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*  Factor XIII
... or fibrin stabilizing factor is an enzyme (EC 2.3.2.13) of the blood coagulation system that crosslinks fibrin. ... Factor XIII is activated by thrombin into factor XIIIa; its activation into Factor XIIIa requires calcium as a cofactor. A ... Factor XIII has two forms: a plasmatic form that flows freely in the blood plasma, and a cellular form carried inside platelet ... Factor XIII deficiency D-dimer Coagulation Dorgalaleh A, Naderi M, Hosseini MS, Alizadeh S, Hosseini S, Tabibian S, et al. ( ...
*  Factor XI
"Activation of human blood coagulation factor XI independent of factor XII. Factor XI is activated by thrombin and factor XIa in ... "Coagulation factor XI: a database of mutations and polymorphisms associated with factor XI deficiency". Blood Coagulation & ... "Expression of human blood coagulation factor XI: characterization of the defect in factor XI type III deficiency". Blood. 79 (6 ... factor XII, factor XI, and factor IX). Factor XIa activates factor IX by selectively cleaving arg-ala and arg-val peptide bonds ...
*  Coagulation factor II receptor
Blood. 82 (5): 1532-7. PMID 8395910. "Entrez Gene: F2R coagulation factor II (thrombin) receptor". "José RJ, Williams AE, ... Proteinase-activated receptor 1 (PAR1) also known as Protease-activated receptor 1 or coagulation factor II (thrombin) receptor ... blood. 105 (8): 3178-84. doi:10.1182/blood-2004-10-3985. PMID 15626732. José RJ, Williams AE, Mercer PF, Sulikowski MG, Brown ... PAR-1 has multifaceted effects and plays a key role in mediating the interplay between coagulation and inflammation, which is ...
*  Factor X
Leytus SP, Foster DC, Kurachi K, Davie EW (September 1986). "Gene for human factor X: a blood coagulation factor whose gene ... Factor Xa is the activated form of the coagulation factor thrombokinase, known eponymously as Stuart-Prower factor. Factor X is ... Factor X is activated, by hydrolysis, into factor Xa by both factor IX (with its cofactor, factor VIII in a complex known as ... The result is a Factor VIIa/TF complex which catalyzes the activation of Factor X and Factor IX. Factor Xa formed on the ...
*  Scott syndrome
Deficiency of factor Xa-factor Va binding sites on the platelets of a patient with a bleeding disorder. Blood 1979; 54:1015- ... Nature online, November 24, 2010 Heemskerk JWM, Bevers EM, Lindhout T. Platelet activation and blood coagulation, Thromb Haem ... such as factor VIIIa-IXa (tenase) and factor Va-Xa (prothrombinase). In Scott syndrome, the mechanism for translocating PS to ... a study of the red blood cells of Scott syndrome. Blood 1992;79:380-388 Kojima H, Newton-Nash D, Weiss HJ, Sims PJ, Zhao J, ...
*  Factor VIII
... participates in blood coagulation; it is a cofactor for factor IXa which, in the presence of Ca2+ and phospholipids ... The active protein (sometimes written as coagulation factor VIIIa) interacts with another coagulation factor called factor IX. ... Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, factor VIII ... "NIH: F8 - coagulation factor VIII". National Institutes of Health. "Entrez Gene: F8 coagulation factor VIII, procoagulant ...
*  Factor V Leiden
May 1994). "Mutation in blood coagulation factor V associated with resistance to activated protein C". Nature. 369 (6475): 64-7 ... Factor V Leiden (rs6025) is a variant (mutated form) of human factor V (one of several substances that helps blood clot), which ... The risk of developing a clot in a blood vessel depends on whether a person inherits one or two copies of the factor V Leiden ... In both methods, the time it takes for blood to clot is decreased in the presence of the factor V Leiden mutation. This is done ...
*  Discovery and development of direct thrombin inhibitors
... factor VII comes into contact with tissue factors which starts a process called the blood coagulation cascade. Its purpose is ... These factors generate more thrombin. Thrombin also activates factor XIII that stabilizes the fibrin complex and therefore the ... Most of those drugs are in the class of direct factor Xa inhibitors, but there is one DTI called AZD0837, which is a follow-up ... When this process is too active due to various problems the risk of blood clots or embolisms increases. As the name indicates ...
*  Discovery and development of direct Xa inhibitors
TAP and antistasin were used to estimate factor Xa as a drug target. Blood coagulation is a complex process by which the blood ... Heparin targets multiple factors in the blood coagulation cascade, one of them being FXa. At first, it had many side effects ... Factor Xa is an activated serine protease that occupies a key role in the blood coagulation pathway by converting prothrombin ... These factors activate each other in a blood coagulation cascade that occurs through two separate pathways that interact, the ...
*  Thrombin
... activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is ... In the blood coagulation pathway, thrombin acts to convert factor XI to XIa, VIII to VIIIa, V to Va, fibrinogen to fibrin, and ... "The life cycle of coagulation factor VIII in view of its structure and function". Blood. 92 (11): 3983-96. PMID 9834200. Plow ... Prothrombin (coagulation factor II) is proteolytically cleaved to form thrombin in the clotting process. Thrombin in turn acts ...
*  Protein C
... , also known as autoprothrombin IIA and blood coagulation factor XIV, is a zymogen, the activated form of which plays ... Factor VIIIa augments Factor X activation by a factor of around 200,000. Because of its importance in clotting, Factor VIII is ... It acts as a serine protease zymogen: APC proteolyses peptide bonds in activated Factor V and Factor VIII (Factor Va and Factor ... Cofactors in the inactivation of Factor Va and Factor VIIIa include protein S, Factor V, high-density lipoprotein, anionic ...
*  Disseminated intravascular coagulation
As clotting factors and platelets are used up, bleeding may occur. This may include blood in the urine, blood in the stool, or ... Upon exposure to blood and platelets, TF binds with activated factor VIIa (normally present in trace amounts in the blood), ... Disseminated intravascular coagulation (DIC) is a condition in which blood clots form throughout the body blocking small blood ... This complex further activates factor IX and X to IXa and Xa, respectively, leading to the common coagulation pathway and the ...
*  DMOZ - Health: Conditions and Diseases: Blood Disorders: Coagulation Disorders: Factor V Leiden
... is a hereditary blood disorder that causes hypercoagulability and an increased risk of thrombosis. ... Factor V Leiden, also known as Activated Protein C Resistance, ... Support for sufferers of the Factor Five Leiden blood clotting ... Health Conditions and Diseases Blood Disorders Coagulation Disorders Factor V Leiden 2 ... Factor V Leiden, also known as Activated Protein C Resistance, is a hereditary blood disorder that causes hypercoagulability ...
*  Kringle domain
These are important in protein-protein interactions with blood coagulation factors. The name Kringle comes from the ... Patthy L (1985). "Evolution of the proteases of blood coagulation and fibrinolysis by assembly from modules". Cell. 41 (3): 657 ... and coagulation factor XII". J. Mol. Evol. 26 (4): 358-369. doi:10.1007/BF02101155. PMID 3131537. ... "Amino acid sequence of the heavy chain of human alpha-factor XIIa (activated Hageman factor)". J. Biol. Chem. 260 (9): 5328- ...
*  Fibronectin type II domain
Type II domains have also been found in a range of proteins including blood coagulation factor XII; bovine seminal plasma ... Structural similarity of the protease precursor to blood coagulation factor XII". J. Biol. Chem. 268 (14): 10024-10028. PMID ... Fibronectins are involved in a number of important functions e.g., wound healing; cell adhesion; blood coagulation; cell ... Kornfeld S (1992). "Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptors". Annu. Rev. ...
*  Snake venom factor V activator
Kisiel, W.; Canfield, W. (1981). "M. Snake venom proteases that activate blood-coagulation factor V". Methods Enzymol. 80: 275- ... Snake venom factor V activator (EC 3.4.21.95) is an enzyme. This enzyme catalyses the following chemical reaction Fully ... Snake venom factor V activator at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ... Tokunaga, F.; Nagasawa, K.; Tamura, S.; Miyata, T.; Iwanaga, S.; Kisiel, W. (1988). "The factor V-activating enzyme (RVV-V) ...
*  Plasma frozen within 24 hours
... of the blood coagulation-factor activity of FFP. Given the fact that there is typically an overabundance of coagulation factors ... Much of the donor blood supply is obtained at "remote" blood donation events, such as blood drives at colleges, community ... However, the (male) donor blood can be separated into packed red blood cells and plasma within 24 hours (and usually less). ... It differs from fresh-frozen plasma (FFP) in that it is frozen within 24 hours of blood collection, whereas FFP is frozen ...
*  Asim Duttaroy
Dutta-Roy, A.; Ray, T.; Sinha, A. (1986). "Prostacyclin stimulation of the activation of blood coagulation factor X by ... Impact of Maternal Nutrition Early Nutrition and Lifestyle Factors: Effects on First Trimester Placenta Human Blood Platelet ... growth factor secretion and expression of several adhesive factors. In addition, hyperactive platelets are involved in the well ... Dutta-Roy, A. K.; Sinha, A. K. (1987). "Purification and properties of prostaglandin E1/prostacyclin receptor of human blood ...
*  Protein-glutamine gamma-glutamyltransferase
Takahashi N, Takahashi Y, Putnam FW (1986). "Primary structure of blood coagulation factor XIIIa (fibrinoligase, ... Other names in common use include: factor XIIIa, fibrin stabilizing factor, fibrinoligase, glutaminylpeptide gamma- ... This enzyme participates in complement and coagulation cascades and Huntington's disease. It employs one cofactor, calcium. ...
*  Thrombophilia
... is caused by abnormalities in blood consistency, which is determined by the levels of coagulation factors and ... The combination activates factor X to factor Xa and factor IX to factor IXa. Factor Xa (in the presence of factor V) activates ... Normal coagulation is initiated by the release of tissue factor from damaged tissue. Tissue factor binds to circulating factor ... and there are higher levels of coagulation proteins such as von Willebrand factor, fibrinogen, factor VII and factor VIII. ...
*  Multicopper oxidase
... blood coagulation factors V (Fa V) and VIII (Fa VIII); yeast Fet3p (FET3) required for ferrous iron uptake; yeast hypothetical ... Mann KG, Jenny RJ, Krishnaswamy S (1988). "Cofactor proteins in the assembly and expression of blood clotting enzyme complexes ...
*  Factor XIII deficiency
1999). "Blood coagulation factor XIII: structure and function". Thrombosis Research. 94 (5): 271-305. doi:10.1016/S0049-3848(99 ... Recombinant factor XIII (rFXIII) is the only drug alternative to receiving blood transfusions, the traditional treatment for ... Factor XIII Dorgalaleh A, Naderi M, Hosseini MS, Alizadeh S, Hosseini S, Tabibian S, et al. (2015). "Factor XIII Deficiency in ... Blood. 108 (1): 57-62. doi:10.1182/blood-2005-02-0788. PMID 16556896. "Recombinant Factor XIII". 2010. http://www.hemophilia. ...
*  F13B
Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a ... Coagulation factor XIII B chain is a protein that in humans is encoded by the F13B gene. This gene encodes coagulation factor ... 1993). "Two genetic defects in a patient with complete deficiency of the b-subunit for coagulation factor XIII". Blood. 82 (1 ... Muszbek L, Adány R, Mikkola H (1997). "Novel aspects of blood coagulation factor XIII. I. Structure, distribution, activation, ...
*  Discoidin domain
... is major protein domain of many blood coagulation factors. Blood coagulation factors V and VIII contain a C-terminal, twice ... Davie EW, Kane WH (1986). "Cloning of a cDNA coding for human factor V, a blood coagulation factor homologous to factor VIII ... Davie EW, Kane WH (1988). "Blood coagulation factors V and VIII: structural and functional similarities and their relationship ... In coagulation factors V and VIII the repeated domains compose part of a larger functional domain which promotes binding to ...
*  Prothrombin activator
... is a complex of a dozen blood coagulation factors that functions in catalyzing prothrombin into thrombin ... Prothrombin activator is released in the body by a cascade of chemical reactions in response to damage in a blood vessel. ...
*  Haemophilia A
Joint damage is not a result of blood in the capsule but rather the healing process. When blood in the joint is broken down by ... The problem is that in these individuals, factor VIII infusions are ineffective. Recently[update] activated factor VII has ... while digestive tract and cerebral haemorrhages are also germane to other coagulation disorders.Though typically not life- ... Factor VIII medication may be used to treat and prevent bleeding in people with haemophilia A. In terms of the symptoms of ...
*  HGFAC
Structural similarity of the protease precursor to blood coagulation factor XII". J Biol Chem. 268 (14): 10024-8. PMID 7683665 ... phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator". ... "Entrez Gene: HGFAC HGF activator". Nakamura T (1992). "Structure and function of hepatocyte growth factor". Prog. Growth Factor ... Blood. 107 (2): 760-8. doi:10.1182/blood-2005-05-1929. PMID 16189274. Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human ...