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*  P-selectin
... which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in ... The P-selectin then promotes platelet aggregation through platelet-fibrin and platelet-platelet binding. P-selectin attaches to ... In quiescent platelet, P-selectin is located on the inner wall of α-granules. Platelet activation (through agonists such as ... Blood. 107 (7): 2736-44. doi:10.1182/blood-2004-07-2698. PMC 1895372 . PMID 16332977. Wein M, Sterbinsky SA, Bickel CA, ...
*  Multiple electrode aggregometry
... is a test of platelet function in whole blood. The test can be used to diagnose platelet disorders, monitor antiplatelet ... cAMP inhibits platelet aggregation, and decreased amounts of cAMP in platelets lead to platelet aggregation. The PGE1 reagent ... Binding of fibrinogen to GPIIb/IIIa receptors leads to platelet-to-platelet bridges and results in platelet aggregation. ... it stimulates the ADP receptors on platelets, activating the platelets. The activation of the platelets leads to shape change ...
*  Eptifibatide
Thrombocytopenia : The drug is contraindicated in patients with platelet counts of less than 100,000 per μl because no clinical ... Sometimes, these events were severe enough to require transfusion of blood or plasma concentrates to stop bleeding and ... It belongs to the class of the arginin-glycin-aspartat-mimetics and reversibly binds to platelets. Eptifibatide has a short ...
*  Thromboregulation
... which is the process of how blood platelets adhere to the endothelium of an injured blood vessel. Platelet aggregation is ... but platelet aggregation must grow exponentially to form a platelet thrombus and prevent blood loss. Platelet aggregation ... Platelet inhibition is important to prevent thrombotic episodes or the formation of blood clot and consequently preventing ... Some thromboregulators enhance platelet aggregation and some others inhibit the process. Platelet aggregation plays a critical ...
*  Discovery and development of direct thrombin inhibitors
When a blood vessel ruptures or gets injured, factor VII comes into contact with tissue factors which starts a process called ... Thrombin also activates factor XIII that stabilizes the fibrin complex and therefore the clot and it stimulates platelets, ... When this process is too active due to various problems the risk of blood clots or embolisms increases. As the name indicates ... Direct thrombin inhibitors (DTIs) are a class of anticoagulant drugs that can be used to prevent and treat embolisms and blood ...
*  Heparin-induced thrombocytopenia
This results in platelet activation and the formation of platelet microparticles, which initiate the formation of blood clots; ... HIT predisposes to thrombosis (the abnormal formation of blood clots inside a blood vessel) because platelets release ... In HIT, the platelet count in the blood falls below the normal range, a condition called thrombocytopenia. However, it is ... This has been referred to as an "iceberg phenomenon". HIT may be suspected if blood tests show a falling platelet count in ...
*  Beta-thromboglobulin
It is measured by ELISA in blood plasma or urine, and often in conjunction with Platelet factor 4) It is elevated in diabetes ... is a protein that is stored in alpha-granules of platelets and released in large amounts after platelet activation. It is a ... Blood. 107 (9): 3520-6. doi:10.1182/blood-2005-10-4285. PMC 1895768 . PMID 16391012. Page 121 in: Sterne, Jonathan; Kirkwood, ... Beta-Thromboglobulin also affects megakaryocyte maturation, and thus helps in regulating platelet production. Levels of Beta- ...
*  Chemokine
Increased CCL11 levels in blood plasma are associated with aging (and reduced neurogenesis) in mice and humans. The two N- ... Platelet factor-4 superfamily or intercrines. Some chemokines are considered pro-inflammatory and can be induced during an ... Murdoch, Craig; Finn, Adam (2000). "Chemokine receptors and their role in inflammation and infectious diseases". Blood. 95 (10 ... the growth of new blood vessels), or guide cells to tissues that provide specific signals critical for cellular maturation. ...
*  Thrombin
In the blood coagulation pathway, thrombin acts to convert factor XI to XIa, VIII to VIIIa, V to Va, fibrinogen to fibrin, and ... As part of its activity in the coagulation cascade, thrombin also promotes platelet activation and aggregation via activation ... Blood from a ruptured cerebral aneurysm clots around a cerebral artery, releasing thrombin. This can induce an acute and ... In human adults, the normal blood level of antithrombin activity has been measured to be around 1.1 units/mL. Newborn levels of ...
*  Platelet factor 4
This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood ... Nath N, Lowery CT, Niewiarowski S (1975). "Antigenic and antiheparin properties of human platelet factor 4 (PF4)". Blood. 45 (4 ... 1987). "Cloning and characterization of platelet factor 4 cDNA derived from a human erythroleukemic cell line". Blood. 69 (1): ... Platelet-activating factor Platelet-derived growth factor GRCh38: Ensembl release 89: ENSG00000163737 - Ensembl, May 2017 ...
*  Prasugrel
Maximum platelet inhibition was about 80%. Mean steady-state inhibition of platelet aggregation was about 70% following three ... Prasugrel (trade name Effient in the US and India, and Efient in the EU) is a drug used to prevent formation of blood clots. It ... Increasing platelet inhibition could increase bleeding risk. The relationship between inhibition of platelet aggregation and ... Platelet aggregation gradually returns to baseline values over five to 9 days after discontinuation of prasugrel, this time ...
*  GP1BA
Wenger RH, Kieffer N, Wicki AN, Clemetson KJ (1988). "Structure of the human blood platelet membrane glycoprotein Ib alpha gene ... Platelet glycoprotein Ib alpha chain also known as glycoprotein Ib (platelet), alpha polypeptide or CD42b (Cluster of ... "Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane". Blood. 69 (5): 1524-7. PMID 2436691. ... "Human signaling protein 14-3-3zeta interacts with platelet glycoprotein Ib subunits Ibalpha and Ibbeta". Blood. 91 (4): 1295- ...
*  Giant platelet disorder
Giant platelets cannot stick adequately to an injured blood vessel walls, resulting in abnormal bleeding when injured. Giant ... Platelet Disorders Overview of Platelet Disorders at eMedicine Mhawech, Paulette (2000). "Inherited Giant Platelet Disorders" ( ... Abnormality of the abdomen, nosebleeds, heavy menstrual bleeding, purpura, too few platelets circulating in the blood, and ... This would utilize platelet aggregation studies and flow cytometry. Giant platelet disorders can be further categorized: caused ...
*  P-selectin glycoprotein ligand-1
White blood cells present in flowing blood can interact with CAM. The first step in this interaction process is carried out by ... 2000). "P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions ... White blood cells normally do not interact with the endothelium of blood vessels. However, inflammation causes the expression ... of the white blood cell on the endothelial cell surface followed by stable adhesion and transmigration of the white blood cell ...
*  Quebec platelet disorder
Blood. 87: 4967-78. Diamandis M, Veljkovic DK, Maurer-Spurej E, Rivard GE, Hayward CPM (2008). "Quebec platelet disorder: ... There is also a quantitative deficiency in the platelet protein multimerin 1 (MMRN1). Furthermore, upon QPD platelet activation ... "Persons with Quebec platelet disorder have a tandem duplication of PLAU, the urokinase plasminogen activator gene". Blood. 115 ... in platelets. Consequently, stored platelet plasminogen is converted to plasmin, which is thought to play a role in degrading a ...
*  DMOZ - Health: Conditions and Diseases: Blood Disorders: Platelet Disorders
... essential for blood clotting. Normally 200.000-300,000 platelets are found in 1 cubic centimeter of blood. Also called ... Platelet is disc-shaped, small cellular element in the blood, ... Platelet is disc-shaped, small cellular element in the blood, ... essential for blood clotting. Normally 200.000-300,000 platelets are found in 1 cubic centimeter of blood. Also called ... "Health ... Platelet Disorders" search on: AOL - Ask - Bing - DuckDuckGo - Gigablast - Google - ixquick - Yahoo - Yandex - Yippy ...
*  Sphingosine kinase
Stoffel W, Heimann G, Hellenbroich B (1973). "Sphingosine kinase in blood platelets". Hoppe-Seyler's Z. Physiol. Chem. 354 (5 ...
*  12-Hydroxyeicosatetraenoic acid
Nugteren, D. H. (1975). "Arachidonate lipoxygenase in blood platelets". Biochimica et Biophysica Acta. 380 (2): 299-307. doi: ... Sub-primate mammals, such as the mouse, rat, rabbit, cow, and pig, express platelet type 12-lipoxygenase but also a leukocyte ... It was first found as a product of arachidonic acid metabolism made by human and bovine platelets through their 12S- ... Thus, the production of hepoxilins from 12(S)-HpETE may result from the intrinsic activity of platelet or leukocyte type 12- ...
*  ALOX12
Based predominantly on the presence of its mRNA, human ALOX12 is distributed predominantly in blood platelets and leukocytes ... Nugteren DH (February 1975). "Arachidonate lipoxygenase in blood platelets". Biochimica et Biophysica Acta. 380 (2): 299-307. ... "Immunocytochemical localization of platelet-type arachidonate 12-lipoxygenase in mouse blood cells". The Journal of ... regulate regional blood flow, and contribute to the regulation of blood pressure in animal models (see Hepoxilins). Far more ...
*  Fibrin
When the lining of a blood vessel is broken, platelets are attracted forming a platelet plug. These platelets have thrombin ... Blood platelets: biochemistry and physiology]". Hamostaseologie (in German). 23 (4): 149-58. PMID 14603379. doi:10.1267/ ... the blockage of a vessel by an agglutination of red blood cells, platelets, polymerized fibrin and other components. ... TGW1916.net, Defibrinated blood harvested from sheep (video) Fibrin: Molecule of the Month, by David Goodsell, RCSB Protein ...
*  Vesicular monoamine transporter
It is also expressed blood platelets. VMAT2 is also co-expressed in chromaffin cells. Expression of the two transporters in ... Activated heterotrimeric G-protein Gαq downregulates VMAT2 mediated serotonin transport in blood platelets, but this is not the ... May 2003). "The vesicular monoamine content regulates VMAT2 activity through Galphaq in mouse platelets. Evidence for ...
*  Copper deficiency
Thrombocytopenia (low blood platelets) is unusual. The peripheral blood and bone marrow aspirate findings in copper deficiency ... The characteristic hematological (blood) effects of copper deficiency are anemia (which may be microcytic, normocytic or ... Bone marrow aspirate in both conditions may show dysplasia of blood cell precursors and the presence of ring sideroblasts ( ... The deficiency in copper can cause many hematological manifestations, such as myelodysplasia, anemia, low white blood cell ...
*  Helge Stormorken
Thaulow, E; Erikssen, J; Sandvik, L; Stormorken, H; Cohn, PF (August 1991). "Blood platelet count and function are related to ... Holmsen, H; Day, HJ; Stormorken, H (1969). "The blood platelet release reaction". Scandinavian Journal of Haematology. ... Gogstad, GO; Stormorken, H; Solum, NO (15 July 1983). "Platelet alpha 2-antiplasmin is located in the platelet alpha-granules ... Day, HJ; Stormorken, H; Holmsen, H (1973). "Subcellular localization of platelet factor 3 and platelet factor 4". Scandinavian ...
*  Anagrelide
... or overproduction of blood platelets. It also has been used in the treatment of chronic myeloid leukemia. Anagrelide controlled ... Anagrelide works by inhibiting the maturation of platelets from megakaryocytes. The exact mechanism of action is unclear, ... age over 60 years platelet count over 1000×109/L a history of thrombosis According to a 2005 Medical Research Council ...
*  Monoamine oxidase
MAO-B is mostly found in blood platelets. MAO-A appears at roughly 80% of adulthood levels at birth, increasing very slightly ... Domino EF, Khanna SS (March 1976). "Decreased blood platelet MAO activity in unmedicated chronic schizophrenic patients". The ... Schildkraut JJ, Herzog JM, Orsulak PJ, Edelman SE, Shein HM, Frazier SH (April 1976). "Reduced platelet monoamine oxidase ... Oreland L (January 2004). "Platelet monoamine oxidase, personality and alcoholism: the rise, fall and resurrection". ...
*  Prostaglandin-endoperoxide synthase 2
... particularly prostacyclin which is found in blood vessel lining. Prostacyclin relaxes or unsticks platelets, so selective COX-2 ... It sticks platelets together and promotes clotting; inhibiting this helps prevent heart disease. On the other hand, PTGS2 (COX- ...
*  Gaseous signaling molecules
CO inhibits blood platelet aggregation and adhesion. CO may play a role as potential therapeutic agent. In mammals, carbon ... It lowers blood pressure and slows hypertensive remodeling of blood vessels, especially thickening of their intima. It also ... Bicarbonate ions are crucial for regulating blood pH. A person's breathing rate influences the level of CO2 in their blood. ... Carbon dioxide is one of the mediators of local autoregulation of blood supply. If its levels are high, the capillaries expand ...