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*  Bicuculline
Sensitivity to bicuculline is defined by IUPHAR as a major criterion in the definition of GABAA receptors Picrotoxin Manske, R ... The action of bicuculline is primarily on the ionotropic GABAA receptors, which are ligand-gated ion channels concerned chiefly ... Bicuculline is a phthalide-isoquinoline compound that is a light-sensitive competitive antagonist of GABAA receptors. It was ... The half-maximal inhibitory concentration (IC50) of bicuculline on GABAA receptors is 3 μM. In addition to being a potent GABAA ...
*  GABAA receptor
... and bicuculline. The protein also contains a number of different allosteric binding sites which modulate the activity of the ... bicuculline, gabazine. Positive allosteric modulators: barbiturates, benzodiazepines, certain carbamates (ex. carisoprodol, ...
*  SK channel
All SK channels can be pharmacologically blocked by quaternary ammonium salts of a plant-derived neurotoxin bicuculline. In ... Quaternary ammonium salts like bicuculline and tetraethylammonium (TEA) enter the pore via the selectivity filter by acting as ... Khawaled R, Bruening-Wright A, Adelman JP, Maylie J (1999). "Bicuculline block of small-conductance calcium-activated potassium ... Lei-Dab7 N-methyl-laudanosine N-Me-bicuculline Pancuronium Atracurium 1-ethyl-1H-benzo[d]imidazol-2(3H)-on 6,7-dichloro-3-( ...
*  Pitrazepin
Bicuculline Strychnine Gähwiler BH, Maurer R, Wüthrich HJ (April 1984). "Pitrazepin, a novel GABAA antagonist". Neuroscience ...
*  GABA receptor
It has long been recognized that the fast response of neurons to GABA that is blocked by bicuculline and picrotoxin is due to ... ISBN 3-456-00390-0. Hill DR, Bowery NG (March 1981). "3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABA B sites in ... This ability of GABA to inhibit neurotransmitter release from these preparations was not blocked by bicuculline, was not ... Takeuchi A, Onodera K (March 1972). "Effect of bicuculline on the GABA receptor of the crayfish neuromuscular junction". Nature ...
*  Convulsant
Advantages of an antagonist: bicuculline and other GABA antagonists. British Journal of Pharmacology. 2013 May;169(2):328-36. ... GABAA receptor antagonists, inverse agonists or negative allosteric modulators Bemegride Bicuculline Cicutoxin Cyclothiazide ... Thujone GABA synthesis inhibitors 3-Mercaptopropionic acid Allylglycine Glycine receptor antagonists Bicuculline Brucine ...
*  Synaptic pharmacology
Ueno S, Bracamontes J, Zorumski C, Weiss DS, Steinbach JH (15 January 1997). "Bicuculline and gabazine are allosteric ...
*  Gabazine
Behrens, CJ; Van Den Boom, LP; Heinemann, U (2007). "Effects of the GABA(A) receptor antagonists bicuculline and gabazine on ... Ueno, S; Bracamontes, J; Zorumski, C; Weiss, DS; Steinbach, JH (1997). "Bicuculline and gabazine are allosteric inhibitors of ...
*  GABAA-rho receptor
Drew CA, Johnston GA, Weatherby RP (December 1984). "Bicuculline-insensitive GABA receptors: studies on the binding of (−)- ... not sensitive to the GABAB agonist baclofen nor the GABAA receptor antagonist bicuculline; not modulated by many GABAA receptor ... gamma-Aminobutyric acid rho 1 receptor RNA induces bicuculline-, barbiturate-, and benzodiazepine-insensitive gamma- ...
*  GABA receptor antagonist
Examples include bicuculline, securinine and metrazol, and the benzodiazepine GABAA receptor antagonist flumazenil. Also ...
*  Muscimol
Woodward, RM; Polenzani, L; Miledi, R (1993). "Characterization of bicuculline/baclofen-insensitive (rho-like) gamma- ...
*  Gamma-Aminobutyric acid
Antagonists/negative allosteric modulators: bicuculline, cicutoxin, flumazenil, furosemide, gabazine, oenanthotoxin, picrotoxin ...
*  Glycine
... whereas bicuculline is a weak one. Glycine is a required co-agonist along with glutamate for NMDA receptors. In contrast to the ...
*  Norman Bowery
Hill, DR; Bowery, NG (12 March 1981). "3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABA B sites in rat brain". ...
*  Alcoholism
"The pentylenetetrazol-like interoceptive stimulus produced by ethanol withdrawal is potentiated by bicuculline and picrotoxinin ...
*  Glycine receptor antagonist
Selective Brucine Strychnine Tutin Non-selective Bicuculline Caffeine Picrotoxin Pitrazepin Thiocolchicoside Glycine receptor ...
*  GABA analogue
GABA-T inhibitor Bamaluzole Bicuculline Deramciclane Ethanol Fengabine Gabapentinoid Loreclezole Propofol Retigabine/ezogabine ...
*  ROD-188
Unlike bicuculline, ROD-188 acts as an agonist at GABAA receptors, being a positive allosteric modulator acting at a novel ... Bicuculline US Patent 6649626 N-substituted 1-(lactone) isoquinolones for treating nervous disorders Thomet U, Baur R, Razet R ... ROD-188 is a sedative drug that was structurally derived from the GABAA antagonist bicuculline by a team at Roche. ...
*  Polybia occidentalis
When tested in mice, denatured venom from P. occidentalis inhibited convulsions during seizures induced by bicuculline, ...
*  Turaga Desiraju
... bicuculline, and picrotoxin". Physiol Behav. 61 (3): 411-418. PMID 9089760. CS1 maint: Multiple names: authors list (link) ...
*  Erythravine
... inhibited seizures evoked by bicuculline, pentylenetetrazole, and kainic acid as well as increasing the latency of ...
*  Fumarioideae
There are 20 genera: Bicuculline, a toxin found in plans of this subfamily Fumariaceae, Hypecoaceae in L. Watson and M.J. ...
*  Cajal-Retzius cell
these sPSCs were reversibly blocked by bicuculline, a light-sensitive competitive antagonist of GABA-A receptors, suggesting ...
*  Nicolas Bazan
Stimulation of free fatty acid and diacylglycerol accumulation in cerebrum and cerebellum during bicuculline induced status ... Enhanced inositide turnover in brain during bicuculline induced status epilepticus. Biochim Biophys Res Comm 136:827-834, 1986 ...
*  Fengabine
... but its antidepressant effects are reversed by GABAA receptor antagonists like bicuculline and it has hence been labeled as ...