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*  White catalyst
Rather than performing allylic C-H cleavage-a relatively slow process-the catalyst quickly transmetallates with a boronic acid ... Key to the development of the reaction was identification of a very acidic nitrogen nucleophile with a pKa close to acetic acid ... Covell, D. J.; White, M. C. (2008). "A Chiral Lewis Acid Strategy for Enantioselective Allylic C-H Oxidation". Angewandte ... a π-acid such as benzoquinone coordinates to the palladium, activating the π-allyl complex to nucleophilic attack (III). A ...
*  Dynamic covalent chemistry
Boronic acid self-condensation or condensation with diols is a well-documented dynamic covalent reaction. The boronic acid ... Boronic acid dehydration, as demonstrated by Yaghi et al. is the most common type of reaction used. COFs have been used in gas ... Scheme 9: Boronic acid self-condensation. Dynamic covalent chemistry has allowed access to a wide variety of supramolecular ... Boronic acid condensation (BAC), and disulfide exchange constitute the two main reactions in this category. Disulfides can ...
*  Boronic acid
In the Liebeskind-Srogl coupling a thiol ester is coupled with a boronic acid to produce a ketone. The boronic acid organic ... Several synthetic routes are now in common use, and many air-stable boronic acids are commercially available. Boronic acids ... the "Gold Book") (1997). Online corrected version: (2006-) "Boronic Acids". Garner, C. W. (1980-06-10). "Boronic acid ... A boronic acid is a compound related to boric acid in which one of the three hydroxyl groups is replaced by an alkyl or aryl ...
*  Carbapenem-resistant enterobacteriaceae
Identification of KPCs, MBLs and OXAs can be achieved by demonstrating synergistic inhibition with phenyl boronic acid, EDTA or ... They are encoded on plasmids and contain a large variability in amino acid sequence. The resistance mechanism for class D ... from the existing spectrum of plasmid-mediated β-lactamases through amino acid substitution. They can acquire genes encoding ...
*  Phenylboronic acid
... or benzeneboronic acid, abbreviated as PhB(OH)2 where Ph is the phenyl group C6H5-, is a boronic acid ... Phenylboronic acid is white powder and is commonly used in organic synthesis. Boronic acids are mild Lewis acids which are ... The dehydration of boronic acids gives boroxines, the trimeric anhydrides of phenylboronic acid. The dehydration reaction is ... Petasis, N. A.; Xavialov, I. A. (1997). "A New and Practical Synthesis of α-Amino Acids from Alkenyl Boronic Acids". J. Am. ...
*  Liebeskind-Srogl coupling
Boronic Acid Coupling. A Mechanistically Unprecedented and General Ketone Synthesis". J. Am. Chem. Soc. 122: 11260-11261. doi: ... Liebeskind-Srogl coupling reaction is an organic reaction forming a new carbon-carbon bond from a thioester and a boronic acid ...
*  Borinic acid
ref 29 Winkle, D. (2001). "boronic acids can be used as viable alternatives to borinic acids in suzuki coupling reactions". ... Borinic acid H 2BOH, also known as boronous acid, is an oxyacid of boron with formula H 2BOH. Borinate is the associated anion ... Delbrayelle, Dominique (15 June 2010). "Boronic Acids Manufacture at Industrial Scale" (PDF). Retrieved 5 October 2013. Lange, ... Diphenylborinic acid has an extra high affinity for catechols compared with carbohydrates Diphenylborinic acid can catalyse the ...
*  Trifluoromethylation
Variations include another CF3 donor potassium (trifluoromethyl)trimethoxyborate, the use of aryl boronic acids or the use of a ... Chu, L.; Qing, F.-L. (2010). "Copper-mediated oxidative trifluoromethylation of boronic acids". Org. Lett. 12 (21): 5060-5063. ... Ruppert's reagent has been used for this purpose in an asymmetric induction approach to functionalise chiral amino acid ... Substrates are thiols, alcohols, phosphines, (hetero) arenes, unactivated olefins and unsaturated carboxylic acids. The ...
*  Bioconjugation
"Boronic acids facilitate rapid oxime condensations at neutral pH". Chemical Science. 6: 3329-3333. doi:10.1039/C5SC00921A. ... several N-terminal amino acids can undergo transamination to yield N-terminal aldehyde, such as glycine and aspartic acid ( ... Since natural amino acid residues are usually present in large quantities, it is often difficult to modify one single site. ... One of the N- termini modifications involves the functionalization of the terminal amino acid. The oxidation of N-terminal ...
*  Boroxine
These compounds are solids that are usually in equilibrium with their respective boronic acids at room temperature. Beside ... As discovered in the 1930s, boroxines are produced from their corresponding boronic acids by dehydration. This dehydration can ... Hall, Dennis G. (2005). Boronic Acids - Preparation and Applications in Organic Synthesis and Medicine. John Wiley & Sons ISBN ... Boroxine derivatives (boronic anhydrides) such as trimethylboroxine and triphenylboroxine also make up a broader class of ...
*  Blood sugar level
Blood glucose monitoring Saccharide recognition by boronic acids Daly, Mark E; Vale, C; Walker, M; Littlefield, A; Alberti, KG ...
*  Organoboron chemistry
... followed by hydrolysis of the boronic ester to the boronic acid with hydrochloric acid. The aldehyde is p-nitrobenzaldehyde. ... Compounds of the type BRn(OR)3-n are called borinic esters (n = 2), boronic esters (n = 1), and borates (n = 0). Boronic acids ... Boronic acids RB(OH)2 react with potassium bifluoride K[HF2] to form trifluoroborate salts K[RBF3] which are precursors to ... This reaction type is exemplified in the Suzuki reaction, which involves coupling of aryl- or vinyl-boronic acid with an aryl- ...
*  4-Nonylphenylboronic acid
"Discovery of Boronic Acids as Novel and Potent Inhibitors of Fatty Acid Amide Hydrolase". Journal of Medicinal Chemistry. 51 ( ... 4-Nonylphenylboronic acid is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC50 of ... "Design and synthesis of boronic acid inhibitors of endothelial lipase". Bioorganic & Medicinal Chemistry Letters. 22 (3): 1397 ...
*  Suzuki reaction
Boronic esters and organotrifluoroborate salts may be used instead of boronic acids. The catalyst can also be a palladium ... Boronic acids are less toxic and safer for the environment than organostannane and organozinc compounds. It is easy to remove ... A wide variety of reagents can be used for the Suzuki coupling, e.g., aryl- or vinyl-boronic acids and aryl- or vinyl-halides. ... The Suzuki reaction is an organic reaction, classified as a coupling reaction, where the coupling partners are a boronic acid ...
*  Arginase
Cox JD, Kim NN, Traish AM, Christianson DW (November 1999). "Arginase-boronic acid complex highlights a physiological role in ... In contrast, inhibiting arginase with ABH or other boronic acid inhibitors will maintain normal cellular levels of arginine, ... Arginase1 is activated by lactic acid in tumors to stimulate macrophages to help a tumor grow. When arginase1 was inhibited in ... Fernandes HS, Teixeira CS, Fernandes PA, Ramos MJ, Cerqueira NM (November 2016). "Amino acid deprivation using enzymes as a ...
*  List of investigational hormonal agents
Fulvestrant-3 boronic acid (ZB716) - estrogen receptor antagonist for breast cancer GTx-758 (Capesaris) - estrogen for prostate ... "Fulvestrant-3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD)". J. Med. Chem. 59 ...
*  ZB716
... , also known as fulvestrant-3-boronic acid, is a synthetic, steroidal, orally active antiestrogen which is under ... It is an analogue of fulvestrant in which the C3 hydroxyl group has been replaced with a boronic acid moiety. In accordance, ... "Fulvestrant-3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD)". J. Med. Chem. 59 ...
*  Dynamic combinatorial chemistry
"Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors". Angew. Chem. Int ... When a DCL is exposed to an external influence (such as proteins or nucleic acids), the equilibrium shifts and those components ... such as nucleic acids) to influence the evolution and generation of components within a DCL. Protein-directed DCC provides a ... "Enzymatic generation and in situ screening of a dynamic combinatorial library of sialic acid analogues". Angew. Chem. Int. Ed. ...
*  Christopher J. Schofield
"Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors". Angew. Chem. Int ... Recent areas of interest include the fat mass and obesity protein which was shown to be a nucleic acid demethylase and JMJD6 ... "Clavulanic Acid Dehydrogenase: Structural and Biochemical Analysis of the Final Step in the Biosynthesis of the β-Lactamase ... Nucleic Acids Research. 42 (7): 4741-4754. doi:10.1093/nar/gku085. ISSN 0305-1048. PMC 3985658 . PMID 24489119. Mackeen, Mukram ...
*  Tetrahydroxydiboron
... is a chemical reagent which can be used to prepare boronic acids. The reaction of boron trichloride with ... On a new boric acid ('Sub-boric acid') of the formula H4B2O4 and its esters]. Ber. Dtsch. Chem. Ges. A/B (in German). 70 (6): ... to produce what they termed sub-boric acid. The methanol used in this process can be recycled: BCl3 → − HCl + CH 3 OH {\ ...
*  Organotrifluoroborate
The organotrifluoroborate hydrolyses to the corresponding boronic acid in situ, so a boronic acid can be used in place of an ... Boronic acids RB(OH)2 react with potassium bifluoride K[HF2] to form trifluoroborate salts K[RBF3]. Organotrifluoroborates are ... They are often used in organic synthesis as alternatives to boronic acids (RB(OH)2), boronate esters (RB(OR′)2), and ... Molander, Gary A.; Ellis, Noel (2007). "Organotrifluoroborates: Protected Boronic Acids That Expand the Versatility of the ...
*  Abigail Doyle
Graham, T. J. A.; Doyle, A. G. Nickel-Catalyzed Cross Coupling of Chromene Acetals and Boronic Acids. Org. Lett. 2012, 14, 1616 ... Evidence for Boronic Acid-Assisted Oxidative Addition and an Iminium Activation Pathway. J. Am. Chem. Soc. 2012, 134, 16967- ...
*  2-oxoglutarate (2OG)-dependent dioxygenases
"Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors". Angew. Chem. Int ... is held by two histidine residues and one aspartic acid or glutamic acid residue. Based on evidence from X-ray crystallography ... The active site contains a highly conserved 2-His-1-carboxylate (HXD/E...H) amino acid residue triad motif, in which the ... Walport LJ, Hopkinson RJ, Schofield CJ (December 2012). "Mechanisms of human histone and nucleic acid demethylases". Curr. Opin ...
*  José Barluenga
"Metal-Free Carbon-Carbon Bond-Forming Reductive Coupling Between Boronic Acids and Tosyl-hydrazones". Nature Chemistry. 1: 494- ...
*  Affinity electrophoresis
Boronate affinity electrophoresis utilizes boronic acid infused acrylimide gels to purify NAD-RNA. This purification allows for ... Nucleic acids or nucleic acid fragments may be characterized by their affinity to other molecules. The methods have been used ... agarose gel electrophoresis is used to separate protein-bound amino acid complexes from free amino acids. Using a low voltage ...
*  Petasis reaction
Apart from vinyl boronic acids, aryl boronic acids and other heterocyclic derivatives can also be used in Petasis ... vinyl boronic acids are stable to air and water and can be removed during workup with a simple extraction. Many boronic acid ... A wide range of aryl boronic acids is tolerated, while the usage of vinyl boronic acids is not reported. It is interesting to ... When certain chiral amines, such as (S)-2-phenylglycinol, are mixed with an α-keto acid and vinyl boronic acid at room ...
*  IgA specific serine endopeptidase
"Inhibition of IgA1 proteinases from Neisseria gonorrhoeae and Hemophilus influenzae by peptide prolyl boronic acids". J. Biol. ... The enzyme is in fact capable of cleavage of proteins with the amino acid sequence Cleaves N-X-Z-Pro-Pro/-Y-Pro-C, where the X ... An IgA protease is a highly specific 106kDa enzyme that cleaves amino acid sequences of certain proteins. The natural substrate ...