Loading...
*  Factor XI
"Activation of human blood coagulation factor XI independent of factor XII. Factor XI is activated by thrombin and factor XIa in ... Factor IXa, in turn, activates factor X. Inhibitors of factor XIa include protein Z-dependent protease inhibitor (ZPI, a member ... "Coagulation factor XI: a database of mutations and polymorphisms associated with factor XI deficiency". Blood Coagulation & ... "Expression of human blood coagulation factor XI: characterization of the defect in factor XI type III deficiency". Blood. 79 (6 ...
*  Factor X
"The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: ... Leytus SP, Foster DC, Kurachi K, Davie EW (September 1986). "Gene for human factor X: a blood coagulation factor whose gene ... Factor Xa is the activated form of the coagulation factor thrombokinase, known eponymously as Stuart-Prower factor. Factor X is ... "The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: ...
*  Factor VIII
... participates in blood coagulation; it is a cofactor for factor IXa which, in the presence of Ca2+ and phospholipids ... the incidence of these inhibitors is dependent of various factors, including the factor VIII product itself. In the 1980s, some ... The active protein (sometimes written as coagulation factor VIIIa) interacts with another coagulation factor called factor IX. ... Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, factor VIII ...
*  Discovery and development of direct thrombin inhibitors
... factor VII comes into contact with tissue factors which starts a process called the blood coagulation cascade. Its purpose is ... but the research focus has shifted towards factor Xa inhibitors, or even dual thrombin and fXa inhibitors that have a broader ... Direct thrombin inhibitors (DTIs) are a class of anticoagulant drugs that can be used to prevent and treat embolisms and blood ... Most of those drugs are in the class of direct factor Xa inhibitors, but there is one DTI called AZD0837, which is a follow-up ...
*  Discovery and development of direct Xa inhibitors
TAP and antistasin were used to estimate factor Xa as a drug target. Blood coagulation is a complex process by which the blood ... and orally bioavailable inhibitor of blood coagulation factor Xa". J Med Chem. 50 (22): 5339-5356. doi:10.1021/jm070245n. PMID ... and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa". Journal of Medicinal Chemistry. CS1 maint: Multiple names: ... and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa". Journal of Medicinal Chemistry. 50 (22): 5339-5356. doi: ...
*  Thrombin
... activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is ... Thrombin bound to thrombomodulin activates protein C, an inhibitor of the coagulation cascade. The activation of protein C is ... In the blood coagulation pathway, thrombin acts to convert factor XI to XIa, VIII to VIIIa, V to Va, fibrinogen to fibrin, and ... "The life cycle of coagulation factor VIII in view of its structure and function". Blood. 92 (11): 3983-96. PMID 9834200. Plow ...
*  Disseminated intravascular coagulation
As clotting factors and platelets are used up, bleeding may occur. This may include blood in the urine, blood in the stool, or ... Coagulation inhibitors are also consumed in this process. Decreased inhibitor levels will permit more clotting so that a ... Upon exposure to blood and platelets, TF binds with activated factor VIIa (normally present in trace amounts in the blood), ... Disseminated intravascular coagulation (DIC) is a condition in which blood clots form throughout the body blocking small blood ...
*  Thromboelastometry
TEM investigates the interaction of coagulation factors, their inhibitors, anticoagulant drugs, blood cells, specifically ... Prolongation of CT may be a result of coagulation deficiencies, primarily coagulation factors, or heparin (dependent on the ... Whole blood coagulation thrombelastographic profiles employing minimal tissue factor activation. J Thromb Haemost. 2003;1:551-8 ... Whole blood thrombelastographic coagulation profiles using minimal tissue factor activation can display hypercoagulation in ...
*  Kunitz domain
This is a highly selective inhibitor of factor Xa in the blood coagulation pathways. TAP molecules are highly dipolar, and are ... tissue factor pathway inhibitor precursor; and Kunitz STI protease inhibitor contained in legume seeds. Kunitz domains are ... bovine pancreatic trypsin inhibitor, BPTI), Alzheimer's amyloid precursor protein (APP), and tissue factor pathway inhibitor ( ... Salier JP (1990). "Inter-alpha-trypsin inhibitor: emergence of a family within the Kunitz-type protease inhibitor superfamily ...
*  C1-inhibitor
This situation is analogous to the low levels of clotting factors found in disseminated intravascular coagulation (DIC). Blood- ... C1-inhibitor is contained in the human blood; it can, therefore, be isolated from donated blood. Risks of infectious disease ... C1-inhibitor (C1-inh, C1 esterase inhibitor) is a protease inhibitor belonging to the serpin superfamily. Its main function is ... Note that C1-inhibitor is the most important physiological inhibitor of plasma kallikrein, fXIa, and fXIIa. C1-inhibitor is the ...
*  Tissue factor pathway inhibitor
Rao LV, Rapaport SI (1987). "Studies of a mechanism inhibiting the initiation of the extrinsic pathway of coagulation". Blood. ... "The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: ... "The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: ... Higuchi DA, Wun TC, Likert KM, Broze GJ (1992). "The effect of leukocyte elastase on tissue factor pathway inhibitor". Blood. ...
*  Protein Z-related protease inhibitor
Z-dependent protease inhibitor is a protein circulating in the blood which inhibits factors Xa and XIa of the coagulation ... Blood 2000;96:3049-55. Fulltext. PMID 11049983. The MEROPS online database for peptidases and their inhibitors: I04.005. ... It is a member of the class of the serine protease inhibitors (serpins). Its name implies that it requires protein Z, another ... Isolation of protein Z-dependent plasma protease inhibitor. Proc Natl Acad Sci U S A 1998;95:9250-5. Fulltext. PMID 9689066. ...
*  Protein C inhibitor
... inhibiting several blood coagulation enzymes counting thrombin and factor Xa. In the beginning, protein C inhibitor(PCI) was ... Protein C inhibitor (PCI) is serine protease inhibitor of serpin type that is found in most tissues and fluids, including blood ... doi:10.1182/blood-2009-04-217240. PMID 19855083. Pratt CW, Church FC (May 1992). "Heparin binding to protein C inhibitor" (PDF ... Hayashi S, Wakizaka A (July 1995). "Urinary protein C inhibitor binding region in the A alpha-chain of human fibrinogen". Blood ...
*  Complications of diabetes mellitus
... blood coagulation factors, and lipids. and subsequently bring about complications like microvascular and cardiovascular ... P. Zaoui, et al, "Role of Metalloproteases and Inhibitors in the Occurrence and Prognosis of Diabetic Renal Lesions," Diabetes ... April 2011). "Coagulation Factors Evaluation in NIDDM Patients". American Journal of Biochemistry and Molecular Biology. 1 (3 ... Non-modifiable risk factors of diabetic complications are type of diabetes, age of onset, and genetic factors, both protective ...
*  Draculin
It functions as an anticoagulant, inhibiting coagulation factors IX (IXa) and X (Xa), thus keeping the blood of the bitten ... "Draculin, the anticoagulant factor in vampire bat saliva, is a tight-binding, noncompetitive inhibitor of activated factor X." ... It may also be used as a blood thinner for the prevention of heart attacks. The protein has shown promise when treating ... Draculin is a reversible, slow tight binding, noncompetitive inhibitor of FXa. It does not act on thrombin, trypsin or ...
*  Hemostasis
... the endothelial cells stop secretion of coagulation and aggregation inhibitors and instead secrete von Willebrand factor which ... This involves coagulation, blood changing from a liquid to a gel. Intact blood vessels are central to moderating blood's ... The third and last step is called coagulation or blood clotting. Coagulation reinforces the platelet plug with fibrin threads ... "blood", and στάσις stásis, "stasis", yielding "motionlessness or stopping of blood". Hemostasis occurs when blood is present ...
*  Octapharma
Granulocyte colony-stimulating factor, long acting) Alpha-1-Antitrypsin C1-Esterase-Inhibitor Human coagulation factor VII ... non-blood-type-specific plasma in bags A new Fibrinogen product Next generation Immunoglobulin A human growth factor product G- ... high-purity coagulation factor concentrates for patients with bleeding disorders Haemophilia A, B and von Willebrand Disease. ... In the name Octapharma, the "octa" is derived from the Greek word for eight, named after the factor which is deficient in ...
*  Noonan syndrome
C Partial deficiency of Factor XI:C Partial deficiency of Factor XII:C Platelet dysfunction Combined coagulation defects ... Blood clotting disorders Von Willebrand disease Prolonged activated partial thromboplastin time Partial deficiency of Factor ... "Imbalance of plasminogen activator inhibitor type-1 (PAI-1) and tissue plasminogen activator (t-PA) activity in patients with ... impaired blood clotting, and a characteristic configuration of facial features including a webbed neck and a flat nose bridge. ...
*  Hirudin
Fibrin is then cross linked by factor XIII (Fibrin Stabilizing Factor) to form a blood clot. The principal inhibitor of ... Factor Xa along with Factor Va as a cofactor), in the final states of coagulation. ... A key event in the final stages of blood coagulation is the conversion of fibrinogen into fibrin by the serine protease enzyme ... On the action of a secretion obtained from the medicinal leech on the coagulation of the blood. Proc R Soc Lond B 36: 478-487 ...
*  Bleeding time
While warfarin and heparin have their major effects on coagulation factors, an increased bleeding time is sometimes seen with ... A blood pressure cuff is used above the wound, to maintain venous pressure at a specified value. The time it takes for the ... Aspirin and other cyclooxygenase inhibitors can prolong bleeding time significantly. ... certain vascular disorders and von Willebrand Disease-not by other coagulation factors such as haemophilia. Diseases that cause ...
*  Rivaroxaban
Inhibition of Factor Xa interrupts the intrinsic and extrinsic pathway of the blood coagulation cascade, inhibiting both ... It is the first available active direct factor Xa inhibitor which is taken by mouth. The maximum inhibition of factor Xa occurs ... decrease a number of coagulation factors, including Factor X. Rivaroxaban has predictable pharmacokinetics across a wide ... It is a highly selective direct Factor Xa inhibitor with oral bioavailability and rapid onset of action. ...
*  Pharmaceutical drug
... aldosterone inhibitors Coagulation: anticoagulants, heparin, antiplatelet drugs, fibrinolytics, anti-hemophilic factors, ... Affecting blood pressure/(antihypertensive drugs): ACE inhibitors, angiotensin receptor blockers, beta-blockers, α blockers, ... aromatase inhibitors, somatostatin inhibitors, recombinant interleukins, G-CSF, erythropoietin contrast media A euthanaticum is ... mast cell inhibitors Anti-glaucoma: adrenergic agonists, beta-blockers, carbonic anhydrase inhibitors/hyperosmotics, ...
*  Andexanet alfa
March 2013). "A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa". ... is a drug under investigation as a potential antidote for factor Xa inhibitors, a group of anticoagulant (anti-blood clotting) ... The drug does not seem to be effective against the factor IIa inhibitor dabigatran. In rats anticoagulated by enoxaparin and ... In 2015, the first randomized control trial showed that andexanet alfa reversed the effects of factor Xa inhibitor drugs ...
*  Judith Graham Pool
The coagulation of the blood, in vitro synthesis of cagulation factors - The coagulation of the blood, antibody inhibitors of ... Ralph W. Gerard), 1942 - The coagulation of the blood, contribution on assays of coagulation factors - ... Pool's work on blood coagulation resulted in the development of a cold-insoluble protein fraction of blood plasma, ... In 1953, she began to do blood coagulation studies at the Stanford School of Medicine as a research fellow supported by a Bank ...
*  Serpin
... which is able to inhibit trypsin and chymotrypsin as well as several blood coagulation factors. However, close relatives of ... a more effective inhibitor of thrombin and factor Xa. Furthermore, both of these coagulation proteases also contain binding ... Miao RQ, Agata J, Chao L, Chao J (November 2002). "Kallistatin is a new inhibitor of angiogenesis and tumor growth". Blood. 100 ... Han X, Fiehler R, Broze GJ (November 2000). "Characterization of the protein Z-dependent protease inhibitor". Blood. 96 (9): ...
*  Haemophilia A
... activated factor VII has become available as a treatment for haemorrhage in individuals with haemophilia and factor inhibitors ... Joint damage is not a result of blood in the capsule but rather the healing process. When blood in the joint is broken down by ... while digestive tract and cerebral haemorrhages are also germane to other coagulation disorders.Though typically not life- ... One therapeutic conundrum is the development of inhibitor antibodies against factor VIII due to frequent infusions. These ...
*  Antithrombin
The inhibitor also inactivates kallikrein and plasmin[citation needed], also involved in blood coagulation. However it ... Factor XI (XIa), Factor XII (XIIa) and, to a greater extent, Factor II (thrombin) (IIa), and also the activated form of Factor ... Antithrombin IV (AT IV) refers to an antithrombin that becomes activated during and shortly after blood coagulation. Only AT ... Yin ET, Wessler S, Stoll PJ (1971). "Identity of plasma-activated factor X inhibitor with antithrombin 3 and heparin cofactor ...