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*  Primary and secondary brain injury
The blood brain barrier and meninges may be damaged in the primary injury, and neurons may die. Cells are killed in a ... low blood pressure); cerebral edema (swelling of the brain); changes in the blood flow to the brain; and raised intracranial ... Other factors in secondary damage are breakdown of the blood-brain barrier, edema, ischemia and hypoxia. Ischemia is one of the ... Primary and secondary brain injury are ways to classify the injury processes that occur in brain injury. In traumatic brain ...
*  Domperidone
... it blocks peripheral D2 receptors but does not cross the blood-brain barrier in normal doses (the barrier between the blood ... Furthermore, anti-nausea drugs, such as metoclopramide, which do cross the blood-brain barrier may worsen the extra-pyramidal ... it minimally crosses the blood-brain-barrier, and for this reason, is rarely associated with such side effects. Due to D2 ... malignant syndrome as a side effect of domperidone due to the drug crossing the child's immature blood-brain-barrier. ...
*  Nanoparticles for drug delivery to the brain
... is a method for transporting drug molecules across the blood-brain barrier (BBB) ... Hwang, Seung Rim; Kim, Kwangmeyung (2013). "Nano-enabled delivery systems across the blood-brain barrier". Archives of ... doi: 10.2217/nnm.15.52 Shityakov, Sergey; Salvador, Ellaine; Pastorin, Giorgia; Förster, Carola (2015). "Blood-brain barrier ... Lo EH, Singhal AB, Torchilin VP, Abbott NJ (2001). "Drug delivery to damaged brain". Brain Res. Brain Res. Rev. 38 (1-2): 140-8 ...
*  CP-615,003
... poor blood-brain barrier penetration make it primarily useful as a research ligand. Shaffer CL, Gunduz M, O'Connell TN, Obach ...
*  Nanoparticle-biomolecule conjugate
The blood-brain barrier (BBB) is composed of a system of capillaries that has an especially dense lining of endothelial cells ... "Nanotechnology approaches to crossing the blood-brain barrier and drug delivery to the CNS." BMC NeuroScience. N.p., n.d. Web. ... Raghnaill, Michelee; Meredith Brown; Dong Ye (April 2011). "Internal benchmarking of a human blood-brain barrier cell model for ... Nanotechnology is helpful in delivering drugs and other molecules across the blood-brain barrier (BBB). Nanoparticles allow ...
*  Blood-brain barrier
Blood-air barrier Blood-ocular barrier Blood-retinal barrier Blood-testis barrier Blood-thymus barrier Choroid plexus for blood ... A few regions in the brain, including the circumventricular organs, do not have a blood-brain barrier. The blood-brain barrier ... "History of Blood-Brain Barrier". Davis Lab. Retrieved 5 January 2015. "History of Blood-Brain Barrier". The Davis Lab. ... MS is a disease of the blood-brain barrier. The weakening of the blood-brain barrier may be a result of a disturbance in the ...
*  Epileptic seizure
Failure of the blood-brain barrier may also be a causal mechanism. Focal seizures begin in one hemisphere of the brain while ... low blood sodium, hyperosmolar nonketotic hyperglycemia, high blood sodium, low blood calcium and high blood urea levels may ... Oby, E; Janigro, D (Nov 2006). "The blood-brain barrier and epilepsy". Epilepsia. 47 (11): 1761-74. doi:10.1111/j.1528- ... Normally brain electrical activity is non synchronous. In epileptic seizures, due to problems within the brain, a group of ...
*  Glutamic acid
Smith, Quentin R. (April 2000). "Transport of glutamate and other amino acids at the blood-brain barrier". The Journal of ... Hawkins, Richard A. (September 2009). "The blood-brain barrier and glutamate". The American Journal of Clinical Nutrition. ... Glutamate does not easily pass the blood brain barrier, but, instead, is transported by a high-affinity transport system. It ... Malignant brain tumors known as glioma or glioblastoma exploit this phenomenon by using glutamate as an energy source, ...
*  John Frank (epidemiologist)
Bilirubin beyond the blood-brain barrier. Pediatrics 1988; 81:304-15. 17. Frank JW. Causation revisited (Editorial). Journal of ... Occult blood screening for colorectal carcinoma: 3. Yield and costs. American Journal of Preventive Medicine 1985; 1(5):18-24. ... Occult blood screening for colorectal carcinoma: 1. The benefits. American Journal of Preventive Medicine 1985; 1(3):3-9. 6. ... Occult blood screening for colorectal carcinoma: 2. The risks. American Journal of Preventive Medicine 1985; 1(5):25-32. 7. ...
*  CLDN12
Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier". Cell. Mol. Neurobiol. 20 (1): 57-76. doi:10.1023/A: ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...
*  Deltorphin I
Fiori A, Cardelli P, Negri L, Savi MR, Strom R, Erspamer V (August 1997). "Deltorphin transport across the blood-brain barrier ... May 1997). "Structure-activity relationships of a series of [D-Ala2]deltorphin I and II analogues; in vitro blood-brain barrier ... and on account of its unusually high blood-brain-barrier penetration rate, produces centrally-mediated analgesic effects in ...
*  Glycosidic bond
"Biousian glycopeptides penetrate the blood-brain barrier". Tetrahedron: Asymmetry. Carbohydrate Science. Part 1. 16 (1): 65-75 ... "Improved bioavailability to the brain of glycosylated Met-enkephalin analogs". Brain Research. 881 (1): 37-46. doi:10.1016/ ...
*  Mobile phone radiation and health
Stam R (2010). "Electromagnetic fields and the blood-brain barrier". Brain Res Rev (Review). 65 (1): 80-97. doi:10.1016/j. ... does not support the hypothesis that mobile phone radiation has an effect on the permeability of the blood-brain barrier. ... with the permittivity of the brain decreasing as one gets older and the higher relative volume of the exposed growing brain in ... Mobile phone use does not increase the risk of getting brain cancer or other head tumors. As the United States National Cancer ...
*  Vascular recruitment
2009 Oct 23;105(9):860-8. What is the blood-brain barrier (not)? Bechmann I, Galea I, Perry VH. Trends Immunol. 2007 Jan;28(1): ... Vascular recruitment in the brain is thought to lead to new capillaries and increase the cerebral blood flow. The existence of ... That insulin can act in this way has been proposed based on increases in limb blood flow and skeletal muscle blood volume which ... Evidence that heterogeneity of cerebral blood flow does not involve vascular recruitment. Williams JL, Shea M, Jones SC. Am J ...
*  Demyelinating disease
"Blood-Brain Barrier Disruption in Multiple Sclerosis". Sage Journals. Retrieved October 28, 2012. Abbott R, Silber E, Felber J ... "Spots" can occur as a result of changes in brain water content. Evoked potential is an electrical potential recorded from the ... deep brain thalamic stimulation (in the case of tremors). The progressive phase of MS appears driven by the innate immune ... depression and other diseases affecting the brain. It has also been used to study the metabolism of other organs such as ...
*  ATP-binding cassette transporter
It is expressed primarily in the blood brain barrier and liver and is thought to be involved in protecting cells from toxins. ... "Challenges for blood-brain barrier (BBB) screening". Xenobiotica. 37 (10-11): 1135-51. doi:10.1080/00498250701570285. PMID ...
*  CLDN14
Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier". Cell. Mol. Neurobiol. 20 (1): 57-76. doi:10.1023/A: ... Sticky cells, blood vessels and cancer - the paradox of Claudin-14 - Marianne Baker, Cancer Research UK Science Update blog, 14 ... Tight junctions form continuous seals around cells and serve as a physical barrier to prevent solutes and water from passing ... There are also suggestions that CLDN14 plays a role in tumour angiogenesis (blood vessel formation), as deletion of a single ...
*  CLDN5
Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier". Cell. Mol. Neurobiol. 20 (1): 57-76. doi:10.1023/A: ... "Paracellular tightness and claudin-5 expression is increased in the BCEC/astrocyte blood-brain barrier model by increasing ... Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular ... Tsukita S, Furuse M (2002). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...
*  Discovery and development of tubulin inhibitors
Poor penetration through the blood-brain barrier. Because of numerous adverse effect and limitations in use, new drugs with ... From the patient, therapy is limited by poor absorption of a drug what lead to low concentration of active agent in the blood ... Some were found to have effect on lower blood sugar levels and others act as hemostatics. The most interesting thing was that ... A high number of white cells in the blood indicates leukemia, so a new anti-cancer drug had been discovered. These two ...
*  S100B
Over the last decade, S100B has emerged as a candidate peripheral biomarker of blood-brain barrier (BBB) permeability and CNS ... Marchi N, Cavaglia M, Fazio V, Bhudia S, Hallene K, Janigro D (April 2004). "Peripheral markers of blood-brain barrier damage ... Czeisler BM, Janigro D (June 2006). "Reading and writing the blood-brain barrier: relevance to therapeutics". Recent patents on ... "Seizure-promoting effect of blood-brain barrier disruption". Epilepsia. 48 (4): 732-42. doi:10.1111/j.1528-1167.2007.00988.x. ...
*  CLDN1
Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier". Cell. Mol. Neurobiol. 20 (1): 57-76. doi:10.1023/A: ... Tsukita S, Furuse M (2002). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ... forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely ...
*  CLDN10
Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier". Cell. Mol. Neurobiol. 20 (1): 57-76. doi:10.1023/A: ... Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...
*  Zafirlukast
In vivo research indicates that zafirlukast has low blood-brain barrier penetration. The blood-brain barrier is a protective ... "The Blood-Brain Barrier in Neuroinflammatory Diseases". Pharmacological Reviews. 49 (2): 143-156. ISSN 0031-6997. Retrieved 7 ... The peak plasma level is the maximum concentration of zafirlukast in the blood. Zafirlukast is moderately distributed into the ... white blood cells that operate in the interstitial space of the lungs), and rarely in epithelial cells. CystLT1 is a receptor ...
*  Flunarizine
It readily passes the blood-brain barrier. When given daily, a steady state is reached after five to eight weeks. ... Concentrations in the brain are about ten times higher than in the plasma. The substance is metabolised in the liver, mainly by ... Flunarizine is well absorbed (>80%) from the gut and reaches maximal blood plasma concentrations after two to four hours, with ...
*  Abacavir
... can cross the blood-brain barrier. Abacavir is metabolized primarily through the enzymes alcohol dehydrogenase and ...
*  Avid Radiopharmaceuticals
... would cross the blood-brain barrier and attach itself to amyloid protein deposits in the brain. Avid raised $500,000 from ... Of the patients included in the study, 29 who died had autopsies performed on their brains and in all but one the brain autopsy ... magnetic resonance imaging scans looking for brain shrinkage and PET scans looking at how glucose was used in the brain, had ... In 2002, a study performed in Sweden on Alzheimer's patients was able to detect the plaque in PET brain scans. Later studies on ...
*  CLDN19
Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier". Cell. Mol. Neurobiol. 20 (1): 57-76. doi:10.1023/A: ... Tight junctions form barriers that control the passage of ions and molecules across an epithelial sheet and the movement of ... Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): ...