Blood-ocular barrier - Physical barrier between the local blood vessels and most parts of the eye itself Blood-retinal barrier ... The blood-brain barrier is formed by the brain capillary endothelium and excludes from the brain 100% of large-molecule ... The border zones between brain tissue "behind" the blood-brain barrier and zones "open" to blood signals in certain CVOs ... thus protecting the brain from harmful or unwanted substances in the blood. The blood-brain barrier is formed by endothelial ...
To treat brain tumours and other brain related diseases, blood-brain barrier disruption is needed for the anti-cancer drugs to ... The blood-brain barrier (BBB) is protected by a network of blood vessels and tissue that shields it from harmful substances. ... Blood-brain barrier disruption is the surgical process whereby drugs are used to create openings between cells in the blood- ... Studies have shown that blood-brain barrier disruption can cause diseases in the central nervous system. "Definition of blood- ...
Hladky, S. B., & Barrand, M. A. (2016). Fluid and ion transfer across the blood-brain and blood-cerebrospinal fluid barriers; a ... Pardridge W. M. (2012). Drug transport across the blood-brain barrier. Journal of cerebral blood flow and metabolism : official ... Brain Res 1989;482:57-66. Cohen DM, Patel CB, Ahobila-Vajjula P, et al. Blood-spinal cord barrier permeability in experimental ... The anatomy of the BSCB is very similar to the anatomy of the blood-brain barrier (BBB); however many key differences exist ...
the blood-brain barrier. Though there are many morphological features conserved among caveolae, the functions of each CAV ... The importance of them for the clearance of LDL from blood was discovered by Richard G. Anderson, Michael S. Brown and Joseph L ... which removes LDL from circulating blood), the transferrin receptor (which brings ferric ions bound by transferrin into the ...
Francesca, B.; Rezzani, R. (2010). "Aquaporin and Blood Brain Barrier". Current Neuropharmacology. 8 (2): 92-96. doi:10.2174/ ... 1988). "The Colton blood group locus. A linkage analysis". Transfusion. 28 (5): 435-8. doi:10.1046/j.1537-2995.1988.28588337331 ... Additionally, it is found in red blood cells, vascular endothelium, the gastrointestinal tract, sweat glands, lungs, and the ... "Entrez Gene: AQP1 aquaporin 1 (Colton blood group)". Knepper MA (July 1994). "The aquaporin family of molecular water channels ...
Smith, Quentin R. (April 2000). "Transport of glutamate and other amino acids at the blood-brain barrier". The Journal of ... Hawkins, Richard A. (September 2009). "The blood-brain barrier and glutamate". The American Journal of Clinical Nutrition. 90 ( ... Glutamate does not easily pass the blood brain barrier, but, instead, is transported by a high-affinity transport system. It ... Malignant brain tumors known as glioma or glioblastoma exploit this phenomenon by using glutamate as an energy source, ...
Failure of the blood-brain barrier may also be a causal mechanism as it would allow substances in the blood to enter the brain ... Oby E, Janigro D (November 2006). "The blood-brain barrier and epilepsy". Epilepsia. 47 (11): 1761-74. doi:10.1111/j.1528- ... This may be partly done by imaging the brain and performing blood tests. Epilepsy can often be confirmed with an EEG, but a ... Mild brain injury increases the risk about two-fold while severe brain injury increases the risk seven-fold. In those who have ...
Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier". Cell. Mol. Neurobiol. 20 (1): 57-76. doi:10.1023/A: ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...
Fiori A, Cardelli P, Negri L, Savi MR, Strom R, Erspamer V (August 1997). "Deltorphin transport across the blood-brain barrier ... May 1997). "Structure-activity relationships of a series of [D-Ala2]deltorphin I and II analogues; in vitro blood-brain barrier ... and on account of its unusually high blood-brain-barrier penetration rate, produces centrally-mediated analgesic effects in ...
When the blood-brain barrier has been compromised, albumin-bound Evans blue enters the CNS. Evans blue is pharmacologically ... Evans blue is also used to assess the permeability of the blood-brain barrier to macromolecules. Because serum albumin cannot ... Hawkins BT, Egleton RD (2006). "Fluorescence imaging of blood-brain barrier disruption". Journal of Neuroscience Methods. 151 ( ... Because of this, it can be useful in physiology in estimating the proportion of body water contained in blood plasma. It ...
Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier". Cell. Mol. Neurobiol. 20 (1): 57-76. doi:10.1023/A: ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...
Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier". Cell. Mol. Neurobiol. 20 (1): 57-76. doi:10.1023/A: ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...
"Biousian glycopeptides penetrate the blood-brain barrier". Tetrahedron: Asymmetry. Carbohydrate Science. Part 1. 16 (1): 65-75 ... October 2000). "Improved bioavailability to the brain of glycosylated Met-enkephalin analogs". Brain Research. 881 (1): 37-46. ...
2009 Oct 23;105(9):860-8. What is the blood-brain barrier (not)? Bechmann I, Galea I, Perry VH. Trends Immunol. 2007 Jan;28(1): ... Vascular recruitment in the brain is thought to lead to new capillaries and increase the cerebral blood flow. The existence of ... That insulin can act in this way has been proposed based on increases in limb blood flow and skeletal muscle blood volume which ... Evidence that heterogeneity of cerebral blood flow does not involve vascular recruitment. Williams JL, Shea M, Jones SC. Am J ...
Minagar A, Alexander JS (December 2003). "Blood-brain barrier disruption in multiple sclerosis". Mult Scler. 9 (6): 540-9. doi: ... "Spots" can occur as a result of changes in brain water content.: 113 Evoked potential is an electrical potential recorded from ... and other diseases affecting the brain. It has also been used to study the metabolism of other organs such as muscles.: 309 ... Brain Sci. 3 (4): 1282-324. doi:10.3390/brainsci3031282. PMC 4061877. PMID 24961530. Hochmeister S, Romauch M, Bauer J, Seifert ...
It is expressed primarily in the blood-brain barrier and liver and is thought to be involved in protecting cells from toxins. ... "Challenges for blood-brain barrier (BBB) screening". Xenobiotica. 37 (10-11): 1135-51. doi:10.1080/00498250701570285. PMID ...
Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier". Cell. Mol. Neurobiol. 20 (1): 57-76. doi:10.1023/A: ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ... and tissue-barrier function. It forms anion-selective paracellular channels and is localized mainly in kidney proximal tubules ... Tissue Barriers. 9 (1): 1848212. doi:10.1080/21688370.2020.1848212. PMC 7849786. PMID 33300427. Krug SM, Günzel D, Conrad MP, ...
Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier". Cell. Mol. Neurobiol. 20 (1): 57-76. doi:10.1023/A: ... Sticky cells, blood vessels and cancer - the paradox of Claudin-14 - Marianne Baker, Cancer Research UK Science Update blog, 14 ... Tight junctions form continuous seals around cells and serve as a physical barrier to prevent solutes and water from passing ... There are also suggestions that CLDN14 plays a role in tumour angiogenesis (blood vessel formation), as deletion of a single ...
Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier". Cell. Mol. Neurobiol. 20 (1): 57-76. doi:10.1023/A: ... "Paracellular tightness and claudin-5 expression is increased in the BCEC/astrocyte blood-brain barrier model by increasing ... Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular ... Tsukita S, Furuse M (2002). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...
... s have an unusually high blood-brain barrier penetration rate. The nonselective opiate antagonist naloxone inhibits ... "Deltorphin transport across the blood-brain barrier". Proceedings of the National Academy of Sciences of the United States of ... deltorphin uptake by brain microvessels, but neither the selective δ-opioid antagonist naltrindole nor a number of opioid ...
Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier". Cell. Mol. Neurobiol. 20 (1): 57-76. doi:10.1023/A: ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...
Poor penetration through the blood-brain barrier. Because of numerous adverse effect and limitations in use, new drugs with ... Some were found to have effect on lower blood sugar levels and others act as hemostatics. The most interesting thing was that ... A high number of white cells in the blood indicates leukemia, so a new anti-cancer drug had been discovered. These two ... It is known that some compounds can inhibit the formation of new blood vessels (inhibit the process of angiogenesis) or shut ...
Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier". Cell. Mol. Neurobiol. 20 (1): 57-76. doi:10.1023/A: ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ... "A claudin-9-based ion permeability barrier is essential for hearing". PLOS Genetics. 5 (8): e1000610. doi:10.1371/journal.pgen. ...
Over the last decade, S100B has emerged as a candidate peripheral biomarker of blood-brain barrier (BBB) permeability and CNS ... Marchi N, Cavaglia M, Fazio V, Bhudia S, Hallene K, Janigro D (April 2004). "Peripheral markers of blood-brain barrier damage ... Czeisler BM, Janigro D (June 2006). "Reading and writing the blood-brain barrier: relevance to therapeutics". Recent Patents on ... "Seizure-promoting effect of blood-brain barrier disruption". Epilepsia. 48 (4): 732-42. doi:10.1111/j.1528-1167.2007.00988.x. ...
Geldenhuys WJ, Mohammad AS, Adkins CE, Lockman PR (2015). "Molecular determinants of blood-brain barrier permeation". ... "Selective expression of the large neutral amino acid transporter at the blood-brain barrier". Proceedings of the National ...
It is thought that HIV uses a "Trojan horse" mechanism to enter the brain. Normally, the blood-brain barrier (BBB) serves as a ... Berger JR, Avison M (September 2004). "The blood brain barrier in HIV infection". Frontiers in Bioscience. 9 (1-3): 2680-5. doi ... further compromising the blood-brain barrier. The toxicity spreads through a gap junction-dependent mechanism. HIV is ... "Human immunodeficiency virus infection of human astrocytes disrupts blood-brain barrier integrity by a gap junction-dependent ...
Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier". Cell. Mol. Neurobiol. 20 (1): 57-76. doi:10.1023/A: ... Tsukita S, Furuse M (2002). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ... forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely ...
Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier". Cell. Mol. Neurobiol. 20 (1): 57-76. doi:10.1023/A: ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...
... some nanoparticles are able to bypass the Blood Brain Barrier to deliver therapeutic drugs to the brain. Nanoparticles have ... Zhou, Yiqun; Peng, Zhili; Seven, Elif S.; Leblanc, Roger M. (2018-01-28). "Crossing the blood-brain barrier with nanoparticles ... They could play an important role in blood vessel cleanup. Theoretically, nanotubes with SHP1i molecules attached to them would ... signal macrophages to clean up plaque in blood vessels without destroying any healthy tissue. Researchers have tested this type ...
Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier". Cell. Mol. Neurobiol. 20 (1): 57-76. doi:10.1023/A: ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...