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*  Discovery and development of direct thrombin inhibitors
... factor VII comes into contact with tissue factors which starts a process called the blood coagulation cascade. Its purpose is ... In a 2012 meta-analysis dabigatran was associated with increased risk of myocardial infarction (MI) or ACS when tested against ... When this process is too active due to various problems the risk of blood clots or embolisms increases. As the name indicates ... Direct thrombin inhibitors (DTIs) are a class of anticoagulant drugs that can be used to prevent and treat embolisms and blood ...
*  Discovery and development of direct Xa inhibitors
Blood coagulation is a complex process by which the blood forms clots. It is an essential part of hemostasis and works by ... The first group to be tested was the non-active site as it needs to be stabilized before SAR testing on the p-methoxyphenyl ... Heparin targets multiple factors in the blood coagulation cascade, one of them being FXa. At first, it had many side effects ... Mackman, N; Tilley, R.E.; Key, N.S. (2007). "Role of the Extrinsic Pathway of Blood Coagulation in Hemostasis and Thrombosis". ...
*  Thrombin
... activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is ... Human testing has not been conducted. Due to its high proteolytic specificity, thrombin is a valuable biochemical tool. The ... In the blood coagulation pathway, thrombin acts to convert factor XI to XIa, VIII to VIIIa, V to Va, fibrinogen to fibrin, and ... "Development of the human coagulation system in the full-term infant". Blood. 70 (1): 165-72. PMID 3593964. Bajzar L, Morser J, ...
*  Thromboelastography
... (TEG) is a method of testing the efficiency of blood coagulation. It is a test mainly used in surgery and ... More common tests of blood coagulation include prothrombin time (PT,INR) and partial thromboplastin time (aPTT) which measure ... The signal of the pin suspended in the blood sample is transmitted via an optical detector system. The test is started by ... The template below (Myeloid blood tests) is being considered for merging. See templates for discussion to help reach a ...
*  Disseminated intravascular coagulation
There are two main types acute (rapid onset) and chronic (slow onset). Diagnosis is typically based on blood tests. Findings ... Disseminated intravascular coagulation (DIC) is a condition in which blood clots form throughout the body blocking small blood ... This may include blood in the urine, blood in the stool, or bleeding into the skin. Complications may include organ failure. ... Upon exposure to blood and platelets, TF binds with activated factor VIIa (normally present in trace amounts in the blood), ...
*  Thromboelastometry
INTEM This test mildly activates the contact phase of haemostasis. The result is influenced by coagulation factors, platelets, ... Reduction of blood transfusion and cost saving by thrombelastometry-based point-of-care coagulation management in visceral and ... The signal of the pin suspended in the blood sample is transmitted via an optical detector system. The test is started by ... The result is influenced by extrinsic coagulation factors, platelets and fibrinogen. EXTEM is a screening test for the ( ...
*  Lupus anticoagulant
The presence of prolonged clotting times on a routine plasma test often triggers functional testing of the blood clotting ... These antibodies tend to delay in-vitro coagulation in phospholipid-dependent laboratory tests such as the partial ... The initial workup of a prolonged PTT is a mixing test whereby the patient's plasma is mixed with normal pooled plasma and the ... If the mixing test indicates an inhibitor, diagnosis of a lupus anticoagulant is then confirmed with phospholipid-sensitive ...
*  Thrombin time
It is used to diagnose blood coagulation disorders and to assess the effectiveness of fibrinolytic therapy. This test is ... is a blood test that measures the time it takes for a clot to form in the plasma of a blood sample containing anticoagulant, ... or under-filled in order to ensure the correct anticoagulant-to-blood ratio: one part anticoagulant per nine parts blood. The ... Whole blood is taken with either citrate or oxalate additive (if using the vacutainer system, this is a light blue top tube). ...
*  Venipuncture
In general, tests requiring whole blood call for blood samples collected in test tubes containing some form of the ... Sodium Citrate is the anticoagulant used in specimens collected for coagulation tests. The majority of chemistry and immunology ... The culture will determine if the patient has pathogens in the blood. Normally blood is sterile. When drawing blood from ... There are also a variety of tube and bottle sizes and volumes for different test requirements. The test tubes in which blood is ...
*  Watershed stroke
... and blood coagulation tests. The Oxfordshire Community Stroke Project classification (OCSP, also known as the Bamford or Oxford ... a disease of the blood vessels Arterial hypotension, or low blood pressure in the arteries Hypertension, or high blood pressure ... which can lead to deformed red blood cells clogging blood vessels and impeding blood flow Carotid artery stenosis, or narrowing ... Blood tests for risk factors also may be ordered, including cholesterol levels, triglyceride levels, homocysteine levels, ...
*  Coagulation testing
Local tests characterize the results of work of the separate components of the blood coagulation system cascade, as well as of ... All the diversity of clinical tests of the blood coagulation system can be divided into 2 groups: global (integral, general) ... Blood clotting tests are the tests used for diagnostics of the hemostasis system. Coagulometer is the medical laboratory ... or prothrombin test, INR, PT) - velocity of passage of the extrinsic blood coagulation pathway poor plasma not sensitive to ...
*  Factitious disorder imposed on self
... including complete blood count (CBC), urine toxicology, drug levels from blood, cultures, coagulation tests, assays for thyroid ... A summary of more common and reported cases of factitious disorder (Munchausen syndrome), and the laboratory tests used to ... In some cases CT scan, magnetic resonance imaging, psychological testing, electroencephalography, or electrocardiography may ...
*  Aminocaproic acid
"Epsilon aminocaproic acid reduces blood transfusion and improves the coagulation test after pediatric open-heart surgery: a ... control of oral bleeding in patients with congenital and acquired coagulation disorders, control of perioperative bleeding ...
*  Automated analyser
These are used to perform complete blood counts, erythrocyte sedimentation rates (ESRs), or coagulation tests. Automated cell ... Some tests and test categories are unique in their mechanism or scope, and require a separate analyser for only a few tests, or ... Depending on the test, different substances can be added to the blood plasma to trigger a clotting reaction. The progress of ... Automated coagulation machines or Coagulometers measure the ability of blood to clot by performing any of several types of ...
*  Winged infusion set
"Influence of the needle bore size on platelet count and routine coagulation testing". Blood Coagul Fibrinolysis. 17 (7): 557-61 ... butterflies based on belief that such small-bore needles hemolyze and/or clot blood samples and hence invalidate blood tests. ... When the needle enters the vein, venous blood pressure generally forces a small amount of blood into the set's transparent ... 25G butterflies connected directly to vacuum tubes caused the same amount of hemolysis and gave the same coagulation panel test ...
*  Partial thromboplastin time
... is a medical test that characterizes blood coagulation, also known as clotting. A historical name for this measure is the ... The test is termed "partial" due to the absence of tissue factor from the reaction mixture. Blood is drawn into a test tube ... The template below (Myeloid blood tests) is being considered for merging. See templates for discussion to help reach a ... The blood is mixed, then centrifuged to separate blood cells from plasma (as Partial thromboplastin time is most commonly ...
*  Vitamin K2
... a laboratory test measure of blood coagulation). Individuals taking anticoagulant medications, such as warfarin (coumarins), ... Blood. 104 (10): 3231-3232. doi:10.1182/blood-2004-04-1277. Koos, R.; Mahnken, A. H.; M├╝hlenbruch, G.; Brandenburg, V.; ... Vitamin K2 has only begun[when?] to be studied, and the few studies on humans suffer from either a small number of test ... Traditionally, K vitamins were recognized as the factor required for coagulation, but the functions performed by this vitamin ...
*  Rotem
... test of blood-coagulation, see thromboelastography article Rotem Control & Management, advanced climate controllers and ...
*  Gen-Probe
... analyzing blood transfusions for immune response, testing coagulation pathways, and organ transplant viability. Their products ... Gen-Probe was a company based in San Diego, California specializing in Clinical Diagnostics, Blood Screening, Transplant ... The Company's molecular diagnostics products were used for diagnosis of infectious diseases, blood screening, ... Lifesaving Benefits of Blood Screening Official website. ...
*  Thrombophlebitis
Doppler ultrasound Extremity arteriography Blood coagulation studies (Blood clotting tests) Prevention consists of walking, ... Frequent checks of the pulse, blood pressure, and temperature may be required. If the cause is not readily identifiable, tests ... Thrombophlebitis causes include disorders related to increased tendency for blood clotting and reduced speed of blood in the ... doi:10.1182/blood-2006-10-053736. ISSN 0006-4971. PMC 1976377 . PMID 17496204. Retrieved 23 October 2016. Tamparo, Carol D. ( ...
*  Anticoagulant
Citrate is in liquid form in the tube and is used for coagulation tests, as well as in blood transfusion bags. It binds the ... In addition, test tubes used for laboratory blood tests will have chemicals added to stop blood clotting. Apart from heparin, ... Anticoagulants, commonly referred to as blood thinners, are chemical substances that prevent or reduce coagulation of blood, ... Vitamin E A Bethesda unit (BU) is a measure of blood coagulation inhibitor activity. It is the amount of inhibitor that will ...
*  TCT
... a test used in blood coagulation Tocotrienol, a group of four isomers occurring in Vitamin E Trans Canada Trail, a proposed ...
*  Gastrointestinal bleeding
Recommended laboratory blood testing includes: cross-matching blood, hemoglobin, hematocrit, platelets, coagulation time, and ... along with blood tests. Small amounts of bleeding may be detected by fecal occult blood test. Endoscopy of the lower and upper ... When there is significant blood loss over a short time, symptoms may include vomiting red blood, vomiting black blood, bloody ... This can be confirmed with a fecal occult blood test. Differentiating between upper and lower bleeding in some cases can be ...
*  Nisoxetine
Doses ranging from 1 mg to 50 mg do not result in any changes in base line values in haematologic tests, routine blood ... chemistries, or coagulation parameters. Larger doses produce some side effects, but no electrocardiographic changes are ... Preclinical test conclude that the drug, in tested doses, appears to be safe for use in humans. Nisoxetine is a racemic ... Richard Kattau in the Rathbun laboratory tested the newly created drugs within the series of PPAs for their ability to reverse ...
*  List of MeSH codes (E01)
... blood coagulation tests MeSH E01.450.375.115.320 --- international normalized ratio MeSH E01.450.375.115.600 --- partial ... whole blood coagulation time MeSH E01.450.375.120 --- blood grouping and crossmatching MeSH E01.450.375.125 --- blood ... blood glucose self-monitoring MeSH E01.370.374.355 --- glucose tolerance test MeSH E01.370.374.530 --- ovarian function tests ... speech articulation tests MeSH E01.450.150.100 --- blood chemical analysis MeSH E01.450.150.100.100 --- blood gas analysis MeSH ...
*  Haemophilia A
... these signs may lead to blood tests which indicates haemophilia. In other people, especially those with moderate or mild ... while digestive tract and cerebral haemorrhages are also germane to other coagulation disorders.Though typically not life- ... Joint damage is not a result of blood in the capsule but rather the healing process. When blood in the joint is broken down by ...
*  Reference ranges for blood tests
MedlinePlus Encyclopedia 003652 Antithrombin III at eMedicine Antithrombin CO000300 in Coagulation Test Handbook at ... and not venous which otherwise is standard for other blood tests. Acid-base and blood gases are among the few blood ... Reference ranges for blood tests are sets of values used by a health professional to interpret a set of medical test results ... are for total blood and not only blood plasma. These values are for total blood and not only blood plasma. Acute phase proteins ...