted to bradykinin by the aminopeptidase enzyme. It can be a substrate for carboxypeptidase M and N. Kallidin is ... identical to bradykinin with an additional lysine residue added at the N-terminal end and signals through the bradykinin ...
*  Sunburn
... causes an inflammation process, including production of prostanoids and bradykinin. These chemical compounds increase ...
*  Kininogen 1
Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not ... Maeda H, Matsumura Y, Kato H (Nov 1988). "Purification and identification of [hydroxyprolyl3]bradykinin in ascitic fluid from a ... Kato H, Matsumura Y, Maeda H (May 1988). "Isolation and identification of hydroxyproline analogues of bradykinin in human urine ... high-molecular-weight kininogen low-molecular-weight kininogen bradykinin GRCh38: Ensembl release 89: ENSG00000113889 - Ensembl ...